《病理性情感記憶的喚起和消退的神經生物學機制》是陸林為項目負責人，北京大學為依託單位的青年科學基金項目。
基本介紹
- 中文名：病理性情感記憶的喚起和消退的神經生物學機制
- 項目類別 ：重點項目
- 依託單位 ：北京大學
- 項目負責人：陸林
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects | 期刊論文 | Li, Su-Xia，Han, Ying，Xu, Ling-Zhi，Yuan, Kai，Zhang, Ruo-Xi，Sun, Cheng-Yu，Xu, De-Feng，Yuan, Ming，Deng, Jia-Hui，Meng, Shi-Qiu，Gao, Xue-Jiao，Wen, Quan，Liu, Li-Jing，Zhu, Wei-Li，Xue, Yan-Xue，Zhao, Mei，Shi, Jie，Lu, Lin(*) |
2 | 一種半抗原與載體共價結合的嗎啡/海洛因疫 苗及其套用 | 專利 | 陸林，孫成玉，李芊芊，羅宜孝，徐凌志 |
3 | Role of Hippocampal beta-Adrenergic and Glucocorticoid Receptors in the Novelty-Induced Enhancement of Fear Extinction | 期刊論文 | Liu, Jian-Feng，Yang, Chang，Deng, Jia-Hui，Yan, Wei，Wang, Hui-Min，Luo, Yi-Xiao，Shi, Hai-Shui，Meng, Shi-Qiu，Chai, Bai-Sheng，Fang, Qin，Chai, Ning，Xue, Yan-Xue，Sun, Jia，Chen, Chen，Wang, Xue-Yi，Wang, Ji-Shi，Lu, Lin(*) |
4 | eIF2alpha dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. | 期刊論文 | Jian, Min，Luo, Yi-Xiao，Xue, Yan-Xue，Han, Ying，Shi, Hai-Shui，Liu, Jian-Feng，Yan, Wei，Wu, Ping，Meng, Shi-Qiu，Deng, Jia-Hui，Shen, Hao-Wei，Shi, Jie，Lu, Lin(*) |
5 | 用於檢測rs7597593位點和rs1344706位點的核苷酸的物質的新用途 | 專利 | 時傑，孫艷，胡蝶，梁潔，陸林，王貴彬，朱維莉 |
6 | DAPK1抑制劑在製備抗抑鬱藥物中的套用 | 專利 | 陸林，李素霞，徐凌志，袁銘，劉麗京，時傑，朱維莉 |
7 | 藥物成癮的神經機制及干預策略研究 | 科研獎勵 | 時傑，陸林，賈忠偉，李素霞，趙勵彥，鮑彥平，吳萍，王貴彬，薛言學，朱維莉，丁增波 |
8 | An Unconditioned Stimulus Retrieval Extinction Procedure to Prevent the Return of Fear Memory | 期刊論文 | Liu, Jianfeng，Zhao, Liyan，Xue, Yanxue，Shi, Jie，Suo, Lin，Luo, Yixiao，Chai, Baisheng，Yang, Chang，Fang, Qin，Zhang, Yan，Bao, Yanping，Pickens, Charles L.，Lu, Lin(*) |
9 | 用於檢測ZNF804A基因中的rs1344706位點的核苷酸的物質的新用途 | 專利 | 時傑，孫艷，王貴彬，陸林，朱維莉，趙勵彥 |
10 | A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking. | 期刊論文 | Luo, Yi-xiao，Xue, Yan-xue，Liu, Jian-feng，Shi, Hai-shui，Jian, Min，Han, Ying，Zhu, Wei-li，Bao, Yan-ping，Wu, Ping，Ding, Zeng-bo，Shen, Hao-wei，Shi, Jie，Shaham, Yavin，Lu, Lin(*) |
11 | Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats. | 期刊論文 | Wu, Ping，Ding, Zeng-Bo，Meng, Shi-Qiu，Shen, Hao-Wei，Sun, Shi-Chao，Luo, Yi-Xiao，Liu, Jian-Feng，Lu, Lin，Zhu, Wei-Li，Shi, Jie |
12 | A Critical Role for Protein Degradation in the Nucleus Accumbens Core in Cocaine Reward Memory | 期刊論文 | Ren, Zhen-Yu，Liu, Meng-Meng，Xue, Yan-Xue，Ding, Zeng-Bo，Xue, Li-Fen，Zhai, Suo-Di，Lu, Lin(*) |
13 | Delayed Noradrenergic Activation in the Dorsal Hippocampus Promotes the Long-Term Persistence of Extinguished Fear | 期刊論文 | Chai, Ning，Liu, Jian-Feng，Xue, Yan-Xue，Yang, Chang，Yan, Wei，Wang, Hui-Min，Luo, Yi-Xiao，Shi, Hai-Shui，Wang, Ji-Shi，Bao, Yan-Ping，Meng, Shi-Qiu，Ding, Zeng-Bo，Wang, Xue-Yi，Lu, Lin(*) |
14 | 成癮相關疾病的臨床特徵及神經基礎 | 科研獎勵 | 時傑，陸林，賈忠偉，李素霞，吳萍，薛言學，鮑彥平，朱維莉，丁增波，李鵬，孫洪強 |
15 | 多肽類似物Tat-NR2BCT 在制 備抗抑鬱藥物中的套用 | 專利 | 陸林，韓盈，李素霞，徐凌志，朱維莉，時傑 |
16 | Role of amygdala in drug memory | 期刊論文 | Luo, Yi-Xiao，Xue, Yan-Xue，Shen, Hao-Wei，Lu, Lin(*) |
