辛敏行，男，博士，西安交通大學醫學部藥學院副教授，碩士生導師。
基本介紹
- 中文名：辛敏行
- 畢業院校：中國藥科大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：新藥分子的發現與開發研究、藥物合成新技術與新工藝研究
- 任職院校：西安交通大學醫學部藥學院
- 職稱：副教授
個人經歷,工作經歷,教育經歷,研究方向,主講課程,學術成果,論文,專利,項目,
個人經歷
工作經歷
2017年11月—至今西安交通大學藥學院 副教授
2016年8月—2017年8月美國喬治亞州立大學 訪問學者
2015年7月起西安交通大學藥學院 碩士生導師
2014年2月—2017年10月西安交通大學藥學院 講師
2011年6月—2014年2月江蘇先聲藥業有限公司 藥物研發 項目經理
教育經歷
2006年9月—2011年6月中國藥科大學 藥物化學 博士
2002年9月—2006年6月中國藥科大學 製藥工程 學士
研究方向
（1）新藥分子的發現與開發研究；
（2）藥物合成新技術與新工藝研究；
（3）具有生物活性的有機化學小分子的設計與合成研究；
主要聚焦於腫瘤與自身免疫性疾病（如內風濕性關節炎症）領域。
主講課程
《藥物化學》《化學製藥工藝學》《藥物合成反應》《製藥工程學》
學術成果
論文
2018
1. Minhang Xin*, Xinyue Ji, Ladie Kimberly De La Cruz, Suresh Thareja, Binghe Wang*, Strategies to target the Hedgehog signaling pathway for cancer therapy, Medicinal Research Reviews, 2018
2. Minhang Xin, Weiming Duan, Yifan Feng, Yuan-Yuan Hei, Hao Zhang, Ying Shen, Hong-Yi Zhao, Shuai Mao, San-Qi Zhang*, Novel 6-aryl substituted 4-pyrrolidineaminoquinazoline derivatives as potent phosphoinositide 3-kinase delta (PI3Kδ) inhibitors, Bioorganic & Medicinal Chemistry, 2018
3. Minhang Xin, Weiming Duan, Yifan Feng, Yuan-Yuan Hei, Hao Zhang, Ying Shen, Hong-Yi Zhao, Weiming Duan, Shuai Mao, San-Qi Zhang * , Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
4. Minhang Xin*, Liandi Zhang, Chongxing Tu, Feng Tang, Jun Wen, Novel 4-(2-Pyrimidinylamino)benzamide Derivatives as Potent Hedgehog Signaling Pathway Inhibitors. Bioorganic & Medicinal Chemistry, 2018
5. Chengyuan Liang*, Danni Tian, Xiaodong Ren, Shunjun Ding, Minyi Jia, Minhang Xin*, Suresh Thareja*, The development of Bruton’s tyrosine kinase (BTK) inhibitors from 2012 to 2017: A mini-review, European Journal of Medicinal Chemistry, 2018
6. Hao Zhang, Jin Wang, Ying Shen, Hui-Yan Wang, Wei-Ming Duan, Hong-Yi Zhao, Yuan-Yuan Hei, Minhang Xin, Yong-Xiao Cao, San-Qi Zhang*, Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs, European Journal of Medicinal Chemistry, 2018
7. Yuan-Yuan Hei, Ying Shen, Jin Wang, Hao Zhang, Hong-Yi Zhao, Minhang Xin, Yong-Xiao Cao, Yan Li, San-Qi Zhang*, Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors, Bioorganic & Medicinal Chemistry, 2018
8. Hao Zhang, Jin Wang, Hong-Yi Zhao, Xue-Yan Yang, Hao Lei, Minhang Xin, Yong-Xiao Cao, San-Qi Zhang*, Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold, Bioorganic & Medicinal Chemistry, 2018
9. Hui-Yan Wang, Hao Zhang, Jin Wang, Ying Shen, Yuan-Yuan Hei, Hong-Yi Zhao, Minhang Xin, Yong-Xiao Cao, San-Qi Zhang*, Discovery of 2-(2-aminopyrimidin-5-yl)-4-(morpholin-4-yl)-6-(N-cyclopropyl-N-(1-benzoylpiperidine-4-yl))aminotriazines/pyrimidines as PI3K and BRAF dual inhibitors, Future Medicinal Chemistry, 2018
