基本介紹
人物生平,研究方向,主要成就,獲得榮譽,研究成果,學術論文,
人物生平
1978.9——1982.7,華東化工學院(現華東理工大學)石油化工系學習,獲學士學位;
1982.9——1985.4,華東化工學院(現華東理工大學)精細化工系學習, 獲碩士學位;
1988.7,獲華東理工大學工學博士學位;
1990.9——1991.12,德國巴伐利亞州維爾茲堡大學洪堡基金(AvH)博士後,從事DNA嵌入劑、切斷荊的研究;
1988——1992.4,華東理工大學講師;
1992.8——1994.7,副教授;
1994.8至今,教授;
1995.12至今,博士生導師;
1986——1987,華東理工大學精細化工系黨總支副書記;
1992.8——1995.4,先後任華東理工大學精細化工學科主任、藥物化工研究所所長;
1995.5——1995.7,國家高級教育行政學院學員;
1995.9——1996.2,華東理工大學校長助理;
1996.3——2000.10,華東理工大學副校長;
2000.9——2004.6,大連理工大學教育部長江學者獎勵計畫特聘教授;
2002.1——2010.1,上海市化學生物學重點實驗室主任(兼);
2003.3——2006,國家南方農藥創製中心(上海)主任(兼);
2004.7——2015.3,華東理工大學校長;
2007.4——,中國化工學會副理事長;
2007——2008,亞洲及太平洋化工聯盟主席;
2011.12,當選中國工程院院士(化工、冶金與材料工程學部);
2018.1——,華東師範大學校長、黨委委員、常委、黨委副書記。
研究方向
錢旭紅主要研究方向,包括:是生物有機化學,化學生物技術與工程,其研究工作主要體現在用作農藥先導、螢光感測器、抗癌先導、人工核酸酶、細胞激活劑的芳香雜環分子設計、合成、構效關係及生物套用。具體研究方向:
研究方向1.染料的化學生物學
其研究主要體現在螢光感測器與抗癌先導,包括以下內容:
螢光感測器:由萘,萘醯亞胺,香豆素,氟硼吡咯,聚合物衍生的高選擇性汞離子銅離子鋅離子銀離子螢光感測器,某些陰離子螢光感測器,以及其它的螢光探針,螢光標記。
抗癌先導:由硫化合物,噻類芳香雜環,羰醯亞胺,萘醯亞胺,萘內醯胺、苯並吲哚酚嗪,吖啶,苊萘醌,苊萘吡咯羰腈,酞菁等衍生的抗癌試劑,BCL蛋白與細胞調亡劑,拓撲異構酶抑制劑、光動力治療劑,色素的藥物化學(抗腫瘤先導、DNA嵌入劑、細胞調亡劑)
研究方向2.農藥的化學與生物學
其研究主要體現在芳香雜環或氟化合物衍生的農藥先導,包括以下內容:
農藥先導:昆蟲生長調節劑、昆蟲行為調節劑、幾丁質合成抑制、蛻皮激動、飛行調控、海藻糖酶抑制,拒食,尼古丁受體激動,殺蟲劑,除草劑,殺菌劑。
新雜環化合物:氟化合物,氟烷氧基化合物,芳香雜環,硫化合物,惡二唑、噻二唑、噠嗪酮、新菸鹼、環亞胺、二芳醯基肼
研究方向3. 化學生物技術與工程
其研究主要體現在人工核酸酶,細胞激活劑和生物轉化,包括以下方面:
人工核酸酶:由萘醯亞胺、硫雜環衍生的人工光核酸酶,光降解,人工核酸水解酶,DNA切斷劑,生物製備過程中轉基因物質的去除。
細胞激活劑:由茉莉酮酸酯、苯並噻二唑等衍生的細胞激活劑,用於人參、紫杉烷、靈芝的次生代謝物的增產與調控。
生物轉化:酵母,植物細胞,立體選擇性還原,化學選擇性還原,芴,芳香硝基、胺、羥胺、酮還原、手性醇。
主要成就
獲得榮譽
1992 霍英東基金會高校優秀青年教師獎(科研類);
1995 全國優秀教師;
1996 國務院政府特殊津貼;
1997 入選國家百千萬人才工程(第一、二層次);
1998 中國青年科技獎;
1999 第六屆上海十大科技精英;
1994 國家教委科技進步一等獎(第二完成人);
1998 上海市科技進步三等獎(第一完成人);
1998 國家教育部科技進步一等獎(第一完成人);
2002 國家教育部科技進步一等獎(第一完成人);
2003 國家教育部自然科學一等獎(第一完成人)。
2000 國家傑出青年科學基金獲得者;
2001 大連市優秀專家;
2001- 中國化工學會農藥委員會副主任委員。J. Fluorine Chemistry,Pesticide Biochemistry and Physiology等編委,在ChemCommun.,Org.Lett.,JACS等 SCI 國際學報發表論文近百十篇。專利十數項。此外,
2003- 國務院學位委員會學科評議組成員;
2004- 國家自然科學基金委員會第十屆有機化學評議組成員,第十一屆化工評議組成員。
2007. 3- 亞洲及太平洋化工聯盟主席。
2011 中國工程院院士
研究成果
上地幔變形作用和地球化學性質之間的關係及其深部動力學意義。運用綜合研究方法,探討了伊通新生代玄武岩中特有的具糜棱結構的橄欖岩包體所經歷的構造熱演化及動力學,證實了上地幔韌性剪下帶的存在。強調其形成與超大斷裂活動性之間的關係;並首次發現了橄欖岩包體中礦物顆粒間的氧同位素不平衡現象,為地幔剪下變形和地幔交代作用提供了時間約束,認為流體的存在並不是剪下變形的先決條件,從而為地幔學術界長期爭論的流體和地幔變形之間的因果關係提供了新的判別依據。根據吉林汪清尖晶石相橄欖岩包體結構、平衡溫度、主元素虧損程度和不相容元素富集程度之間的相關關係,提出了上地幔底辟上升和熱擴散平衡的動力學模式,闡明了不同結構類型包體在底辟體中的空間展布及其對交代流體遷移的控制。認為所有研究樣品均來自岩石圈地幔,但由於下伏軟流圈的上涌而導致其流變學性質的改變,從而同軟流圈一起發生底辟。這一成果為華北自中生代以來發生的大規模熱侵蝕-減薄機制提供了一個可行的動力學模式。
上地幔熔體-岩石反應機理及其微量元素理論模擬通過對伊通含富鉀矽酸鹽玻璃體的異剝橄欖岩和法國中央高原具鑲嵌結構I型尖晶石相方輝橄欖岩包體的研究,橄欖岩包體的研究,鑑定出了單斜輝石生成反應和橄欖石生成反應兩個系列。這是對構造橄欖岩體研究的重要補充,對地幔不均一性及岩漿源區混合作用的研究具有重要意義。後者還提供了岩石圈最底部-地幔熱柱相互作用的證據。運用0-維數值模型計算了微量元素在上地幔熔體遷移/反應過程中地球化學行為。該成果對認識熔體/流體在深部岩石圈地幔演化過程中的作用具有重要意義。
地幔地質溫壓計的檢測,套用和中國東部地幔岩石圈熱演化系統總結和科學評價了常用的二十多種溫度計和五種壓力計的優缺點,為國內學者更加審慎地選用溫壓計提供了依據,在此基礎上,探討了中國東部上地幔熱結構和熱演化歷史。以在特定熱演化階段中古老岩石圈/軟流圈相互作用程度為思路,結合實驗岩石學資料和岩石圈拉張歷史,提出了一個熱-構造演化模式,從而比較合理地解釋了中國東部中生代末期-新生代玄武岩的岩性,微量元素和同位素地球化學演化特徵,為深部地幔研究提供了新思路。
