王在照，男，1969年5月出生，山東省蒙陰縣人，畢業於中國科學院海洋研究所，博士，西北農林科技大學動物科技學院教授教授，博士生導師。
基本介紹
- 中文名：王在照
- 出生地：山東省蒙陰縣
- 出生日期：1969年5月
- 畢業院校：中國科學院海洋研究所
- 學位/學歷：博士
- 職業：教師
- 專業方向：海洋生物學
- 任職院校：西北農林科技大學
- 性別：男
- 職稱：教授
人物經歷,研究方向,開設課程,研究項目,發表論文,
人物經歷
1997年至2000年中國科學院海洋研究所攻讀海洋生物學博士學位，2000年至2004年中國科學院海洋研究所實驗海洋生物學重點實驗室工作，2004年至2007年在美國喬治亞醫學院生物技術與基因組醫學中心進行博士後工作，2008年至今在西北農林科技大學動物科技學院工作。
研究方向
水域環境中環境激素化合物、抗生素和重金屬的分布及水生生物生物毒性效應研究；環境內分泌干擾物作用下的魚類毒理轉錄組和表觀遺傳學研究；水環境中抗生素耐藥菌及抗生素耐藥基因的選擇和傳播機制研究；魚類耳石在魚類生態上的套用及相關機制研究。
開設課程
從事水域生態學、水生生物學、分子生物學等教學工作，承擔本科課程《水域生態學》、《學科導論》、《分子生物學》的理論與實踐課程，碩士研究生《水域環境保護》及博士研究生《高級水生生物學專題》課程。
研究項目
國家自然科學基金面上項目，雙酚A對魚類精子發生的危害及其分子機制研究（31670523），2017-2020，主持；
國家自然科學基金面上項目，雙酚A干擾稀有鮈鯽性腺類固醇激素合成和效應的DNA甲基化調控及其機制研究（31470553），2015-2018，主持；
國家自然科學基金面上項目，雙酚A影響稀有鮈鯽卵巢發育的生態毒理基因組學研究（31270547），2013-2016，主持；
國家自然科學基金青年項目，中國對蝦CHH家族神經肽基因的克隆及表達研究（40106018），2002-2004，主持；
橫向課題，西安市戶縣澇浴河流水生野生動物專題調研，2018-2019，主持；
橫向課題，額勒賽下游水電站上電站水庫魚類資源現狀調查,2018-2019，主持；
橫向課題，輞川河葛牌古鎮段河道治理提升工程對其水環境的影響評價專題報告，2018，主持；
橫向課題，增殖放流跟蹤監測，2017-2018，主持；
橫向課題，增殖放流標記試驗，2016-2017，主持；
橫向課題，漢城湖水生生物群落結構及水質監測，2015-2016，主持；
橫向課題，灞河城市段垂釣魚類資源調查與評價，2015-2016，主持；
橫向課題，灃河梁家灘橡膠壩工程上下游水生生物群落結構及水質監測，2016-2017，主持；
橫向課題，延安市延河水生生物現狀調查與影響評價，2019年，主持；
中央高校基本科研業務費項目，漢江上游生態漁業開發的關鍵技術研究（QN2011062），2011-2014，主持；
西北農林科技大學引進人才科研啟動項目（z111020824），2008-2011，主持。
發表論文
（為通訊作者）：
[1] Yuan, C., Wang, L., Zhu, L., Ran, B., Xue, X ., Wang, Z., 2019. N-acetylcysteine alleviated bisphenol A-induced testicular DNA hypermethylation of rare minnow (Gobiocypris rarus) by increasing cysteine contents. Ecotox. Environ. Safe. 173, 243-250. (IF:3.974)
[2] Tao, S., Wang, L., Zhu, Z., Liu, Y., Wu, L., Yuan, C., Zhang, G., Wang, Z., 2019. Adverse effects of bisphenol A on Sertoli cel l blood-testis barrier in rare minnow Gobiocypris rarus. Ecotox. Environ. Safe. 171, 475–483. (IF: 3.974)
[3] Guan, Y., Jia, J., Wu, L., Xue, X., Zhang, G., Wang, Z., 2019. Analysis of Bacterial Community Characteristics, Abundance of Antibiotics and Antibiotic Resistance Genes Along a Pollution Gradient of Ba River in Xi'an, China. Front. Microbiol. 9，3191. (IF: 4.019)
[4] Guan, Y., Zhang, T., He, J., Jia, J., Zhu, L., Wang, Z., 2019. Bisphenol A disturbed the lipid metabolism mediated by sterol regulatory element binding protein 1 in rare minnow Gobiocypris rarus. Aquat. Toxicol. 207, 179-186. (IF: 3.884)
[5] Wu, L., Yu, Q., Zhang, G., Wu, F., Zhang, Y., Yuan, C., Zhang, T., Wang, Z., 2019. Single and combined exposures of waterborne Cu and Cd induced oxidative stress responses and tissue injury in female rare minnow (Gobiocypris rarus) Comp. Biochem. Physiol. C 222, 90–99. (IF: 2.426)
[6] 陳紅,劉清,潘建雄,王松,王在照, 2019. 灞河城市段浮游生物群落結構時空變化及其與環境因子的關係.生態學報2019,39(1):173-184.