2017年
1. Minhang Xin, Yuan-Yuan Hei, Hao Zhang, Ying Shen, San-Qi Zhang*, Design and synthesis of novel 6-aryl substituted 4-anilinequinazoline derivatives as potential PI3Kδ inhibitors, Bioorganic & Medicinal Chemistry Letters, 2017
2. Minhang Xin, Yuan-Yuan Hei, Hao Zhang, Xiao-Xiao Xie, Shuai Mao, Sai-Jie Zuo, San-Qi Zhang*, Discovery of 6-benzamide containing 4-phenylquinazoline derivatives as novel PI3Kδ Inhibitors, Letters in Drug Design & Discovery, 2017
3. Minhang Xin*, Liandi Zhang, Jun Wen, Han Shen, Xinge Zhao, Qiu Jin, Introduction of Fluorine to Phenyl Group of 4-(2-Pyrimidinylamino)benzamides Leading to a Series of Potent Hedgehog Signaling Pathway Inhibitors, Bioorganic & Medicinal Chemistry Letters, 2017
4. Yazhou Wang*, Wei Huang*, Minhang Xin, Pan Chen, Li Gui, Xinge Zhao, Feng Tang, Jia Wang, Fei Liu*, Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors, Bioorganic & Medicinal Chemistry, 2017
5. Hong-Yi Zhao, Hui-Yan Wang, Shuai Mao, Minhang Xin, San-Qi Zhang*, Discovery of 2-(pyridin-2-yl)aniline as a directing group for the sp2 C–H bond amination mediated by cupric acetate, Organic & Biomolecular Chemistry, 2017
2016年
1. Minhang Xin*, Liandi Zhang, Qiu Jin, Feng Tang, Jun Wen, Liyun Gu, Lingfei Cheng, Yong Zhao, Discovery of novel 4-(2-pyrimidinylamino)benzamide derivatives as highly potent and orally available hedgehog signaling pathway inhibitors, European Journal of Medicinal Chemistry, 2016
2. Minhang Xin*, Liandi Zhang, Jun Wen, Han Shen, Zhaoyu Liu, Xinge Zhao, Mengyu Wang, Lingfei Cheng, Wei Huang, Feng Tang, Synthesis and pharmacological evaluation of trifluoromethyl containing 4-(2-pyrimidinylamino)benzamides as hedgehog signaling pathway inhibitors, Bioorganic & Medicinal Chemistry, 2016
3. Yuan-Yuan Hei, Minhang Xin*, Hao Zhang, Xiao-Xiao Xie, Shuai Mao, San-Qi Zhang*, Synthesis and antitumor activity evaluation of 4,6-disubstituted quinazoline derivatives as novel PI3K inhibitors. Bioorganic & Medicinal Chemistry Letters, 2016
4. Sai-Jie Zuo, Sai Zhang, Shuai Mao, Xiao-Xiao Xie, Xue Xiao, Min-Hang Xin, Wei Xuan, Yuan-Yuan He, Yong-Xiao Cao, San-Qi Zhang*, Combination of 4-anilinoquinazoline, arylurea and tertiary amine moiety to discover novel anticancer agents, Bioorganic & Medicinal Chemistry, 2016
5. 辛敏行， 張三奇*，選擇性PI3Kδ抑制劑的研究進展，中國藥科大學學報, 2016
6. 王曉朦，辛敏行，張三奇*，低毒性 PI3K/mTOR抑制劑的研究進展，中國藥物化學雜誌，2016
2015年
1. Minhang Xin*, Hedgehog inhibitors: a patent review (2013 - present), Expert Opinion on Therapeutic Patents, 2015
