王喆，南開大學藥學院教授。主持發明Enanta新一代大環內酯類抗生素3等，擁有超過100項美國發明專利。招生方向： 藥物化學。
基本介紹
- 中文名：王喆
- 國籍：中國
- 民族：漢
- 職業：教師
- 學位/學歷：博士
- 性別：男
- 職稱：教授
人物經歷,研究方向,主要貢獻,
人物經歷
1991,1 - 1993,8: 美國哈佛大學化學系有機合成化學專業, 指導教授: Elias J.Corey （1990年諾貝爾化學獎得主），博士後。
1986,9 - 1991,1: 美國田納西州大學化學系有機合成化學專業, 指導教授: George W. Kabalka，博士學位。
1982, 2 - 1985, 1: 中國蘭州大學化學系天然產物化學產物專業及及昆明植物研究所, 指導教授: 朱子清, 賈忠健，周俊,揚崇仁, 碩士學位。
1985, 2 – 1986, 9: 蘭州大學化學系天然產物化學產物專業, 博士候選人, 因公派留學而赴美。
1978, 2 – 1982, 1: 中國蘭州大學化學系分析化學專業, 學士學位。
研究方向
藥物化學方向。
主要貢獻
成立美國Longwood藥物研究所，開始抗丙，B型肝炎，抗腫瘤，及心血管藥物的研究與開發。其中，一個抗癌藥已成功以1000萬元人民幣轉讓給中國維和藥業。
主持領導Enanta抗C型肝炎病毒NS3蛋白酶抑制劑項目，該項目完成向雅培(Abbott)的技術合作轉讓(總價值3.07億美元)。
抗C型肝炎藥物ABT/EDP-450 臨床實驗I及臨床實驗II顯示非常好的結果。臨床實驗III已開始。
抗C型肝炎藥藥物ABT/EDP-148臨床實驗已開始。
多個類型的後續抗C型肝炎化合物的臨床前毒理及安全性研究已展開。
主持發明Enanta新一代大環內酯類抗生素3，6 – Bicyclolide (EDP-877，臨床前實驗證明了針對甲氧西林耐藥金黃色葡萄球菌MRSA，及針對社區獲得性肺炎CAP的優異活性)。
主持CMC開發第三代大環內酯類抗生素EDP-420，臨床I，II效果優良。與日本鹽野義（Shionogi）藥業合作開發亞洲市場，鹽野義藥業付 Enanta 2500萬美元頭期臨床專利授權費)。
主持CMC開發EDP-322(針對甲氧西林耐藥金黃色葡萄球菌 MRSA，及針對社區獲得性肺炎CAP) 臨床I已完成。
主持CMC開發EDP-5xx及EDP-1xx(針對社區獲得性肺炎CAP)，臨床實驗I準備工作已完成。
參與開發Sustiva(HIV NNRTI非核苷逆轉錄酶抑制劑類抗愛滋病毒藥物)化學製造工藝。
作為Enanta製藥公司項目領導參與雅培公司 (Abbott) 合作開發抗C肝新藥。
作為Enanta製藥公司CMC(化學、製造與控制）及cGMP管理領導參與日本Shionogi公司合作開發抗生素新藥。
擁有超過100項美國發明專利。
發表文章
Xu, G. Y; Tang, D. T.; Gai, Y.; Wang, G. Q.; Kim, H.; Chen, Z.; Phan, L. T.; Or, Y. S. and Wang, Zhe; An Efficient Large-Scale Synthesis of EDP-420, a First-in-Class Bridged Bicyclic Macrolide (BBM) Antibiotic Drug Candidate. Org. Proc. Res & Dev. 2010, 14, 504–510
Gai, Y.; Tang, D.; Xu, G.; Chen, Z.; Polemeropoulos, A.; Wang, Z.; Or, Y. S. Synthesis of 3,6-bicyclolides: A novel class of macrolide antibiotics. Bioorg. Med. Chem. Lett. 2008, 18, 6315.
