王富安 武漢大學 化學與分子科學學院 教授、博導。 中組部第五批“青年千人計畫”獲選人，主要在包括生物感測器、功能化核酸類酶/蛋白酶的恆溫信號擴增新體系、DNA超分子納米結構、核酸納米機器、核酸分子邏輯計算器件和線路等領域開展了系統工作，積累了豐富的經驗，取得了一些突破性進展和原創性成果。研究工作受到國際同行認可，相關成果全部以科技論文形式發表在相關領域國際權威學術期刊上，截至目前，已經累計發表論文近60篇（21篇第一作者論文，其中影響因子大於40的1篇，10-40的8篇，5-9的10篇，小於5的2篇），包括在自然系列Nat. Nanotechnol.發表1篇，美國化學會Chem. Rev.發表1篇，J. Am. Chem. Soc.發表5篇，Nano lett.發表3篇，ACS Nano發表3篇，德國Angew. Chem. Int. Ed.發表4篇，Adv. Mater.發表2篇，Adv. Func. Mater.發表1篇等。申請美國專利一項，參與編寫關於核酸納米機器和器件的書目章節兩個。發表文章總影響因子超過450，獲得他人引用超過2000，H因子25。長年招收碩士，博士研究生，歡迎有相關化學，生物，醫學，材料背景的同學報考；並隨時歡迎博士後和研究助理的加入，共同學習，提供儘量寬鬆的學習氛圍和儘量好的生活科研條件。
基本介紹
個人資料,學習經歷,主要成就,
個人資料
主要在包括生物感測器、功能化核酸類酶/蛋白酶的恆溫信號擴增新體系、DNA超分子納米結構、核酸納米機器、核酸分子邏輯計算器件和電路等研究領域開展了系統工作，積累了豐富的經驗，取得了一些突破性進展和原創性成果。研究工作受到國際同行認可，相關成果全部以科技論文形式發表在相關領域國際權威學術期刊上，截至目前，已經累計發表論文50多篇（21篇第一作者論文，其中影響因子大於40的1篇，10-40的8篇，5-9的10篇，小於5的2篇），包括在自然系列Nat. Nanotechnol.發表1篇，美國化學會Chem. Rev.發表1篇，J. Am. Chem. Soc.發表5篇，Nano lett.發表3篇，ACS Nano發表3篇，德國Angew. Chem. Int. Ed.發表3篇，Adv. Mater.發表1篇，Adv. Func. Mater.發表1篇等。申請美國專利一項，參與編寫關於核酸納米機器和器件的書目章節兩個。發表文章總影響因子超過450，獲得他人正面引用超過1600，H因子23。歡迎報考碩士，博士；並隨時歡迎博士後加入，共同學習。
學習經歷
1999.09-2003.07 鄭州大學化學系 化學學士
2003.09-2009.01 中科院長春應化所 電分析化學國家重點實驗室 分析化學博士
2009.02-2014.06 耶路撒冷希伯來大學 化學研究所 博士後
2014.07-現在 武漢大學 化學與分子科學學院 教授
2003.09-2009.01 中科院長春應化所 電分析化學國家重點實驗室 分析化學博士
2009.02-2014.06 耶路撒冷希伯來大學 化學研究所 博士後
2014.07-現在 武漢大學 化學與分子科學學院 教授
研究方向
主要成就
1. Masayuki Endo, Yuki Suzuki, Tomoko Emura, Kumi Hidaka, Fuan Wang, Itamar Willner, Hiroshi Sugiyama. Single-Molecule Visualization of the Zn-Dependent DNAzyme Functions. Angew. Chem. Int. Ed. 2015, In Press. DOI: 10.1002/anie.201504656
2. Wei-Ching Liao, Chun-Hua Lu, Raimo Hartmann, Fuan Wang, Yang Sung Sohn, Wolfgang J. Parak,* Itamar Willner,* ATP-Triggered Release of Macromolecular and Nanoparticle Loads from Aptamer/DNA-Crosslinked Microcapsules. ACS Nano 2015, In Press. DOI: 10.1021/nn503223e
3. Sivan Lilienthal, Zohar Shpilt, Fuan Wang, Ron Orbach, Itamar Willner*. Programmed DNAzyme-Triggered Dissolution of DNA-Based Hydrogels: Means for Controlled Release of Biocatalysts and for the Activation of Enzyme Cascades. ACS Appl. Mater. Interfaces. 2015, 7, 8923–8931. DOI: 10.1021/acsami.5b02156