2. Minhang Xin*，#, Xinge Zhao#, Wei Huang, Qiu Jin, Gang Wu, Yazhou Wang, Feng Tang, Hua Xiang*, Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl) thieno[3,2-c]pyridine-4-amines as novel Bruton’s tyrosine kinase (BTK) inhibitors, Bioorganic & Medicinal Chemistry, 2015
3. Xinge Zhao#, Minhang Xin#, Wei Huang, Yanliang Ren, Qiu Jin, Feng Tang, Hailong Jiang, Yazhou Wang, Jie Yang, Shifu Mo, Hua Xiang*, Design, synthesi and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible brution’s tyrosine kinase inhibitors, Bioorganic & Medicinal Chemistry, 2015
4. Xinge Zhao#, Minhang Xin#, Yazhou Wang, Wei Huang, Qiu Jin, Feng Tang, Gang Wu, Yong Zhao, Hua Xiang*, Discovery of thieno[3,2-c]pyridine-4-amines as novel Bruton’s tyrosine kinase (BTK) inhibitors, Bioorganic & Medicinal Chemistry, 2015
5. Hao Zhang, Min-Hang Xin, Xiao-Xiao Xie, Shuai Mao, Sai-Jie Zuo, She-Min Lu, San-Qi Zhang*, Synthesis and antitumor activity evaluation of PI3K inhibitors containing 3-substituted quinazolin-4(3H)-one moiety, Bioorganic & Medicinal Chemistry, 2015
6. Xinge Zhao, Wei Huang, Yazhou Wang, Minhang Xin, Qiu Jin, Jianfeng Cai, Feng Tang, Yong Zhao, Hua Xiang*, Discovery of novel brution’s tyrosine kinase (BTK) inhibitors bearing a pyrrolo[2,3-d]pyrimidine scaffold, Bioorganic & Medicinal Chemistry, 2015
7. Xinge Zhao, Wei Huang, Yazhou Wang, Minhang Xin, Qiu Jin, Jianfeng Cai, Feng Tang, Yong Zhao, Hua Xiang*, Pyrrolo[2,3-b]pyridine derivatives as potent Bruton’s tyrosine kinase inhibitors, Bioorganic & Medicinal Chemistry, 2015
8. Xiao-Meng Wang, Jing Xu, Min-Hang Xin, She-Min Lu, San-Qi Zhang*, Design, synthesis and antiproliferative activity evaluation of m-(4-morpholinyl-1,3,5-triazin-2-yl)benzamides in vitro, Bioorganic & Medicinal Chemistry Letters, 2015
9. Xiao-Meng Wang, Min-Hang Xin, Jing Xu, Bo-Rui Kang, Yan Li, She-Min Lu, San-Qi Zhang*, Synthesis and antitumor activities evaluation of m-(4-morpholinoquinazolin-2-yl)benzamides in vitro and in vivo, European Journal of Medicinal Chemistry, 2015
10. Xiao-Meng Wang, Shuai Mao, Lei Cao, Xiao-Xiao Xie, Min-Hang Xin, Jia-Fang Lian, Yong-Xiao Cao, San-Qi Zhang*, Modification of N-(6-(2-methoxy-3-(4-fluorophenylsulfonamido) pyridine-5-yl)-[1,2,4]triazolo[1,5-a]pyridine-2yl)acetamide as PI3Ks inhibitor by replacement of the acetamide group with alkylurea, Bioorganic & Medicinal Chemistry, 2015
11. Xiao-Xiao Xie, Huan Li, Juan Wang, Shuai Mao, Min-Hang Xin, She-Min Lu, Qi-Bing Mei, San-Qi Zhang*, Synthesis and anticancer effects evaluation of 1-alkyl-3-(6-(2-methoxy-3- sulfonylaminopyridin-5-yl)benzo[d]thiazol-2-yl)urea as PI3Ks anticancer agents with low toxicity, Bioorganic & Medicinal Chemistry, 2015
2014年
