邢曦雯

邢曦雯

邢曦雯，女，博士、副研究員、研究生導師。

主要研究方向為DNA甲基化、酶活性測定、生物反應可視化觀測。工作3年來作為項目負責人主持了國家自然科學基金、廣東省自然科學基金項目。發表文章23篇，申請專利2項。

碩士研究生招生方向：生物工程、化學生物學、生物化學與分子生物學、微生物學、生物醫藥

基本介紹

  • 中文名：邢曦雯
  • 畢業院校：武漢大學 
  • 學歷：博士研究生
  • 職稱：副研究員
  • 在職：暨南大學生命科學技術學院
  • 工作時間：2017.3
研究方向,學習經歷,工作經歷,主要論文,主要著作,承擔課題,講授課程,社會職務,

研究方向

分子生物學方面：表達蛋白、可視化觀測、構建納米材料
生物學分析：製備超高效檢測方法，更新現有檢測方法
DNA甲基化：為什麼一個細胞可以分化出鼻子耳朵?研究甲基化及去甲基化機理

學習經歷

2010.9 -2015.6武漢大學化學與分子科學學院化學生物學碩博連讀
指導老師：周翔教授
2014.9 - 2015.3日本京都大學物質細胞研究所（iCeMS）
指導老師：Hiroshi Sugiyama教授&Masayuki Endo教授
2013.6 - 2014.1武漢大學基礎醫學部免疫學，交流合作
指導老師：章曉聯教授
2011.9 - 2013.6武漢大學化學與分子科學學院分析化學，交流合作
指導老師：馮鈺棋教授&袁必峰教授
2006.9 - 2010.6武漢大學化學與分子科學學院化學基地班理學學士

工作經歷

2017.3 - 2017.12日本京都大學物質細胞研究所（iCeMS）
Hiroshi Sugiyama教授&Masayuki Endo教授 實驗室訪學
2015.12起 暨南大學生科院
2016年 暨南大學第四屆新任教師教學競賽二等獎