中國東部幔源橄欖岩的鉑族元素地球化學研究在國內率先開展了中國東部幔源橄欖岩的PGE地球化學研究,填補了中國在地幔岩PGE研究領域的空白。初步了解了不同類型岩石中這些元素的豐度和分布規律,揭示了中國東部上地幔特有的PGE分配型式(即富集Pt,虧損Ir和Pd)。探討了PGE在多種重要上地幔過程中的地球化學行為。
學術論文
研究方向1.染料的化學生物學
ORG. LETT.-2006-3721: A series of polyamide receptor based PET fluorescent sensor molecules: Positively cooperative Hg2+ ion binding with high sensitivity
ORG. LETT. 2005-3029: Colorimetric and ratiometric fluorescent chemosensor with a large red-shift in emission: Cu(Ⅱ)-only sensing by deprotonation of secondary amines as receptor conjugated to naphthalimide fluorophore
ORG. LETT.-2005-889: Ratiometric and selective fluorescent sensor for Cu-Ⅱ based on internal charge transfer (ICT)
ORG. LETT. 2004-2757: Novel fluorescent pH sensors based on intramolecular hydrogen bonding ability of naphthalimide (SS)
J. ORG. CHEM.-2006-4308: Detecting Hg2+ ions with an ICT fluorescent sensor molecule: Remarkable emission spectra shift and unique selectivity
J. ORG. CHEM.-2007-3554: Ratiometric and highly selective fluorescent sensor for cadmium under physiological pH range: A new strategy to discriminate cadmium from zinc
CHEM. COMMUN.-2006-109: Two regioisomeric and exclusively selective Hg(Ⅱ) sensor molecules composed of a naphthalimide fluorophore and an o-phenylenediamine derived triamide receptor
CHEM. COMMUN.-2005-239: A new class of long-wavelength fluorophores: strong red fluorescence,convenient synthesis and easy derivation
CHEM. COMMUN.-2001-2656: Intramolecular aromatic 1,5-hydrogen transfer in preparation of oxacyclic naphthalic anhydride via unusual Pschorr cyclisation
NEW J. CHEM.-2003-337: A polyamidoamine dendrimer with peripheral 1,8-naphthalimide groups capable of acting as a PET fluorescent sensor for metal cations
NEW J. CHEM.-2002-920: Novel heterogeneous PET fluorescent sensors selective for transition metal ions or protons: polymers regularly labelled with naphthalimide
J. AM. CHEM. SOC.-2004-2272: A highly selective and sensitive fluorescent chemosensor for Hg2+ in neutral buffer aqueous solution
KIDNEY INTERNATIONAL-2004-2279: Fluorescent imaging of acute mercuric chloride exposure on cultured human kidney tubular epithelial cells
CHEM. RES. TOⅪC.-2005-1814: Visible study of mercuric ion and its conjugate in living cells of mammals and plants
CHEMBIOCHEM-2007-113: Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents (SS)
J. MATER. CHEM. -2005-2836: A pH-resistant Zn(Ⅱ) sensor derived from 4-aminonaphthalimide: design,synthesis and intracellular applications
MOL. CANCER THER.-2007-484: R16,a novel amonafide analogue,induces apoptosis and G2-M arrest via poisoning topoisomerase Ⅱ (SS)
BIOORG. MED. CHEM. LETT.-2006-1562: Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor
BIOORG. MED. CHEM. LETT.-2005-5909: Novel synthetic isoquinolino[5,4-ab]phenazines: Inhibition toward topoisomerase I,antitumor and DNA photo-cleaving activities
