江中興

江中興

江中興，博士、教授、武漢大學藥學院博士生導師、楚天學者特聘教授。

在研項目： “基於單一分子量聚乙二醇的生物材料的設計、合成及其在生物大分子藥物研發中的套用”，國家自然科學基金面上項目，批准號21572168，65萬元，2016年-2019年； “F-19 MRI 可視化5-FU 傳輸載體的合成與套用研究”， 國家自然科學基金面上項目，批准號21372181，78萬元，2014年-2017年； “含氟樹枝狀大分子顯影材料的製備與套用”，東華大學纖維材料改性國家重點實驗室開放課題，10萬元，2015年-2017年； “鹽黴素的結構改造及活性研究”，中科院天然產物有機合成化學重點實驗室開放課題，3萬元，2015年-2016年

在SCI期刊上發表文章30餘篇，文章被引用600餘次，H-index>14；申請美國專利4項，中國專利4項，其中2項美國專利及1項中國專利已經獲的授權；任Journal of Biomolecular Research & Therapeutics編委，受邀為Bioconjugate Chemistry，Journal of Organic Chemistry，Journal of Fluorine Chemistry等10餘個英文學術期刊審稿人，相關研究成果被Faculty of 1000, F-blog, RSC Advances等多次評述；主持國家自然科學基金面上項目等多個研究項目，指導多個國家級大學生創新創業項目.

基本介紹

  • 中文名：江中興
  • 國籍：中國
  • 職業：教授，博士生導師
  • 畢業院校：西南大學
  • 主要成就：申請美國專利4項，中國專利3項，其中3項美國專利已經獲批
  • 代表作品：在SCI期刊上發表文章31篇
基本情況,學習簡歷：,工作簡歷：,主要研究方向及業績：,研究方向,業績概要,主要科研專利及論著,批准專利及專利申請：,發表專著：,發表文章：,

基本情況

學習簡歷：

1995年9月至1999年7月 西南大學化學化工學院獲學士學位
1999年8月至2004年7月 中科院上海有機化學研究所獲博士學位

工作簡歷：

2004年8月至2007年4月 美國猶他大學藥學院博士後
2007年4月至2008年8月 美國印第安納大學醫學院博士後
2008年8月至2011年10月 美國馬里蘭大學藥學院研究助理教授
2011年10月至今 武漢大學藥學院教授

主要研究方向及業績：

研究方向

藥物化學，有機化學，分子影像學，新型生物材料，藥物的可視化傳輸與緩釋

業績概要

在SCI期刊上發表文章31篇，文章被引用550餘次，H-index>12；申請美國專利4項，中國專利3項，其中3項美國專利已經獲批；任 Journal of Biomolecular Research & Therapeutics 編委，受邀為Bioconjugate Chemistry, Journal of Organic Chemistry，Journal of Fluorine Chemistry等英文學術期刊審稿人，相關研究成果被Faculty of 1000, F-blog, RSC Advances等多次評述。

主要科研專利及論著

批准專利及專利申請：

1. Yu Y.B., Jiang Z.-X. “Highly fluorinated ß-amino acids and methods of making and using same” 美國專利號 US 8,052,961B2
2. Yu Y.B., Jiang Z.-X. “Highly fluorinated oils and surfactants and methods of making and using same” 美國專利號 US 8,252,778B2
3. Yu Y.B., Jiang Z.-X., Xiao N. “Protected enantiopure trifluorothreonines and methods of making and using same” 申請號 PCT/US2007/078552，國際公開號 WO2008034095
4. Yu Y.B., Jiang Z.-X.“Conjugates of F MR imaging tracers for use in multi-chromic MRI imaging” 申請號 PCT/US2009/63381
5. 江中興，張華，李學飛，李昱 “一種單一分子量聚乙二醇及其衍生物的合成方法” CN201310710498.6
6. 江中興，李學飛，李昱，夏桂全 “一種新型大環環硫酸酯及其製備方法與運用”CN201310656494.4
7. 江中興，余偉江， 薄少偉 “一種樹枝狀大分子氟-19磁共振顯影劑及其製備方法和套用” CN20150037920.5

發表專著：

Jiang Z.-X., Li X., Qing F.-L. “A green chemistry strategy: fluorous catalysis” Book chapter in “Bridging Heterogeneous and Homogenous Catalysis” Edited by Li C., Liu Y. Wiley-VCH，p253-282, 2014.