4. Lina Freage, Alexander Trifonov, Ran Tel-Vered, Eyal Golub, Fuan Wang, John S. McCaskill, Itamar Willner*. Addressing, amplifying and switching DNAzyme functions by electrochemically-triggered release of metal ions. Chem. Sci. 2015, 6, 3544-3549. DOI: 10.1039/C5SC00744E
5. Fuan Wang, Xiaoqing Liu, Itamar Willner*. DNA Switches: From Principles to Applications. Angew. Chem. Int. Ed. 2015, 54, 1098-1129.DOI: 10.1002/anie.201404652
6. Weiwei Guo, Chun-Hua Lu, Ron Orbach, Fuan Wang, Xiu-Juan Qi, Alessandro Cecconello, Dror Seliktar, Itamar Willner*. pH Stimulated DNA Hydrogels Exhibiting Shape-Memory Properties. Adv. Mater.2015, 27, 73–78. DOI: 10.1002/adma.201403702
7. Lina Freage, Fuan Wang, Itamar Willner*. Multiplexed Analysis of Genes and of Metal Ions Using Enzyme/DNAzyme Amplification Machineries. Anal. Chem. 2014, 86, 11326–11333.DOI: 10.1021/ac5030667
8. Natalie Enkin, Fuan Wang, Etery Sharon, Itamer Willner*. Multiplexed Analysis of Genes Using Nucleic Acid-Stabilized Ag Nanocluster Quantum Dots. ACS Nano 2014, 8, 11666–11673.DOI: 10.1021/nn504983j
9. Yuwei Hu, Fuan Wang, Chun-Hua Lu, Julia Girsh, Eyal Golub, Itamar Willner*. Switchable Enzyme/DNAzyme Cascades by the Reconfiguration of DNA Nanostructures. Chem. Eur. J. 2014, 20, 16203–16209.DOI: 10.1002/chem.201404122
10. Zhanxia Zhang, Fuan Wang, Sohn Yang Sung, Rachel Nechushtai, Itamar Willner*. Gated Mesoporous SiO2 Nanoparticles using K-Stabilized G-Quadruplexes. Adv. Funct. Mater. 2014, 36, 5662–5670). DOI: 10.1002/adfm.201400939 (selected as the Cover of the issue 36 on 2014.)
11. Zhanxia Zhang, Fuan Wang, Dora Balogh, Itamar Willner*. pH-Controlled Release of Substrates from Mesoporous SiO2 Nanoparticles Gated By Metal Ion-Dependent DNAzymes. J. Mater. Chem. B 2014, 2, 4449–4455. DOI: 10.1039/c4tb00558a
12. Ron Orbach, Fuan Wang, Oleg Lioubashevski, Raphael D. Levine, Françoise Remacle, Itamar Willner*. A Full-Adder Based on Reconfigurable DNA-Hairpin Inputs and DNAzyme Computing Modules. Chem. Sci. 2014, 5, 3381–3387. DOI: 10.1039/C4SC00914B (selected as the Back Cover of the issue 5 on 2014.)
13. Fuan Wang, Chun-Hua Lu, Itamar Willner*. From Cascaded Catalytic Nucleic Acids to Enzyme-DNA Nanostructures: Controlling Reactivity, Sensing, Logic Operations and Assembly of Complex Structures. Chem. Rev. 2014, 114, 2881–2941. DOI: 10.1021/cr400354z (selected as the Cover of the issue 5 on 2014.)