BIOORG. MED. CHEM. LETT.-2005-4864: Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation,side chains,and substituent groups (SS)
BIOORG. MED. CHEM. LETT.-2005-4864: Synthesis,antitumor evaluation and DNA photocleaving activity of novel methylthiazonaphthalimides with aminoalkyl side chains (SS)
BIOORG. MED. CHEM. LETT.-2005-1139: Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: intercalation and photocleavage to DNA (SS)
BIOORG. MED. CHEM. LETT.-2003-5427: Novel naphthalimide hydroperoxide photonucleases: The role of thiocyclic-fused area and the difference in spectra,photochemistry and photobiological activity (SS)
BIOORG. MED. CHEM.-2007-1356: Novel antitumor agent family of 1H-benzo[c,d]indol-2-one with flexible basic side chains: Synthesis and biological evaluation (SS)
BIOORG. MED. CHEM.-2006-6962:Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: Various DNA binding geometry and interesting antitumor capacity (SS)
BIOORG. MED. CHEM.-2006-4639: Design,synthesis,and antitumor evaluation of novel acenaphtho[1,2-b]pyrrole-carboxylic acid esters with amino chain substitution (SS)
BIOORG. MED. CHEM. -2005-3149: Novel heterocyclic family of phenyl naphthothiazole carboxamides derived from naphthalimides: synthesis,antitumor evaluation,and DNA photocleavage (SS)
BIOORG. MED. CHEM.-2005-1615: Thio-heterocylic naphthalimides with aminoalkyl side chains: novel alternative tools for photodegradation of genomic DNA without impairment on bioactivities of proteins (SS)
TETRAHEDRON LETT.-2005-6289: A proton sponge-based fluorescent switch
TETRAHEDRON LETT.-2004-3969: A novel chromatism switcher with double receptors selectively for Ag+ in neutral aqueous solution: 4,5-diaminoalkeneamino-N-alkyl-1,8-naphthalimides
TETRAHEDRON LETT.-2003-2087: Novel highly efficient fluoroionophores with a peri-effect and strong electron-donating receptors: TICT-promoted PET and signaling response to transition metal cations with low background emission
TETRAHEDRON LETT.-2003-795: Promoting effects of the hydroxymethyl group on the fluorescent signaling recognition of anions by thioureas
TETRAHEDRON LETT.-2002-2991: 4-Amino-1,8-dicyanonaphthalene derivatives as novel fluorophore and fluorescence switches: efficient synthesis and fluorescence enhancement induced by transition metal ions and protons
TETRAHEDRON LETT.-2002-2995: Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: an efficient 'time-resolved' DNA photocleaver with long-wavelength (SS)
TETRAHEDRON LETT.-2001-6175: N-aroyloxynaphthalimides as novel highly efficient DNA photocleavers: substituent effects
TETRAHEDRON LETT.-2000-7711: Novel and highly efficient DNA photocleavers: hydroperoxides of heterocyclic-fused naphthalimides
