華中農業大學教授、博士生導師，“千人計畫”青年人才，作物遺傳改良國家重點實驗室固定研究人員，油菜遺傳改良團隊成員。2001-2006年先後獲四川大學本科學位(生物技術)和碩士學位(植物學)，2006-2011年獲美國密蘇里大學聖路易斯校區細胞與分子生物學博士學位，2012-2014年在美國Donald Danforth Plant Science Center從事博士後研究。
基本介紹
- 中文名：郭亮
- 國籍：中華人民共和國
- 職業：教授
- 畢業院校：美國密蘇里大學聖路易斯校區
- 主要成就：千人計畫”青年人才
個人簡介,人物生平,科研項目,獲獎情況,論文及著作,
個人簡介
課題組圍繞油菜籽含油量和油菜抗非生物逆境，主要開展以下研究：
1. 油菜脂質代謝與功能：1) 油菜油脂合成的遺傳基礎和分子機制,發掘調控油菜籽油分積累的關鍵基因和代謝途徑; 2) 磷脂、鞘脂和表面脂的合成與代謝途徑，以及這些脂質參與調控油菜生長、發育和抗逆的分子機制研究; 3) 油菜脂質組分析方法的建立和套用，開展全面的脂質組學研究，致力於建立高通量、高靈敏度和系統性的脂質組分析方法；
2. 油菜抗旱、耐鹽和抗凍等性狀的遺傳基礎和分子機制：包括油菜抗逆種質資源的篩選、評價和利用，通過全基因組關聯分析等手段解析調控油菜抗逆的分子機制；
3. 代謝組分析及其在油菜代謝和抗逆中的套用：通過代謝組分析，篩選和鑑定油菜逆境回響過程中的代謝標記物以及相關代謝途徑和關鍵基因。
課題組利用豐富的油菜種質資源，結合基因組、代謝組和表型組等手段全面解析油菜脂質代謝與抗非生物逆境的遺傳基礎和分子機制，實現油菜優異種質資源創新與利用→優異基因挖掘→優異基因功能解析→優異基因利用，為培育高含油量和抗逆強的油菜品種打下基礎，將一批實用的基因套用到油菜遺傳改良中。
歡迎熱愛農業科學研究的優秀學生報考本題組研究生！
1. 油菜脂質代謝與功能：1) 油菜油脂合成的遺傳基礎和分子機制,發掘調控油菜籽油分積累的關鍵基因和代謝途徑; 2) 磷脂、鞘脂和表面脂的合成與代謝途徑，以及這些脂質參與調控油菜生長、發育和抗逆的分子機制研究; 3) 油菜脂質組分析方法的建立和套用，開展全面的脂質組學研究，致力於建立高通量、高靈敏度和系統性的脂質組分析方法；
2. 油菜抗旱、耐鹽和抗凍等性狀的遺傳基礎和分子機制：包括油菜抗逆種質資源的篩選、評價和利用，通過全基因組關聯分析等手段解析調控油菜抗逆的分子機制；
3. 代謝組分析及其在油菜代謝和抗逆中的套用：通過代謝組分析，篩選和鑑定油菜逆境回響過程中的代謝標記物以及相關代謝途徑和關鍵基因。
課題組利用豐富的油菜種質資源，結合基因組、代謝組和表型組等手段全面解析油菜脂質代謝與抗非生物逆境的遺傳基礎和分子機制，實現油菜優異種質資源創新與利用→優異基因挖掘→優異基因功能解析→優異基因利用，為培育高含油量和抗逆強的油菜品種打下基礎，將一批實用的基因套用到油菜遺傳改良中。
歡迎熱愛農業科學研究的優秀學生報考本題組研究生！
人物生平
2001-2006年先後獲四川大學本科學位(生物技術)和碩士學位(植物學)，2006-2011年獲美國密蘇里大學聖路易斯校區細胞與分子生物學博士學位，2012-2014年在美國Donald Danforth Plant Science Center從事博士後研究。
科研項目
1.“七大物育種”小麥等作物功能基因組研究與套用,項目骨幹 (2016-2020)
2.“千人計畫”青年人才項目，主持 (2016-2018)
3. 國家自然科學基金面上項目：植物鞘脂介導的信號傳導研究，主持 (2016-2019)
4. 華中農業大學自主科技創新基金:基於脂質組分析解析油菜種子高含油量的分子機制，主持 (2015-2020))
5. 華中農業大學引進人才科研啟動項目：植物脂質代謝與功能研究，主持 (2015-2019）
6. 作物遺傳改良國家重點實驗室科研啟動項目：植物脂質組分析方法的建立與套用，主持 (2015-2019)
2.“千人計畫”青年人才項目，主持 (2016-2018)
3. 國家自然科學基金面上項目：植物鞘脂介導的信號傳導研究，主持 (2016-2019)
4. 華中農業大學自主科技創新基金:基於脂質組分析解析油菜種子高含油量的分子機制，主持 (2015-2020))
5. 華中農業大學引進人才科研啟動項目：植物脂質代謝與功能研究，主持 (2015-2019）
6. 作物遺傳改良國家重點實驗室科研啟動項目：植物脂質組分析方法的建立與套用，主持 (2015-2019)
獲獎情況
第十二批“千人計畫”青年人才 (2016)
Raju Mehra Awards (University of Missouri-St Louis, 2011）
Raju Mehra Awards (University of Missouri-St Louis, 2011）
論文及著作
1. Fang Wei, Brian Fanella, Liang Guo* and Xuemin Wang* (2016) Membrane glycerolipidome of soybean root hairs and its response to nitrogen and phosphate availability. Scientific Reports 6: 36172
2. Yueyun Hong*, Jian Zhao*, Liang Guo, Sang-Chul Kim, Xianjun Deng, Geliang Wang, Gaoyang Zhang, Maoyin Li, and Xuemin Wang* (2016) Plant Phospholipases D and C and Their Diverse Functions in Stress Responses. Progress in Lipid Research 62: 55-74
3. Shaoping Lu*, Shuaibing Yao, Geliang Wang, Liang Guo, Yongming Zhou, Yueyun Hong and Xuemin Wang* (2016) Phospholipase Dε enhances Braasca napus growth and seed production in response to nitrogen availability. Plant Biotechnol J 14:926-937
