基本介紹
- 中文名：王賀瑤
- 國籍：中國
- 畢業院校：河南醫科大學
- 單位：上海藥物研究所
- 學位：醫學學士
- 職稱：研究員
基本信息,研究方向,專家類別,職務,科研項目,代表論著,
基本信息
990年赴日留學，1997年畢業於日本神戶大學大學院醫學研究科，獲得醫學博士學位。1997 至 2005 年先後在日本千葉大學醫學研究院、日本國立國際醫療中心研究所代謝疾病研究部，從事糖尿病及代謝性疾病的研究工作。2005 年回國進入中國科學院上海藥物研究所工作，至今任上海藥物研究所研究員、代謝性疾病藥理課題組組長。
研究方向
主要研究方向為代謝失調性疾病的新藥發現與藥理藥效學研究，以及代謝失調性疾病發生髮展分子機制和藥物新靶標確認研究。
1. 選擇與代謝性疾病相關(肥胖、糖尿病、高脂、高尿酸血症、脂肪肝以及皮膚色素代謝失調)的G-蛋白偶聯受體、酶分子作為藥物篩選的主要靶點，建立細胞或分子水平的高通量篩選模型，通過篩選和評價，從中發現具有良好開發前景的藥物先導化合物。
2. 胰島β-細胞糖脂毒性機制的研究以及β-細胞保護藥物的發現研究。
3. 棕色、白色脂肪細胞分化的分子機制研究及其藥物干預的研發。
4. 黑色素代謝的信號通路研究以及黑色素代謝失調性疾病干預的藥物研發。
5. 基於激酶B-RafV600E的抗皮膚黑色素瘤藥物發現與研究。
專家類別
研究員
職務
中科院上海藥物所研究員、博士生導師、研究組長
科研項目
主持科技部“863”項目，國家自然科學基金委面上項目，上海市科委項目、中國科學院創新工程項目多項，參與科技部“973”項目，科技部重大新藥創製項目等。
代表論著
Jinwei Wu, Peng Sun, Xiaodong Zhang, Hong Liu, Hualiang Jiang, Weiliang Zhu, Heyao Wang*. Inhibition of GPR40 protects MIN6 β-cells from palmitate-induced ER stress and apoptosis. Journal of Cellular Biochemistry.
Xiao Hu, Jinwei Wu, Xiaodong Zhang, Qinshi Zhao, Jianming Huang, He-Yao Wang and Aijun Hou. Isoprenylated Flavonoids and Adipogenesis-Promoting Constituents from Morus nigra. Journal of Natural Products
Xiao Hu, Jun Ji, Meng Wang, Jinwei Wu, Qinshi Zhao, Heyao Wang, Aijun Hou. New isoprenylated flavonoids and adipogenesis-promoting constituents from Morus notabilis. Bioorganic & Medicinal Chemistry Letters
Liangcai Zhao, Xiaodong Zhang, Heyao Wang, Donghai Lin. H NMR-based metabonomic analysis of metabolic changes of serum and liver in Zucker obese rats. Analytical Letters
Liang-Cai Zhao, Xiao-Dong Zhang, Shi-Xian Liao, Hong-Chang Gao, Heyao Wang, Dong-Hai Lin. A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats. Journal of Biomedicine and Biotechnology
Xiao-dong Zhang Jian-wei Yan, Gui-rui Yan Xiao-yun Sun, Jun Ji, Yi-ming Li, You-hong Hu*, He-yao Wang*. Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight gain, hyperlipidemia, and hepatic steatosis in db/db mice. Acta Pharmacologica Sinica
Xiaodong Zhang, Guirui Yan, Yiming Li,Weiliang Zhu, Heyao Wang, DC260126, a small molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomedicine & Pharmacotherapy.
Xiangyu Guo，Ying Duan，Juane Li，Lixia Yang，Liansha Huang，Zhicheng Wang，HeyaoWang. Tonghua Liu. Antidiabetic effects of Tangnaikang on obese Zucker rats and the mechanism. Journal of Chinese Integrative Medicine.
Xiaodong Zhang, Jun Ji, Gurui Yan, Jinwei Wu, Xiaoyun Sun, Jingshan Shen, Hualiang Jiang, Heyao Wang. Sildenafil promotes adipogenesis through a PKG pathway. Biochemical and Biophysical Research Communications.