[7] Wang, S., Zhu, Z., He, J., Yue, X., Pan, J., Wang, Z., 2018. Steroidal and phenolic endocrine disrupting chemicals (EDCs) in surface water of Bahe River, China: Distribution, bioaccumulation, risk assessment and estrogenic effect on Hemiculter leucisculus. Environ. Pollut. 243,103-114. (IF: 4.358)
[8] Jia J., Guan Y., Cheng, M., Chen, H., He, J., Wang, S., Wang, Z., 2018. Occurrence and distribution of antibiotics and antibiotic resistance genes in Ba River, China. Sci. Total Environ. 642, 1136-1144. (IF: 4.61)
[9] Zhang, Y., Guan, Y., Zhang, T., Yuan, C., Liu, Y., Wang, Z., 2018. Adult exposure to bisphenol A in rare minnow Gobiocypris rarus reduces sperm quality with disruption of testicular aquaporins. Chemosphere 193, 365-375. (IF: 4.427)
[10] Fan, X., Wu, L., Hou, T., He, J., Wang, C., Liu, Y., Wang, Z., 2018. Maternal Bisphenol A exposure impaired endochondral ossification in craniofacial cartilage of rare minnow (Gobiocypris rarus) offspring. Ecotox. Environ. Safe. 163, 514-520. (IF: 3.974)
[11] Zhang, Y., Guan, Y., Fan, X., Wu, L., Wang, Z., 2018. Bisphenol A regulates rare minnow testicular vitellogenin expression via reducing its promoter Er recruitment. Ecotox. Environ. Safe. 147,423-429. (IF: 3.974)
[12] Zhang, T., Guan, Y., Wang, S., Wang, L., Cheng, M., Yuan, C., Liu, Y., Wang, Z., 2018. Bisphenol A induced abnormal DNA methylation of ovarian steroidogenic genes in rare minnow Gobiocypris rarus. Gen. Comp. Endocr. 269,156-165 (IF: 2.564).
[13] Yuan, C., Li, M., Zhen, Y., Zhou, Y., Wu, F., Wang, Z., 2017. Accumulation and detoxification dynamics of chromium and antioxidant responses in juvenile rare minnow, Gobiocypris rarus. Aquat. Toxicol. 190, 174-180. (IF: 3.884)
[14] Yuan, C., Zhang, Y., Liu, Y., Wang, S., Wang, Z., 2017. DNA demethylation mediated by down-regulated TETs in the testes of rare minnow Gobiocypris rarus under bisphenol A exposure. Chemosphere 171, 355-361. (IF: 4.427)
[15] Gao, J., Zhang, Y., Zhang, T., Yang, Y., Yuan, C., Jia, J., Wang, Z., 2017. Responses of gonadal transcriptome and physiological analysis following exposure to 17 alpha-ethynylestradiol in adult rare minnow Gobiocypris rarus. Ecotox. Environ. Safe. 2017, 141, 209-215. (IF: 3.974)
[16] Zhang, T., Liu, Y., Chen, H., Gao, J., Zhang, Y., Yuan, C., Wang, Z., 2017. The DNA methylation status alteration of two steroidogenic genes in gonads of rare minnow after bisphenol A exposure. Comp. Biochem. Physiol. C 198, 9-18. (IF: 2.426)
[17] 劉清，王松，許江娟，陳紅，吳朗，袁聰，王在照，2017. 西安市漢城湖浮游植物群落結構與水質狀況分析. 安全與環境工程，24（3）：48-56.