TETRAHEDRON-2005-11895: Novel DNA bis-intercalators of isoquinolino[4,5-bc]acridines: design,synthesis and evaluation of cytotoxic activity
TETRAHEDRON-2005-8717: Synthesis,antitumor and DNA photocleaving activities of novel naphthalene carboxamides: effects of different thio-heterocyclic rings and aminoalkyl side chains (SS)
TETRAHEDRON-2005-6634: Synthesis of thiazo- or thiadiazo- naphthalene carboxamides via mercuric intermediates and their antitumor and DNA photocleavage activities (SS)
TETRAHEDRON-2006-10117: Exploiting the deprotonation mechanism for the design of ratiometric and colorimetric Zn2+ fluorescent chemosensor with a large red-shift in emission
DYES PIGMENTS-2002-247: Synthesis and properties of oligonucleotides containing fluorescent ethenodeoxyadeno sine and ethenodeoxycytidine
DYES PIGMENTS-2001-51: Absorption and fluorescence spectral properties of tetra (fluoroalkoxy) metallophthalocyanines (FF)
DYES PIGMENTS-2001-43: Oxazolonaphthalimides and their hydroperoxides: photophysical and photobiological properties
DYES PIGMENTS-2004-9: Benzothioxanthene dyes as fluorescent label for DNA hybridization: synthesis and application (SS)
DYES PIGMENTS-2004-17: Synthesis and peroxidase-staining properties of novel water soluble polyhydroxylalkyl benzidine dyes
J. FLUORINE CHEM.-2002-161: Synthesis and photosensitizing properties of fluoroalkoxyl phthalocyanine metal complexes (FF)
J. FLUORINE CHEM.-2000-69: Synthesis of fluorine-containing oxazolonaphthalimide hydroperoxides as DNA photocleavers (FF)
CHINESE J. ORG. CHEM.1997-329: Synthesis and characterizations of the dye sensitized photooxygenation products and the heterocycles of naphthofuran derivatives
CHINESE J. ORG. CHEM.-1997-428: Synthesis,characterization and DNA intercalation of a furonaphthopyronone as a novel analogue of furocoumarin
CHINESE J. ORG. CHEM.-2000-338: Synthesis and structure characterization of two thienonaphthopyrones (SS)
CHINESE J. ORG. CHEM. 2006-504: Synthesis and properties of N-butyl-4-(aza-15-crown-5)-1,8-naphthalimide as a fluorescent probe
CHEM. RESEARCH IN CHINESE UNⅣ.-2005-480: A novel photocleaver with long wavelength absorption - Highly efficient antitumor agent: 4-(2-diethylamino -ethylamino)-8-oxo-8H-acenaphtho-[ 1,2-b] pyrrole-9-carbonitrile
CHEM. J. CHINESE UNⅣ.-1996-1399: Syntheses,DNA Intercalation Activities and Molecular Modelling on Structures of Tatramethyldifuronaphthalenes
J. PHOTOCHEM. PHOTOBIO. B-2001-35: Tetra-trifluoroethoxyl zinc phthalocyanine: potential photosensitizer for use in the photodynamic therapy of cancer (SS)
J. PHOTOCHEM. PHOTOBIO. B-2006-221: Isoquino[4,5-bc]acridines: Design,synthesis and evaluation of DNA binding,anti-tumor and DNA photo-damaging ability
J. CHEM. SOC.-PERKIN TRANSACTIONS 2-2000-715: Interaction of naphthyl heterocycles with DNA: effects of thiono and thio groups (SS)