4. Jian Wu, Qing Zhao, Qingyong Yang, Han Liu, Qingyuan Li, Xinqi Yi, Yan Cheng, Liang Guo, Chuchuan Fan, Yongming Zhou* (2016) Comparative transcriptomic analysis uncovers the complex genetic network for resistance to Sclerotinia sclerotiorum in Brassica napus. Scientific Reports 6:19007
5. Liang Guo, Fangfang Ma, Fang Wei, Brian Fanella, Doug K. Allen and Xuemin Wang* (2014) Cytosolic Glyceraldehyde-3-Phosphate Dehydrogenase Affects Arabidopsis Cellular Metabolism and Promotes Seed Oil Accumulation. Plant Cell 26:3023-3035
6. Xuemin Wang, Liang Guo, Geliang Wang, Maoyin Li (2014) PLD: Phospholipase Ds in Plant Signaling, Phospholipases in Plant Signaling, Springer: 3-26
7. Hongyan Yao, Geliang Wang, Liang Guo and Xuemin Wang* (2013) Phosphatidic Acid Interacts with WEREWOLF MYB and Regulates Its Nuclear Localization and Function in Arabidopsis. Plant Cell 25:5030-5042
8. Sang-Chul Kim, Liang Guo and Xuemin Wang* (2013) Phosphatidic Acid Binds to Cytosolic Glyceraldehyde-3-Phosphase Dehydrogenase and Promotes Its Cleavage in Arabidopsis. J Biol Chem 288:11834-11844
9. Liang Guo, Shivakumar P. Devaiah, Rama Narasimhan, Xiangqing Pan, Yanyan Zhang, Wenhua Zhang and Xuemin Wang* (2012) Cytosolic glyceraldehyde-3-phosphate dehydrogenases interact with phospholipase Dδ to transduce hydrogen peroxide signals in stress response in Arabidopsis. Plant Cell 24:2200-2212
10. Liang Guo, Girish Mishra, Jonathan E. Markham, Maoyin Li, Amanda Tawfall, Ruth Welti and Xuemin Wang* (2012) Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis. J Biol Chem 287:8286-8296
11. Liang Guo and Xuemin Wang* (2012) Crosstalk between phospholipase D and sphingosine kinase in plant stress signaling. Frontiers Plant Science 3:1-7
12. Liang Guo, Girish Mishra, Kyle Taylor, Xuemin Wang* (2011) Phosphatidic acid binds and stimulates Arabidopsis sphingosine kinases. J Biol Chem 286:13336-13345
13. Maoyin Li, Sung Chul Bahn, Liang Guo, William Musgrave, Howard Berg, Ruth Welti and Xuemin Wang* (2011) Patatin-related phospholipase pPLAIIIbeta-induced changes in lipid metabolism alter cellulose content and cell elongation in Arabidopsis. Plant Cell 23:1107-1123
14. Liang Guo, Renwei Qing, Wei He, Ying Xu, Lin Tang, Shenghua Wang and Fang Chen* (2008) Identification and characterization of a plastidial ω3-fatty acid desaturase gene from Jatrophacurcas.Chin J Appl Environ Biol 14:469-474
15. Bei Niu, Liang Guo, Mingming Zhao, Tong Luo, Rong Zhang, Fuli Zhang, Pei Hou, Ying Zhang, Ying Xu, Shenghua Wang and Fang Chen* (2008) Molecular cloning, characterization, and expression of an ω-3 fatty acid desaturase gene from Sapiumsebiferu. J BiosciBioeng106:375-380