1. Minhang Xin*, Liandi Zhang, Han Shen, Jun Wen, Chongxin Tu, Zhaoyu Liu, Lingfei Cheng, Xinge Zhao, Design, synthesis, and biological study of 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine derivatives as novel hedgehog signaling pathway inhibitors, Medicinal Chemistry Research, 2014
2. Minhang Xin*, Liandi Zhang, Feng Tang, Chongxin Tu, Jun Wen, Xinge Zhao, Zhaoyu Liu, Lingfei Cheng, Han Shen, Design, synthesis and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors, Bioorganic & Medicinal Chemistry, 2014
3. Minhang Xin*, Jun Wen, Feng Tang, Chongxin Tu, Wei Huang, Han Shen, Xinge Zhao, Lingfei Cheng, Mengyu Wang, Liandi Zhang, Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of hedgehog signaling pathway, Bioorganic & Medicinal Chemistry Letters, 2014
4. Liandi Zhang, Minhang Xin*, Han Shen, Jun Wen, Feng Tang, Chongxing Tu, Xinge Zhao, Ping Wei*, Five-membered heteroaromatic ring fused-pyrimidine derivatives: design, synthesis, and hedgehog signaling pathway inhibition study. Bioorganic & Medicinal Chemistry Letters, 2014
5. 張連第, 辛敏行*, 文珺, 唐鋒, 塗崇興, 沈晗, 韋萍*, 4-（嘧啶-2-氨基）苯甲醯胺衍生物的設計、合成及Hedgehog信號通路抑制研究. 有機化學, 2014
2014年以前
1. Minhang Xin*, Jun Wen, Feng Tang, Chongxin Tu, Han Shen, Xinge Zhao, The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors, Bioorganic & Medicinal Chemistry Letters, 2013
2. Minhang Xin, Ying Gao, Hua Xiang*, Dong Chen, Yi He, Qidong You*, A general and facile synthesis of novel polysubstituted quinazolin-4(3H)-ones, Journal of Heterocyclic Chemistry, 2013
3.Minhang Xin, Qidong You, Hua Xiang*, An efficient, practical synthesis of 2-methoxyestradiol, Steroids, 2010
4. 辛敏行，向華*，司文博，趙維，肖紅，尤啟冬*. 2-甲氧基雌二醇-RGD肽綴合物的合成及其抗血管生成作用. 中國藥科大學學報, 2011
5.金秋,辛敏行, 叢欣, 尤啟冬*, 苯並呋喃類聚腺苷二磷酸核糖聚合酶（PARP）抑制劑的設計、合成及活性研究. 有機化學, 2013
6. 高瑛，辛敏行，向華*，老年黃斑變性發病機制及相關藥物研究進展. 中國醫藥導刊, 2009
專利
辛敏行，張三奇，張浩，謝肖肖，黑媛媛，左賽傑，毛帥，一類6-芳基取代的喹啉類化合物及其套用，2015，中國
辛敏行，張三奇，張浩，謝肖肖，黑媛媛，左賽傑，毛帥，一類6-芳基取代的喹啉類化合物及其套用，2015，中國
張三奇，左賽傑，曹永孝，辛敏行，謝肖肖，張賽，1-取代苯基-3-（4-取代苯基氨基-6-喹唑啉基）脲類化合物及製備方法和用途，2015 ，中國
張三奇，汪慧岩，張浩，黑媛媛，辛敏行， 2-(5-嘧啶基)-4-嗎啉基-6-取代均三嗪類化合物及其鹽、製備方法和套用，2017 ，中國
張三奇， 汪慧岩， 曹永孝， 王瑾， 張浩，辛敏行， 呂社民， 2-(4-嗎啉基)-4,6-二取代嘧啶/均三嗪類化合物及其鹽和套用
2014年以前
辛敏行，沈晗，文珺，劉肇彧，塗崇興，王夢妤，趙勇, 一類二氫吡喃並嘧啶衍生物及其醫藥套用，2013，中國
辛敏行，文珺，塗崇興，劉肇彧，沈晗，王夢妤，趙興俄, 雜環胺類Hedgehog信號通路抑制劑，2013，中國
辛敏行，唐鋒，文珺，沈晗，劉肇彧，塗崇興，雙環雜環胺類Hedgehog信號通路抑制劑，2013，中國
辛敏行，金秋，叢欣，袁雲霞，陳吉，劉肇彧，趙勇，吳剛，沈晗，宋琦，一類苯並噁唑衍生物及其醫藥套用，2012，中國
辛敏行，金秋，叢欣，袁雲霞，陳吉，劉肇彧，趙勇，一類苯並呋喃衍生物及其醫藥套用，2012，中國
辛敏行，唐鋒，黃偉，文珺，沈晗，劉肇彧，塗崇興，趙興俄, 作為Hedgehog信號傳導的嘧啶胺類和吡啶胺類抑制劑
金秋，辛敏行，叢欣，劉肇彧，袁雲霞，趙勇，陳吉，一類酞嗪酮衍生物及其套用，2012，中國
金秋，辛敏行，劉肇彧，袁雲霞，叢欣，陳吉，趙勇，一類苯並咪唑類衍生物及其套用，2012，中國
項目
國家自然科學基金青年項目1項
中國博士後科學基金面上一等資助1項
中國博士後特別資助1項
國家自然科學基金陝西省配套資助1項
陝西省博士後一等資助1項
西安交通大學新教師科研啟動基金1項
曾作為骨幹成員參與：國家自然科學基金、“十二五”國家重大新藥創製科技重大專項等項目。
