楊建華(中山大學生命科學學院教授)

楊建華，男，博士，中山大學生命科學學院教授、博士生導師。

基本介紹

• 中文名：楊建華
• 畢業院校：中山大學
• 學位/學歷：博士
• 專業方向：生物化學與分子生物學
• 任職院校：中山大學

研究方向

1、解碼非編碼RNA基因的功能調控網路

2、非編碼RNA和RNA修飾的功能和作用機制

3、非編碼RNA和RNA修飾在疾病發生髮展中的作用

個人經歷

教育經歷

1. 2003/9–2008/7， 中山大學，生物化學與分子生物學， 博士，導師：屈良鵠

2. 1998/9–2002/7， 西南農業大學（現西南大學）， 生物科學與農學， 學士

工作經歷

1. 2016/1-至今，中山大學，生命科學學院，教授

2. 2011/1-2015/12，中山大學，生命科學學院，副教授

3. 2008/7-2010/12，中山大學，生命科學學院，講師（師資博士後）

講授課程

本科生

《電腦程式設計語言》

《科技論文寫作》

研究生

《RNA分子生物學》

學術成就

長期致力於研究非編碼RNA基因和RNA修飾及其互作蛋白的結構、功能和作用機制。

以通訊作者或第一作者身份在Nature、Nature Cell Biology、European Urology、Cell Research、Nucleic Acids Res.、Cell Reports等雜誌發表20多篇研究論文，以合作者身份在Nature Methods、Cell Stem Cell等雜誌發表10多篇研究論文。通訊作者或第一作者的研究論文有15篇IF>10.0，其中8篇研究論文被選為ESI高引用論文，1篇被Nature Reviews Genetics和Nature Chemical Biology雜誌亮點評述，1篇被Nature Cell Biology雜誌亮點評述，1篇被選為Cell Research雜誌的封面和亮點評述,1篇被European Urology雜誌亮點評述,1篇論文入選“2014年中國百篇最具影響國際學術論文”，單篇最高SCI他引超過600次。開發的工具被Nature等雜誌引用超過1800次，受邀在Springer出版社出版了4篇關於非編碼RNA研究方法的論著章節。期刊Non-coding RNA journal的編委，主持該雜誌的首期Special Issue。是Nucleic Acids Res., Mol. Biol. Evol.，Bioinformatics, ‎Brief. Bioinform等雜誌審稿人。是海外French National Alliance (AVIESAN) andFrench National Cancer Institute (INCa)、Netherlands Organisation for Scientific Research (NWO)等基金評審專家。

率先利用CLIP-seq、ChIP-seq和Epitranscriptome數據和機率罰分模型等開發新的算法和平台，包括starBase、snoSeeker、StarScan、circScan、RMBase、tRF2cancer、ChIPBase、deepBase等。starBase平台已成為國際同行最廣泛使用的非編碼RNA功能網路預測工具之一(starBase平台在Google Scholar總引用超過2300次)。

承擔課題

主持項目

2018-2021，國家自然科學面上項目

2015-2017，國家自然科學基金重大研究計畫培育項目

2014-2017，國家自然科學面上項目

2010-2012，國家自然科學青年項目

2013-2015， 珠江科技新星項目

課題骨幹

2017-2021， 國家重點研發項目

論文專著

研究論文

2019年

Huang H+, Weng H+, Zhou K+, Wu T+, Zhao B. S+, Sun M, Chen Z, Deng X, Xiao G, Auer F, Klemm L, Wu H, Zuo Z, Qin X, Dong Y, Zhou Y, Qin H, Tao S, Du J, Liu J, Lu Z, Yin H, Mesquita A, Yuan C. L, Hu Y.-C, Sun W, Su R, Dong L, Shen C, Li C, Qing Y, Jiang X, Wu X, Sun M, Guan J.-L, Qu L, Wei M, Müschen M, Huang G*, He C*,Yang J*, Chen J*. Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally.Nature.2019 Mar;567(7748):414-419.(* Correspondence Author,+Co-first author)HighlightinNature Reviews Genetics&HighlightinNature Chemical Biology.

