王炳和，男，1962年4月生，山東大學藥學院教授，1996年受聘北卡羅萊納州立大學化學系助理教授，2000年任終身教授。2003年7月，受聘喬治亞州立大學化學系教授及喬治亞研究聯合會藥物研究領域傑出學者，2007年4月，受聘教育部長江學者講座教授。
基本介紹
- 中文名：王炳和
- 國籍：中國
- 民族：漢族
- 出生日期：1962-04
- 主要成就：喬治亞研究聯合會藥物研究領域傑出學者
- 性別：男
人物信息,研究領域,工作經歷,主要作品,科研項目,
人物信息
學歷 | 博士研究生 | 學位 | 博士學位 | |||
專業技術職務 | 教授 | 行政職務 | ||||
所在學院 | 山東大學藥學院 | |||||
所在一級學科名稱 | 藥學 | 學科代碼 | 1007 | |||
所在二級學科名稱 | 藥物化學 | 學科代碼 | 100701 | |||
研究方向 | 化學生物學 | |||||
學術身份 | 長江學者 | |||||
學術兼職 | 1) American Chemical Society 2) American Association for the Advancement of Sciences 3) American Association of Colleges of Pharmacy 4) American Peptide Society 5) Kappa Psi Pharmaceutical Fraternity 6) Psi Lambda Upsilon Honor Society in Chemistry 7) Rho Chi Pharmacy Honor Societ | |||||
研究領域
1. Organic/Medicinal chemistry: Design and synthesis of new imaging and therapeutic agents targeted on cancer and microbial pathogens.
2. Peptide chemistry: Development of novel linkers for solid phase peptide synthesis.
3. Pharmaceutical Chemistry: Design and synthesis of novel prodrugs of peptides and peptide mimetics aimed at enhancing their bioavailability and target selectivity; design and synthesis of substrates for the intestinal small peptide transporter as potential vectors for drug delivery.
4. Bioorganic chemistry/molecular recognition: Development of fluorescent sensors for the recognition and analysis of molecules of biological importance.
2. Peptide chemistry: Development of novel linkers for solid phase peptide synthesis.
3. Pharmaceutical Chemistry: Design and synthesis of novel prodrugs of peptides and peptide mimetics aimed at enhancing their bioavailability and target selectivity; design and synthesis of substrates for the intestinal small peptide transporter as potential vectors for drug delivery.
4. Bioorganic chemistry/molecular recognition: Development of fluorescent sensors for the recognition and analysis of molecules of biological importance.
工作經歷
1982年畢業於北京醫科大學(現北京大學醫學部)藥物化學系獲學士學位.
1991年在美國堪薩斯大學藥學院藥化系獲博士學位。
1991年-1993年 美國亞利桑那大學化學系和堪薩斯大學藥學院藥物化學系進行博士後研究工作。
1994年受聘俄克拉荷馬大學醫學中心藥學院助理教授
1996年受聘北卡羅萊納州立大學化學系助理教授，2000年任終身教授。
2003年7月，受聘喬治亞州立大學化學系教授及喬治亞研究聯合會藥物研究領域傑出學者
2007年4月，受聘教育部長江學者講座教授
1991年在美國堪薩斯大學藥學院藥化系獲博士學位。
1991年-1993年 美國亞利桑那大學化學系和堪薩斯大學藥學院藥物化學系進行博士後研究工作。
1994年受聘俄克拉荷馬大學醫學中心藥學院助理教授
1996年受聘北卡羅萊納州立大學化學系助理教授，2000年任終身教授。
2003年7月，受聘喬治亞州立大學化學系教授及喬治亞研究聯合會藥物研究領域傑出學者
2007年4月，受聘教育部長江學者講座教授
主要作品
1. Jin S, Choudhary G, Cheng Y, Dai C, Li M, Wang B*. Fluoride protects boronic acids in the copper(I)-mediated click reaction. Chem Commun (Camb). 2009 Sep 21;(35):5251
2. Li M, Lin N, Huang Z, Du L, Altier C, Fang H, Wang B*.Selecting aptamers for a glycoprotein through the incorporation of the boronic acid moiety. J Am Chem Soc. 2008 Sep 24;130(38):12636-8.
3.Peng H, Cheng Y, Ni N, Li M, Choudhary G, Chou HT, Lu CD, Tai PC, Wang B*. Synthesis and evaluation of new antagonists of bacterial quorum sensing in Vibrio harveyi.ChemMedChem. 2009 Sep;4(9):1457-68.
4. Ni N, Choudhary G, Peng H, Li M, Chou HT, Lu CD, Gilbert ES, Wang B*.Inhibition of quorum sensing in Vibrio harveyi by boronic acids.Chem Biol Drug Des. 2009 Jul;74(1):51-6.
5.Jin S, Cheng Y, Reid S, Li M, Wang B*.Carbohydrate recognition by boronolectins, small molecules, and lectins.Med Res Rev. 2009 Mar 16.