14. Fuan Wang, Chun-Hua Lu, Xiaoqing Liu, Lina Freage, Itamar Willner*. Amplified and Multiplexed Detection of DNA Using the Dendritic Rolling Circle Amplified Synthesis of DNAzyme Reporter Units. Anal. Chem. 2014, 86, 1614–1621. DOI: 10.1021/ac4033033
15. Ron Orbach, Weiwei Guo, Fuan Wang, Oleg Lioubashevski, Itamar Willner*. Self-Assembly of Luminescent Ag Nanocluster Nanowires. Langmuir 2013, 29, 13066–13071. DOI: 10.1021/la402888b
16. Zhanxia Zhang, Dora Balogh, Fuan Wang, Sohn Yang Sung, Rachel Nechushtai, Itamar Willner*. Biocatalytic Release of an Anticancer Drug from Nucleic-Acids-Capped Mesoporous SiO2 Using DNA or Molecular Biomarkers as Triggering Stimuli. ACS Nano 2013, 7, 8455–8468. DOI: 10.1021/nn403772j
17. Fuan Wang, Lina Freage, Ron Orbach, Itamar Willner*. Autonomous Replication of Nucleic Acids by Polymerization/Nicking Enzyme/DNAzyme Cascades for the Amplified Detection of DNA and the Aptamer-Cocaine Complex. Anal. Chem. 2013, 85, 8196–8203. DOI: 10.1021/ac4013094 Highlight by HispanicBusiness
18. Xiaoqing Liu, Fuan Wang, Ruth Aizen, Omer Yehezkeli, Itamar Willner*. Graphene Oxide/Nucleic Acid-Stabilized Silver Nanoclusters: Functional Hybrid Materials for Optical Aptamer Sensing and Multi-plexed Analysis of Pathogenic DNAs. J. Am. Chem. Soc. 2013, 135, 11832–11839. DOI: 10.1021/ja403485r
19. Fuan Wang, Xiaoqing Liu, Chun-Hua Lu, Itamar Willner. Cysteine-Mediated Aggregation of Au Nanoparticles: A Process for the Sensitive Detection of H2O2 and the Development of Oxidase-Based Biosensors. ACS Nano 2013, 7, 7278–7286. DOI: 10.1021/nn402810x
20. Fuan Wang, Bilha Willner, Itamar Willner* DNA Nanotechnology with One-Dimensional Self-Assembled Nanostructures. Curr. Opin. Biotechnol. 2013, 24, 562–574. DOI: 10.1016/j.copbio.2013.02.005
21. Zhanxia Zhang, Dora Balogh, Fuan Wang, Ran Tel-Vered, Naomi Levy, Sohn Yang Sung, Rachel Nechushtai, Itamar Willner*. Light-Induced and Redox-Triggered Uptake and Release of Substrates to and from Mesoporous SiO2 Nanoparticles. J. Mater. Chem. B 2013, 1, 3159–3166. DOI: 10.1039/C3TB20292E
22. Zhanxia Zhang, Dora Balogh, Fuan Wang, Itamar Willner*. Smart Mesoporous SiO2 Nanoparticles for the DNAzyme-Induced Multiplexed Release of Substrates. J. Am. Chem. Soc. 2013, 135, 1934–1940.DOI: 10.10021/ja311385y
23. Fuan Wang, Xiaoqing Liu, Itamar Willner* Integration of Photoswitchable Proteins, Photosynthetic Reaction Centers and Semiconductor/Biomolecule Hybrids with Electrode Supports for Optobioelectronic Applications. Adv. Mater. 2013, 25, 349–377. DOI: 10.1002/adma.201201772
24. Xiaoqing Liu, Fuan Wang, Angelica Niazov-Elkan, Weiwei Guo, Itamar Willner*. Probing Biocatalytic Transformations with Luminescent DNA/Silver Nanoclusters. Nano Lett. 2013, 13, 309–314. DOI: 10.1021/nl304283c
25. Xiaoqing Liu, Angelica Niazov-Elkan, Fuan Wang, Itamar Willner*. Switching Photonic and Electrochemical Functions of a DNAzyme by DNA Machines. Nano Lett. 2013, 13, 219–225. DOI: 10.1021/nl303894h
26. Johann Elbaz†, Fuan Wang†, Raphael D. Levine, Francoise Remacle, Itamar Willner*. Programmable Functional Logic Circuits Driven by Modular DNAzyme Libraries. Nano Lett. 2012, 12, 6049−6054. DOI: 10.1021/nl300051g(† Equal contributor) (selected as the Cover of the issue 12 on 2012.)
