郭俊明(寧波大學教授)

郭俊明,男,1965年9月生,漢族,江西贛州南康人,教授,中山醫科大學生物化學與分子生物學博士。現任寧波大學醫學院生物化學與分子生物學研究所所長。浙江省“新世紀151人才工程”第二層次人才,寧波市高校名師培養對象;寧波大學生物化學與分子生物學碩士點負責人、上海交通大學醫學院博士生導師。主要學術兼職有:浙江省抗癌協會理事、寧波市營養學會常務理事。

基本介紹

  • 中文名:郭俊明
  • 國籍:中國
  • 民族:漢族
  • 出生地:江西南康
  • 出生日期:1965年9月
  • 職業:教授
  • 畢業院校:中山醫科大學
人物簡介,人物經歷,

人物簡介

 主要從事腫瘤分子生物學、基因診斷與基因治療等方面的研究。近年來,主持完成和在研國家和省部級科研課題5項,如國家自然科學基金項目“中國畲族人群DNA多態性研究”(39360024)、“胃癌相關piRNA的鑑定及其診斷價值分析” (30872420);浙江省自然科學基金項目“胃癌組織中Hiwi相互作用RNA的鑑定及其功能分析”(Y207240);浙江省科技攻關項目“新型胃癌標誌物的篩選與胃癌診斷試劑的研製” (2008C33020)等。
郭俊明

