《細胞鈣信號轉導與調控機理研究》是程和平為項目負責人，北京大學為依託單位的重點項目。
基本介紹
- 中文名：細胞鈣信號轉導與調控機理研究
- 項目類別 ：重點項目
- 項目負責人：程和平
- 依託單位 ：北京大學
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | CARDIOPROTECTION BY MG53 MEDIATED MEMBRANE REPAIR | 會議論文 | Chen, Zheng|Takeshima, Hiroshi|Cheng, Heping|Xie, Wenjun|Wang, Yanru|Zhang, Yi|Weisleder, Noah|Ma, Jianjie|Zheng, Ming|Wang, Xianhua|Han, Liang|Ji, Guangju|Han, Peidong| |
2 | Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes | 期刊論文 | Yang, D|Cheng HP|Lakatta, E. G.|Chen, S. R. W.|Xiao, R.P.|Brochet, D. X. P.|Xiao, B|Zhu, W.Z| |
3 | Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle | 期刊論文 | Chu, Y.|Weisleder, N.|Takeshima, H.|Cheng HP|Collet, C.|Hirata, Y.|Ma, J.|Ferrante, C.| |
4 | Rad As a Novel Regulator of Excitation-Contraction Coupling and beta-Adrenergic Signaling in Heart | 期刊論文 | Chen, Chunlei|Liu, Jie|Zhang, Jifeng|Li, Kaitao|Wu, Caihong|Cao, Chunmei|Sun, Zhongcui|Cheng, Heping|Wang, Yanru|Xie, Wenjun|Zhu, Xiaojun|Wang, Gang|Song, Ruisheng|Han, Peidong| |
5 | Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes | 期刊論文 | Cheng, Heping|Wei, Chaoliang|Yan, Yuan|Li, Kaitao|Wang, Yanru|Liu, Jie|Xie, Wenjun| |
6 | Superoxide flashes in single mitochondria | 期刊論文 | Mattson MP|Zheng M|Zhang WR|Chen J|Dirksen RT|Wang W|Fang HQ|Cheng A|Yin J|Sheu SS|Ouyang KF|Li KL|Lakatta EG|Liu J|Wang XH|Wang WD|Groom L|Cheng HP|Han PD|Kao JPY| |
7 | Cardioprotection of Ischemia/Reperfusion Injury by Cholesterol-Dependent MG53-Mediated Membrane Repair | 期刊論文 | Zheng, Ming|Lin, Peihui|Ji, Guangju|Wang, Yanru|Cheng, Heping|Zhang, Yi|Han, Liang|Han, Peidong|Wang, Xianhua|Weisleder, Noah|Xiao, Rui-Ping|Xie, Wenjun|Ma, Jianjie|Chen, Zheng|Takeshima, Hiroshi| |
8 | beta-Adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel | 期刊論文 | Bai SH|Zhao YT|Xu SM|Lakatta EG|Hao XM|Guo YB|Wang SQ|Zhou P|Cheng HP| |
9 | Flickering calcium microdomains signal turning of migrating cells | 期刊論文 | Zheng, Ming|Cheng, Heping|Wei, Chaoliang|Wang, Xianhua|Chen, Min|Ouyang, Kunfu| |
10 | Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor - Sensitization of store overload-induced Ca2+ release | 期刊論文 | Xiao, Bailong|Wang, Xianhua|Tian, Xixi|Chen, Keyun|Cheng, Heping|Jiang, Dawei|Kong, Huihui|Jones, Peter P.|Zhang, Lin|Xie, Wenjun|Chen, S. R. Wayne|Walsh, Michael P.|Cai, Shitian| |
11 | Calcium sparks | 期刊論文 | Lederer WJ.|Cheng HP| |
12 | Calcium flickers steer cell migration | 期刊論文 | Chen M|Wang XH|Ouyang KF|Song LS|Wei CL|Cheng HP| |
項目摘要
細胞鈣信號轉導研究是一重大前沿生物醫學課題。鈣離子是細胞內最重要的信使物質之一，細胞鈣信號網路包含超過兩萬種相關蛋白質，功能上表現出極大的多樣性。在可興奮性及非可興奮性細胞中，鈣火花（Calcium Sparks）構成細胞內鈣信號轉導的基本單位，使得鈣信號具有多層次、多尺度的時-空特性，體現了簡單性與複雜性的統一。本項目擬從分子（鈣火花、鈣通道）、細胞器（線粒體、內質網、細胞核），信號通路和鈣信號
