基本介紹
- 中文名：董肖椿
- 畢業院校：復旦大學藥學院
- 學位/學歷：博士
- 職業：教師
- 專業方向：藥物化學
- 職務：復旦大學藥學院碩士生導師
- 任職院校：復旦大學藥學院
- 職稱：副教授
個人經歷,教育經歷,工作經歷,研究方向,學術成果,科研項目,代表性論著,
個人經歷
教育經歷
2000.9.-2003.6：復旦大學藥學院藥物化學專業，碩士；
1993.9.-1997.6：華東師範大學化學系化學專業，學士
工作經歷
2013.12- 至今：復旦大學藥學院藥謎微船炒物化學教研室，副教授；
2008.9 -2009.9：美國明尼蘇達大學藥學院藥物化學系，博士後；
1997.7- 2013.11：復旦大學藥學院藥物化學教研室，助恥充乘教/講師。
研究方向
1. 基於分子靶向、腫瘤信號通路及碑說辯免疫相關小分子抗腫瘤藥物先導化合物研究；
2. 有甩寒阿贈機藥物合成方法研究。
學術成果
科研項目
1. 國家自然科學基金面上項目（21572037），新結構類型Hedgehog通路抑制劑的設計、合成和構效關係研究，主持；
2. 上海市自然科學基金面上項目（12ZR1403300），含氮雜四元環骨架的新型Hedgehog通路抑制劑的設計、合殼歸成及抗腫瘤活性研究，主持；
3. 國家自然科學基金面淚辣兵上項目（鑽酷承81573363），基於水淬滅近紅外螢光探針的口服脂質納米給藥系統體內命運與作用機制研究，參與；
4. 國家自然科學基金面上項目（81872816），新型水淬滅近紅外螢光探針的設計及其在納米粒體內過程研究中的套用，參與。
代表性論著
1. Mingfei Zhu, Hong Wang, Chenglin Wang, Yanfen Fang, Tong Zhu, Weili Zhao,Xiaochun Dong*, Xiongwen Zhang*, L-4, a well-tolerated and orally active inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against medulloblastoma in vitro and in vivo.Front. Pharmacol.,2019, 10, e89.
2.Xiaochun Dong, Chenglin Wang, Zhongjian Chen*, Weili Zhao*. Overcoming the Resistance mechanisms of Smoothened inhibitors,Drug Discovery Today2018, 23: 704-710
3. Chenglin Wang, Mingfei Zhu, Xiuhong Lu, Hong Wang, Weili Zhao, Xiongwen Zhang*,Xiaochun Dong*. Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors.Bioorg. Med. Chem.2018, 26, 3308-3320
4. Xiuhong Lu, Zhongjian Chen*,Xiaochun Dong*, Weili Zhao*. Water -Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos.ACS Sensors,2018, 3: 59-64
5. Xiuhong Lu, Yuanqiu Peng, Chenglin Wang, Jun Yang, Xiaolong Bao, Qian Dong, Weili Zhao*, Wenfu Tan*,Xiaochun Dong*. Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors.Eur. J Med. Chem.2017, 138, 384-395.
6. Feng Yang, Wen Wang, Kaidi Li, Weili Zhao*,Xiaochun Dong*. Efficient one-pot construction of unsymmetrical disulfide bonds with TCCA.Tetrahedron Lett.,2017, 58, 218–222.
7. Xiaolong Bao, Yuanqiu Peng, Xiuhong Lu, Jun Yang, Weili Zhao*, Wenfu Tan*,Xiaochun Dong*. Synthesis and evaluation of novel benzylphthalazine derivatives as hedgehog signaling pathway inhibitors.Bioorg. Med. Chem, Lett.2016, 26, 3048-3051.
8. Lu Xiuhong, Wang Wen, Dong Qian, Bao Xiaolong, Lin Xianfeng, Zhang Weixing,Dong Xiaochun*, Zhao Weili*. A multi-functional probe to discriminate Lys, Arg, His, Cys, Hcy and GSH from common amino acids.Chemical Communications,2015, 51(8): 1498-1501.
4. Xiuhong Lu, Zhongjian Chen*,Xiaochun Dong*, Weili Zhao*. Water -Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos.ACS Sensors,2018, 3: 59-64
5. Xiuhong Lu, Yuanqiu Peng, Chenglin Wang, Jun Yang, Xiaolong Bao, Qian Dong, Weili Zhao*, Wenfu Tan*,Xiaochun Dong*. Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors.Eur. J Med. Chem.2017, 138, 384-395.
6. Feng Yang, Wen Wang, Kaidi Li, Weili Zhao*,Xiaochun Dong*. Efficient one-pot construction of unsymmetrical disulfide bonds with TCCA.Tetrahedron Lett.,2017, 58, 218–222.
7. Xiaolong Bao, Yuanqiu Peng, Xiuhong Lu, Jun Yang, Weili Zhao*, Wenfu Tan*,Xiaochun Dong*. Synthesis and evaluation of novel benzylphthalazine derivatives as hedgehog signaling pathway inhibitors.Bioorg. Med. Chem, Lett.2016, 26, 3048-3051.
8. Lu Xiuhong, Wang Wen, Dong Qian, Bao Xiaolong, Lin Xianfeng, Zhang Weixing,Dong Xiaochun*, Zhao Weili*. A multi-functional probe to discriminate Lys, Arg, His, Cys, Hcy and GSH from common amino acids.Chemical Communications,2015, 51(8): 1498-1501.