MONATSH CHEM.-1999-1109: Synthesis of novel DNA-intercalating naphthopyrone derivatives with improved water solubility and photophysical properties
BULL. CHEM. SOC. JAPAN-1999-1571: Highly efficient photoinduced DNA cleavage by naphthopyrone hydroperoxides
CHEM. LETT.-2005-696: Novel naphthalimide fluorescent sensors selective for certain proteins on basis of non-covalent interactions between enzyme and inhibitor (SS)
SYNTHESIS-STUTTGART-1999-1109: General synthesis of thioxo-1,8-naphthalimides via thioxo-1,8-naphthalic anhydrides (SS)
HETEROATOM CHEM.-1999-141: The improved synthesis,Diels-Alder reactions,and desulfuration of trithio-1,8-naphthalic anhydride (SS)
POLYMER-2002-5731: Synthesis and photophysical properties of 1,8-naphthalimide-labelled PAMAM as PET sensors of protons and of transition metal ions
CHINESE J. ANAL. CHEM. -2004-837: Studies on the room temperature phosphorescence of halogen naphthalic anhydrides
CHINESE CHEM. LETT.-2004-118: Anthracylmethyl benzoazacrown ether as selective fluorescence sensors for Zn2+
HETEROCYCL. COMMUN.-2003-229: A new class of DNA intercalator and photocleaver: Bis-naphthailimides with bromo and nitro substituents
MONATSH. CHEM.-2003-393: New fluorescent conjugates of uridine nucleoside and substituted 1,8-naphthalimide: Synthesis,weak interactions and solvent effects on spectra
INT. J. BIO. MACROMOL.-2006-59: Study on the interaction between 4-(2-diethylanuno- ethylamino)-8-oxo-8H- acenaphtho[1,2-b]pyrrole-9-carbonitrile and DNA by molecular spectra
研究方向2.農藥的化學與生物學
J. AGRI. FOOD CHEM.-2007-2288: Synthesis,insecticidal activity,and QSAR of novel nitromethylene neonicotinoids with tetrahydropyridine fixed cis configuration and exo-ring ether modification
J. AGRI. FOOD CHEM.-2006-125: Synthesis and herbicidal activity of novel 3-aminocarbonyl-2-oxazolidinethione derivatives containing a substituted pyridine ring
J. AGRI. FOOD CHEM.-2006-8793: Novel,unnatural benzo-1,2,3-thiadiazole-7-carboxylate elicitors of taxoid biosynthesis (SS,FF)
J. AGRI. FOOD CHEM.-2005-3120: Syntheses,antifeedant activity,and QSAR analysis of new oxa(thia)diazolyl 3(2H)-pyridazinones (SS)
J. AGRI. FOOD CHEM.-2005-3120: Syntheses,Antifeedant Activity,and QSAR Analysis of New Oxa(thia)diazolyl 3(2 H)-Pyridazinones (SS)
J. AGRI. FOOD CHEM.-2003-152: Synthesis and Antifeedant Activity of New Oxadiazolyl 3(2H)-Pyridazinones
J. AGRI. FOOD CHEM.-2001-124: Synthesis and Quantitative Structure-Activity Relationships of New 2,5-Disubstituted-1,3,4-oxadiazoles (FF)
J. AGRI. FOOD CHEM.-2001-5279: Synthesis and Quantitative Structure-Activity Relationships of Fluorine-Containing 4,4-Dihydroxylmethyl-2-aryl imino- oxazo (thiazo)lidines as Trehalase Inhibitors (SS,FF)