16. 何瑋，郭亮，王嵐，楊威，唐琳，陳放* (2007) 麻瘋樹種質資源遺傳多樣性的 ISSR 分析. 套用與環境生物學報 13: 466-470
17. Meng Xiao, Qun Li, Li Wang, Liang Guo, Jing Li, Lin Tang, Ying Xu and Fang Chen* (2006) ISSR analysis of genetic diversity and genetic structure in natural populations of an endangered species Sinopodophyllumhexandrum (Royle) Ying from the Tibetan region of Sichuan province, China. J Integr Plant Biol 48:1140-1146
18. Qun Li, Meng Xiao, Liang Guo, Li Wang, Lin Tang, Ying Xu, Fang Yan and Fang Chen* (2005) Genetic diversity and genetic structure of an endangered species, Trillium tschonoskii. Biochemical Genetics 43:445-458
19. Meng Xiao, Qun Li, Liang Guo, Tong Luo, Wenxing He, Li Wang and Fang Chen* (2005) AFLP analysis on genetic diversity of an endangered species Sinopodophyllumhexandrum (Royle) Ying in the Tibetan region of Sichuan province, China. Biochemical Genetics 44:47-60
20. 李群，肖猛，郭亮，李靜，段文霞，陳放*，王麗 (2005) 四川省珍稀瀕危植物延齡草遺傳多樣性分析. 北京林業大學學報 27: 1-6
21. 戎芳，王勝華，趙小光，郭亮，魏琴，唐琳，徐鶯，陳放* (2005) 麻瘋樹外植體愈傷組織中毒蛋白的 Westem-blot 鑑定. 四川大學學報: 自然科學版 42: 206-209
2. Yueyun Hong*, Jian Zhao*, Liang Guo, Sang-Chul Kim, Xianjun Deng, Geliang Wang, Gaoyang Zhang, Maoyin Li, and Xuemin Wang* (2016) Plant Phospholipases D and C and Their Diverse Functions in Stress Responses. Progress in Lipid Research 62: 55-74
3. Shaoping Lu*, Shuaibing Yao, Geliang Wang, Liang Guo, Yongming Zhou, Yueyun Hong and Xuemin Wang* (2016) Phospholipase Dε enhances Braasca napus growth and seed production in response to nitrogen availability. Plant Biotechnol J 14:926-937
4. Jian Wu, Qing Zhao, Qingyong Yang, Han Liu, Qingyuan Li, Xinqi Yi, Yan Cheng, Liang Guo, Chuchuan Fan, Yongming Zhou* (2016) Comparative transcriptomic analysis uncovers the complex genetic network for resistance to Sclerotinia sclerotiorum in Brassica napus. Scientific Reports 6:19007
5. Liang Guo, Fangfang Ma, Fang Wei, Brian Fanella, Doug K. Allen and Xuemin Wang* (2014) Cytosolic Glyceraldehyde-3-Phosphate Dehydrogenase Affects Arabidopsis Cellular Metabolism and Promotes Seed Oil Accumulation. Plant Cell 26:3023-3035
6. Xuemin Wang, Liang Guo, Geliang Wang, Maoyin Li (2014) PLD: Phospholipase Ds in Plant Signaling, Phospholipases in Plant Signaling, Springer: 3-26
7. Hongyan Yao, Geliang Wang, Liang Guo and Xuemin Wang* (2013) Phosphatidic Acid Interacts with WEREWOLF MYB and Regulates Its Nuclear Localization and Function in Arabidopsis. Plant Cell 25:5030-5042
8. Sang-Chul Kim, Liang Guo and Xuemin Wang* (2013) Phosphatidic Acid Binds to Cytosolic Glyceraldehyde-3-Phosphase Dehydrogenase and Promotes Its Cleavage in Arabidopsis. J Biol Chem 288:11834-11844
