葛亮 ，博士，清華大學研究員，助理教授。
基本介紹
- 中文名：葛亮
- 職業：研究員
- 畢業院校：山東師範大學
個人簡歷,主要科研領域與方向,代表論文,獲獎情況,
個人簡歷
葛亮，博士，清華大學研究員，助理教授。
2001-2005年，山東師範大學生命科學院 學士
2005-2011年，中科院上海生化細胞所 生物化學博士
2011-2015年，美國加州大學伯克利分校 博士後
2015-2017年，美國加州大學伯克利分校 研究員（Research Specialist）
2017- 清華大學生命科學學院-生命科學聯合中心 助理教授， 研究員
主要科研領域與方向
細胞自噬是細胞內物質自我清理和更新的重要機制，與衰老和許多重大疾病密切相關。我們運用最新的細胞生物學和生物化學手段研究細胞自噬的分子機制和生物學功能，集中於自噬體膜形成的分子機制，以及其調節毒性蛋白聚集體的降解和非典型分泌的研究。我們也同時致力於細胞自噬對細胞內穩態維持以及相關重大疾病（如癌症和神經退行疾病）的研究。
代表論文
1.Liang Ge*, Min Zhang, Sam Kenny, Anandita Mathur, Dawei Liu, Miharu Maeda, Kota Saito, Ke Xu, and Randy Schekman. Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis. EMBO Report (2017) 18(9):1586-1603. * Corresponding author.
2. Livia W Brier, Min Zhang, Liang Ge*. Mechanistically dissecting autophagy: insights from in vitro reconstitution. J Mol Biol (2016) 8;428(9 Pt A):1700-13.*Corresponding author
3.Liang Ge, Livia Wilz and Randy Schekman. Biogenesis of autophagosomal precursors for LC3 lipidation from the ER-Golgi intermediate compartment. Autophagy (2015) 11(12):2372-4
4.Liang Ge, Min Zhang and Randy Schekman. Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment. eLife (2014) Nov 28; 3:e04135.
5.Liang Ge, Sulochanadevi Baskaran, Randy Schekman and James H Hurley. The protein-vesicle network of autophagy. Curr Opin Cell Biol (2014) 29C:18-24.
6.Liang Ge and Randy Schekman. The ER-Golgi intermediate compartment feeds the phagophore membrane. Autophagy (2013) 10(1):170-2
7.Liang Ge, David Melville, Min Zhang and Randy Schekman. The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. eLife (2013) Aug 6; 2:e00947. Selected for F1000Prime and highlighted by Daniel Klionsky [Amélie Bernard and Daniel J Klionsky. Defining the membrane precursor supporting the nucleation of the phagophore. Autophagy (2014) 10(1):1-2].
8.Liang Ge, Wei Qi, Li-Juan Wang, Hong-Hua Miao, Yu-Xiu Qu, Bo-Liang Li and Bao-Liang Song. Flotillins play an essential role in Niemann-Pick C1 Like 1-mediated cholesterol uptake. Proc Natl Acad Sci USA (2011) 108(2):551-556
9.Liang Ge, Jing Wang, Wei Qi, Hong-Hua Miao, Jian Cao, Yu-Xiu Qu, Bo-Liang Li and Bao-Liang Song. The cholesterol absorption inhibitor Ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Cell Metabolism (2008) 7:508-519. Selected for F1000Prime; Featured Article; Commented in Cell Metabolism (2008) 7:469-471
10.Jin-Hui Zhang*,Liang Ge*, Wei Qi, Liqing Zhang, Hong-Hua Miao, Bo-Liang Li, Maojun Yang and Bao-Liang Song. The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. J Biol Chem (2011) 286(28):25088-097 *Equal contribution
11.Bei-Bei Chu*, Liang Ge*, Yang Zhao, Jing Wang, Bo-Liang Li and Bao-Liang Song. Requirement of myosin Vb·Rab11a·Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. J Biol Chem (2009) 284(33):22481-90. *Equal contribution
獲獎情況
NIH Pathway to Independence Award (K99/R00) (2015-2017)
Jane Coffin Child Foundation Fellowship (2013-2015)
Human Frontier Science Program Fellowship (2012)