J. AGRI. FOOD CHEM.-1999-4415: Quantitative studies on structure-activity relationship of sulfonylurea and benzoylphenylurea type pesticides and their substituents' bioisosterism using synthons' activity contribution (SS,FF)
J. AGRI. FOOD CHEM.-1996-1538: Molecular modeling study on the structure-activity relationship of substituted dibenzoyl-1-tert-butylhydrazines and their structural similarity to 20-hydroxyecdysone
ACS SYMPOSIUM SERIES-2005(892)-273: Oxadiazole derivatives as novel insect-growth regulators: Synthesis and structure-bioactivity relationship (FF)
J. FLUORINE CHEM.-2006-182: Synthesis and herbicidal activities of fluorine-containing 3-pyridylmethyl-2- phenyliminothiazolidine derivatives (SS,FF)
J. FLUORINE CHEM.-2005-297: Synthesis and fungicidal activity of fluorine-containing phenylimino-thiazolidines derivatives (SS,FF)
J. FLUORINE CHEM.-2005-53: Synthesis and biological activities of hydroxyl-protected fluorine-containing 4,4-dihydroxylmethyl-2-aryl-iminothiazolidines (SS,FF)
J. FLUORINE CHEM.-2004-1159: Synthesis and fungicidal activity of Fluorine-containing Phenylimino-thiazolidines Derivatives (SS,FF)
J. FLUORINE CHEM.-2004-1609: Syntheses,structures and bioactivities of fluorine-containing phenylimino-thia(oxa)zolidine derivatives as agricultural bioregulators (SS,FF)
J. FLUORINE CHEM.-2003-163: Synthesis and insecticidal activities of novel 2,5-disubstituted 1,3,4-oxadiazoles (FF)
J. FLUORINE CHEM.-2003-51: Synthesis and insecticidal activity of new substituted N-aryl-N’-benzoylthiourea compounds (SS,FF)
J. FLUORINE CHEM.-2002-63: Syntheses and insecticidal activity of new 2-(5-(trifluoromethyl)pyridyloxymethyl) -1,3,4-oxadiazoles] (FF)
J. FLUORINE CHEM.-2000-111: Fluorine containing heterocyclic compounds: synthesis of 6-substituted-2-substituted-aryl-1,2,4-triazolo[5,1-b] 1,3,5- thia- diazin-7-one derivatives (SS,FF)
J. FLUORINE CHEM.-2000-173: Syntheses and insecticidal activities of novel 2-fluorophenyl-5-aryl/cyclopropyl-1,3,4-oxadiazoles (FF)
J. FLUORINE CHEM.-2001-143: Synthesis and biological activities of fluorine-containing N,N’-diphenylcarbamimidothioates (SS,FF)
J. FLUORINE CHEM.-1999-39: Syntheses and characterization of 2-amino-5-aryl-1,3,4-oxadiazoles containing trifluoroethoxy groups (FF)
J. FLUORINE CHEM.-1998-9: Polyfluoroalkoxylation and methoxylation of polychloropyridines (FF)
J. FLUORINE CHEM.-1996-9: Alcoholysis of trifluoromethyl groups attached to the pyridine ring (FF)
J. FLUORINE CHEM.-1991-143: A synthetic and MO-SCF study of the trifluoroethoxylation of chloro(trifluoromethyl)pyridine derivatives (FF)
CHEM. PHYS. LETT.-2003-489: Intramolecular noncovalent force in cyclic amidines: nonbonded interaction between carbon atoms and heteroatoms (SS,FF)
PEST. MANAG. SCI. -2003-933: The toxic and anti-feedant activity of 2H-pyridazin-3-one-substituted 1,3,4-oxadiazoles against the armyworm Pseudaletia separata (Walker) and other insects and mite
