鐘大放，中國科學院上海藥物研究所研究員。
基本介紹
- 中文名：鐘大放
- 國籍：中國
- 民族：漢
- 畢業院校：瀋陽藥學院
- 性別：男
- 政治面貌：民眾
人物生平,代表論著,
人物生平
1982 年畢業於瀋陽藥學院化學製藥專業，
1985 年獲藥物分析專業碩士學位，
1989 年在聯邦德國波恩大學獲藥物化學專業博士學位，其後在德國藥師中心實驗室 從事 博士後研究。
1994 年 7 月回國，歷任瀋陽藥科大學教授、博士生導師、藥物代謝與藥物動力學實驗室主任。
1996 年獲國家傑出青年科學基金。
2005 年 6 月起任中國科學院上海藥物研究所研究員、藥物代謝研究中心主任。
承擔科研項目情況： |
曾主持國家自然科學基金重點項目和國家“863”項目等課題，為國內製藥企業完成新藥代謝和藥動學臨床前研究 20 餘項，為國內外製藥企業完成藥物動力學和製劑生物等效性試驗300餘項。現承擔科研課題有國家自然科學基金、國家 863 課題、上海市科委研發公共服務平台“上海藥物代謝研究中心”建設項目，以及為國內外製藥企業和研究院所提供藥物代謝研究技術服務。 |
代表論著
Liu J, Chen XY, Liu K, Li L, Zhong DF*. Derivatization of (5R)-hydroxytriptolide with benzylamine to enhance mass spectrometric detection: Application to a Phase I pharmacokinetic studie. Analytica Chimica Acta, 2011, 689: 69-76
Li L, Chen XY, Li D, Zhong DF*. Identification of 20(S)-protopanaxadiol metabolites in human liver microsomes and human hepatocytes. Drug Metabolism and Disposition, 2011, 39: 472-483
Deng P, You TG, Chen XY, Yuan T, Huang HH, Zhong DF*. Identification of amiodarone metabolites in human bile by ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry. Drug Metabolism and Disposition, 2011, 39: 1058-1069
Gao CY, Chen XY, Zhong DF*. Absorption and disposition of scutellarin in rats: a pharmacokinetic explanation for the high exposure of its isomeric metabolite. Drug Metabolism and Disposition, 2011, 39: 2034-2044
Zhong DF. Bioanalysis in China. Bioanalysis, 2010, 2: 153-156
Gong Aishen, Chen XY, Deng P, Zhong DF*. Metabolism of flumatinib, a novel antineoplastic tyrosine kinase inhibitor, in chronic myelogenous leukemia patients. Drug Metabolism and Disposition, 2010, 38: 1328-1340
Tan B, Zhang YF, Chen XY, Zhao XH, Li GX, Zhong DF*. The effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of glipizide in Chinese subjects. European Journal of Clinical Pharmacology, 2010, 66: 145-151
Liu J, Chen XY, Hu YH, Cheng G, Zhong DF*. Quantification of the major metabolites of bromhexine in human plasma using RRLC-MS/MS and its application to pharmacokinetics. Journal of Pharmaceutical and Biochemical Analysis, 2010, 51: 1134-1141
Deng P, Chen XY, Zhang GD, Zhong DF*. Bioanalysis of an oligonucleotide and its metabolites by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biochemical Analysis, 2010, 52: 571-579
Deng P, Chen XY, Zhong DF*. Quantification of polar drugs in human plasma with LC-MS/MS. Bioanalysis, 2009, 1: 187-203
Liu J, Duan XT, Chen XY, Zhong DF*. Determination of eptifibatide concentration in human plasma utilizing the liquid chromatography–tandem mass spectrometry method. Journal of Chromatography B, 2009, 877: 527-532
Zhan Y, Chen XY, Zhao XH, Zhong DF*. Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the determination of leuprolide in human serum. Journal of Chromatography B, 2009, 877: 3194-3200
Meng J, Zhao LZ, Hu YH, Chen XY, Zhong DF*. Synthesis of [3-3H]20(S)-protopanaxadiol. Journal of Labelled Compounds and Radiopharmaceuticals, 2009, 52: 482-484
Wang YY, Chen XY, Li Q, Zhong DF*. Metabolite identification of arbidol in human urine by the study of CID fragmentation pathways using HPLC coupled with ion trap mass spectrometry. Journal of Mass Spectrometry, 2008, 43: 1099-1109
Wang YY, Chen XY, Li Q, Zhong DF*. Characterization of metabolites of a novel histamine H2-receptor antagonist, lafutidine, in human liver microsomes by liquid chromatography coupled with ion trap mass spectrometry. Rapid Communications in Mass Spectrometry, 2008, 22: 1843-1852
Guan ZM, Chen XY, Wang YX, Zhong DF*. Metabolite identification of a new antitumor agent icotinib in rats using liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2008, 22: 2176-2184
Zhang YF, Si DY, Chen XY, Lin N, Guo YJ, Zhou H, Zhong DF*. Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics of gliclazide MR in Chinese subjects. British Journal of Clinical Pharmacology, 2007, 64: 67-74
Li XY, Chen XY, Zhong DF*. Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 2007, 852: 128-137
Duan XT, Chen XY, Yang YM, Zhong DF*. Precolumn derivatization of cysteine residues for quantitative analysis of five major cytochrome P450 isoenzymes by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2007, 21: 3234-3244
Huang HH, Yang XW, Li Qiang, Sun L, Zhong DF*. Biotransformation of tolbutamide to 4’-tolbutamide by the fungus Cunninghamella blakesleeana. Applied Microbiology and Biotechnology, 2006, 72: 486-491
