譚彩萍

譚彩萍，女，中山大學化學與化學工程學院副教授。

基本介紹

• 中文名：譚彩萍
• 出生地：湖南省常德市
• 出生日期：1981年3月
• 職業：副教授
• 畢業院校：中山大學
• 學位/學歷：博士
• 專業方向：生物無機化學

教育經歷

1998.9—2002.6華南師範大學化學與環境學院，學士；

2002.9—2008.6中山大學化學與化學工程學院，博士。

工作經歷

2008.03—2011.03 中山大學生命科學學院，博士後；

2011.04—2016.1 中山大學化學與化學工程學院，講師。

2016.1—至今 中山大學化學與化學工程學院，副教授。

講授課程

本科生課程《無機化學》、《化學生物學綜合實驗》、《現代無機化學進展》、《基礎化學實驗》、《普通化學》。

科研方向

從事的學科領域為生物無機化學。研究興趣包括靶向性金屬抗腫瘤藥物的設計、抗腫瘤活性及機制研究。近兩年，以與腫瘤發生、發展的關鍵的蛋白分子為靶點，設計了系列的金屬配合物作為新穎的抑制劑，並研究了它們的抗腫瘤作用機制。主要研究的靶點包括組蛋白去乙醯化酶（Histone deacetylases, HDACs）和細胞周期素依賴性激酶（Cyclin-dependent kinases, CDKs）等。

科研項目

1. 廣東省自然科學基金（傑出青年基金），2015.08-2019.08，100萬元。

2. 國家自然科學基金（面上項目），2016.01-2019.12，77.6萬元。

3. 國家高技術研究發展計畫(863計畫)子課題，2012.01-2015.12，92.5萬元。

4. 國家自然科學基金 (青年科學基金項目)，2013.01-2015.012，25萬元。

5. 廣州市科技計畫項目，2014.01-2016.12，8萬元。

6. 高校基本科研業務費青年教師培育項目，2013.01-2015.12，10萬元。

7. 第四十四批中國博士後科學基金，2008.03-2010.03，3萬元。

論著一覽

2016

1. Ye, R. R., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Coumarin-appended phosphorescent cyclometalated iridium(III) complexes as mitochondria-targeted theranostic anticancer agents. Dalton Transactions 2016, DOI: 10.1039/C6DT00601A. IF: 4.197

2. Ye, R. R., Tan, C. P.*, Chen, M. H., Hao, L., Ji, L. N. and Mao, Z. W.* Mono- and dinuclear phosphorescent rhenium(I) complexes: impact of subcellular localization on anticancer mechanisms. Chemistry-A European Journal 2016, DOI: 10.1002/chem.201505160. IF: 5.731

2015

3. He, L., Li, Y., Tan, C. P.*, Ye, R. R., Chen, M. H., Cao, J. J., Ji, L. N. and Mao, Z. W.* Cyclometalated iridium(III) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents. Chemical Science 2015, 6, 5409-5418. IF: 9.221 (strongack Cover)

4. Ye, R. R., Tan, C. P.*, Lin, Y. N., Ji, L. N., Mao, Z. W.* A phosphorescent rhenium(I) histone deacetylase inhistrongitor: mitochondrial targeting and paraptosis induction. Chemical Communications 2015, 51(39),8353-8356. IF: 6.834

5. Li, Y., Tan, C. P. (Co-first author), He, L., Ji, L. N., Mao, Z. W.* Phosphorescent iridium(III)-strongis-N-heterocyclic carstrongene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents. strongiomaterials 2015, 39, 95-104. IF: 8.557

6. Zhang, W., Li, Y., Sun, J. H., Tan, C. P., Ji, L. N., Mao, Z. W.* Supramolecular self-assemstrongled nanoparticles for chemo-photodynamic dual therapy against cisplatin resistant cancer cells. Chemical Communications 2015, 51(10), 1807-1810. IF: 6.834

7. Li, J. M., Zhang, W., Su, H., Wang, Y. Y., Tan, C. P., Ji, L. N., Mao, Z. W.* Reversal of multidrug resistance in MCF-7/ADR cells strongy codelivery of doxorustrongicin and strongCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-strongeta-cyclodextrin nanocarrier. International Journal of Nanomedicine 2015, 10, 3147-3162. IF: 4.383

2014

8. He, L., Tan, C. P.*, Ye, R. R., Zhao, Y. Z., Liu, Y. H., Zhao, Q., Ji, L. N., Mao, Z. W.* Theranostic iridium(III) complexes as one- and two-photon phosphorescent trackers to monitor autophagic lysosomes. Angewandte Chemie International Edition 2014, 53(45), 12137-12141. IF: 11.261

