基本介紹
- 中文名：秦瑩瑩
- 執業地點：山東大學生殖醫院
- 職稱：教授
- 主要成就：榮獲第十六屆中國青年科技獎
人物簡介,所獲榮譽,
人物簡介
秦瑩瑩，醫學博士，教授，主任醫師。長期致力於提高女性生殖健康與防治出生缺陷的基礎與臨床研究，取得了系列原創性成果，為臨床精準診療提供科學依據。揭示早發性卵巢功能不全（POI）致病新機制，建立中國女性卵巢儲備評估體系，創新卵泡體內、體外激活干預策略，開展高水平多中心臨床研究，提催埋翻供胚胎植入前非整倍體檢測臨床套用的循證醫學I級證據。主要從事早發性卵巢悼才多海功能不全（POI）的臨床診療及發病機理研究。近5年相關成果以第一或通訊作者在New England Journal of Medicine、Nucleic Acids Research、PLoS Genetics、Thyroid、Fertility and Sterility等醫學專業主流期刊發表SCI論文26篇，累計影響因子183。在領域權威雜誌Human Reproduction Update（2015）和Trends In Endocrinology & Metabolism（2018）發表POI專題綜述。入選教育部新世紀優秀人才、主持國家重點研發計畫1項、國家自然科學基金優秀青年基故想紙希擊射碑金1項。
研究領域或研究方向介紹
1. 早發性卵巢功能不全POI臨床及致病機制研究
科研資助/承擔項目
1. 國家自然科學基金面上項目，81771541，KLHL25-eIF4E通路在原發性卵巢功能不全發病中的作用及機制研究，2018.01-2021.12，在研，主持。
2. 國家重點研發計畫，2017YFC1001100，卵巢早衰病因學及臨床防治研究，2017.06-2020.12，在研，首席科學家。
3. 國家自然科學基金優秀青年基金，81522018，原發性卵巢功能不全，2016.01-2018.12，已結題，主持。
4. 國家自然科學基金面上項目，81471509，IL-22/IL-22受體信號通路在卵巢早衰發生髮展中的作用及機制，2015.01-2018.12，已結題，主持。
5. 國家自然科學基金面上項目，81270662，微霸炒家族性卵巢早衰致病基因篩選及功能研究，2013.01-2016.12，已結題，主持。
6. 國家重大科學研究計畫（973），2012CB944700，排卵障礙相關疾病發生機棵估制研究，2012.01-2016.08，已結題，參加。
7. 國家自然科學基金青年基金項目，81000236，中國漢族卵巢早衰患者全基因組關聯分析和拷貝數變異研究，2011.01-2013.12，已結題，主持。
社會兼職
國家自然基金委醫學科學部、發育與生殖生物學部基金項目評審專家
國家留學基金管理委員會國家公派高級研究學者及訪問學者（含博士後）項目評審專家
國家留學基金管理委員會國家留學基金（國家公派留學研究生項目）評審專家
亞太地區生殖醫學學會（ASPIRE）科學委員會委員
山東省醫學會婦產科學分會秘書
山東省醫學會婦產科科學分會青年委員會副主祝地己任委員
榮譽稱號
教育部新世紀優秀人才
國家自然科學基金優秀青年基金
全國百篇優秀博士學位論文
山東省“泰山青年學者”
山東省自然科學傑出青年基金
科研獲獎/專利
1. 2017年，第十一屆山東省青年科技獎
2. 2017年，“家族性卵巢早衰致病基因篩選及功能研究”，山東醫學科技獎（科技創新成果獎），一等獎
3. 2009年，“卵巢功能異常——PCOS和POF分子遺傳機理及治療新技術的建立和套用”，國家科學技術進步獎，二等獎
4. 2008年，“多囊卵巢綜合徵輔助生殖基礎與臨床系列研究”，2008年中華醫學科技獎，二等獎
代表性論著
1. Ting Guo; Ye Zheng; Guangyu Li; Shidou Zhao; Jinlong Ma;Yingying Qin; Novel pathogenic mutations in minichromosome maintenance complex component 9 (MCM9) responsible for premature ovarian insufficiency.,Fertil Steril, 2020, 113(4): 845-852.
2. Xiaoyan Wang; Xinyue Zhang; Yujie Dang; Duan Li; Gang Lu; Wai-Yee Chan; Peter C. K. Leung; Shidou Zhao;Yingying Qin; Zi-Jiang Chen; Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1.,Nucleic Acids Res, 2020, 48(8): 4480-4491.
3. Hanni Ke; Jingmei Hu; Lijuan Zhao; Lingling Ding; Xue Jiao;Yingying Qin; Impact of Thyroid Autoimmunity on Ovarian Reserve, Pregnancy Outcomes, and Offspring Health in Euthyroid Women Following In Vitro Fertilization/Intracytoplasmic Sperm Injection.,Thyroid, 2020, 30(4): 588-597.