[18] Zhang, Y., Wu, L., Zhang, G., Guan, Y., Wang, Z., 2016. Effect of low-dose malathion on the gonadal development of adult rare minnow Gobiocypris rarus. Ecotox. Environ. Safe. 125 135–140. (IF: 3.743)
[19] Yuan, C., Zhang, Y., Liu, Y., Zhang, T., Wang, Z., 2016. Enhanced GSH synthesis by Bisphenol A exposure promoted DNA methylation process in the testes of adult rare minnow Gobiocypris rarus. Aquat. Toxicol. 178, 99-105. (IF: 4.129)
[20] Zhang, Y., Cheng, M., Wu, L., Zhang, G., Wang, Z., 2016.Bisphenol A induces spermatocyte apoptosis in rare minnow Gobiocypris rarus. Aquat. Toxicol. 2016, 179: 18–26. (IF: 4.129)
[21] Yuan, J., Gu, Z., Zheng, Y., Zhang, Y., Gao, J., Chen, S., Wang, Z., 2016. Accumulation and detoxification dynamics of microcystin-LR andantioxidant responses in male red swamp crayfish Procambarus clarkii. Aquat. Toxicol. 177, 8-18. (IF: 4.129)
[22] Yang, Y., Gao, J., Yuan, C., Zhang, Y., Guan, Y., Wang, Z., 2016. Molecular identification of Kiss/GPR54 and function analysis with mRNA expression profiles exposure to 17a-ethinylestradiol in rare minnow Gobiocypris rarus. Mol. Biol. Rep. 43(7), 737-749. (IF: 1.828)
[23] Zhang, Y., Yuan, C., Gao, J., Liu, Y., Wang Z., 2016. Testicular transcript responses in rare minnow Gobiocypris rarus following different concentrations bisphenol A exposure. Chemosphere 156, 357-366. (IF: 4.208)
[24] Zheng, Y., Chen, J., Liu, Y., Gao, J., Yang, Y., Zhang, Y., Bing, X., Gao, Z., Liang H., Wang, Z., 2016. Molecular mechanism of endocrine system impairment by 17α- methyltestosterone in gynogenic Pengze crucian carp offspring. Ecotox. Environ. Safe. 128, 143-152. (IF: 3.743)
[25] Guan, Y., Gao, J., Zhang, Y., Chen, S., Yuan, C., Wang, Z., 2016. Effects of bisphenol A on lipid metabolism in rare minnow Gobiocypris rarus. Comp. Biochem. Physiol. C 179, 144–149. (IF: 2.416)
[26] Tao, S., Zhang, Y., Yuan, C., Gao, J., Wu, F., Wang, Z., 2016. Oxidative stress and immunotoxic effects of bisphenol A on the larvae of rare minnow Gobiocypris rarus. Ecotox. Environ. Safe. 124, 377–385. (IF: 3.743)
[27] Zhang, Y., Tao, S., Yuan, C., Liu, Y., Wang, Z., 2016. Non-monotonic dose-response effect of bisphenol A on rare minnow Gobiocypris rarus ovarian development. Chemosphere 144, 304-311. (IF: 4.208)
[28] Liu, Y., Zhang, Y., Tao S., Guan, Y., Zhang, T., Wang, Z., 2016. Global DNA methylation in gonads of adult zebrafish Danio rerio under bisphenol A exposure. Ecotox. Environ. Safe. 130, 124–132. (IF: 3.743)
[29] Yuan, J., Wang, X., Gu, Z., Zhang, Y., Wang, Z., 2015. Activity and transcriptional responses of hepatopancreatic biotransformation and antioxidant enzymes in the oriental river prawn Macrobrachium nipponense exposed to microcystin-LR. Toxins 7, 4006-4022. (IF: 2.938)
[30] Gao, J., Liu, S., Zhang, Y., Yang, Y., Yuan, C., Chen, S., Wang, Z., 2015. Effects of 17 α-methyltestosterone on transcriptome, gonadal histology and sex steroid hormones in rare minnow Gobiocypris rarus. Comp. Biochem. Physiol. D 15, 20–27. (IF: 2.055)
[31] 袁聰，陶詩雨，張瑩瑩，高建操，楊彥平，王在照, 2015. 安康水庫表層浮游藻類群落結構及其與環境因子的關係. 套用生態學報26 ( 7) : 2167-2176.