9. Liang Guo, Shivakumar P. Devaiah, Rama Narasimhan, Xiangqing Pan, Yanyan Zhang, Wenhua Zhang and Xuemin Wang* (2012) Cytosolic glyceraldehyde-3-phosphate dehydrogenases interact with phospholipase Dδ to transduce hydrogen peroxide signals in stress response in Arabidopsis. Plant Cell 24:2200-2212
10. Liang Guo, Girish Mishra, Jonathan E. Markham, Maoyin Li, Amanda Tawfall, Ruth Welti and Xuemin Wang* (2012) Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis. J Biol Chem 287:8286-8296
11. Liang Guo and Xuemin Wang* (2012) Crosstalk between phospholipase D and sphingosine kinase in plant stress signaling. Frontiers Plant Science 3:1-7
12. Liang Guo, Girish Mishra, Kyle Taylor, Xuemin Wang* (2011) Phosphatidic acid binds and stimulates Arabidopsis sphingosine kinases. J Biol Chem 286:13336-13345
13. Maoyin Li, Sung Chul Bahn, Liang Guo, William Musgrave, Howard Berg, Ruth Welti and Xuemin Wang* (2011) Patatin-related phospholipase pPLAIIIbeta-induced changes in lipid metabolism alter cellulose content and cell elongation in Arabidopsis. Plant Cell 23:1107-1123
14. Liang Guo, Renwei Qing, Wei He, Ying Xu, Lin Tang, Shenghua Wang and Fang Chen* (2008) Identification and characterization of a plastidial ω3-fatty acid desaturase gene from Jatrophacurcas.Chin J Appl Environ Biol 14:469-474
15. Bei Niu, Liang Guo, Mingming Zhao, Tong Luo, Rong Zhang, Fuli Zhang, Pei Hou, Ying Zhang, Ying Xu, Shenghua Wang and Fang Chen* (2008) Molecular cloning, characterization, and expression of an ω-3 fatty acid desaturase gene from Sapiumsebiferu. J BiosciBioeng106:375-380
16. 何瑋，郭亮，王嵐，楊威，唐琳，陳放* (2007) 麻瘋樹種質資源遺傳多樣性的 ISSR 分析. 套用與環境生物學報 13: 466-470
17. Meng Xiao, Qun Li, Li Wang, Liang Guo, Jing Li, Lin Tang, Ying Xu and Fang Chen* (2006) ISSR analysis of genetic diversity and genetic structure in natural populations of an endangered species Sinopodophyllumhexandrum (Royle) Ying from the Tibetan region of Sichuan province, China. J Integr Plant Biol 48:1140-1146
18. Qun Li, Meng Xiao, Liang Guo, Li Wang, Lin Tang, Ying Xu, Fang Yan and Fang Chen* (2005) Genetic diversity and genetic structure of an endangered species, Trillium tschonoskii. Biochemical Genetics 43:445-458
19. Meng Xiao, Qun Li, Liang Guo, Tong Luo, Wenxing He, Li Wang and Fang Chen* (2005) AFLP analysis on genetic diversity of an endangered species Sinopodophyllumhexandrum (Royle) Ying in the Tibetan region of Sichuan province, China. Biochemical Genetics 44:47-60
20. 李群，肖猛，郭亮，李靜，段文霞，陳放*，王麗 (2005) 四川省珍稀瀕危植物延齡草遺傳多樣性分析. 北京林業大學學報 27: 1-6
21. 戎芳，王勝華，趙小光，郭亮，魏琴，唐琳，徐鶯，陳放* (2005) 麻瘋樹外植體愈傷組織中毒蛋白的 Westem-blot 鑑定. 四川大學學報: 自然科學版 42: 206-209