發表文章：

  1. Yu W., Yang Y., Bo S., Li Y., Chen S., Yang Z., Zheng X., Jiang Z.-X.*, Zhou X. “The Design and Synthesis of Fluorinated Dendrimers for Highly Sensitive F MR” J. Org. Chem. 2015, in print (IF 4.64).
  2. Zhang H., Li X., Shi Q., Li Y., Xia G., Chen L., Yang Z., Jiang Z.-X.* “Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)” Angew. Chem. Int. Ed. 2015, DOI: 10.1002/anie.201410309 (IF 11.34).
  3. Taraban M. B., Li Y., Yue F., Jouravleva E. V., Anisimov M. A., Jiang Z.-X., Yu Y. B.* “Conformational transition of a non-associative fluorinated amphiphile in aqueous solution” RSC Adv. 2014, 4(97), 54565-54575.
  4. Xia G., Li Y., Li Y., Li X., Zhang H., Yu Y. B., Jiang Z.-X.* “Optimize the separation of fluorinated amphiles using high-performance liquid chromatography” J. Fluorine Chem. 2014, 165, 39-42.
  5. Li Y., Guo Q., Li X., Zhang H., Yu F., Yu W., Xia G., Fu M., Yang Z., Jiang Z. -X.* “Fluorous synthesis of mono-dispersed poly(ethylene glycols)” Tetrahedron Lett. 2014, 55，2110-2113.
  6. Jiang Z.-X., Zhi S., Zhang W.* “Recent progress on fluorous synthesis of biologically interesting compounds” Mol. Divers. 2014, 18, 203-218.
  7. Li Y., Thapa B., Zhang H., Li X., Yu F., Jeong E.-K., Yang Z., Jiang Z.-X.* “Synthesis of gemini surfactants with twelve symmetric fluorine atoms and one singlet F MR signal as novel F MRI agents” Tetrahedron 2013, 69, 9586-9590.
  8. Zhang H., Li Y., Jiang Z.-X.* “Fluorine is flourishing in pharmaceuticals” J. Biomol. Res. Thera. 2012, 1:e107.
  9. Yu Y. B.,* Jiang Z.-X. “Prospect of F MRI-guided drug delivery” J. Pharm. Drug Deliv. Res. 2012, 1, 1
  10. Jiang Z.-X., Feng Y., Yu Y.B.* “Fluorinated paramagnetic chelates as potential multi-chromic F tracer agents” Chem. Comm. 2011, 47, 7233-7235.
  11. Jiang Z.-X., Yu Y.B.* “Fluorous mixture synthesis of asymmetric dendrimers” J. Org. Chem., 2010, 75, 2044–2049.
  12. He R., Yu Z., He Y., Zeng L.-F., Xu J., Wu L., Gunawan A. M., Wang L., Jiang Z.-X., Zhang Z.-Y.* "Double click reaction for the acquisition of a highly potent and selective mPTPB inhibitor" ChemMedChem, 2010, 5, 2051-2056.
  13. Zhang X., He Y., Liu S., Yu Z., Jiang Z.-X., Yang Z., Dong Y., Nabinger S.C., Wu L., Gunawan A.M., Wang L., Chan R.J., Zhang Z.-Y.* “Salicylic acid-based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) ” J. Med. Chem., 2010, 53, 2482–2493.
  14. Zhang X.,* Fan S., He C.-Y., Wan X., Min Q.-Q., Yang J., Jiang Z.-X. “Pd(OAc)2 Catalyzed olefination of highly electron-deficient perfluoroarenes” J. Am. Chem. Soc., 2010, 132, 4506–4507.
  15. Jiang Z.-X., Liu X., Jeong E.-K., Yu Y.B.* “Symmetry-guided design and fluorous synthesis of a stable and rapidly excreted imaging tracer for F MRI” Angew. Chem. Int. Ed. 2009, 48, 4755-4758.
  16. Jiang Z.-X., Zhang Z.-Y.* “Targeting PTPs with small molecule inhibitors in cancer treatment” Cancer and Metastasis Reviews. 2008, 27, 263-272.
  17. Jiang Z.-X., Yu Y.B.* “The design and synthesis of highly branched and spherically symmetric fluorinated macrocyclic chelators” Synthesis. 2008, 2, 215-220.