[32] Wu, F.,Zheng, Y., Gao, J., Chen, S., Wang, Z., 2014. Induction of oxidative stress and the transcription of genes related to apoptosis in rare minnow (Gobiocypris rarus) larvae with Aroclor 1254 exposure. Ecotox. Environ. Safe. 110, 254-260. (IF: 2.762)
[33] Qin, F., Wang, X., Liu, S., Zheng, Y., Li, M., Zhang, Y., Wang, Z., 2014. Gene expression profiling of key genes in hypothalamus-pituitary-gonad axis of rare minnow Gobiocypris rarus in response to EE2. Gene 552 (1), 8-17. ( IF: 2.082)
[34] Zhang, Y., Gao, J., Xu, P., Yuan, C., Qin, F., Liu, S., Zheng, Y., Yang, Y., Wang, Z., 2014. Low-dose bisphenol A disrupts gonad development and steroidogenic genes expression in adult female rare minnow Gobiocypris rarus. Chemosphere 112, 435- 442. (IF: 3.499)
[36] Gao, J., Zhang, Y., Yang, Y., Yuan, C., Qin, F., Liu, S., Zheng, Y., Wang Z., 2014. Molecular characterization of PXR and two sulfotransferases and hepatic transcripts of PXR, two sulfotransferases and CYP3A responsive to bisphenol A in rare minnow Gobiocypris rarus. Mol. Biol. Rep. 41(11), 7153-7165. (IF: 2.024)
[37] Zheng, Y., Liang, H., Xu, P., Li, M., Wang, Z., 2014. Molecular cloning of Pcc-dmrt1s and their specific expression patterns in Pengze crucian carp (Carassius auratus var. Pengze) affected by 17α-methyltestosterone. Fish Physiol. Biochem. 40 (4), 1141-1155. (IF: 1.676)
[38] Liu, S., Wang, L., Qin, F., Zheng, Y., Li, M., Zhang, Y., Yuan, C., Wang, Z., 2014. Gonadal development and transcript profiling of steroidogenic enzymes in response to 17 α-methyltestosterone in the rare minnow Gobiocypris rarus . J. Steroid Biochem. Mol. Biol. 143, 223-232. (IF: 4.049)
[39] Liu, Y., Chen, S., Liu, S., Zhang, Y., Yuan, C., Wang, Z., 2014. DNA methylation in the 5′ flanking region of cytochrome P450 17 in adult rare minnow Gobiocypris rarus- Tissue difference and effects of 17α-ethinylestradiol and 17α-methyltestoterone exposures. Comp. Biochem. Physiol. C 162, 16-22. (IF: 2.829)
[40] Zhang, Y., Yuan, C., Qin, F., Hu, G., Wang, Z., 2014. Molecular characterization of gdf9 and bmp15 genes in rare minnow Gobiocypris rarus and their expression upon bisphenol A exposure in adult females. Gene 546, 214-221. (IF: 2.082)
[41] Gao, J., Liu, S., Zhang, Y., Yuan, C., Yang, Y., Wang, Z., 2014. Hepatic expression patterns of aryl hydrocarbon receptor, pregnane X receptor, two cytochrome P450s and five phase II metabolism genes responsive to 17alpha-methyltestosterone in rare minnow Gobiocypris rarus. Environ.Toxicol. Pharmacol. 37 (3), 1157-1168. (IF:1.862)
[42] Yuan, C., Wu, T., Zhang, Y., Gao, J., Yang, Y., Qin, F., Liu, S., Zheng, Y., Wang, Z., 2014. Responsiveness of four gender-specific genes, figla, foxl2, scp3 and sox9a to 17α- ethinylestradiol in adult rare minnow Gobiocypris rarus . Gen. Comp. Endocr. 200, 44-53. (IF: 2.674)
[43] Zhang, Y., Yuan, C., Hu, G., Li, M., Zheng, Y., Gao, J., Yang, Y., Zhou, Y., Wang, Z., 2013. Characterization of four nr5a genes and gene expression profiling for testicular steroidogenesis-related genes and their regulatory factors in response to bisphenol A in rare minnow Gobiocypris rarus. Gen. Comp. Endocr. 194, 31-44. (IF: 2.823)
