畢惠嫦

畢惠嫦

畢惠，女，博士，中山大學藥學院教授、博士生導師、副院長，美國匹茲堡大學藥學院兼職副教授。研究方向為代謝調控，專注於核受體/代謝酶/轉運蛋白影響下內/外源物代謝與調控對疾病發生髮展轉歸及合理用藥的研究。主持國家自然科學基金、國家重點研發計畫等國家及省部級科研基金近20項。已出版專著2部（主編、副主編），參編專著5部，在國內外期刊發表研究論文130多篇，其中SCI收錄90多篇，以通訊作者或第一作者在Hepatology, Cell Death & Differentiation, Cell Death & Disease, British Journal of Pharmacology, Carcinogenesis, Drug Metabolism and Disposition, Toxico Sci等發表SCI論文50多篇。申請專利多項。獲2014年中國藥理學會-SERVIER青年藥理學工作者獎、2015年國家自然科學優秀青年科學基金、2018年亞太藥物代謝青年學者獎（2018 Asia Pacific New Investigator Award）。

基本介紹

  • 中文名：畢惠嫦
  • 職業：教師
  • 畢業院校：中山大學
  • 學位/學歷：博士
  • 專業方向：代謝組學、代謝調控與疾病及臨床合理用藥
  • 職務：中山大學藥學院副院長
  • 職稱：教授
研究方向,人物經歷,教育經歷,工作經歷,社會兼職,科研項目,學術成果,

研究方向

代謝組學、代謝調控與疾病及臨床合理用藥。

人物經歷

教育經歷

1993.09 ~ 1997.06：中國藥科大學，獲英語藥學學士學位
2002.09 ~ 2007.06：中山大學藥學院，獲藥理學博士學位

工作經歷

2007.07 ~ 至今：中山大學藥學院藥物代謝與藥代動力學實驗室、中山大學臨床藥理研究所
2011.10 ~ 2012.11：美國國立衛生研究院、國家癌症研究所（NCI/NIH）

社會兼職

目前目前擔任中國藥理學會藥物代謝與藥動學專業委員會青委會主任委員、中國藥理學會臨床藥理學專業委員會副秘書長/常委、廣東省藥理學會常務理事、廣東省藥理學會治療藥物監測專業委員會副主任委員、藥物篩選與評價專業委員會常務委員、藥物毒理專業委員會委員、廣東省執業藥師協會第三屆理事會理事。擔任SCI期刊《Journal of Biochemical and Molecular Toxicology》、《Acta Pharmaceutica Sinica B》、《Chinese Medicine》、《Chinese Journal of Natural Medicines》編委，《藥學學報》、《Journal of Pharmaceutical Analysis》青年編委、《中國生化藥物雜誌》編委。同時是中國藥理學學會會員、國際外源物代謝研究學會(ISSX)會員、國際代謝組學學會會員。並擔任20多種國際學術期刊的特邀審稿人。

科研項目

  1. 國家重點研發計畫政府間國際科技創新合作重點專項，2018.07～2022.06，負責。
  2. 國家自然科學基金優青項目，2016.01～2018.12，負責。
  3. 國家自然科學基金面上項目，2016.01～2019.12，負責。
  4. 國家自然科學基金面上項目，2014.01～2017.12，負責。
  5. 國家自然科學基金青年項目，2011.01～2013.12，負責。
  6. 廣東省自然科學基金重點項目，2017.08～2020.08，負責。
  7. 廣東省自然科學基金面上項目，2015.08～2018.08，負責。
  8. 廣州市科技計畫項目（健康醫療協同創新重大專項），2014.06～2017.06，分題負責。
  9. 廣州市科技計畫項目（科技惠民專項），2014.06～2017.06，負責。
  10. 廣東省新藥設計與評價重點實驗室開放基金，2014.01～2014.11，負責。
  11. 高校基本科研業務費“中山大學青年教師培育項目”，2013.11～2016.11，負責。
  12. 國家科技支撐計畫課題（國家中醫藥管理局），2012.01～2013.12，分題負責。
  13. 高等學校博士學科點專項科研基金（新教師基金課題），2011.01～2013.12，負責。
  14. 國家重點基礎研究發展計畫（973計畫），分題負責。
  15. 澳門大學-澳門科學技術發展局聯合基金，2009.01～2010.12，聯席負責。
  16. 廣州市科技計畫項目（科技支撐引導項目），2011.09～2013.09，負責。
  17. 廣東省醫學科研基金，2009.01～2010.12，負責。
  18. 廣東省中醫藥局科研基金，2009.01～2010.12，負責。