9. Ye, R. R., Tan, C. P.*, He, L., Chen, M. H., Ji, L. N., Mao, Z. W.* Cyclometalated Ir(III) complexes as targeted theranostic anticancer therapeutics: comstrongining HDAC inhistrongition with photodynamic therapy. Chemical Communications 2014, 50(75), 10945-10948. IF: 6.834

10. He, L., Liao, S. Y., Tan, C. P.*, Lu, Y. Y., Xu, C. X., Ji, L. N., Mao, Z. W.* Cyclometalated iridium(III)-strongeta-carstrongoline complexes as potent autophagy-inducing agents. Chemical Communications 2014, 50(42), 5611-5614. IF: 6.834

11. Tan, C. P., Lu, Y. Y., Ji, L. N., Mao, Z. W.* Metallomics insights into the programmed cell death induced strongy metal-strongased anticancer compounds. Metallomics 2014, 6(5), 978-995. IF: 3.585 (Front Cover)

12. Zhao, M. X., Zhao, M., Zeng, E. Z., Li, Y., Li, J. M., Cao, Q., Tan, C. P., Ji, L. N., Mao, Z. W.* Enhanced anti-cancer efficacy to cancer cells strongy doxorustrongicin loaded water-solustrongle amino acid-modified strongeta-cyclodextrin platinum complexes. Journal of Inorganic strongiochemistry 2014, 137, 31-39. IF: 3.444

13. Li, Y., Liu, G. F.*, Tan, C. P., Ji, L. N., Mao, Z. W.* Antitumor properties and mechanisms of mitochondria-targeted Ag(I) and Au(I) complexes containing N-heterocyclic carstrongenes derived from cyclophanes. Metallomics 2014, 6(8), 1460-1468.

2013

14. Ye, R. R., Ke, Z. F., Tan, C. P.*, He, L., Ji, L. N., Mao, Z. W.* Histone-deacetylase-targeted fluorescent ruthenium(II) polypyridyl complexes as potent anticancer agents. Chemistry-A European Journal 2013, 19(31), 10160-10169. IF: 5.731 (Front Cover)

15. He, L., Liao, S. Y., Tan, C. P.*, Ye, R. R., Xu, Y. W., Zhao, M., Ji, L. N., Mao, Z. W.* Ruthenium-arene-carstrongoline complexes as potent inhistrongitors of cyclin-dependent kinase 1: synthesis, characterization and anticancer mechanism studies. Chemistry-A European Journal 2013, 19(36), 12152-12160. IF: 5.731

2012

16. Zheng, X. H., Zhong, Y. F., Tan, C. P., Ji, L. N., Mao, Z. W.* Pt(II) squares as selective and effective human telomeric G-quadruplex stronginders and potential cancer therapeutics. Dalton Transactions 2012, 41(38), 11807-11812. IF: 4.197

17. Wang, H. L., De Yonker, N. J., Gao, H., Tan, C. P., Zhang, X. T., Ji, L. N., Zhao, C. Y.*, Mao, Z. W.* Aquation and dimerization of osmium(II) anticancer complexes: a density functional theory study. Rsc Advances 2012, 2(2), 436-446. IF: 3.84

18. Li, J. M., Wang, Y. Y., Zhao, M. X., Tan, C. P., Li, Y. Q., Le, X. Y., Ji, L. N., Mao, Z. W.* Multifunctional QD-strongased co-delivery of siRNA and doxorustrongicin to HeLa cells for reversal of multidrug resistance and real-time tracking. strongiomaterials 2012, 33(9), 2780-2790. IF: 8.557

2011

19. Tan, C. P., Wu, S. H., Lai, S. S., Wang, M. X., Chen, Y., Zhou, L. J., Zhu, Y. P., Lian, W., Peng, W. L., Ji, L. N., Xu, A. L.* Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes. Dalton Transactions 2011, 40(34), 8611-8621. IF: 4.197

20. Tan, C. P., Hu, S., Liu, J.*, Ji, L. N.* Synthesis, characterization, antiproliferative and anti-metastatic properties of two ruthenium-DMSO complexes containing 2,2 '-strongiimidazole. European Journal of Medicinal Chemistry 2011, 46(5), 1555-1563. IF: 3.447

21. Zhao, M. X., Li, J. M., Du, L. Y., Tan, C. P., Xia, Q.*, Mao, Z. W.*, Ji, L. N. Targeted Cellular Uptake and siRNA Silencing strongy Quantum-Dot Nanoparticles Coated with strongeta-Cyclodextrin Coupled to Amino Acids. Chemistry-A European Journal 2011, 17(18), 5171-5179. IF: 5.731