[44] Zheng, Y., Wang, L., Li, M., Liang, H., Qin, F., Liu, S., Wang, H., Wu, T., Zhang, Y., Wang, Z., 2013. Molecular characterization of five steroid receptors from pengze crucian carp and their expression profiles of juveniles in response to 17α-ethinylestradiol and 17α-methyltestosterone. Gen. Comp. Endocr. 191, 113-122. (IF: 2.823)
[45] Qin, F., Wang, L.,Wang, X.,Liu, S.,Xu, P., Wang, H., Wu, T., Zhang, Y.,Zheng, Y.,Li, M., Zhang, X., Yuan, C., Hu, G., Wang, Z., 2013. Bisphenol A affects gene expression of gonadotropin-releasing hormones and type I GnRH receptors in brains of adult rare minnow Gobiocypris rarus. Comp. Biochem. Physiol. C 157(2), 192-202. (IF:2.829)
[46] Li, M., Zheng, Y., Liang, H., Zou, L., Sun, J., Zhang, Y., Qin, F., Liu, S., Wang, Z., 2013. Molecular cloning and characterization of cat, gpx1 and Cu/Zn-sod genes in pengze crucian carp (Carassius auratus var. Pengze) and antioxidant enzyme modulation induced by hexavalent chromium in juveniles. Comp. Biochem. Physiol. C 157(3), 310-321. (IF:2.829)
[47] Li, M., Wang, L., Wang, H., Liang, H., Zheng, Y., Qin, F., Liu, S., Zhang, Y., Wang, Z., 2013. Molecular cloning and characterization of amh, dax1 and cyp19a1a genes and their response to 17α-methyltestosterone in Pengze crucian carp. Comp. Biochem. Physiol. C 157(4), 372-381. (IF: 2.829)
[48]Yuan, C., Zhang, Y., Hu, G., Li, M., Zheng, Y., Gao, J., Yang, Y., Zhou, Y., Wang, Z., 2013. Expression of two zona pellucida genes is regulated by 17α-ethinylestradiol in adult rare minnow Gobiocypris rarus. Comp. Biochem. Physiol. C 158(1), 1-9. (IF:2.829)
[49] QinF.,Wang, L., Liu, S., Wang, Z., 2013.Characterization of reference genes in rare minnow,Gobiocypris rarus(Actinopterygii: Cypriniformes: Cyprinidae), in early postembryonic development and in response to Edcs treatment.Acta Ichthyol. Piscat.43(2), 127-138. (IF: 0.691)
[50] 章霞，張瑩瑩，李蒙，鄭堯，王在照, 2013. 大鱗副泥鰍GPR30基因的克隆及EE2暴露對其表達的影響.《西北農林科技大學學報》（自然科學版），41(12) , 21-29.
[51] Wang, H., Wu, T., Qin, F., Wang, L., Wang, Z., 2012. Molecular cloning of Foxl2 gene and the effects of endocrine-disrupting chemicals on its mRNA level in rare minnow, Gobiocypris rarus. Fish Physiol. Biochem. 38(3), 653-664. (IF: 1.676)
[52] Wu, T., Wang, H., Qin, F., Liu, S., Li, M., Xu, P., Wang, Z., 2012. Expression of zona pellucida B proteins in juvenile rare minnow (Gobiocypris rarus) exposed to 17α-ethinylestradiol, 4-nonylphenol and bisphenol A. Comp. Biochem. Physiol. C 155(2), 259-268. (IF:2.707)
[53] Zhang, Y., Wang, H., Qin F., Liu, S., Wu, T., Li, M., Xu, P., Zhang, X., Wang, X., Hu, G., Yuan, C., Wang, Z., 2012. Molecular characterization of estrogen receptor genes in loach Paramisgurnus dabryanus and their expression upon 17α- ethinylestradiol exposure in juveniles. Gen. Comp. Endocr. 178(2), 194-205. (IF: 2.823)
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[65] 張繼泉, 李富花, 王在照, 吳長功, 相建海, 2006. 中國明對蝦蛻皮抑制激素在大腸桿菌中的表達與分離純化. 高技術通訊 16(3), 301-306.
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