學術成果

出版專著
1．《藥物臨床試驗標準操作規程實用指南》.廣東科技出版社. 2004.（副主編）
2．案例版《臨床藥物代謝動力學》，科學出版社，2010.（參編2萬字）
3．普通高等教育“十一五”國家級規劃教材《臨床藥理學》，高等教育出版社，2010.（參編2萬字）
4．《英漢藥物詞典》. 商務出版社. 2010年出版. (第一編者，參編5萬字)
5．《量體裁藥不是夢——從基因到個體化用藥》. 廣東科技出版社. 2011.（主編）
6．Dextromethorphan: Pharmacology, Clinical Uses and Health Effects.Chapter 2--Pharmacogenetics of dextromethorphan: a systematic review. Zhang Yu, Huang Min,Bi Huichang*. ISBN: 978-1-63484-016-3. Nova Science Publisher, Pub. Date: November 2015. (Corresponding author for Chapter 2, 9000 words).
7．普通高等教育“十一五”國家級規劃教材案例版《臨床藥物代謝動力學》，科學出版社，2016，第三版.（參編2萬字）
近3年發表的部分通訊及一作論文
  1. Jiang Yiming, Feng Dechun, Ma Xiaochao, Fan Shicheng, Gao Yue, Fu Kaili, Wang Ying, Sun Jiahong, Yao Xinpeng, Liu Conghui, Zhang Huizhen, Xu Leqian, Liu Aiming, Gonzalez J Frank, Yang Yingzi, Gao Bin, Huang Min,Bi Huichang*. Pregnane X receptor regulates liver size and liver cell fate via yes-associated protein activation.Hepatology, 2018 May 30, accepted.
  2. Wang Yongtao, Chen Yixin, Guan Lihuan, Zhang Huizheng, Huang Yaoyao, Johnson H Caroline, Wu Zeming, Gonzalez J Frank, Yu Aiming, Huang Peng, Wang Ying, Yang Shouhui, Chen Pan, Fan Xiaomei, Huang Min,Bi Huichang*. Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming.Cell Death and Differentiation. 2018 Mar; 25(4):733-746.
  3. Sun Jiahong#, Wen Yajie#, Zhou Yanying#, Jiang Yiming, Chen Yixin, Zhang Huizheng, Guan Lihuan, Yao Xinpeng, Huang Min*,Bi Huichang*. P53 attenuates acetaminophen-induced hepatotoxicity by regulating drug-metabolizing enzymes and transporter expression.Cell Death and Disease. 2018 May, 9(5): 536-547.
  4. Li Jingjie#, Guan Lihuan#, Zhang Huizhen, Gao Yue, Sun Jiahong, Gong Xiao, Li Dongshun, Chen Pan, Liao Xiaoyan, Huang Min,Bi Huichang*. Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages.Reproductive Biology and Endocrinology. 2018 April, 16(1): 42-51.
  5. Li Jingjie#, Gao Yue#, Guan Lihuan, Zhang Huizhen, Sun Jiahong, Gong Xiao, Li Dongshun, Chen Pan, Ma Zheng, Liang Xiaoyan, Huang Min,Bi Huichang*.Discovery of phosphatidic acid, phosphatidylcholine, and phosphatidylserine as biomarkers for early diagnosis of endometriosis.Frontiers in Physiology, 2018 Jan. 9(14): doi: 10.3389/fphys.2018.00014.
  6. Li Xi#, Sun Jiahong#, Fan Xiaomei, Guan Lihuan; Li Dongshun, Zhou Yawen, Zeng Xuezhen,Chen Yixin, Zhang Huizhen, Xu Leqian, Jiang Fulin, Huang Min,Bi Huichang*. Schisandrol B promotes liver regeneration after partial hepatectomy in mice.European Journal of Pharmacology,2018 Jan 5; 818:96-102.
  7. Chen Pan#, Li Dongshun#, Chen Yixin#, Sun Jiahong, Fu Kaili, Guan Lihuan, Zhang Huizhen, Jiang Yiming, Li Xi, Zeng Xuezhen, Chen Xiao, Huang Min,Bi Huichang*.p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice.British Journal of Pharmacology. 2017 Dec; 174(23):4345-4361.
  8. Zeng X, Li X, Xu C, Jiang F, Mo Y, Fan X, Li Y, Jiang Y, Li D, Huang M,Bi Huichang*.Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice.Acta Pharm Sin B. 2017 Sep; 7(5):583-592.