Tang, D.; Gai, Y.; Chen, Z.; Polemeropoulos, A.; Wang, Z.; Or, Y. S. Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: Length optimization and zero carbon linker oximes. Bioorg. Med. Chem. Lett. 2008, 18, 5078.
Choudhury, A.; Jin, F.; Wang, D.; Wang, Z.; Xu, G.; Confalone, P. N.; Pierce, M. E.; Nguyen, D. "A Concise Synthesis of anti-Viral Agent F-ddA, Starting from (S)-dihydro-5-(hydroxymethyl)-2(3H)-Furanone”, Tetrahedron Lett. 2003, 247.
Yang, Y.; Wang, Z.; Pan, X.; Lignans with Anti-HIV Properties” Huaxue Jinzhan. . 2003, 327.
Jin, F.; Wang, D.; Confalone, P. N.; Pierce, M. E.; Wang, Z.; Xu, G.; Choudhury, A.; Nguyen, D. "(2R, 3S, 5S)-2-Acetoxy-3-fluoro-5-(p-touloyloxymethyl) tetrahydrofuran: A Key Intermediate for the Synthesis of 9-(2,3-Dideoxy-2-fluoro-D-threo-pentofuranolsyl)adenine (F-ddA)", Tetrahedron Lett. 2001, 4787.
Kabalka, G. W.; Yang, K.; Wang, Z.; “Synthesis of Tertiary -Hydroxy Carboxylic Acids¾Allylboration of -keto Carboxylic Aicds via Neighboring Group Control”, Syn. Commun. 2001, 31, 511.
Wang, Z.; Xu, G.; Pierce, M. E. “Synthesis of Tertiary -Hydroxy Carboxylic Acids via Hypervalent Silicate”, Tetrahedron Lett. 2000, 41, 4523.
Kabalka, G. W.; Yang, K.; Wang, Z.; “The Reaction of -Ketoacids with Allylboronates”, in Contemporary Boron Chemistry, A. K. Hughes, M. Davidson Ed.; Royal Society of Chemistry, UK; 2000, 253, 454.
Wang, Z.; Campana, S.; Fortunak. J. “A New Method for the Synthesis of Vinyl Dihalides and Its Application to the Synthesis of Terminal Acetylenes." Tetrahedron Lett. 2000, 41, 4007.
Wang, Z.; Campana, S.; Yang, K.; Xu, G.; Pierce, M. E.; Fortunak. J. “A Practical Preparation of Terminal Acetylene from Aldehydes”, J. Org. Chem.;1999, 64, 1889.
Wang, Z.; Yin, J. G.; Campagna, S. A.; Pesti, J. A.; Fortunak, J. M. “An Alternative Approach for the Conversion of Aldehydes to Terminal Alkynes”, J. Org. Chem. 1999, 64, 6918.
Wang, Z.; Zhao, C. L.; Pierce, M. E.; Fortunak, J. M. “Enantioselective Synthesis of -Hydroxy Carboxylic Acids: Direct Conversion of -Oxocarboxylic Acids to Enantiomerically Enriched -Hydroxy Carboxylic Acids via Neighboring Group Control”, Tetrahedron Asymmetry, 1999, 10, 225.
Wang, Z.; La, B.; Fortunak, J. M.; Meng, X. J.; and Kabalka, G. W. “Enantioselective Synthesis of -Hydroxy Carboxylic Acids: Direct Conversion of -Oxocarboxylic Acids to Enantiomerically Enriched -Hydroxy Carboxylic Acids via Neighboring Group Control”, Tetrahedron Lett. 1998, 39, 5501.
Corey, E. J.; Wang, Z. "Conversion of Arachidonic Acid to the Prostaglandin Endoperoxide PGG2, A Chemical Analog of the Biosynthetic Pathway," Tetrahedron Lett. 1994, 35, 539.
