郁韻秋,女,研究生,復旦大學藥學院研究生導師。
基本介紹
- 中文名:郁韻秋
- 出生日期:1957年
- 學位/學歷:研究生
- 職業:老師
- 專業方向:新藥質量標準的建立、體內藥物分析方法研究、代謝組學研究
- 職稱:教授
個人經歷,教育經歷,工作經歷,研究方向,學術成果,科研貢獻,科研項目,代表論著,榮譽獎勵,
個人經歷
教育經歷
1979.09-1983.08華東師範大學化學系(本科)
1983.09-1986.06華東師範大學化學系(研究生)
工作經歷
1986.07-1988.09上海醫科大學藥學院,助教
1988.10-1994.09上海醫科大學藥學院,講師
1994.10-2011.08復旦大學藥學院,副教授
2011.09-至今復旦大學藥學院,教授
1997.09- 1998.03日本長崎大學藥學部進修
研究方向
1.新藥質量標準的建立
2.體內藥物分析方法研究
3.代謝組學研究
學術成果
科研貢獻
1.建立了多種體內藥物濃度的測定方法,藥物涉及多種類別,包括小分子蛋白(多肽)藥物的測定,比如建立了測定人血中和尿中重組雙功能水蛭素方法,該方法具有準確、靈敏,選擇性好,血漿用量少等優點,成功套用於該藥物的臨床試驗和研究。
2.開展了多個藥物的質量標準研究,在此過程中,通過定性定量分析為合成工藝的改進提供了非常重要的幫助,為藥品的質量控制提供了合理有用的方法。
3.近年來開始進入疾病的代謝組學研究領域,目前運用代謝組學方法對CTCL生物標誌物進行研究、已經篩尋得到數十個潛在的生物標誌物。 通過代謝組學的研究將為疾病的診斷提供依據,進一步可展望靶點藥物研發。
4.發表論文50餘篇,申請專利6項(獲得授權4項)。
5.培養的博士生2人; 培養碩士生15人,獲得上海市優秀碩士畢業論文1人,上海市優秀碩士畢業生1人。
科研項目
代表論著
1.Xia Li, Yu Wang, Qingyuan Zhou, Yunqiu Yu*, Lihong Chen, Jie Zheng, A sensitive method for digoxin determination using formate-adduct ion based on the effect of ionization enhancement in liquid chromatograph-mass spectrometer, Journal of Chromatography B[J], 2015, 978–979: 138-44.
2.Qing-Yuan Zhou, Yue-Lin Wang, Xia Li, Xiao-Yan Shen, Ke-Jia Li, Jie Zheng, Yun-Qiu Yu*, Metabolics Investigation of Cutaneous T Cell Lymphpma Based on UHPLC-QTOF/MS. Asian Pacific journal of cancer prevention[J]. 2014;15(13):5417-21.
3.Xiaoyun Liu, Shuiqing Zheng, Zheng Jiang, Chen Liang, Rong Wang, Zhe Zhou, Yurong Zhang, Yunqiu Yu*, Rapid separation and identification of Strychnos alkaloids metabolites in rats by ultra high performance liquid chromatography with linear ion trap Orbitrap mass spectrometry Journal of Separation Science2014(37),764–774
4.Qixin Dong,Jiajun Zhu,Qiang Sui,Chao Tang,Xiaomei Wang,Yunqiu Yu*,Optimization of mobile phase for the determination of Esomeprazole and related compounds and investigation of stress degradation by LC–MSJournal of Separation Science2013(36),1200–1208
5.Zhuhong Yu,Zhongping Wu,Feijun Gong,Rong Wong,Chen Liang,Yurong Zhang*,Yunqiu Yu*Simultaneous determination of six toxic alkaloids in human plasma and urine using capillary zone electrophoresis coupled to time-of-flight mass spectrometryJournal of Separation Science2012, 35(20), 2773–2780ISSN 1615-9314
6.Zhi-Yan Lin, Xiaoyun Liu, Fan Yang, Yun-Qiu Yu,Structural characterization and identification of five triterpenoid saponins isolated from Momordica cochinchinensis extracts by liquid chromatography/tandem mass spectrometry International Journal of Mass Spectrometry328–329 (2012) , 43–66 ISSN 1387-3806
7.Le Pan, Yunqiu Yu*, Longwei Sun An LC–MS Method for a Hexokinase Inhibitor Study Based on Adenosine 50-Triphosphate Determination and Application to the Anticancer Mechanism of Momordica cochinchinensis, Chromatographia,2010(72)425-430ISSN 0009-5893(print) 1612-1112(online)
8.Le Pan, Yanping Guo, Zhongdong Li, Jun Chen, Tian Jiang, Yunqiu Yu*, Longwei Sun,Simultaneous Determination of Levodopa, Benserazide and 3-O-Methyldopa in Human Serum by LC–MS–MS,Chromatographia, 2010(72)627-633ISSN 0009-5893(print) 1612-1112(online)
9.Shengmin Su, Yunqiu Yu*, Online preconcentration of recombinant Arg-Gly-Asp-hirudin using dynamic pH junction for analysis in human urine samples by capillary electrophoresis-mass spectrometry. Journal of Chromatography A, 2009, (1216) 1490–1495 ISSN 0021-9673
10.Shengmin Su, Yunqiu Yu, Wei Mob, Yanling Zhang, Houyan Song, Qinfen Chen, Yi Xie,A development of LC–MS method combining ultrafiltration and lyophilization for determination of r-RGD-Hirudin in human serum Journal of Chromatography B,2008,870 27-31ISSN 1570-0232
榮譽獎勵
2009.11上海市科技進步三等獎
2009.12上海市研究生優秀成果(學位論文),導師
2011.05上海市優秀髮明選拔賽優秀髮明銀獎