石德利 ，男，山東大學講座教授，博士生導師。多年來一直從事發育生物學研究。 利用兩棲類（非洲爪蟾）和斑馬魚胚胎為動物模式，對動物胚胎髮育過程中的信號傳遞通路和基因功能，調控機理用分子生物學，細胞生物學，生物化學和生物物理學等手段和實驗工具進行跨學科的研究。特別是通過對Wnt信號通路的結構和功能研究來篩選對治療和預防腫瘤發生的化學藥物在國際領先。另一個研究方向集中在人類遺傳疾病相關基因在胚胎髮育中的功能和作用機理，為人類遺傳疾病的致病機理提供重要的理論基礎。
基本介紹
- 中文名：石德利
- 國籍：中國
- 民族：漢族
- 職業：導師
主要經歷,學術兼職,論文,
主要經歷
1978年-1982年：山東大學生物學系動物胚胎學專業學生，1982年獲得學士學位。
1983年-1988年：在法國巴黎第六大學博士研究生，發育生物學專業，1988年獲得博士學位。
1988年-1989年：在法國原子能中心作博士後研究。
1989年-1997年：任法國國家科學研究中心研究員。
1998-至今：任法國國家科學研究中心主任研究員。
2006-至今：任山東大學講座教授。
學術兼職
教育部長江學者海外評審專家
The ScientificWorldJournal雜誌編委
Developmental Biology Journal雜誌編委
Development, Mechanism of Development, Developmental Dynamics, Development Genes and Evolution 等10多種國際雜誌審稿人。
中國青年科技工作者協會理事
中國科協“海外智利為國服務行動計畫”顧問
The ScientificWorldJournal雜誌編委
Developmental Biology Journal雜誌編委
Development, Mechanism of Development, Developmental Dynamics, Development Genes and Evolution 等10多種國際雜誌審稿人。
中國青年科技工作者協會理事
中國科協“海外智利為國服務行動計畫”顧問
論文
研究成果及發表論文：
多幾年來在研究胚胎髮育機制及研究信號通路機理等領域取得令國際同行公認的成果,並有廣泛的國際合作。在Development, Molecular Cell, EMBO J, Developmental Biology等影響因子高的發育生物學和分子生物學國際權威雜誌上已發表論文60餘篇。累計被引用超過1800次，部分論文的單篇引用次數超過200次。個人H因子達到24。
近5年內發表學術論文：
1）Cao, J.M., Li, S.Q., Zhang, H.W. and Shi, D.L. (2012). High mobility group B proteins regulate mesoderm formation and dorsoventral patterning during zebrafish and Xenopus early development. Mech. Dev.
2）Havis, E., Coumailleau, P., Bonnet, A., Bismuth, K., Bonnin, M.A., Johnson, R., Fan, C.M., Relaix, F., Shi, D.L. and Duprez, D. (1012). Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis. Development
3）Kong, W., Yang, Y., Zhang, T., Shi*, D.L. and Zhang*, Y. （2012). Characterization of sFRP2-like in amphioxus: insights into the evolutionary conservation of Wnt antagonizing function. Evol. Dev.*Corresponding authors.
4）Li, H.Y., Bourdelas, A., Carron, C. and Shi, D.L. (2010). The RNA-binding protein Seb4 is a target of MyoD and is required for myogenesis during Xenopus early development. Mech. Dev.
5）Lee, H.J., Finkelstein, D., Li, X.F., Wu, D., Shi, D.L. and Zheng, J. (2010). Identification of Transmembrane Protein 88 (TMEM88) as a Dishevelled-Binding Protein. J. Biol. Chem.
6）Shao, M., Liu, Z.Z., Wang, C.D., Li, H.Y., Carron, C., Zhang, H.W. and Shi, D.L. (2009). Down syndrome critical region protein 5 regulates membrane localization of Wnt receptors and Dishevelled stability and convergent extension in vertebrate embryos. Development
7）Lee, H.J., Shao, Y.M., Wang, N.X., Shi*, D.L. and Zheng*, J. (2009). Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of Dishevelled. Angewandte Chimie International Edition *Corresponding authors.