Corey, E. J.; Wang, Z. "Enantioselective Conversion of Aldehydes to cyanohydrins by a Catalytic System with Separate Chiral Binding Sites for Aldehydes and Cyanide Components," Tetrahedron Lett. 1993, 34, 4001.
Wang, Z.; Chatla, N.; Wadgaonkar, P. P.; Kabalka, G. W. "Methylphenylborane, A New Hydroborating Reagent for the Syntheses of Totally Mixed Triorganoboranes," J. Organomet. Chem., 1992, 440, 243.
Kabalka, G. W.; Wang, Z.; Goodman, M. M. "Synthesis of Isomerically Pure N-13 Labeled -Aminobutyric Acid and Putrescine," Int. J. Radiat. Appl. Instrum. [A] 1992, 43, 389.
Wang, Z.; Meng, X.-J.; Kabalka, G. W. "The Stereoselective Crotylboration of -Oxocarboxylic Acids," Tetrahedron Lett. 1991, 32, 5677.
Wang, Z.; Meng, X.-J.; Kabalka, G. W. "The Addition of Allylboronates to -Oxocarboxylic Acids," Tetrahedron Lett. 1991, 32, 4619.
Wang, Z.; Meng, X.-J.; Kabalka, G. W. "The Stereoselective Allyl- and Crotylboration of -Hydroxyketones," Tetrahedron Lett. 1991, 32, 1945.
Kabalka, G. W.; Green, J. F.; Goodman, M. M.; Wang, Z.; Wadgaonkar, P. P. "Syntheses of Organoborane Polymers for Use in the Preparation of Nitrogen-13 Labeled Amines," J. Labeled Compds. & Radiopharm. 1991, 30, 409.
Kabalka, G. W.; Wang, Z. "Hydroboration / Amination of N-trimethylsilyl Protected Olefinic Amines and Diolefins: Syntheses of Isomerically Pure Diamines," Synth. Commun. 1990, 20, 2113.
Kabalka, G. W.; Wang, Z. "Preparation of Isomerically Pure Dialkylamines via the Reaction of Dimethylboranes with Chloralkylamine," Synth. Commun. 1990, 20, 231.
Kabalka, G W.; Wang, Z.; Goudgaon, N. M. "Preparation of Isomerically Pure Alkylamines via the Reaction of Dimethylboranes with Chloramine," Synth. Commun. 1989, 19, 2409.
Kabalka, G. W.; Wang, Z. "Reaction of Trialkylboranes with Alkylamines: Synthesis of Dialkylamines," Organometallics 1989, 8, 1093
Kabalka, G. W.; Green, J. F.; Wang, Z.; Goodman, M. M. "The Synthesis of Nitrogen-13 Labeled Butylamine Using Organoborane Polymers," J. Labeled Compds. & Radiopharm. 1988, 26, 90.
Yang, C. R.; Wang, Z. "Steroid Saponins from the Fresh Fruits of Dracaena Cambodiana," Acta Botanica Yunanica (Ch.) 1986, 8, 355.
Wang, Z.; Jia, Z.-j.; Zhu, T.-t.; Yang, C.-r.; Zhou, J. "Flavonoid Constituents from the Seeds of Camellia Oleifera," Acta Botanica Yunnanica (Ch.) 1986, 8, 157.
Wang, Z.; Jia, Z.-j.; Zhu, T.-t.; Yang, C.-r.; Zhou, J.; Kasai, R.; Tanaka, O. "The Triterpenoid Saponins of Rhizomes of Panax Japonicus C. A. Meyer Var. Angustifolius (Burk.) Chen et Chu," Acta Botanica Sinica (Ch.) 1985, 27, 618.
Ye, S.-b.; Wang, Z.; Chen, C.-y. "Syntheses of Chelating Resins and Their Applications in Analytical Chemistry," Journal of Suzhou Railway Teacher's University, Natural Science Edition (Ch.), 1984, 1, 60.