27. Fuan Wang, Ron Orbach, Itamar Willner* Detection of Metal Ions (Cu, Hg) and of Cocaine Using a Ligation DNAzyme Machinery. Chem. Eur. J. 2012, 18, 16030–16036.DOI: 10.1002/chem.201201479
28. Ron Orbach, Lena Mostinski, Fuan Wang, Itamar Willner* Nucleic Acid-Driven DNA Machineries Synthesizing Mg-Dependent DNAzymes: An Interplay Between DNA Sensing and Logic Gate Operations. Chem. Eur. J. 2012, 18, 14689–14694. DOI: 10.1002/chem.201201995
29. Fuan Wang, Johann Elbaz, Itamar Willner*. Enzyme-Free Amplified Detection of DNA by an Autonomous Ligation and Replication DNAzyme Machinery. J. Am. Chem. Soc. 2012, 134, 5504–5507. DOI: 10.1021/ja300616w
30. Chunhua Lu†, Fuan Wang†, Itamar Willner* Zn-Ligation DNAzyme-Driven Enzymatic and Non-Enzymatic Cascades for the Amplified Detection of DNA. J. Am. Chem. Soc. 2012, 134, 10651–10658. († Equal contributor), DOI: 10.1021/ja3037838
31. Chunhua Lu†, Fuan Wang†, Itamar Willner* Amplified Optical Aptasensors through the Endonuclease-Stimulated Regeneration of the Analyte. Chem. Sci. 2012, 3, 2616–2622. († Equal contributor), DOI: 10.1039/C2SC20426F
32. Johann Elbaz, Zhengang Wang, Fuan Wang, Itamar Willner*. Programmed Dynamic Topologies in DNA Catenanes. Angew. Chem. Int. Ed. 2012,51, 2349-2353. DOI: 10.1002/anie.201107591(Selected as the Inside Cover of the issue 10 on 2012.)