8）Grandy, D., Shan, J.F., Akunuru, S., Rao, S., Li, H.Y., Zhang, Y.H.A., Alpatov, I., Zhang, X.A., Lang, R., Shi, D.L. and Zheng, J. (2009). Discovery and characterization of a small molecule inhibitor of the PDZ domain of Dishevelled. J. Biol. Chem.
9）Bourdelas, A. Li, H.Y., Carron, C. and Shi, D.L. (2009). Dynamic expression pattern of distinct genes in the presomitic and somitic mesoderm during Xenopus development. Intl. J. Dev. Biol.
10）Coolen, M., Sauka-Spengler, T., Nicolle, D., Le-Mentec, C., Lallemand, Y., Da Silva, C., Plouhinec, J.L., Robert, B., Wincker, P., Shi, D.L. and Mazan, S. (2007). Molecular characterisation of the early dogfish embryo: evolutionary implications on the mechanisms of early head and antero-posterior specification in jawed vertebrates. PloS ONE
多幾年來在研究胚胎髮育機制及研究信號通路機理等領域取得令國際同行公認的成果,並有廣泛的國際合作。在Development, Molecular Cell, EMBO J, Developmental Biology等影響因子高的發育生物學和分子生物學國際權威雜誌上已發表論文60餘篇。累計被引用超過1800次，部分論文的單篇引用次數超過200次。個人H因子達到24。
近5年內發表學術論文：
1）Cao, J.M., Li, S.Q., Zhang, H.W. and Shi, D.L. (2012). High mobility group B proteins regulate mesoderm formation and dorsoventral patterning during zebrafish and Xenopus early development. Mech. Dev.
2）Havis, E., Coumailleau, P., Bonnet, A., Bismuth, K., Bonnin, M.A., Johnson, R., Fan, C.M., Relaix, F., Shi, D.L. and Duprez, D. (1012). Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis. Development
3）Kong, W., Yang, Y., Zhang, T., Shi*, D.L. and Zhang*, Y. （2012). Characterization of sFRP2-like in amphioxus: insights into the evolutionary conservation of Wnt antagonizing function. Evol. Dev.*Corresponding authors.
4）Li, H.Y., Bourdelas, A., Carron, C. and Shi, D.L. (2010). The RNA-binding protein Seb4 is a target of MyoD and is required for myogenesis during Xenopus early development. Mech. Dev.
5）Lee, H.J., Finkelstein, D., Li, X.F., Wu, D., Shi, D.L. and Zheng, J. (2010). Identification of Transmembrane Protein 88 (TMEM88) as a Dishevelled-Binding Protein. J. Biol. Chem.
6）Shao, M., Liu, Z.Z., Wang, C.D., Li, H.Y., Carron, C., Zhang, H.W. and Shi, D.L. (2009). Down syndrome critical region protein 5 regulates membrane localization of Wnt receptors and Dishevelled stability and convergent extension in vertebrate embryos. Development
7）Lee, H.J., Shao, Y.M., Wang, N.X., Shi*, D.L. and Zheng*, J. (2009). Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of Dishevelled. Angewandte Chimie International Edition *Corresponding authors.
8）Grandy, D., Shan, J.F., Akunuru, S., Rao, S., Li, H.Y., Zhang, Y.H.A., Alpatov, I., Zhang, X.A., Lang, R., Shi, D.L. and Zheng, J. (2009). Discovery and characterization of a small molecule inhibitor of the PDZ domain of Dishevelled. J. Biol. Chem.
9）Bourdelas, A. Li, H.Y., Carron, C. and Shi, D.L. (2009). Dynamic expression pattern of distinct genes in the presomitic and somitic mesoderm during Xenopus development. Intl. J. Dev. Biol.
10）Coolen, M., Sauka-Spengler, T., Nicolle, D., Le-Mentec, C., Lallemand, Y., Da Silva, C., Plouhinec, J.L., Robert, B., Wincker, P., Shi, D.L. and Mazan, S. (2007). Molecular characterisation of the early dogfish embryo: evolutionary implications on the mechanisms of early head and antero-posterior specification in jawed vertebrates. PloS ONE