  9. Zhang Huizhen, Gao Yue, Sun Jiahong, Fan Shicheng, Yao Xinpeng, Ran Xiaorong, Zheng Chuanqi, Huang Min,Bi Huichang*.Optimization of lipid extraction and analytical protocols for UHPLC-ESI-HRMS-based lipidomic analysis of adherent mammalian cancer cells.Analytical and Bioanalytical Chemistry, 2017; 409(22): 5349-5258.
  10. Chen Yixin, Wang Yongtao, Huang Yaoyao, Zeng Hang, Hu Bingfang, Guan Lihuan, Zhang Huizhen, Yu Aiming, Johnson H Caroline, Gonzalez J Frank, Huang Min,Bi Huichang*. PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C.Carcinogenesis, 2017; 38(4):474-483.
  11. Zeng Hang#, Jiang Yiming#, Chen Pan, Fan Xiaomei, Li Dongshu, Liu Aiming, Ma Xiaochao, Xie Wen, Liu Peiqing, Gonzalez Frank J, Huang Min,Bi Huichang.Schisandrol B protects against cholestatic liver injury through pregnane X receptor.British Journal of Pharmacology. 2017; 174(8):672-688.
  12. Zhang Huizhen#, Jiang Yiming#, Wu Jingjing, Zheng Chuanqi, Ran Xiaorong, Li Dongshun, Huang Min,Bi Huichang*. Metabolic mapping of Schisandra Sphenanthera extract and its active lignans using ultrahigh-performance liquid chromatography coupled with electronspray ionization high-resolution mass spectrometry based metabolomics approach. Journal of Separation Science, 2017; 40(2):574-586.
  13. Li Yuhua#, Huang Ling#, Sun Jiahong, Wei Xiaohua, Wen Jinhua, Zhong Guoping, Huang Min,Bi Huichang*. Mulberroside A suppresses PXR-mediated transactivationand gene expression of P-gp in LS174T cells. Journal of Biochemical and Molecular Toxicology. 2017 May;31(5). doi: 10.1002/jbt.21884.
  14. Xu Chenshu, Huang Min,Bi Huichang*.PXR- and CAR-mediated herbal effect on human diseases.Biochim Biophys Acta - Gene Regulatory Mechanisms.2016; 1859(9):1121-1129.
  15. Yu Tao#, Wang Yongtao#, Zhang Huizhen, Caroline H Johnson, Jiang Yiming, Li Xiangjun, Wu Zeming, Liu Tian, Kristopher W Krausz, Yu Aiming, Frank J Gonzalez, Huang Min,Bi Huichang*. Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells.Analytical and Bioanalytical Chemistry. 2016; 408(16):4267-4273.
  16. Li Xi, Fan Xiaomei, Li Dongshun, Zeng Xuezhen, Zeng Hang, Wang Yongtao, Zhou Yawen, Chen Yixin, Huang Min*,Bi Huichang*. Schisandra sphenanthera extract facilitates liver regeneration after partial hepatectomy in mice.Drug Metab Dispos.2016; 44(5):647-652.
  17. Zeng Hang, Li Dongshun, Qin Xiaoling, Chen Pan, Tan Huasen, Zeng Xuezhen, Li Xi, Fan Xiaomei, Jiang Yiming, Zhou Yawen, Chen Yixin, Wang Ying, Huang Min*,Bi Huichang*. Hepato-protective effects of schisandra sphenanthera extract against lithocholic acid-induced cholestasis in male mice are associated with the activation of PXR pathway and promotion of liver regeneration.Drug Metab Dispos.2016;44(3):337-342.
  18. Jiang Yiming#, Wang Ying#, Tan Huasen, Yu Tao, Fan Xiaomei, Chen Pan, Zeng Hang, Huang Min*,Bi Huichang*.Schisandrol B protectsagainst acetaminophen-induced acute hepatotoxicityvia the activation of NRF2/ARE pathway.Acta Pharmacologica Sinica.2016; 37(3):382-389.