33. Simcha Shimron†, Fuan Wang†, Ron Orbach, Itamar Willner* Amplified Detection of DNA through the Enzyme-Free Autonomous Assembly of Hemin/G-Quadruplex DNAzyme Nanowires. Anal. Chem. 2012, 84, 1042-1048. DOI: 10.1021/ac202643y(† Equal contributor)
34. Fuan Wang, Johann Elbaz, Ron Orbach, Nimrod Magen, Itamar Willner*. Amplified Analysis of DNA by the Autonomous Assembly of Polymers Consisting of DNAzyme Wires. J. Am. Chem. Soc. 2011, 133, 17149-17151. DOI: 10.1021/ja2076789 Highlight by Life Science Weekly on December 20, 2011
35. Fuan Wang, Johann Elbaz, Carsten Teller, Itamar Willner*. Amplified Detection of DNA through the Autocatalytic, Catabolic Generation of the Analyte by a DNAzyme. Angew. Chem. Int. Ed. 2011, 50, 295-299. DOI: 10.1002/anie.201005246
36. Johann Elbaz, Oleg Lioubashevski, Fuan Wang, Françoise Remacle, Raphael D. Levine, Itamar Willner*. DNA computing circuits using libraries of DNAzyme subunits. Nat. Nanotechnol. 2010, 5, 417-422. DOI: 10.1038/nnano.2010.88 Highlight by New Scientist
37. Ming Zhou, Fuan Wang, Shaojun Dong *. Boolean logic gates based on oxygen-controlled biofuel cell in "one pot". Electrochim. Acta 2011, 56, 4112-4118. DOI: 10.1016/j.electacta.2011.01.113
38. Xiaoqing Liu, Fuan Wang, Shuang Han, Lihong Shi, Guobao Xu*. Self-Assembly of gold nanoparticles/electroactive polyelectrolyte multilayer films for tunable electrocatalysis. Electroanalysis 2010, 22, 963-968. DOI: 10.1002/elan.200900479
39. Li Wang, Fuan Wang, Li Shang, Chengzhou Zhu, Wen Ren, Shaojun Dong*. AuAg bimetallic nanoparticles film fabricated based on H2O2-mediated silver reduction and its application. Talanta 2010, 82, 113-117. DOI: 10.1016/j.talanta.2010.04.009
40. Xiaoqing Liu, Haijuan Li, Fuan Wang, Yuling Wang, Shuyun Zhu, Guobao Xu*. Functionalized single-walled carbon nanohorns for electrochemical biosensing. Biosens. Bioelectron. 2010, 25, 2194-2199. DOI: 10.1016/j.bios.2010.02.027
41. Fuan Wang, Xiaoqing Liu, Gaiping Li, Dan Li, Shaojun Dong*. Selective Electrodissolution of Inorganic Ions/DNA Multilayer Film for Tunable DNA Release. J. Mater. Chem. 2009, 19, 286-291. DOI: 10.1039/B812940A
42. Jianlong Wang, Fuan Wang, Shaojun Dong*. Methylene Blue as an Indicator for Sensitive Electrochemical Detection of Adenosine Based on Aptamer Switch. J. Electroanal. Chem. 2009, 626, 1-5. DOI: 10.1016/j.jelechem.2008.08.008
43. Yan Du, Bingling Li, Fuan Wang, Shaojun Dong*. Au Nanoparticles Grafted Sandwich Platform Used Amplified Small Molecule Electrochemical Aptasensor. Biosens. Bioelectron. 2009, 24, 1979-1983. DOI: 10.1016/j.bios.2008.10.019
44. Liu Deng, Lihua Zhang, Li Shang, Shaojun Guo, Dan Wen, Fuan Wang, Shaojun Dong*. Electrochemiluminescence Detection of NADH, Ethanol Based on Partial Sulfonation of Sol-gel Network with Gold Nanoparticles. Biosens. Bioelectron. 2009, 24, 2273-2276. DOI: 10.1016/j.bios.2008.10.031
45. Ming Zhou, Yuling Wang, Yueming Zhai, Junfeng Zhai, Wen Ren, Fuan Wang, Shaojun Dong*. Controlled Synthesis of Large-Area and Patterned Electrochemically Reduced Graphene Oxide Films. Chem. Eur. J. 2009, 15, 6116-6120. DOI: 10.1002/chem.200900596