4. Yajuan Yang; Ting Guo; Ran Liu; Hanni Ke; Weiwei Xu; Shidou Zhao;Yingying Qin; FANCL gene mutations in premature ovarian insufficiency.,Hum Mutat, 2020, 41(5): 1033-1041.
5.Yingying Qin; Feng Zhang; Zi-Jiang Chen; BRCA2 in Ovarian Development and Function,N Engl J Med, 2019, 380(11): 1086-1086.
6. Tuo Zhang; Xinhua Du; Lihua Zhao; Meina He; Lin Lin; Chuanhui Guo; Xinran Zhang; Jun Han; Hao Yan; Kun Huang; Guanghong Sun; Lei Yan; Bo Zhou; Guoliang Xia;Yingying Qin; Chao Wang; SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription.,FASEB J, 2019, 33(12): 14703-14716.
7. Hongli Liu; Ting Guo; Zheng Gong; Yongze Yu; Yingxin Zhang; Shidou Zhao;Yingying Qin; Novel FSHR mutations in Han Chinese women with sporadic premature ovarian insufficiency,Mol Cell Endocrinol, 2019, 492: 0-UNSP 110446.
8. Yang Zhou; Yan Qin;Yingying Qin; Binyang Xu; Ting Guo; Hanni Ke; Min Chen; Lianjun Zhang; Feng Han; Yaqiong Li; Min Chen; Axel Behrens; Yaqing Wang; Zhiheng Xu; Zi-Jiang Chen; Fei Gao; Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans.,PLoS Genet, 2018, 14(8): 0-e1007463.
9. Yujie Dang; Xiaoyan Wang; Yajing Hao; Xinyue Zhang; Shidou Zhao; Jinlong Ma;Yingying Qin; Zi-Jiang Chen; MicroRNA-379-5p is associate with biochemical premature ovarian insufficiency through PARP1 and XRCC6,Cell Death Dis, 2018, 9(2).
10. Xue Jiao; Hanni Ke;Yingying Qin; Zi-Jiang Chen; Molecular Genetics of Premature Ovarian Insufficiency,Trends Endocrinol Metab, 2018, 29(11): 795-807.
11. Ting Guo; Shidou Zhao; Shigang Zhao; Min Chen; Guangyu Li; Xue Jiao; Zhao Wang; Yueran Zhao;Yingying Qin; Fei Gao; Zi-jiang Chen; Mutationsin MSH5 in Primary Ovarian Insufficiency.,Hum Mol Genet, 2017, 26(8): 1452-1457.
12. Xiaoyun Dou; Ting Guo; Guangyu Li; LiGuang Zhou;Yingying Qin; Zi-Jiang Chen; Minichromosome maintenance complex component 8 mutations cause primary ovarian insufficiency,Fertil Steril, 2016, 106(6): 1485-1489.
13. Linlin Cui;Yingying Qin; Xuan Gao; Jun Lu; Ling Geng; Lingling Ding; Zhongyu Qu; Xiruo Zhang; Zi-Jiang Chen; Antimüllerian hormone: correlation with age and androgenic and metabolic factors in women from birth to postmenopause.,Fertil Steril, 2016, 105(2): 481-485.
14.Yingying Qin; Xue Jiao; Joe Leigh Simpson; Zi-Jiang Chen; Genetics of primary ovarian insufficiency: new developments and opportunities,Hum Reprod Update, 2015, 21(6): 787-808.
15.Yingying Qin; Ting Guo; Guangyu Li; Tie-Shan Tang; Shidou Zhao; Xue Jiao; Juanjuan Gong; Fei Gao; Caixia Guo; Joe Leigh Simpson; Zi-Jiang Chen; CSB-PGBD3 Mutations Cause Premature Ovarian Failure,PLoS Genet, 2015, 11(7): e1005419.
16.Yingying Qin; Xue Jiao; Raymond Dalgleish; Svetlana Vujovic; Jin Li; Joe Leigh Simpson; Farook Al-Azzawi; Zi-Jiang Chen; Novel variants in the SOHLH2 gene are implicated in human premature ovarian failure,Fertil Steril, 2014, 101(4): 1104-1109.
17.Yingying Qin; Svetlana Vujovic; Guangyu Li; Jin Li; Raymond Dalgleish; Joe Leigh Simpson; Maja Ivanisevic; Miomira Ivovic; Milina Tancic; Farook Al Azzawi; Zi-Jiang Chen; Ethnic specificity of variants of the ESR1, HK3, BRSK1 genes and the 8q22.3 locus: No association with premature ovarian failure (POF) in Serbian women,Maturitas, 2014, 77(1): 64-67.