主要論文

  1. Xing X., Feng Y.,Yu Z., Liu F., Hidaka K., Sugiyama H.*, Endo M.*. Metalion-induced base pair formation in the nanoscale structure. A European journal. doi: 10.1002/chem.201805394.（IF：5.317；A1二區，第一作者，Hot paper，從投稿到online下載，29天周期）
  2. Li W.; Liu Y.; Wang Y.; Li R.; Trang P.; Tang W.; Yang Z.; Wang Y.; Sun X.;Xing X.*; Lu S.*; Liu F.*. Engineered RNase P Ribozymes Effectively Inhibit the Infection of Murine Cytomegalovirus in Animals. Theranostics, 2018, 8, 5634（IF：8.854；A1一區，共通訊作者，封面文章）
  3. Wang Y.; Yang L.; Li N.; Sun C.; Xia Y.; Yuan L.; Lu J.;Liu F.*; Xing X.*.A versatile assay for alkaline phosphatase det4ection based onthymine-HgII-thymine structure generation mediated by TdT.Talanta 10.1016/j.talanta.2018.11.061（IF：4.244；A1二區，通訊作者）
  4. Wang Y., Sun X., Zeng J., Deng M., Li N., Chen Q., Zhu H.,Liu F.*, Xing X.*.Label-free and sensitive detection assay for terminal deoxynucleotidyl transferase viapolyadenosine-coralyne fluorescence enhancement strategyAnalytical Biochemistry,2018,18, 30613 (IF=2.27, A2三區，通訊作者)
  5. Xing X.W.; Liu F.Y.; Xiao J*; So K.F.*. Neuro-protective Mechanisms of Lycium barbarum.Neuromolecular Med.,2016,18,253 (IF: 3.287，A1二區)
  6. Endo M.*;Xing X.W.; Zhou X.; Emura T.; Hidaka K.; Tuesuwan B.; Sugiyama H.*. Single-Molecule manipulation of the duplex formation and dissociation at the G-quadruplex/i-motif site in the DNA nanostructure.ACS NANO.,2015, 9, 9922.(IF: 13.334，A1一區)
  7. Tang F.; Xing X. W.; Chu J. M.; Yuan Q.; Zhou X.; Feng YQ. *; Yuan B. F. *. A highly sensitive fluorescence assay for methyltransferase activity by exonuclease-aided signal amplification.Analyst.,2015,140, 4636 (共同一作)(IF: 4.033，A1二區)
  8. Xing X. W.;Tang F.; Wu J.; Chu J. M.; Feng Y. Q.; Zhou X.*; Yuan B. F.*Sensitive detection of DNA methyltransferase activity based on exonuclease-mediated target recycling.Anal. Chem.,2014,86,11269-11274.(IF: 6.320，A1二區)
  9. Xing X. W.;Liu Y. L.; Vargas M.; Wang Y.; Feng Y. Q.; Zhou X.*; Yuan B. F.*Mutagenic and cytotoxic properties of oxidation products of 5-methylcytosine revealed by next-generation sequencing.PLoS One.,2013,8, e72993.(IF: 3.534，A2三區)
  10. Chen M. L.;Liu Y. L.;Xing X. W.; Zhou X.; Feng Y. Q.*; Yuan B. F.*Preparation of a hyper-cross-linked polymer monolithic column and its application to the sensitive determination of genomic DNA methylation.Chem-Eur. J.,2013,19,1035-1041. (共同一作)(IF: 5.696，A1二區)
11. Xing X.; Wang X.; Xu L.; Tai Y.; Dai L.; Zheng X.; Mao W.; Xu X.; Zhou X.*. Light-driven conformational regulation of human telomeric G-quadruplex DNA in physiological conditions.Org. Biomol. Chem.,2011,9,6639-6645. (共同一作)(IF: 3.696，A2三區)
Hu, J.; Chen, Y.; Xu, X.; Wu, F.;Xing, X.; Xu, Z.; Xu, J.; Weng, X.; Zhou, X. Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling.Bioorg. Med. Chem. Lett.2014,24, 294-297.
Huang, R.; Wang, J.; Mao, W.; Fu, B.;Xing, X.; Guo, G.; Zhou, X. A novel combined bisulfite UDG assay for selective 5-methylcytosine detection.Talanta.2013,117, 445-448 .
Hong, T.; Wang, T.; Guo, P.;Xing, X.; Ding, F.; Chen, Y.; Wu, J.; Ma, J.; Wu, F.; Zhou, X. Fluorescent strategy based on cationic conjugated polymer fluorescence resonance energy transfer for the quantification of 5-(hydroxymethyl)cytosine in genomic DNA.Anal. Chem.2013,85, 10797-10802.
Guo, P.; Yan, S.; Hu, J.;Xing, X.; Wang, C.; Xu, X.; Qiu, X.; Ma, W.; Lu, C.; Weng, X.; Zhou, X. Selective detection of 5-formyl-2'-deoxycytidine in DNA using a fluorogenic hydroxylamine reagent.Org. Lett.2013,15, 3266-3269.
Yuan, L.; Tian, T.; Chen, Y.; Yan, S.;Xing, X.; Zhang, Z.; Zhai, Q.; Xu, L.; Wang, S.; Weng, X.; Yuan, B.; Feng, Y.; Zhou, X. Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy.Sci. Rep.2013, 3, 1811.
Mao, W.; Hu, J.; Hong, T.;Xing, X.; Wang, S.; Chen, X.; Zhou, X. A convenient method for selective detection of 5-hydroxymethylcytosine and 5-formylcytosine sites in DNA sequences.Org. Biomol. Chem.2013,11, 3568-3572.
Tang, Y.; Chu, J. M.; Huang, W.; Xiong, J.;Xing, X. W.; Zhou, X.; Feng, Y. Q.; Yuan, B. F. Hydrophilic material for the selective enrichment of 5-hydroxymethylcytosine and its liquid chromatography-tandem mass spectrometry detection.Anal. Chem.2013,85, 6129-6135.
Hu, J.;Xing, X.; Xu, X.; Wu, F.; Guo, P.; Yan, S.; Xu, Z.; Xu, J.; Weng, X.; Zhou, X. Selective chemical labelling of 5-formylcytosine in DNA by fluorescent dyes.Chem-Eur. J.2013,19,5836-5840.
Wang, T.; Hong, T.; Tang, T.; Zhai, Q.;Xing, X.; Mao, W.; Zheng, X.; Xu, L.; Wu, J.; Weng, X.; Wang, S.; Tian, T.; Yuan, B.; Huang, B.; Zhuang, L.; Zhou, X.Application of N-halogeno-N-sodiobenzene sulfonamide reagents to the selective detection of 5-methylcytosine in DNA sequences.J. Am. Chem. Soc.2013, 135, 1240-1243.

