他是著名科學家，是多項發明專利的發明人。作為主要負責人成功開發了中國國家一類抗癌新藥UTD1。已獲得中國食品和藥品監督管理局頒發的臨床批件並已進入臨床試驗。
基本介紹
- 中文名：邱榮國
- 外文名：無
- 國籍：中國
- 職業：科學家
主要學歷及工作經歷:,研究領域:,主要論文：,科研成果及所受獎勵:,
主要學歷及工作經歷:
1983 武漢大學病毒學學士
1986 武漢大學病毒生化碩士
1986-1989 中山醫科大學助教、講師
1990-1992 University of California-San Francisco 研究學者
1992-1997 美國恩尼克斯生物製藥有限公司助理科學家
1997 Utrecht University 細胞與分子生物學博士
1998-2000 University of California-Berkeley 博士後
2000-2002 美國寇山生命科學有限公司科學家
2003-2006 美國北進緣有限公司總裁
2006-今 大連理工大學教授、博士生導師
研究領域:
分子靶向抗腫瘤新藥的研製；藥物作用機制和信號傳導研究；細胞的生長和極性調控及癌變機理研究；藥物基因組學及藥物新靶點的發現；多藥耐藥性的分子機理研究
主要在研課題：
1．國家863計畫目標導向專題：組合生物合成技術開發新型埃博黴素抗腫瘤新藥。2007.1-2010.12
2．北京市海淀區科技項目：蛋白磷酸酶I特異性抑制劑TMC作為抗癌藥的研製2006.1-2007.12；
3．中美合資企業合作資金：國家一類抗癌新藥UTD1的開發及臨床研究。2003-；
指導碩、博士生研究方向:
藥物作用機制及信號傳導；
藥物基因組學；
小GTPases與細胞生長和細胞極性的調控
出版著作和論文:
在國內外權威學術期刊上發表論文30餘篇，影響因子總和超過200，被他人引用3000多次。論文所發期刊包括Nature, Cell, Curr. Biol.，Genes & Dev., PNAS, Mol. Cell. Biol., JBC等。
主要論文：
1. P. Li, Z. Deng, Z. Hu and R.-G. Qiu: In Vivo and In Vitro Studies for Evaluating Metabolic Interaction of a Anticancer Drug Candidate UTD1 on Dog and Human Cytochrome P450 Isoforms, Accepted，Academic J. Shanghai Jiaotong University, 2007
2. L. Tang, R.-G. Qiu, Y. Li, and L. Katz: Generation of Novel Epothilone Analogs with Cytotoxic Activity by Biotransformation, J. Antibiotics 56:16-23, 2003
3. R. Arslanian, L. Tang, S. Blough, R.-G. Qiu, L. Katz and J. R. Carney: A New Cytotoxic Epothilone From Modified Polyketide Synthases Heterologously Expressed in Myxococcusxanthus, J. Nat. Prod. 65:1061-1064, 2002.
4. N. Malecz, P. McCabe, C. Spaargaren, R.-G. Qiu and M. Symons: Synaptojanin 2, a Novel Effector that Regulates Clathrin-mediated Endocytosis, Curr. Biol. 10: 1383-1386, 2000
5. M. Ahram, M. Sameni, R.-G. Qiu, D. Kirn and B. Sloane: Rac1-induced Invasion: Intracellular Proteolysis of Extracellular Matrix, Exp. Cell Res. 260: 292-303, 2000
6. R.-G. Qiu, A. Abo and G. S. Martin: A Human Homologue of the C. elegans Polarity Determinant Par-6 Links Rac and Cdc42 to PKCz Signaling and Cell Transformation, Curr. Biol. 10: 697-707, 2000
7. B. Anand-Apte, B. Zetter, A. Viswanathan, R.-G. Qiu, R. Ruggieri, J. Chen and M. Symons: PDGF and Fibronectin-stimulated Migration Are Differentially Regulated by the Rac and ERK Pathways, J. Biol. Chem. 272: 30688-30692, 1997
8. R.-G. Qiu, A. Abo, F. McCormick and M. Symons: Cdc42 Regulates Anchorage-independent Growth and Is Necessary for Ras Transformation, Mol. Cell. Biol. 17: 3449-3458, 1997
9. R.-G. Qiu: All the Roads Leading to Rho: Rho-like GTPases and Cell Signaling (a review), in The Role of Rho-like GTPases in Cell Proliferation and Ras Transformation, p13-73, Published by FEBO-druk, Enschede, the Netherlands, 1997