18.Yingying Qin; Han Zhao; Jianfeng Xu; Yongyong Shi; Zhiqiang Li; Jie Qiao; Jiayin Liu; Chunrong Qin; Chune Ren; Jie Li; Shiling Chen; Yunxia Cao; China POF Study Group; Joe Leigh Simpson; Zi-Jiang Chen; Association of 8q22.3 locus in Chinese Han with idiopathic premature ovarian failure (POF),Human Molecular Genetics, 2012, 21(2): 430-436.
19. Yujie Dang;Yingying Qin; Rong Tang; Yulan Mu; Guangyu Li; Mingdi Xia; Zi-Jiang Chen; Variants of the WNT7A gene in Chinese patients with müllerian duct abnormalities,Fertil Steril, 2012, 97(2): 391-394.
20.Yingying Qin; Youngsok Choi; Han Zhao; Joe Leigh Simpson; Zi-Jiang Chen; Aleksandar Rajkovic; NOBOX homeobox mutation causes premature ovarian failure,Am J Hum Genet, 2007, 81(3): 576-581.
所獲榮譽
2022年7月，被公示為第十八屆中國青年女科學家獎擬獲獎人選。
2023年2月，被評為全國巾幗建功標兵。
2023年4月，獲第十八屆“中國青年女科學家獎”。
國家留學基金管理委員會國家留學基金（國家公派留學研究生項目）評審專家
亞太地區生殖醫學學會（ASPIRE）科學委員會委員
山東省醫學會婦產科學分會秘書
山東省醫學會婦產科科學分會青年委員會副主任委員
榮譽稱號
教育部新世紀優秀人才
國家自然科學基金優秀青年基金
全國百篇優秀博士學位論文
山東省“泰山青年學者”
山東省自然科學傑出青年基金
科研獲獎/專利
1. 2017年，第十一屆山東省青年科技獎
2. 2017年，“家族性卵巢早衰致病基因篩選及功能研究”，山東醫學科技獎（科技創新成果獎），一等獎
3. 2009年，“卵巢功能異常——PCOS和POF分子遺傳機理及治療新技術的建立和套用”，國家科學技術進步獎，二等獎
4. 2008年，“多囊卵巢綜合徵輔助生殖基礎與臨床系列研究”，2008年中華醫學科技獎，二等獎
代表性論著
1. Ting Guo; Ye Zheng; Guangyu Li; Shidou Zhao; Jinlong Ma;Yingying Qin; Novel pathogenic mutations in minichromosome maintenance complex component 9 (MCM9) responsible for premature ovarian insufficiency.,Fertil Steril, 2020, 113(4): 845-852.
2. Xiaoyan Wang; Xinyue Zhang; Yujie Dang; Duan Li; Gang Lu; Wai-Yee Chan; Peter C. K. Leung; Shidou Zhao;Yingying Qin; Zi-Jiang Chen; Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1.,Nucleic Acids Res, 2020, 48(8): 4480-4491.
3. Hanni Ke; Jingmei Hu; Lijuan Zhao; Lingling Ding; Xue Jiao;Yingying Qin; Impact of Thyroid Autoimmunity on Ovarian Reserve, Pregnancy Outcomes, and Offspring Health in Euthyroid Women Following In Vitro Fertilization/Intracytoplasmic Sperm Injection.,Thyroid, 2020, 30(4): 588-597.
4. Yajuan Yang; Ting Guo; Ran Liu; Hanni Ke; Weiwei Xu; Shidou Zhao;Yingying Qin; FANCL gene mutations in premature ovarian insufficiency.,Hum Mutat, 2020, 41(5): 1033-1041.
5.Yingying Qin; Feng Zhang; Zi-Jiang Chen; BRCA2 in Ovarian Development and Function,N Engl J Med, 2019, 380(11): 1086-1086.
6. Tuo Zhang; Xinhua Du; Lihua Zhao; Meina He; Lin Lin; Chuanhui Guo; Xinran Zhang; Jun Han; Hao Yan; Kun Huang; Guanghong Sun; Lei Yan; Bo Zhou; Guoliang Xia;Yingying Qin; Chao Wang; SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription.,FASEB J, 2019, 33(12): 14703-14716.
7. Hongli Liu; Ting Guo; Zheng Gong; Yongze Yu; Yingxin Zhang; Shidou Zhao;Yingying Qin; Novel FSHR mutations in Han Chinese women with sporadic premature ovarian insufficiency,Mol Cell Endocrinol, 2019, 492: 0-UNSP 110446.
