許家林，男，博士，東北大學生命科學與健康學院生化與分子生物學研究所教授、碩士研究生導師。
基本介紹
- 中文名：許家林
- 職業：教師
- 畢業院校：北京協和醫學院
- 學位/學歷：博士
- 專業方向：生命科學與健康
- 任職院校：東北大學
人物經歷,學習經歷,工作經歷,學術兼職,研究方向,學術成果,科研項目,發表論文,
人物經歷
學習經歷
2009年於北京協和醫學院畢業並獲得博士學位。從2009年11月起，在美國羅德島大學藥學院（University of Rhode Island）從事博士後研究。
工作經歷
2013年8月進入東北大學生命科學與健康學院任職。
學術兼職
Journal of Biochemical and Molecular Toxicology,British Journal of Nutrition, Clinical Nutrition,BMC Pharmacology and Toxicology, PLoS ONE, andToxicology and Applied Pharmacology等雜誌專業審稿人。
研究方向
隨著人類飲食結構的改變和現代化程度的加深，肥胖發生呈現不斷增高的趨勢，並誘發多種其他種類的疾病：糖尿病、心血管疾病、老年病、癌症等，所以阻止肥胖發生至關重要。通過使用多種轉基因小鼠動物模型和細胞模型，探索肥胖發生和糖尿病發展的疾病機理；並通過研究多種天然化合物對糖尿病和肥胖等疾病病症的影響，尋求可以有效抑制肥胖和糖尿病等疾病發生和發展的治療策略。
學術成果
先後主持國家級相關課題5項，發表SCI論文二十餘篇。
科研項目
1．國家自然科學基金面上項目：BAP31調節脂肪組織堆積和肥胖發生的作用研究(項目批准號：81974120)。55萬元，項目主持者。
2．國家自然科學基金面上項目：BAP31在非酒精性脂肪肝和糖代謝中的作用研究（項目批准號：81570788）。58萬元，項目主持者。
3．國家自然科學基金主任基金：Nrf2對高脂飲食誘導肥胖引起的免疫紊亂的調節機制的探討（項目批准號：81341102）。15萬元，項目主持者。
4．中央高校基本科研業務費探索導向重點項目：PTP-PEP對肥胖誘導的免疫紊亂的調節機制的探討。40萬元，項目主持者。
5. 中央高校基本科研業務費青年教師科研創新基金項目：BAP31基因敲除誘導SREBP1C激活並促進非酒精性脂肪肝形成。10萬元，項目主持者。
發表論文
1.Jialin Xu, Tingting Liu, Yuanyuan Li, Wei Liu, Zhanjun Ding, Hang Ma,Navindra P. Seeram, Yu Mu, Xueshi Huang, and Liya Li.Jamun (Eugenia jambolana Lam.) Fruit Extract PreventsObesity by Modulating the Gut Microbiome inHigh-Fat-Diet-Fed Mice. Molecular Nutrition Food Research. 2019, 63(9):e1801307.
2. Zhenhua Wu, Fan Yang, Shan Jiang, Xiaoyu Sun and Jialin Xu.Induction of Liver Steatosis in BAP31-Deficient MiceBurdened with Tunicamycin-Induced EndoplasmicReticulum Stress. InternationalJournal of Molecular Sciences. 2018, 19, 2291; doi:10.3390/ijms19082291.
3. Jialin Xu,Tingting Liu, Yuanyuan Li, Chunhui Yuan, Hang Ma, Navindra P. Seeram, Feifei Liu, Yu Mu, Xueshi Huang and Liya Li.Hypoglycemic and hypolipidemic effects oftriterpenoid-enriched Jamun (Eugenia jambolanaLam.) fruit extract in streptozotocin-induced type1 diabetic mice. Food and Function.2018, 9, 3330.
4.Jialin Xu, Chunhui Yuan, Guihua Wang,Jiaming Luo, Hang Ma, Li Xu, Yu Mu, Yuanyuan Li, Navindra P. Seeram, Xueshi Huang, and Liya Li. Urolithins Attenuate LPS-Induced Neuroinflammation inBV2Microglia via MAPK, Akt, and NF-κB Signaling Pathways. J Agric Food Chem.2018,24;66(3):571-580.
5. Jialin Xu,Liya Li,Yanqing Wang,Yaqi Li, Mu Shan, Shizhuo Sun, Yang Yu, Bing Wang. Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice. J Lipid Res.2018, 59(1):35-47.
6. Kunwei Niu, JialinXu, YuhuaCao, Yue Hou, Mu Shan, YanqingWang, YangXu, Mingyi Sun & BingWang. BAP31 is involved in T cell activation through TCR signal pathwaysactivation through TCR signalpathways. Sci.Rep.2017, 7, 44809; doi: 10.1038/srep44809.
7. HangMa, JialinXu, NicholasA.DaSilva,LingWang, ZhengxiWei,LiangranGuo,ShelbyL.Johnson,WeiLu,JunXu,QiongGu,NavindraP.Seeram. Cosmetic applications of glucitol-core containing gallotannins from a proprietary phenolic-enriched red maple (Acer rubrum) leaves extract: inhibition of melanogenesis via down-regulation of tyrosinase and melanogenic gene expression in B16F10 melanoma cells.Arch Dermatol Res,2017, 309:265–274.