主要著作

  1. Xing X., Feng Y.,Yu Z., Liu F., Hidaka K., Sugiyama H.*, Endo M.*. Metalion-induced base pair formation in the nanoscale structure. A European journal. doi: 10.1002/chem.201805394.（IF：5.317；A1二區，第一作者，Hot paper，從投稿到online下載，29天周期）
  2. Li W.; Liu Y.; Wang Y.; Li R.; Trang P.; Tang W.; Yang Z.; Wang Y.; Sun X.;Xing X.*; Lu S.*; Liu F.*. Engineered RNase P Ribozymes Effectively Inhibit the Infection of Murine Cytomegalovirus in Animals. Theranostics, 2018, 8, 5634（IF：8.854；A1一區，共通訊作者，Front Cover）
  3. Wang Y.; Yang L.; Li N.; Sun C.; Xia Y.; Yuan L.; Lu J.;Liu F.*; Xing X.*.A versatile assay for alkaline phosphatase det4ection based onthymine-HgII-thymine structure generation mediated by TdT.Talanta 10.1016/j.talanta.2018.11.061（IF：4.244；A1二區，通訊作者）
  4. Wang Y., Sun X., Zeng J., Deng M., Li N., Chen Q., Zhu H.,Liu F.*, Xing X.*.Label-free and sensitive detection assay for terminal deoxynucleotidyl transferase viapolyadenosine-coralyne fluorescence enhancement strategyAnalytical Biochemistry,2018,18, 30613 (IF=2.27, A2三區，通訊作者)
  5. Xing X.W.; Liu F.Y.; Xiao J*; So K.F.*. Neuro-protective Mechanisms of Lycium barbarum.Neuromolecular Med.,2016,18,253 (IF: 3.287，A1二區)
  6. Endo M.*;Xing X.W.; Zhou X.; Emura T.; Hidaka K.; Tuesuwan B.; Sugiyama H.*. Single-Molecule manipulation of the duplex formation and dissociation at the G-quadruplex/i-motif site in the DNA nanostructure.ACS NANO.,2015, 9, 9922.(IF: 13.334，A1一區)
  7. Tang F.; Xing X. W.; Chu J. M.; Yuan Q.; Zhou X.; Feng YQ. *; Yuan B. F. *. A highly sensitive fluorescence assay for methyltransferase activity by exonuclease-aided signal amplification.Analyst.,2015,140, 4636 (共同一作)(IF: 4.033，A1二區)
  8. Xing X. W.;Tang F.; Wu J.; Chu J. M.; Feng Y. Q.; Zhou X.*; Yuan B. F.*Sensitive detection of DNA methyltransferase activity based on exonuclease-mediated target recycling.Anal. Chem.,2014,86,11269-11274.(IF: 6.320，A1二區)
  9. Xing X. W.;Liu Y. L.; Vargas M.; Wang Y.; Feng Y. Q.; Zhou X.*; Yuan B. F.*Mutagenic and cytotoxic properties of oxidation products of 5-methylcytosine revealed by next-generation sequencing.PLoS One.,2013,8, e72993.(IF: 3.534，A2三區)
  10. Chen M. L.;Liu Y. L.;Xing X. W.; Zhou X.; Feng Y. Q.*; Yuan B. F.*Preparation of a hyper-cross-linked polymer monolithic column and its application to the sensitive determination of genomic DNA methylation.Chem-Eur. J.,2013,19,1035-1041. (共同一作)(IF: 5.696，A1二區)

承擔課題

1.國家青年基金《HCV解旋酶長路運動行為的分子研究》
2.省青年基金《基於核酸探針的HCV 解旋酶活性及單分子觀測》
3.校青年基金《基於納米材料修飾核酸適配子的策略高靈敏度檢測生物樣本中的HCV》

講授課程

《儀器分析》，所講課程深受本科生喜愛，每年學生打分都高於90分（top 3%），創下一天內選課人數超過60人的記錄
《核酸與蛋白質》，《先進研究進展》等

社會職務

1.生物系教學秘書
2.生物系教工支部宣傳委員

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