8. Yang Zhou; Yan Qin;Yingying Qin; Binyang Xu; Ting Guo; Hanni Ke; Min Chen; Lianjun Zhang; Feng Han; Yaqiong Li; Min Chen; Axel Behrens; Yaqing Wang; Zhiheng Xu; Zi-Jiang Chen; Fei Gao; Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans.,PLoS Genet, 2018, 14(8): 0-e1007463.
9. Yujie Dang; Xiaoyan Wang; Yajing Hao; Xinyue Zhang; Shidou Zhao; Jinlong Ma;Yingying Qin; Zi-Jiang Chen; MicroRNA-379-5p is associate with biochemical premature ovarian insufficiency through PARP1 and XRCC6,Cell Death Dis, 2018, 9(2).
10. Xue Jiao; Hanni Ke;Yingying Qin; Zi-Jiang Chen; Molecular Genetics of Premature Ovarian Insufficiency,Trends Endocrinol Metab, 2018, 29(11): 795-807.
11. Ting Guo; Shidou Zhao; Shigang Zhao; Min Chen; Guangyu Li; Xue Jiao; Zhao Wang; Yueran Zhao;Yingying Qin; Fei Gao; Zi-jiang Chen; Mutationsin MSH5 in Primary Ovarian Insufficiency.,Hum Mol Genet, 2017, 26(8): 1452-1457.
12. Xiaoyun Dou; Ting Guo; Guangyu Li; LiGuang Zhou;Yingying Qin; Zi-Jiang Chen; Minichromosome maintenance complex component 8 mutations cause primary ovarian insufficiency,Fertil Steril, 2016, 106(6): 1485-1489.
13. Linlin Cui;Yingying Qin; Xuan Gao; Jun Lu; Ling Geng; Lingling Ding; Zhongyu Qu; Xiruo Zhang; Zi-Jiang Chen; Antimüllerian hormone: correlation with age and androgenic and metabolic factors in women from birth to postmenopause.,Fertil Steril, 2016, 105(2): 481-485.
14.Yingying Qin; Xue Jiao; Joe Leigh Simpson; Zi-Jiang Chen; Genetics of primary ovarian insufficiency: new developments and opportunities,Hum Reprod Update, 2015, 21(6): 787-808.
15.Yingying Qin; Ting Guo; Guangyu Li; Tie-Shan Tang; Shidou Zhao; Xue Jiao; Juanjuan Gong; Fei Gao; Caixia Guo; Joe Leigh Simpson; Zi-Jiang Chen; CSB-PGBD3 Mutations Cause Premature Ovarian Failure,PLoS Genet, 2015, 11(7): e1005419.
16.Yingying Qin; Xue Jiao; Raymond Dalgleish; Svetlana Vujovic; Jin Li; Joe Leigh Simpson; Farook Al-Azzawi; Zi-Jiang Chen; Novel variants in the SOHLH2 gene are implicated in human premature ovarian failure,Fertil Steril, 2014, 101(4): 1104-1109.
17.Yingying Qin; Svetlana Vujovic; Guangyu Li; Jin Li; Raymond Dalgleish; Joe Leigh Simpson; Maja Ivanisevic; Miomira Ivovic; Milina Tancic; Farook Al Azzawi; Zi-Jiang Chen; Ethnic specificity of variants of the ESR1, HK3, BRSK1 genes and the 8q22.3 locus: No association with premature ovarian failure (POF) in Serbian women,Maturitas, 2014, 77(1): 64-67.
18.Yingying Qin; Han Zhao; Jianfeng Xu; Yongyong Shi; Zhiqiang Li; Jie Qiao; Jiayin Liu; Chunrong Qin; Chune Ren; Jie Li; Shiling Chen; Yunxia Cao; China POF Study Group; Joe Leigh Simpson; Zi-Jiang Chen; Association of 8q22.3 locus in Chinese Han with idiopathic premature ovarian failure (POF),Human Molecular Genetics, 2012, 21(2): 430-436.
19. Yujie Dang;Yingying Qin; Rong Tang; Yulan Mu; Guangyu Li; Mingdi Xia; Zi-Jiang Chen; Variants of the WNT7A gene in Chinese patients with müllerian duct abnormalities,Fertil Steril, 2012, 97(2): 391-394.
20.Yingying Qin; Youngsok Choi; Han Zhao; Joe Leigh Simpson; Zi-Jiang Chen; Aleksandar Rajkovic; NOBOX homeobox mutation causes premature ovarian failure,Am J Hum Genet, 2007, 81(3): 576-581.
所獲榮譽
2022年7月，被公示為第十八屆中國青年女科學家獎擬獲獎人選。
2023年2月，被評為全國巾幗建功標兵。
2023年4月，獲第十八屆“中國青年女科學家獎”。