  19. Tan Huasen#, Xu Chenshu#, Zeng Hang, Wang Ying, Li Yingmei, Fan Xiaomei, Chen Pan, Jiang Yiming, Chen Xiao, Huang Min*,Bi Huichang*. SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells.Journal of Pharmacological Sciences.2016;130(2):66-71.
  20. Chen Pan#, Li Jingjie#, Fan Xiaomei, Zeng Hang, Deng Rongrong, Li Dongshun, Huang Min,Bi Huichang*.Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism.European Journal of Pharmacology. 2015; 765:131-139.
  21. Wang Ying#, Jiang Yiming#, Fan Xiaomei, Tan Huasen, Zeng Hang, Wang Yongtao, Chen Pan, Huang Min,Bi Huichang*.Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways.Toxicol Lett.2015;236(2):82-89.
  22. Jiang Yiming#, Fan Xiaomei#, Wang Ying, Tan Huasen, Chen Pan, Zeng Hang, Huang Min*,Bi Huichang*.Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are associated with the inhibition of CYP-mediated bioactivation.Chem Biol Interact. 2015; 231: 83-89.
  23. Jiang Yiming#, Fan Xiaomei#, Wang Ying, Chen Pan, Zeng Hang, Tan Huasen, Gonzalez J Frank, Huang Min,Bi Huichang*.Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.Toxicological Sciences. 2015;143(1):107-115.
  24. Fan Xiaomei, ChenPan,Jiang Yiming, Wang Ying, Tan Huasen, Zeng Hang, Wang Yongtao,Qu Aijuan, Gonzalez Frank, Huang Min,Bi Huichang*. Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine.Drug Metab Dispos.2015;43(3):317-324.
  25. Yu Tao#, Wang Yongtao#, Chen Pan, Li Yuhua, Chen Yixin, Zeng Hang, Yu Aiming, Huang Min,Bi Huichang*. Effects of Nicotinamide N-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress.Cellular Physiology and Biochemistry.2015;35(2):710-721.
  26. FanXiaomei#,JiangYiming#, Wang Ying, Tan Huasen, Zeng Hang, Wang Yongtao,ChenPan,Qu Aijuan,Gonzalez Frank J., Huang Min,Bi Huichang*.Wuzhi tablet (Schisandra sphenantheraextract) protects against acetaminophen-inducedhepatotoxicityby inhibition of CYP-mediatedbioactivationand regulation of NRF2-ARE and p53/p21 pathways.Drug Metab Dispos.2014;42(12):1982-1990.
  27. Wang Ying, Jiang Yiming, Wang Yongtao, Kang Junwei, Yu Tao, Zhao Haiyu, Bian Baolin, Huang Min,Bi Huichang*. Inhibiton of cytochrome P450 isoenzymes and P-gp activity by multiple extracts of Huang-Lian-Jie-Du Decoction.Journal of Ethnopharmacology.2014;156:175-181.
  28. Deng Rongrong#, Xu Chenshu#, Chen Xiao*, Chen Pan, Wang Yongtao, Zhou Xunian, Jin Jing, Niu Lu, Ying Mengjia, Huang Min,Bi Huichang*. Resveratrol suppresses the inducible expression of CYP3A4 through the Pregnane X Receptor.Journal of Pharmacological Sciences. 2014;126(2):146-154.
  29. Bi Huichang, Pan Yuzhuo,Krausz W Kristopher,Li Fei,Johnson H Caroline,Jiang Changtao,Gonzalez J Frank, Yu Aiming*.N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291 altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis.Carcinogenesis. 2014, 35(10):2264-2272.