人物經歷

先後發表論文50餘篇,其中SCI收錄20篇。出版專著和教材6部,如《人體基因學》(主編,浙江科技出版社,2004年)等。主講國家雙語教學示範課程《生物化學與分子生物學》。近5年獲得的獎項和榮譽主要有:2006和2008年浙江省科技獎三等獎(排名第一);2006年浙江省醫藥衛生科技創新獎一等獎(排名第一);2007年度浙江省高校科研成果獎一等獎(排名第一);2008年寧波市高校教學成果獎一等獎(排名第一);榮獲2008年寧波大學最受學生歡迎的教授(“十佳教授”);2009年度寧波大學榮華學者獎勵計畫一級獎等。
一、近5年內發表主要論文:
1. Guo J, Jiang C, Wang Z, Lee HJ, Hu H, Malewicz B, Lee HJ, Lee JH, Baek NI, Jeong JH, Kim DK, Kang KS, Kim SH, Lu J. A novel class of pyranocoumarin anti-androgen receptor signaling compounds. Mol Cancer Ther. 2007;6(3):907-17. (SCI,IF 5.003)
2. Jiang C, Guo J, Wang Z, Xiao B, Lee HJ, Lee EO, Kim SH, Lu J. Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells. Breast Cancer Res. 2007;9(6):R77. (SCI,IF 5.052; Contributed equally)
3. Guo J*, Xiao B, Zhang X, Jin Z, Chen J, Qin L, Mao X, Shen G, Chen H, Liu Z. Combined use of positive and negative immunomagnetic isolation followed by real-time RT-PCR for detection of the circulating tumor cells in patients with colorectal cancers. J Mol Med. 2004;82(11):768-74. (SCI IF 4.37)
4. Xiao B, Guo J*, Miao Y, Jiang Z, Huan R, Zhang Y, Li D, Zhong J. Detection of miR-106a in gastric carcinoma and its clinical significance. Clin Chim Acta. 2009;400(1-2):97-102. (SCI IF 2.96)
5. Xiao B, Guo J*, Liu D, Zhang S. Aloe-emodin induces in vitro G2/M arrest and alkaline phosphatase activation in human oral cancer KB cells. Oral Oncol. 2007;43(9):905-10. (SCI IF 2.928)
6. Yao F, Guo JM*, Xu CF, Lou YL, Xiao BX, Zhou WH, Chen J, Hu YR, Liu Z, Hong GF. Detecting AFP mRNA in peripheral blood of the patients with hepatocellular carcinoma, liver cirrhosis and hepatitis. Clin Chim Acta. 2005;361(1-2):119-27. (SCI IF 2.96)
7. Guo J*, Miao Y, Xiao B, Huan R, Jiang Z, Meng D, Wang Y. Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues. J Gastroenterol Hepatol. 2009;24(4):652-7. (SCI IF2.275)
8. Guo J*, Yao F, Lou Y, Xu C, Xiao B, Zhou W, Chen J, Hu Y, Liu Z. Detecting carcinoma cells in peripheral blood of patients with hepatocellular carcinoma by immunomagnetic beads and rt-PCR. J Clin Gastroenterol. 2007;41(8):783-8. (SCI IF 2.775)
9. Guo J*, Xiao B, Zhang S, Liu D, Liao Y, Sun Q. Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin. Cancer Biol Ther. 2007;6(1):85-8. (SCI IF 2.761)
10. Guo J*, Xiao B, Lou Y, Yan C, Zhan L, Wang D, Zhao W. Antitumor effects of all-trans-retinoic acid on cultured human pancreatic cancer cells. J Gastroenterol Hepatol. 2006 Feb;21(2):443-8. (SCI IF 2.275)
11. Guo J*, Xiao B, Jin Z, Qin L, Chen J, Chen H, Zhang X, Liu Z. Detection of cytokeratin 20 mRNA in the peripheral blood of patients with colorectal cancer by immunomagnetic bead enrichment and real-time reverse transcriptase-polymeras chain reaction. J Gastroenterol Hepatol. 2005;20(8):1279-84. (SCI IF 2.275)
12. Guo JM*, Xiao BX, Liu DH, Grant M, Zhang S, Lai YF, Guo YB, Liu Q. Biphasic effect of daidzein on cell growth of human colon cancer cells. Food Chem Toxicol. 2004;42(10):1641-6. (SCI IF 2.321)
13. Guo J*, Xiao B, Liu Q, Gong Z, Le Y. Suppression of C-myc Expression Associates with Anti-Proliferation of Aloe-Emodin on Gastric Cancer Cells. Cancer Investigation, 2008 26:4, 369 – 374 (SCI IF1.976)
14. Guo JM*, Xiao BX, Liu Q, Zhang S, Liu DH, Gong ZH. Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation. Acta Pharmacol Sin. 2007 Dec;28(12):1991-5. (SCI IF 1.676)
15. Lu J, Kim SH, Jiang C, Lee H, Guo J. Oriental herbs as a source of novel anti-androgen and prostate cancer chemopreventive agents. Acta Pharmacol Sin. 2007;28(9):1365-72. (SCI IF 1.676)
16. Xiao B, Guo J*, Lou Y, Meng D, Zhao W, Zhang L, Yan C, Wang D. Inhibition of growth and increase of alkaline phosphatase activity in cultured human oral cancer cells by all-trans retinoic acid. Int J Oral Maxillofac Surg. 2006;35(7):643-8. (SCI IF 1.487)
17. Guo JM*, Xiao BX, Kang GZ, Liu DH, Chen H, Zhang S, Zhang XN. Suppression of telomerase activity and arrest at G1 phase in human cervical cancer HeLa cells by all-trans retinoic acid. Int J Gynecol Cancer. 2006 Jan-Feb;16(1):341-6. (SCI IF 1.932)
18. Malewicz B, Wang Z, Jiang C, Guo J, Cleary MP, Grande JP, Lü J. Enhancement of mammary carcinogenesis in two rodent models by silymarin dietary supplements. Carcinogenesis. 2006;27(9):1739-47. (SCI,IF 4.93)
19. Jiang C, Lee HJ, Li GX, Guo J, Malewicz B, Zhao Y, Lee EO, Lee HJ, Lee JH, Kim MS, Kim SH, Lu J. Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer. Cancer Res. 2006 Jan 1;66(1):453-63. (SCI,IF 7.514)
20. Guo JM*, Kang GZ, Xiao BX, Liu DH, Zhang S. Effect of daidzein on cell growth, cell cycle, and telomerase activity of human cervical cancer in vitro. Int J Gynecol Cancer. 2004;14(5):882-8. (SCI IF 1.932)
二、近5年內發表主要專著:
1.郭俊明主編.人體基因學.杭州.浙江科技出版社.2004.
三、近5年內獲得主要科研獎項:
1. 郭俊明、肖丙秀、劉東海、樓燕茹、賴依峰、張順、劉瓊、汪東輝、詹麗、嚴春紅. 浙江省科學技術獎.用現代分子生物學技術闡明常見營養成分的抗癌機制.2008年度.三等獎.
2. 郭俊明、肖丙秀、張新軍、陳健、樓燕茹、徐長風. 浙江省科技獎.外周血中微量消化系統惡性腫瘤細胞的分析及其臨床套用.2006年度.三等獎.
3. 郭俊明、肖丙秀、張新軍、陳健、樓燕茹、徐長風. 浙江省醫藥衛生科技創新獎.外周血中微量消化系統惡性腫瘤細胞的分析.2006年度.一等獎.
4. 郭俊明、肖丙秀、劉東海、賴依峰、張順、劉瓊. 浙江省高校科研成果獎.大豆苷原防治常見惡性腫瘤的研究.2007年度.一等獎.
5. 肖丙秀 郭俊明 樓燕茹 劉東海 汪東輝 詹麗 嚴春紅. 寧波市科技進步獎.全反式維甲酸誘導分化實體瘤分子機制的系列研究.2008年度.三等獎.

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