  18. Liu S., Zhou B., Yang H., He Y., Jiang Z.-X., Kumar S., Wu, L., Zhang Z.-Y.* “Aryl vinyl sulfones and sulfonates as active site-directed and mechanism-based probes for protein tyrosine phosphatases” J. Am. Chem. Soc. 2008, 130, 8251-8260.
  19. Jiang Z.-X., Yu Y.B.* “The design and synthesis of highly branched and spherically symmetric fluorinated oils and amphiles” Tetrahedron. 2007, 63, 3982-3988.
  20. Jiang Z.-X., Yu Y.B.* “The synthesis of a geminally perfluoro-tert-butylated b-amino acid and its protected forms as a potential pharmacokinetic modulator and reporter for peptide-based pharmaceuticals” J. Org. Chem. 2007, 72, 1464-1467.
  21. Wang B.-L., Jiang Z.-X., You Z.-W., Qing F.-L.* “Total synthesis of trifluoromethylated analogs of macrosphelide A” Tetrahedron. 2007, 63, 12671-12680.
  22. Xiao N., Jiang Z.-X., Yu Y.B.* “Enantioselective synthesis of (2R, 3S)- and (2S, 3R)-4,4,4- trifluoro-N-Fmoc-O-tert-butyl-threonine and their racemization-free incorporation into oligopeptides via solid-phase synthesis” Biopolymers (Peptide Science). 2007, 88, 781-796.
  23. You Z.-W., Jiang Z.-X., Wang B.-L., Qing F.-L.* “An efficient and general route to gem-difluoromethylenated a,b-unsaturated d-lactones: high enantioselective synthesis of gem- difluoromethylenated goniothalamins” J. Org. Chem. 2006, 71, 7261-7267.
  24. Wang B.-L, Yu F., Qiu X.-L., Jiang Z.-X, Qing F.-L.* “Synthesis of trifluoromethylated analogues of b-L-fucofuranose and b-L-4, 6-dideoxyxylohexopyranose” J. Fluorine Chem. 2006, 127, 580-587
  25. Jiang Z.-X., Liu X.-P., Qiu X.-L., Qing F.-L.* “Asymmetric synthesis of both enantiomers of syn-3-(trifluoromethyl)cysteine derivatives” J. Fluorine Chem. 2005, 126, 499-505.
  26. Jiang Z.-X., Qing F.-L.* “Regioselective and stereoselective nucleophilic ring opening of trifluoromethylated cyclic sulfates: asymmetric synthesis of both enantiomers of syn-(3-trifluoromethyl)isoserine” J. Org. Chem. 2004, 69, 5486-5489.
  27. Jiang Z.-X., Qin Y.-Y., Qing F.-L.* “Asymmetric synthesis of both enantiomers of anti-4,4,4-trifluorothreonine and 2-amino-4,4,4-trifluorobutanoic acid” J. Org. Chem. 2003, 68, 7544-7547.
  28. Jiang Z.-X., Qing F.-L.* “Sodium carbonate as carbon dioxide source for the synthesis of cyclic carbonates containing the trifluoromethyl group” J. Fluorine Chem. 2003, 123, 57-60.
  29. Qing F.-L.,* Jiang Z.-X. “Synthesis of trifluoromethylated b-and g-lactones through the palladium-catalyzed cyclocarbonylation” J. Fluorine Chem. 2002, 114, 177-180.
  30. Jiang Z.-X., Qing F.-L.* “Palladium-catalyzed cyclocarbonylation of trifluoromethyl propargylic alcohols producing 3-trifluoromethyl-2(5H)-furanones (g-lactones)” Tetrahedron Lett. 2001, 42, 9051-9053.
  31. Qing F.-L.,* Jiang Z.-X. “Palladium-catalyzed cyclocarbonylation of (Z)-3-iodo-3- trifluoromethyl allylic alcohols producing 3-trifluoromethyl-2(5H)-furanones (g-lactones)” Tetrahedron Lett. 2001, 42, 5933-5935.

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