Haiyan Cai, Guirui Yan, Xiaodong Zhang, Gorbenko O, Heyao Wang, Weiliang Zhu. Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. Bioorg Med Chem Lett
Hui Hu, Ling-Yan He, Zhen Gong, Ning Li, Yi-Na Lu, Qi-Wei Zhai, Hong Liu, Hua-Liang Jiang, Wei-Liang Zhu, and He-Yao Wang. A novel class of antagonists for the FFAs receptor GPR40. Biochemical and Biophysical Research Communications
Ting Zhao, Gui-Rui Yan, Sheng-Li Pan, He-Yao Wang*, Ai-Jun Hou*.New Isoprenylated 2-Arylbenzofurans and Pancreatic Lipase Inhibitory Constituents from Artocarpus nitidus. Chemistry & Biodiversity
Xu Sun, Xiao-dong Zhang, Hui Hu, Yi-Na Lu, Jie Chen, He-Yao Wang. Berberine induces G1 arrest by regulating nuclear translocation of FoxO1 in hepatic stellate cells and prevents experimental liver fibrosis. Biological & Pharmaceutical Bulletin
Xu Sun, Xiaodong Zhang, Gang Cheng, Youhong Hu, Heyao Wang*. Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro. Molecular and Cellular Biochemistry
Kazuaki Miyake, Woosung Yang, Kazuo Hara, Kazuki Yasuda, Yukio Horikawa, Haruhiko Osawa, Hiroto Furuta, Maggie CY Ng, Yushi Hirota1, Hiroyuki Mori1, Keisuke Ido, Kazuya Yamagata, Yoshinori Hinoki, Yoshitomo Oka, Naoko Iwasaki, Yasuhiko Iwamoto, Yuichiro Yamada, Yutaka Seino, Hiroshi Maegawa, Atsunori Kashiwagi, He-Yao Wang, Toshihito Tanahashi, Naoto Nakamura, Jun Takeda, Eiichi Maeda, Ken Yamamoto, Katsushi Tokunaga, Ronald CW Ma Wing-Yee So, Juliana CN Chan, Naoyuki Kamatani, Hideichi Makino, Kishio Nanjo, Takashi Kadowaki and Masato Kasuga. Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. Journal of Human Genetics
Yonggang Wang , Fengrong Zhu , Jie Chen, Fusen Han, Heyao Wang*. Effects of Pro-Arg, a novel dipeptide derived from protamine hydrolysate on H2O2-induced oxidative stress in human diploid fibroblasts. Biological & Pharmaceutical Bulletin
Xiaodong Zhang, Xiao Hu, Aijun Hou,* Heyao Wang*. Inhibitory Effect of 2, 4, 2, 4-tetrahydroxy-3- (3-methyl-2-butenyl)-chalcone on effectivly dth an nd may und a natural tyrosinase inhibitor Tyrosinase Activity and Melanin Biosynthesis. Biological & Pharmaceutical Bulletin.
YongGang Wang, FengRong Zhu, FuSeng Han and He-Yao Wang*. Production and characterization of anti-oxidative peptides from protamine hydrolysate. Journal of Food Biochemistry
Kazuki Yasuda, Kazuaki Miyake, Yukio Horikawa, Kazuo Hara, Haruhiko Osawa, Hiroto Furuta, Yushi Hirota, Hiroyuki Mori, Anna Jonsson, Yoshifumi Sato, Kazuya Yamagata, Yoshinori Hinokio, He-Yao Wang, Toshihito Tanahashi, Naoto Nakamura, Yoshitomo Oka, Naoko Iwasaki,Yasuhiko Iwamoto, Yuichiro Yamada, Yutaka Seino, Hiroshi Maegawa, Atsunori Kashiwagi, Jun Takeda, Eiichi Maeda, Hyoung Doo Shin, Young Min Cho, Kyong Soo Park, Hong Kyu Lee, Maggie C Y Ng, Ronald C W Ma, Wing-Yee So, Juliana C N Chan, Valeriya Lyssenk, Tiinamaija Tuomi, Peter Nilsson, Leif Groop, Naoyuki Kamatani, Akihiro Sekine, Yusuke Nakamura, Ken Yamamoto, Teruhiko Yoshida, Katsushi Tokunaga, Mitsuo Itakura, Hideichi Makino, Kishio Nanjo, Takashi Kadowaki & Masato Kasuga. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nature genetics
Norihide Yokoi, Chihiro Hayashi, Yuuka Fujiwara, He-Yao Wang, and Susumu Seino. Genetic Reconstitution of Autoimmune Type 1 Diabetes With Two Major Susceptibility Genes in the Rat. Diabetes.