17 | Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse | 期刊論文 | Zhang, Yan，Xue, Yanxue，Meng, Shiqiu，Luo, Yixiao，Liang, Jie，Li, Jiali，Ai, Sizhi，Sun, Chengyu，Shen, Haowei，Zhu, Weili，Wu, Ping，Lu, Lin，Shi, Jie |
18 | Region-specific role of Rac in nucleus accumbens core and basolateral amygdala in consolidation and reconsolidation of cocaine-associated cue memory in rats | 期刊論文 | Ding, Zeng-Bo，Wu, Ping(*)，Luo, Yi-Xiao，Shi, Hai-Shui，Shen, Hao-Wei，Wang, Shen-Jun，Lu, Lin(*) |
19 | Overexpression of Protein Kinase Mzeta in the Prelimbic Cortex Enhances the Formation of Long-Term Fear Memory. | 期刊論文 | Xue, Yan-Xue，Zhu, Zhen-Zhen，Han, Hai-Bin，Liu, Jian-Feng，Meng, Shi-Qiu，Chen, Chen，Yang, Jian-Li，Wu, Ping，Lu, Lin(*) |
20 | AMPK Signaling in the Dorsal Hippocampus Negatively Regulates Contextual Fear Memory Formation | 期刊論文 | Han, Ying，Luo, Yixiao，Sun, Jia，Ding, Zengbo，Liu, Jianfeng，Yan, Wei，Jian, Min，Xue, Yanxue，Shi, Jie，Wang, Ji-Shi，Lu, Lin(*) |
21 | Protein kinase Mζ in medial prefrontal cortex mediates depressive-like behavior and antidepressant response | 期刊論文 | Yan, Wei，Liu, Jian-Feng，Han, Ying，Zhang, Wen，Luo, Yi-Xiao，Xue, Yan-Xue，Zhu, Wei-Li，Yang, Chang，Chen, Wen-Hao，Guo, Hong-Ling，Ma, Yu-Nu，Yuan, Kai，Wang, Ji-Shi，Shi, Jie，Lu, Lin(*) |
22 | 一種多肽及其在製備抑鬱症治療藥物中的套用 | 專利 | 陸林，孫成玉，孟適秋，朱維莉，時傑 |
23 | Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood | 期刊論文 | Suo, Lin，Zhao, Liyan，Si, Jijian，Liu, Jianfeng，Zhu, Weili，Chai, Baisheng，Zhang, Yan，Feng, Jiajia，Ding, Zengbo，Luo, Yixiao，Shi, Haishui，Shi, Jie，Lu, Lin(*) |
24 | Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving | 期刊論文 | Xue, Yan-Xue，Deng, Jia-Hui，Chen, Ya-Yun，Zhang, Li-Bo，Wu, Ping，Huang, Geng-Di，Luo, Yi-Xiao，Bao, Yan-Ping，Wang, Yu-Mei，Shaham, Yavin，Shi, Jie，Lu, Lin(*) |
25 | Selective Inhibition of Amygdala Neuronal Ensembles Encoding Nicotine-Associated Memories Inhibits Nicotine Preference and Relapse | 期刊論文 | Xue, Yan-Xue，Chen, Ya-Yun，Zhang, Li-Bo，Zhang, Li-Qun，Huang, Geng-Di，Sun, Shi-Chao，Deng, Jia-Hui，Luo, Yi-Xiao，Bao, Yan-Ping，Wu, Ping，Han, Ying，Hope, Bruce T.，Shaham, Yavin，Shi, Jie，Lu, Lin(*) |
26 | Effect of Conditioned Stimulus Exposure during Slow Wave Sleep on Fear Memory Extinction in Humans | 期刊論文 | He, Jia，Sun, Hong-Qiang，Li, Su-Xia，Zhang, Wei-Hua，Shi, Jie，Ai, Si-Zhi，Li, Yun，Li, Xiao-Jun，Tang, Xiang-Dong，Lu, Lin(*) |
27 | Depletion of perineuronal nets in the amygdala to enhance the erasure of drug memories. | 期刊論文 | Xue, Yan-Xue，Xue, Li-Fen，Liu, Jian-Feng，He, Jia，Deng, Jia-Hui，Sun, Shi-Chao，Han, Hai-Bin，Luo, Yi-Xiao，Xu, Ling-Zhi，Wu, Ping，Lu, Lin(*) |
項目摘要
創傷後應激障礙（PTSD）和藥物成癮是認知障礙性疾病，也是全球普遍存在的社會和公共衛生問題。研究表明認知和情感失調節而形成的持久強烈的病理性情感記憶是PTSD患者症狀反覆發作和吸毒者反覆復吸的根本原因，但目前對已形成的病理性記憶缺乏有效的消除手段。最近研究發現學習並穩定下來的記憶在特異性的條件下會被喚起並被誘導進入不穩定狀態，在不穩定時間窗內進行消退訓練可以將原有的記憶抹除。但病理性記憶喚起與消退的神經生物學機制以及喚起-消退模式是否可以用來消除病理性情感記憶未得到系統的闡明。本項目擬採用行為學和分子生物學方法，探索病理性記憶喚起、去穩定化以及消退的臨界條件；然後利用喚起-消退相互作用，探索一種新型的用於治療認知情感障礙相關疾病的方法並闡明其神經生物學機制；最後利用行為學和功能性核磁共振技術研究喚起-消退模式在病人中發揮作用的神經環路，從而為情感與認知障礙相關精神疾病的臨床治療提供理論基礎