CARBOHYDRATE RESEARCH-2001-79: Syntheses and activities as trehalase inhibitors of N-arylglycosylamines derived from fluorinated anilines (FF)
J. CHEM. TECH. BIOTECH.-1996-124: Syntheses and insecticidal activities of novel 2,5-disubstituted-1,3,4-oxadiazoles (FF)
CAN. J. CHEM. -2003-272: N'-tert-Butyl-N'-aroyl-N-(alkoxycarbonylmethyl)-N-aroylhydrazines,a novel nonsteroidal ecdysone agonist: syntheses,insecticidal activity,conformational and crystal structure analysis
MONATSH CHEM.-2006-779: An efficient and practical method for the synthesis of 1-(2,6-difluorobenzoyl)-3-(2-alkyl-3-oxopyridazin-4-yl)ureas as potential chitin synthesis inhibitors (FF)
MONATSH CHEM.-2000-953: Novel fused heterocycles: Synthesis and activity of 5,6-dihydro-7-thia-1,3,3a,5-tetraazainden-4-one and 1-thia-3,4a,9-triazafluoren-4-one derivatives (SS)
J. CHEM. RES.-2006- 626: Synthesis and bioactivities of novel neonicotinoids dioxolane compounds
J. CHEM. RES.-2000-88: The crystal structure of 1-phenyl-3-methyl-5-[2 '-(4 ''-phenylmethoxylphenyl)ethoxyl]pyrazole,a potential insect juvenile hormone mimic
J. CHEM. RES.-1999-66: The crystal structure of N-(5-phenyl-1,3,4-oxadiazol-2-yl)-N '-benzoyl urea,a novel insect-growth regulator
J. CHEM. RES. -1998-478: Crystal structure of 1-(3,5-dichloro-2,4-difluorophenyl)-3-(2,6-difluorobenzoyl)urea,an inhibitor of chitin synthesis (SS,FF)
CHEM. J. CHINESE UNⅣ.-1994-224: Synthesis and bioactivities of novel trifluoromethylpyridine derivatives
CHINESE CHEM. LETT. -2004-7: Novel Analogues of -Terthienyl,Thienyl 1,3,4-Thia(oxa)diazoles as Potential Photoactivated Insecticides:Synthesis and Bioactivity (SS)
PESTICIDE BIOCHEM. PHYSIOLOGY-2004-42: Photolarvicidal effect of thienyl 1,3,4-thia(oxa)diazoles and their potential DNA photocleavage (SS)
ARKⅣOC-2003-141: Synthesis and insecticidal activity of 1,2,4-triazole derivatives
CHEM. LETT.-2001-54: A Novel and Practical Amination of 4,5-Dichloropyridazin-3-ones via Reduction with Hydrazine Hydrate
ORG. PREP. PROCEDURE INTL.-2000-571: A facile synthesis of aryl isothiocyanates from arylamines (SS)
ORG. PREP. PROCEDURE INTL.-1999-110: A facile synthesis of 3-chloro-4-(2 ',2 ',2 '-trifluoroethoxy)benzonitrile (FF)
研究方向3.化學生物技術與工程
CHEM. COMMUN.-2006-865: Baker's yeast-mediated enantioselective reduction of substituted fluorenones (FF)
CHEM. COMMUN.-2005-2338: A novel strategy for the preparation of arylhydroxylamines: chemoselective reduction of aromatic nitro compounds using bakers' yeast
CHEM. COMMUN.-2004-2339: A novel strategy for the preparation of arylhydroxylamines: chemoselective reduction of aromatic nitro compounds using bakers’ yeast
APPL. MICROBIO. BIOT.-2005-98: A novel synthetic fluoro-containing jasmonate derivative acts as a chemical inducing signal for plant secondary metabolism (FF)