10. M. Falasca, A. Carvelli, C. Iurisci, R.-G. Qiu, M. Symons and D. Corda: Fast Receptor-induced Formation of Glycerophosphoinositol-4-phosphate, a Putative Novel Intracellular Messenger in the Ras Pathway, Mol. Biol. Cell. 8: 443-453, 1997
11. J. A. Hess, A H. Ross, R.-G. Qiu, M. Symons and J. Exton: Role of Rho Family Proteins in Phospholipase D Activation by Growth Factors, J. Biol. Chem. 272: 1615-1620, 1997
12. M. Hart, S. Sharma, N. elMastry, R.-G. Qiu, P. McCabe, P. Polakis and G. Bollag: Cloning of a Novel GDP/GTP Exchange Factor for Rho GTPase, J. Biol. Chem. 271: 25452-25458, 1996
13. M. Peppelenbosch, L. Tertoolen, A. Vries-Smits, R.-G. Qiu, M. Symons, S. de Laat, and J. Bos: Rac-dependent and -independent Pathways Mediate Growth Factor Induced Ca2+ Influx, J. Biol. Chem. 271: 7883-7886, 1996
14. R.-G. Qiu, J. Chen, F. McCormick, and M. Symons: A Role for Rho in Ras Transformation, Proc. Natl. Acad. Sci. USA 92: 11781-11785, 1995
15. M. Peppelenbosch, R.-G. Qiu, A. de Vries-Smits, L. Tertoolen, S. de Laat, F. McCormick, A. Hall, M. Symons, and J. Bos: Rac Mediates Growth Factor-Induced Arachidonic Acid Release, Cell 81: 849-856, 1995
16. P. Hawkins, A. Eguinoa, R.-G. Qiu, D. Stokoe, F. Cooke, R. Walters, S. Wennstrom, L. Claesson-Welsh, T. Evans, M. Symons, and L. Stephens: PDGF Stimulates an Increase in GTP-Rac via Activation of Phosphoinositide 3-Kinase, Curr. Biol. 5: 393-403, 1995
17. A. Siddiqi, J. Smith, A. Ross, R.-G. Qiu, M. Symons, and J. Exton: Regulation of Phospholipase D in HL60 Cells: Evidence for a Cytosolic Phospholipase D, J. Biol. Chem. 270: 8466-8473, 1995
18. R.-G. Qiu, J. Chen, D. Kirn, F. McCormick, and M. Symons: An Essential Role for Rac in Ras Transformation, Nature 374: 457-459, 1995
19. K. Malcom, A. Ross, R.-G. Qiu, M. Symons, and J. Exton: Activation of Rat Liver Phospholipase D by the Small GTP-binding Protein RhoA, J. Biol. Chem. 269: 25951-25954, 1994
20. C. van Genderen, R. Okamura, I. Farinas, R.-G. Qiu, T. Parslow, L. Bruhn, and R. Grosschedl: Development of Several Organs That Require Inductive Epithelial-mesenchymal Interactions Is Impaired in LEF-1 Deficient Mice, Genes & Dev. 8: 2691-2703, 1994
21.A. Milatovich, R.-G. Qiu, R. Grosschedl, and U. Francke: Gene for a Tissue-specific Transcriptional Activator (EBF or Olf-1), Expressed in early B Lymphocytes, Adipocytes, and Olfactory Neurons, Is Located on Human Chromosome 5, Band q34, and Proximal Mouse Chromosome 11, Mamm. Genome 5: 211-215, 1994
22. T. Jenuwein, W. Forrester, R.-G. Qiu, and R. Grosschedl: The Immunoglobulin m Enhancer Core Establishes Local Factor Access in Nuclear Chromatin Independent of Transcriptional Stimulation, Genes & Dev. 7: 2016-2032, 1993
科研成果及所受獎勵:
其它獎勵：
2000-2002 美國癌症學會Diane Beardsley 研究獎
1998-1999 美國衛生研究院（NIH）博士後研究獎（NRSA）
在讀碩士、博士人數:n