  30. Fan Xiaomei, Chen Pan, Tan Huasen, Zeng Hang, Jiang Yiming, Wang Ying, Wang Yongtao, Hou Xiangyu,Bi Huichang*, Huang Min*. Dynamic and coordinated regulation of KEAP1-NRF2-ARE and p53/p21 signaling pathways is associated with acetaminophen injury responsive liver regeneration.Drug Metab Dispos.2014;42(9):1532-1539.
  31. Cai Yike#, Xu Chenshu#, Chen Peiyi, Hu Junqing, Hu Rong, Huang Min,Bi Huichang*. Development, Validation, and Application of a Novel 7-Day Caco-2 Cell Culture System.Journal of Pharmacological and Toxicological Methods.2014;70(2):175-181.
  32. Li Yuhua, Huang Ling, Zeng Xuezhen, Zhong Guoping, Ying Mengjia, Huang Min*,Bi Huichang*. Down-regulation of P-gp expression and function after Mulberroside A treatment: potential role of protein kinase C and NF-kappa B.Chemico-Biological Interactions.2014;213:44-50.
  33. Pan Chen, Hang Zeng, Yongtao Wang, Xiaomei Fan, Chenshu Xu, Rongrong Deng, Xunian Zhou,Bi Huichang*, Min Huang*. Low dose of oleanolic acid protects against lithocholic acid-induced cholestasis in mice: potential involvement of Nrf2 mediated up-regulation of Mrps.Drug Metab Dispos. 2014, 42(5):844-852.
  34. Qin Xiaoling, Chen Xiao*, Zhong Guoping, Fan Xiaomei, Wang Ying, Xue Xinping, Wang Ying, Huang Min,Bi Huichang*.Effect of Tacrolimus on thepharmacokinetics of bioactive lignans of Wuzhi Tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp.Phytomedicine. 2014,21(5):766-772.
  35. Qin Xiaoling, Chen Xiao, Wang Ying, Xue Xinping, Wang Ying, Li Jiali, Wang Xueding, Zhong Guoping, Wang Changxi, Yang Hui, Huang Min*,Bi Huichang*]. In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra Sphenanthera extract) on the CYP3A/P-gp mediated absorption and metabolism of tacrolimus.Drug Metab Dispos;2014, 42(1):193-199.
  36. Huang Ling, Wu Qian, Li Yuhua, Wang Yitao,Bi Huichang*. PXR mediated upregulation of CYP3A expression by herb compound Praeruptorin C from Peucedanum praeruptorum Dunn.Evidence-Based Complementary and Alternative Medicine. 2013;156574. doi: 10.1155/2013/156574. Epub 2013 Nov 26.
  37. Zhou Xunian,Bi Huichang*, Jin Jing, Niu Lu, Cai Dake, Deng Rongrong, Li Yuhua, Wang Yongtao, Huang Min*. Effects of praeruptorin A and praeruptorin C, a racemate isolated from Peucedanum praeruptorum Dunn, on MRP2 through CAR pathway.Planta Med. 2013. 79(17):1641-7.
  38. Huang Ling, Huang Min, Li Yuhua, Li Ruiming, Zeng Yu, Kuang Shaoyi, Zhang Li, Wang Yitao,Bi Huichang*. Up-regulatation of CYP3A expression through Pregnent X Receptor by Praeruptorin D Isolated from Peucedanum praeruptorum Dunn.Journal of Ethnopharmacology. 2013. 148(2):596-602.
  39. Bi Huichang*, Krausz W Kristopher, Soumen K. Manna, Li Fei, Johnson H Caroline, Gonzalez J Frank. Optimization of harvesting, extraction and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells.Analytical and Bioanalytical Chemistry. 2013. 405(15):5279-5289.

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