基本介紹
- 中文名：鄒輝
- 學位/學歷：博士
- 職務：湖南師範大學醫學院藥學系支部書記
- 職稱：副教授
人物經歷,社會兼職,主持的科研項目,代表性學術論文,
人物經歷
主要研究方向基於化學生物學研究模式，以治療腫瘤、神經退行性疾病等重大疾病的藥物發現為目標，尋找和發現新穎活性天然產物，開展結構修飾和生物學功能研究。先後從卷柏、翠雲草、白朮、蔓荊子等植物中分離鑑定化合物200餘個，新化合物40餘個。主持國家自然科學基金項目1項，湖南省自然科學基金項目1項，廳局級項目多項，參與國家自然科學基金、湖南省科技廳項目、湖南省中醫藥管理局重點項目等科研項目10餘項；以第一作者或通訊作者身份發表科研論文20餘篇，其中SCI論文12篇，論文發表在《Tetrahedron Letters》、《Hepatology International》、《Fitoterapia》、《Oncology Reports》等期刊。
社會兼職
湖南省藥物會藥學教育委員會副秘書長；中國藥學會會員。
主持的科研項目
國家自然科學基金青年項目，31400311，蔓荊子總黃酮靶向肝癌幹細胞活性成分及作用機制研究，2014.01-2017.12，23萬元，項目負責人。
湖南省自然科學基金青年項目，2017JJ3213，藥用植物雞骨草抑制肝癌幹細胞乾性的活性成分及作用機制研究，2017.01-2019.12，5萬元，項目負責人。
湖南省教育廳課題，14C0709，中藥白朮抗老年性痴呆先導化合物的發現，2014.09-2016.9，2萬元，項目負責人。
湖南師範大學青年優秀人才培養計畫，ET15108，中藥雞骨草抗肝癌先導化合物的發現、結構表征及構效關係研究，2015.09-2018.06，10萬元，項目負責人。
企業橫向課題，藍金口服液臨床前研究，2019.06-2020.12，20萬元，項目負責人。
國家自然科學基金青年基金項目，81703199，p62依賴的選擇性自噬對實驗性矽肺纖維化的作用及機制研究，2018.01-2020.12，20萬元，在研，項目主要參與人。
代表性學術論文
- Fuxuan Wu#, Miaomiao Yu#, Wanling Chen, Lu Zhou, Dan Zhang, Yujie Peng, Xifeng Sheng, Hui Zou*, Junjiang Fu*. A New Isoflavonolignan Glycoside from Abrus cantoniensis, Records of Natural Products, 2019,13:(5):418-423.
- Miaomiao Yu, Fuxuan Wu, Wanling Chen, Junwei Kuang, Lu Zhou, Junjiang Fu, Xifeng Sheng*, Hui Zou*. A new isoflavone glycoside from Abrus cantoniensis, 2019, online. Doi:10.1080/10286020.2019.1598394.
- Ting Tao, Caimei He, Jun Deng, Yanjun Huang, Qiongli Su, Mei Peng, Meiling Yi, Kwame Oteng Darko, Hui Zou*, Xiaoping Yang*. A novel synthetic derivative of quercetin, 8-trifluoromethyl- 3,5,7,3',4'-O-pentamethyl-quercetin, inhibits bladder cancer growth by targeting the AMPK/mTOR signaling pathway. Oncotarget, 2017, 8(42): 71657.
- Hui Zou, Pingsheng Xu, Rui Liu, Zhenxing Zou, Jing Li, Aiguo Zhong, Jianzhong Hu, Kangping Xu*, Guishan Tan*. Selacyclicbiflavone A, an unusual macrocyclic biflavone from Selaginella uncinata (Desv.) Spring. Tetrahedron Letters, 2016, 57(8): 892-894.
- Hui Zou, Xiaozheng Cao, Qiao Xiao, Xifeng Sheng, Kaiqun Ren, Meifang Quan, Zhenwei Song, Duo Li, Yu Zheng, Wenbing Zeng, Jianguo Cao, Yaojin Peng*. Synergistic inhibition of characteristics of liver cancer stem-like cells with a combination of sorafenib and 8-bromo-7-methoxychrysin in SMMC-7721 cell line. Oncology Reports, 2016, 36(3): 1731-1738.
- Xiaozheng Cao, Kaiqun Ren, Zhenwei Song, Duo Li, Meifang Quan, Yu Zheng, Jianguo Cao, Wenbing Zeng, Hui Zou*. 7-Difluoromethoxyl-5,4'-di-n-octyl genistein inhibits the stem-like characteristics of gastric cancer stem-like cells and reverses the phenotype of epithelial-mesenchymal transition in gastric cancer cells. Oncology Reports, 2016, 36(2): 1157-1165.
- Xiaocheng Cao#, Hui Zou#, Jianguo Cao, Yinghong Cui, Suwen Sun, Kaiqun Ren, Zhenwei Song, Duo Li, Meifang Quan*. A candidate Chinese medicine preparation-Fructus Viticis Total Flavonoids inhibits stem-like characteristics of lung cancer stem-like cells. BMC Complementary and Alternative Medicine. 2016, 16: 364.
- Hui Zou*, Xing Feng, Jianguo Cao. Twist in hepatocellular carcinoma: pathophysiology and therapeutics. Hepatology International, 2015, 9(3): 399-405.
- Hui Zou, Meiling Yi, Kangping Xu, Xifeng Sheng, Guishan Tan*. Two new flavonoids from Selaginella uncinata. Journal of Asian Natural Products Research, 2015, 18(3): 248-252.
- Hui Zou, Kangping Xu, Fushuang Li, Zhenxing Zou, Rui Liu, Ruihuan Liu, Jing Li, Leihong Tan, Guishan Tan*. Unciflavones A-F, six novel flavonoids from Selaginella uncinata (Desv.) Spring. Fitoterapia, 2014; 99: 328-333.
- Hui Zou, Kangping Xu, Zhenxing Zou, Hongping Long, Hui Wang, Fushuang Li, Jing Li, Junwei Kuang, Guang Li, Guishan Tan. A new flavonoid with 6-phenyl substituent from Selaginella uncinata. Journal of Asian Natural Products Research, 2013, 15(1): 84-88.
- Hui Zou, Kangping Xu, Fushuang Li, Zhenxing Zou, Hongping Long, Guang Li, Hui Wang, Guishan Tan*. Uncinataflavone, a new flavonoid with a methyl benzoate substituent from Selaginella uncinata. Journal of Asian Natural Products Research, 2013, 15(4): 408-412.