8. Yuanyuan Li*, Jialin Xu*, Chunhui Yuan, Hang Ma, Tingting Liu, Feifei Liu, Navindra P. Seeram,Yu Mu, Xueshi Huang,Liya Li. Chemical composition and anti-hyperglycaemic effects of triterpenoidenriched Eugenia jambolana Lam. berry extract. Journal of Functional Foods2017, 28:1–10.（*共同第一作者）
9.Jialin Xu,Prajakta Shimpi, Laura Armstrong, Deanna Salter, Angela L. Slitt. PFOS induces adipogenesis and glucose uptake in association withactivation of Nrf2 signaling pathway. Toxicology and Applied Pharmacology. 2016, 290:21-30.
10. Liya Li*, Jialin Xu*, Yu Mu, Li Han, Ruohan Liu, Yaping Cai, Xueshi Huang. Chemical characterization and antihyperglycaemiceffects of polyphenolenriched longan (Dimocarpus longan Lour.)pericarp extracts. Journal of Functional Foods. 2015,13:314-322.（*共同第一作者）
11. JialinXu,AjayC Donepudi,VijayR More,SupriyaR Kulkarni,LiyaLi, Liangran Guo,BingfangYan,ChatterjeeTapan,Weintraub Neal,and AngelaL Slitt. Deficiency in Nrf2 Transcription Factor Decreases Adipose TissueMass and Hepatic Lipid Accumulation in Leptin-Deficient Mice. Obesity. 2014, 23:335-344.
12. Supriya R. Kulkarni, Ajay C Donepudi, Jialin Xu, Wei Wei, Qiuqiong C. Cheng, Maureen Varina Driscoll, Jeffrey A. Johnson, and Angela L. Slitt. Fasting Induces Nuclear Factor E2-Related Factor 2and ATP-Binding Cassette Transporters via ProteinKinase A and Sirtuin-1 in Mouse and Human. Antioxidants & Redox Signaling. 2014,20(1):15-30.
13. Jialin Xu, Ajay C. Donepudi, Jamie E. Moscovitz, and Angela L. Slitt. Keap1-knockdown Decreases Fasting-Induced Fatty Liver via Altered Lipid Metabolism and Decreased Fatty Acid Mobilization from Adipose Tissue. PlOS ONE. 2013,8(11).
14.Kulkarni SR, Xu J, Donepudi AC, Wei W, Slitt.Effect of Caloric Restriction andAMPK Activation on Hepatic Nuclear Receptor, Biotransformation Enzyme, and Transporter Expression in Lean and Obese Mice. Pharmaceutical Research. 2013,30(9):2232-47.
15. Vijay More, Jialin Xu, Prajakta Shimpi, Clyde Belgrave, James Luyendyk, Masayuki Yamamoto, Angela Slitt. Keap1 Knockdown increases markers of metabolic syndrome after long-term high fat diet feeding. Free Radical Biology and Medicine. 2013,61:85–94.
16. Lauren M. Aleksunes,Jialin Xu, Eugenia Lin, Xia Wen, Michael J. Goedken and Angela L. Slitt. Pregnancy Represses Induction of Efflux Transporters in Livers of type I Diabetic Mice. PharmaceuticalResearch. 2013, 30(9):2209-20.
17. Laura E. Armstrong, Maureen V. Driscoll, Ajay C. Donepudi, Jialin Xu, Angela A. Baker, Lauren Aleksunes, Jason R. Richardson, and Angela L. Slitt. Effects of Developmental Deltamethrin Exposure on White Adipose Tissue Gene Expression. Journal of Biochemical and Molecular Toxicology. 2013, 27(2):165-71.
18. Jialin Xu, Supriya R. Kulkarni, Ajay C. Donepudi, Vijay R. More, and Angela L. Slitt. Enhanced Nrf2 Activity Worsens Insulin Resistance,Impairs Lipid Accumulation in Adipose Tissue, andIncreases Hepatic Steatosis in Leptin-Deficient Mice. Diabetes. 2012,61:3208–3218.
19. Jialin Xu, Supriya Kulkarni, Liya Li and Angela L. Slitt. UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis. Drug Metabolism and Disposition. 2012, 40 (2):259-66.
20. Yao Song*, Jialin Xu*, Yanfeng Li, Chunshi Jia, Xiaowei Ma, Lei Zhang, Xiaojie Xie, Yong Zhang, Xiang Gao, Youyi Zhang, Dahai Zhu. Cardiac ankyrin repeat protein attenuates cardiac hypertrophy by inhibition of ERK1/2 and TGF-β signaling pathways (*共同第一作者). PlOS ONE. 2012,7(12): e50436.
21. Tao Yuan, Yuanqing Ding, Chunpeng Wan, Liya Li, Jialin Xu, Ke Liu, Angela Slitt, Daneel Ferreira, Ikhlas A. Khan, Navindra P. Seeram. Antidiabetic Ellagitannins fromPomegranate Flowers: Inhibition ofαGlucosidase and Lipogenic GeneExpression.Organic Letters. 2012,14 (20):5358–5361.
22. Seeram Navindra, Jialin Xu, Liya Li, Angela Slitt. Pharmacy research at URI: mining red maple (Acer rubrum) trees for novel therapeutics to manage diabetes.Med Health RI. 2012, 95(9):283-4.
23.許家林，李艷鳳，朱大海。心肌錨定重複序列蛋白基因心臟特異敲除小鼠模型構建與鑑定。基礎醫學與臨床, 2011, 31(11):1217-1222。
24. Jianwei Ye, Yong Zhang, Jialin Xu, Qiang Zhang, Dahai Zhu. FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy. Gene.2007, 404: 53–60.