6. Ni N, Choudhary G, Li M, Wang B*.A new phenothiazine structural scaffold as inhibitors of bacterial quorum sensing in Vibrio harveyi.Biochem Biophys Res Commun. 2009 Apr 24;382(1):153-6.
7. Jin S, Zhu C, Li M, Wang B*.Identification of the first fluorescent alpha-amidoboronic acids that change fluorescent properties upon sugar binding.Bioorg Med Chem Lett. 2009 Mar 15;19(6):1596-9.
8. Du L, Li M, Zheng S, Wang B*.Rational Design of a Fluorescent Hydrogen Peroxide Probe Based on the Umbelliferone Fluorophore.Tetrahedron Lett. 2008 May 5;49(19):3045-3048.
9. Zheng S, Kaur G, Wang H, Li M, Macnaughtan M, Yang X, Reid S, Prestegard J, Wang B, Ke H.Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors.J Med Chem. 2008 Dec 25;51(24):7673-88.
10.Ni N, Li M, Wang J, Wang B*.Inhibitors and antagonists of bacterial quorum sensing. Med Res Rev. 2009 Jan;29(1):65-124.
11.Li M, Ni N, Chou HT, Lu CD, Tai PC, Wang B*. Structure-based discovery and experimental verification of novel AI-2 quorum sensing inhibitors against Vibrio harveyi. ChemMedChem. 2008 Aug;3(8):1242-9.
12. Jin S, Li M, Zhu C, Tran V, Wang B*.Computer-based de novo design, synthesis, and evaluation of boronic acid-based artificial receptors for selective recognition of dopamine.Chembiochem. 2008 Jun 16;9(9):1431-8.
2. Li M, Lin N, Huang Z, Du L, Altier C, Fang H, Wang B*.Selecting aptamers for a glycoprotein through the incorporation of the boronic acid moiety. J Am Chem Soc. 2008 Sep 24;130(38):12636-8.
3.Peng H, Cheng Y, Ni N, Li M, Choudhary G, Chou HT, Lu CD, Tai PC, Wang B*. Synthesis and evaluation of new antagonists of bacterial quorum sensing in Vibrio harveyi.ChemMedChem. 2009 Sep;4(9):1457-68.
4. Ni N, Choudhary G, Peng H, Li M, Chou HT, Lu CD, Gilbert ES, Wang B*.Inhibition of quorum sensing in Vibrio harveyi by boronic acids.Chem Biol Drug Des. 2009 Jul;74(1):51-6.
5.Jin S, Cheng Y, Reid S, Li M, Wang B*.Carbohydrate recognition by boronolectins, small molecules, and lectins.Med Res Rev. 2009 Mar 16.
6. Ni N, Choudhary G, Li M, Wang B*.A new phenothiazine structural scaffold as inhibitors of bacterial quorum sensing in Vibrio harveyi.Biochem Biophys Res Commun. 2009 Apr 24;382(1):153-6.
7. Jin S, Zhu C, Li M, Wang B*.Identification of the first fluorescent alpha-amidoboronic acids that change fluorescent properties upon sugar binding.Bioorg Med Chem Lett. 2009 Mar 15;19(6):1596-9.
8. Du L, Li M, Zheng S, Wang B*.Rational Design of a Fluorescent Hydrogen Peroxide Probe Based on the Umbelliferone Fluorophore.Tetrahedron Lett. 2008 May 5;49(19):3045-3048.
9. Zheng S, Kaur G, Wang H, Li M, Macnaughtan M, Yang X, Reid S, Prestegard J, Wang B, Ke H.Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors.J Med Chem. 2008 Dec 25;51(24):7673-88.
10.Ni N, Li M, Wang J, Wang B*.Inhibitors and antagonists of bacterial quorum sensing. Med Res Rev. 2009 Jan;29(1):65-124.
11.Li M, Ni N, Chou HT, Lu CD, Tai PC, Wang B*. Structure-based discovery and experimental verification of novel AI-2 quorum sensing inhibitors against Vibrio harveyi. ChemMedChem. 2008 Aug;3(8):1242-9.
12. Jin S, Li M, Zhu C, Tran V, Wang B*.Computer-based de novo design, synthesis, and evaluation of boronic acid-based artificial receptors for selective recognition of dopamine.Chembiochem. 2008 Jun 16;9(9):1431-8.
科研項目
1) Biomarker-based MRI Contrast Agents, PI, NIH (CA123329), $1,140,875, 9/20/2006-8/31/2010.
2）Development of Novel Small Molecules for Malignant Brain Tumor, Sub-contract PI (PI: Erwin Van Meir, Emory), NIH, $383,584, 9/1/2007-3/31/2012
2）Development of Novel Small Molecules for Malignant Brain Tumor, Sub-contract PI (PI: Erwin Van Meir, Emory), NIH, $383,584, 9/1/2007-3/31/2012