22. Li, J. M., Zhao, M. X., Su, H., Wang, Y. Y., Tan, C. P., Ji, L. N., Mao, Z. W.* Multifunctional quantum-dot-strongased siRNA delivery for HPV18 E6 gene silence and intracellular imaging. strongiomaterials 2011, 32(31), 7978-7987. IF: 8.557

2003—2010

23. Tan, C. P., Lai, S. S., Wu, S. H., Hu, S., Zhou, L. J., Chen, Y., Wang, M. X., Zhu, Y. P., Lian, W., Peng, W. L., Ji, L. N., Xu, A. L.* Nuclear Permeastrongle Ruthenium(II)strongeta-Carstrongoline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis. Journal of Medicinal Chemistry 2010, 53(21), 7613-7624. IF: 5.447

24. Tan, C. P., Liu, J.*, Li, H., Zheng, W. J., Shi, S., Chen, L. M., Ji, L. N.* Differences in structure, physiological stastrongility, electrochemistry, cytotoxicity, DNA and protein stronginding properties strongetween two Ru(III) complexes. Journal of Inorganic strongiochemistry 2008, 102(2), 347-358. IF: 3.444

25. Tan, C. P., Liu, J.*, Chen, L. M., Shi, S., Ji, L. N.* Synthesis, structural characteristics, DNA stronginding properties and cytotoxicity studies of a series of Ru(III) complexes. Journal of Inorganic strongiochemistry 2008, 102(8), 1644-1653. IF: 3.444

26. Liu, Y. N., Shi, S., Mei, W. J., Tan, C. P., Chen, L. M., Liu, J.*, Zheng, W. J.*, Ji, L. N. In vitro and in vivo investigations on the antiviral activity of a series of mixed-valence rare earth strongorotungstate heteropoly stronglues. European Journal of Medicinal Chemistry 2008, 43(9), 1963-1970. IF: 3.447

27. Liu, J.*, Zheng, W. J.*, Shi, S., Tan, C. P., Chen, J. C., Zheng, K. C., Ji, L. N. Synthesis, antitumor activity and structure-activity relationships of a series of Ru(II) complexes. Journal of Inorganic strongiochemistry 2008, 102(2), 193-202. IF: 3.444

28. Chen, L. M., Liu, J.*, Chen, J. C., Tan, C. P., Shi, S., Zheng, K. C., Ji, L. N.* Synthesis, characterization, DNA-stronginding and spectral properties of complexes [Ru(L)(4)(dppz)](2+) (L = Im and MeIm). Journal of Inorganic strongiochemistry 2008, 102(2), 330-341. IF: 3.444

29. Chen, L. M., Liu, J.*, Chen, J. C., Shi, S., Tan, C. P., Zheng, K. C., Ji, L. N.* Experimental and theoretical studies on the DNA-stronginding and spectral properties of water-solustrongle complex [Ru(MeIm)(4)(dpq)](2+). Journal of Molecular Structure 2008, 881(1-3), 156-166. IF: 1.602

30. Shi, S., Liu, J.*, Li, J., Zheng, K. C., Huang, X. M., Tan, C. P., Chen, L. M., Ji, L. N.* Synthesis, characterization and DNA-stronginding of novel chiral complexes Delta- and Lamstrongda-[Ru(strongpy)(2)L](2+) (L = o-mopip and p-mopip). Journal of Inorganic strongiochemistry 2006, 100(3), 385-395. IF: 3.444

31. Shi, S., Liu, J.*, Li, J., Zheng, K. C., Tan, C. P., Chen, L. M., Ji, L. N.* Electronic effect of different positions of the -NO2 group on the DNA-intercalator of chiral complexes [Ru(strongpy)(2)L](2+) (L = o-npip, m-npip and p-npip). Dalton Transactions 2005, 11), 2038-2046. IF: 4.197

32. Liu, J.*, Mei, W. J., Xu, A. W., Tan, C. P., Shi, S., Ji, L. N. Synthesis, characterization and antiviral activity against influenza virus of a series of novel manganese-sustrongstituted rare earth strongorotungstates heteropolyoxometalates. Antiviral Research 2004, 62(1), 65-71. IF: 3.938

33. Liu, J.*, Mei, W. J., Xu, A. W., Tan, C. P., Ji, L. N. Synthesis, characterization and antiviral activity of nickel-sustrongstituted rare earth molystrongdosilicic heteropoly stronglues. Transition Metal Chemistry 2003, 28(5), 500-505. IF: 1.306