46. Fuan Wang, Jianlong Wang, Yueming Zhai, Dan Li, Gaiping Li, Shaojun Dong*. Layer-by-layer Assembly of Biologically Inert Inorganic Ions/DNA Multilayer Films for Tunable DNA Release by Chelation. J. Controlled Release 2008, 132, 65-73. DOI: 10.1016/j.jconrel.2008.08.016
47. Fuan Wang, Dan Li, Gaiping Li, Xiaoqing Liu, Shaojun Dong*. Electrodissolution of Inorganic ions/DNA Multilayer Film for Tunable DNA Release. Biomacromolecules 2008, 9, 2645-2652. DOI: 10.1021/bm800766t
48. Fuan Wang, Jianlong Wang, Xiaoqing Liu, Shaojun Dong*. Nanoparticle-amplified Surface Plasmon Resonance Study of Protein Conformational Change at Interface. Talanta 2008, 77, 628-634. DOI: 10.1016/j.talanta.2008.06.042
49. Liu Deng, Fuan Wang, Hongjun Chen, Li Shang, Liang Wang, Tie Wang, Shaojun Dong*. A Biofuel Cell with Enhanced Performance by Multilayer Biocatalyst Immobilized on Highly Ordered Macroporous Electrode. Biosens. Bioelectron. 2008, 24, 329-333. DOI: 10.1016/j.bios.2008.04.006
50. Jianlong Wang, Fuan Wang, Hongjun Chen, Xiaohua Liu, Shaojun Dong*. Electrochemical Surface Plasmon Resonance Detection of Enzymatic Reaction in Bilayer Lipid Membranes. Talanta 2008, 75, 666-670. DOI: 10.1016/j.talanta.2007.11.062
51. Lihua Zhang, Fuan Wang, Shaojun Dong*. Layer-by-layer Assembly of Functional Silica and Au Nanoparticles for Fabricating Electrogenerated Chemiluminescence Sensor. Electrochim. Acta 2008, 53, 6423-6427. DOI: 10.1016/j.electacta.2008.04.059
52. Liu Deng, Yizhe Wang, Li Shang, Dan Wen, Fuan Wang, Shaojun Dong*. A Sensitive NADH and Glucose Biosensor Tuned by Visible Light Based on Thionine Bridged Carbon Nanotubes and Gold Nanoparticles Multilayer. Biosens. Bioelectron. 2008, 24, 951-957. DOI: 10.1016/j.bios.2008.07.066
53. Fuan Wang, Jianlong Wang, Hongjun Chen, Shaojun Dong*. Assembly Process of CuHCF/MPA Multilayers on Gold Nanoparticles Modified Electrode and Characterization by Electrochemical SPR. J. Electroanal. Chem. 2007, 600, 265-274. DOI: 10.1016/j.jelechem.2006.10.008
54. Jianlong Wang, Fuan Wang, Xiangqin Zou, Zhiai Xu, Shaojun Dong*. Surface Plasmon Resonance and Electrochemistry for Detection of Small Molecules Using Catalyzed Deposition of Metal Ions on Gold Substrate. Electrochem. Commun. 2007, 9, 343-347. DOI: 10.1016/j.elecom.2006.09.011
55. Jianlong Wang, Fuan Wang, Zhiai Xu, Yizhe Wang, Shaojun Dong*. Surface Plasmon Resonance and Electrochemistry Characterization of Layer-by-Layer Self-Assembled DNA and Zr Thin Films and Their Interaction with Cytochrome c. Talanta 2007,74, 104-109. DOI: 10.1016/j.talanta.2007.05.033
56. Na Gao, Zhiai Xu, Fuan Wang, Shaojun Dong*. Sensitive Biomimetic Sensor Based on Molecular Imprinting at Functionalized Indium Tin Oxide Electrodes. Electroanalysis 2007, 19, 1655-1660. DOI: 10.1002/elan.200703919
57. Liu Deng, Ying Liu, Guocheng Yang, Li Shang, Dan Wen, Fuan Wang, Zhiai Xu, Shaojun Dong*. Molecular "Wiring" Glucose Oxidase in Supramolecular Architecture. Biomacromolecules 2007, 8, 2063-2071. DOI: 10.1021/bm061049l
58. Jianlong Wang, Yong Shao, Yongdong Jin, Fuan Wang, Shaojun Dong*. Electrochemical Thinning of Thick Gold Film with Controlled Thickness for SPR Sensing. Anal. Chem. 2005, 77, 5760-5765. DOI: 10.1021/ac0507035