APPL. MICROBIOL. BIOT.-2006-164: Novel synthetic 2,6-dichloroisonicotinate derivatives as effective elicitors for inducing the biosynthesis of plant secondary metabolites
APPLIED MICROBIO.BIOTECH.-2006-298: Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate
BIOORG. MED. CHEM. LETT.-2005-1769: Novel 2-aminothiazonaphthalimides as visible light activatable photonucleases: effects of intercalation,heterocyclic-fused area and side chains (SS)
BIOORG. MED. CHEM. LETT.-2003-3513: Thiadiazole: A new family of intercalative photonuclease with electron transfer and radical mechanisms (SS,FF)
BIOORG. MED. CHEM. LETT.-2004-2665: Highly-efficient DNA photocleavers with long wavelength absorptions: thio-heterocyclic fused naphthalimides containing aminoalkyl side chains (SS)
BIOORG. MED. CHEM. LETT.-2004-2335: N-aroyloxylthioxo-naphthalimides as DNA photocleavers of aroyloxyl oxygen radicals: synthesis,evaluation,and substituents' effect (SS)
BIOORG. MED. CHEM. LETT.-2004-4755: Novel fluoro- and hydroxyl-containing jasmonate derivatives as highly efficient elicitors in suspension cultures of Taxus chinensis (FF)
BIOORG. MED. CHEM. LETT.-2006-803: Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease (SS)
BIOORG. MED. CHEM.-2006-2935: Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding
BIOORG. MED. CHEM.-2006-23: Eliminating nucleic acids contaminants by hydrogen peroxide-induced free radicals during the preparation of proteins (SS)
BIOTECH. BIOENG-2005-516: Highly efficient strategy for enhancing taxoid production by repeated elicitation with a newly synthesized jasmonate in fed- batch cultivation of Taxus chinensis cells
BIOTECH. BIOENG.-2004-809: Novel chemically synthesized hydroxyl-containing jasmonates as powerful inducing signals for plant secondary metabolism
BIOTECH. BIOENG.-2004-595: Novel synthetic jasmonates as highly efficient elicitors for taxoid production by suspension cultures of Taxus chinensis
BIOTECH. PROGR.-2006-331: Novel chemically synthesized salicylate derivative as an effective elicitor for inducing the biosynthesis of plant secondary metabolites
BIOTECH. AND BIOPROCESS ENGI.-2005-162: Efficient elicitation of ginsenoside biosynthesis in cell cultures of Panax notoginseng by using self-chemically-synthesized jasmonates
BIOCHEM. ENGINEERING. J.-2006-23: Eliminating nucleic acids contaminants by hydrogen peroxide-induced free radicals during the preparation of proteins
TETRAHEDRON LETT.-2004-1247: Naphthalimide-thiazoles as novel photonucleases: molecular design,synthesis,and evaluation (SS)
TETRAHEDRON-2005-11264: Versatile acenaphtho[1,2-b]pyrrol-carbonitriles as a new family of heterocycles: diverse Snar(H)H reactions,cytotoxicity and spectral behavior (SS)
DYES AND PIGMENTS-1999-139: Naphthalimide hydroperoxides as photonucleases: substituent effects and structural basis