Deng B+, Xu W+, Wang Z, Liu C, Lin P, Li B, Huang Q,Yang J*, Zhou H*, Qu L*. An LTR retrotransposon-derived lncRNA interacts with RNF169 to promote homologous recombination.EMBO Rep.2019 Sep 5:e47650.(* Correspondence Author,+Co-first author)

2018年

Huang H+, Weng H+, Sun W+, Qin X+, Shi H+, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Hüttelmaier S, Skibbe JR, Su R, Deng X, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C*,Yang J*, Chen J*. Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.NatureCell Biology.2018 Mar;20(3):285-295.(* Correspondence Author,+Co-first author)ESI Highly Cited Paper,News & ViewsinNature Cell Biology.

Qu L+, Wang ZL+, Chen Q+, Li YM+, He HW, Hsieh JJ, Xue S, Wu ZJ, Liu B, Tang H, Xu XF, Xu F, Wang J, Bao Y, Wang AB, Wang D, Yi XM, Zhou ZK, Shi CJ, Zhong K, Sheng ZC, Zhou YL, Jiang J, Chu XY, He J, Ge JP, Zhang ZY, Zhou WQ*, Chen C*,Yang JH*, Sun YH*, Wang LH*. Prognostic Value of a Long Non-coding RNA Signature in Localized Clear Cell Renal Cell Carcinoma.European Urology2018 Dec;74(6):756-763.(* Correspondence Author,+Co-first author)Highlightin European Urology

Bao X, Guo X, Yin M, Tariq M, Lai Y, Kanwal S, Zhou J, Li N, Lv Y, Pulido-Quetglas C, Wang X, Ji L, Khan MJ, Zhu X, Luo Z, Shao C, Lim DH, Liu X, Li N, Wang W, He M, Liu YL, Ward C, Wang T, Zhang G, Wang D,Yang J, Chen Y, Zhang C, Jauch R, Yang YG, Wang Y, Qin B, Anko ML, Hutchins AP, Sun H, Wang H, Fu XD, Zhang B, Esteban MA. Capturing the interactome of newly transcribed RNA.Nat Methods.2018 Mar;15(3):213-220.

Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC,Yang J,Qian Z, Wei M, He C, Chen J. METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification.Cell Stem Cell.2018 Feb 1;22(2):191-205.ESI Highly Cited Paper,HighlightinCell Stem Cell.

Wang ZL+, Li B+, Luo YX, Lin Q, Liu SR, Zhang XQ, Zhou H,Yang JH*,Qu LH*. Comprehensive Genomic Characterization of RNA-Binding Proteins across Human Cancers.Cell Reports.2018 Jan 2;22(1):286-298. (* Correspondence Author,+Co-first author)

Zheng LL+, Zhou KR+, Liu S, Zhang DY, Wang ZL, Chen ZR,Yang JH*,Qu LH*. dreamBase: DNA modification, RNA regulation and protein binding of expressed pseudogenes in human health and disease.Nucleic Acids Res.2018 Jan 4;46(D1):D85-D91.(* Correspondence Author,+Co-first author)

Xuan JJ, Sun WJ, Lin PH, Zhou KR, Liu S, Zheng LL, Qu LH*,Yang JH*. RMBase v2.0: deciphering the map of RNA modifications from epitranscriptome sequencing data.Nucleic Acids Res.2018 Jan 4;46(D1):D327-D334.(* Correspondence Author)

2017年

Zhang XQ*+, Wang ZL+, Poon MW+,Yang JH*.Spatial-temporal transcriptional dynamicsof long non-coding RNAs in human brain.Hum Mol Genet.2017 Aug15;26(16):3202-3211.(* Correspondence Author,+Co-first author)

Zheng LL, Deng KW, Deng AC, Wu J,Yang JH, Lun ZR, Qu LH. Exo-miRExplorer: A Comprehensive Resource for Exploring and Comparatively Analyzing Exogenous MicroRNAs.Front Microbiol.2017 Feb 1;8:126.

Zhou KR, Liu S, Sun WJ, Zheng LL, Zhou H,Yang JH*, Qu LH*. ChIPBase v2.0: decoding transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP-seq data.Nucleic Acids Res.2017 Jan 4;45(D1):D43-D50. (* Correspondence Author)ESI Highly Cited Paper

2016年

Huang ZP, Ding Y, Chen J, Wu G, Kataoka M, Hu Y,Yang JH, Liu J, Drakos SG, Selzman CH, Kyselovic J, Qu LH, Dos Remedios CG, Pu WT, Wang DZ. Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy.Cardiovasc Res.2016 Aug 24. pii: cvw201.

Guo YH, Wang LQ, Li B, Xu H,Yang JH, Zheng LS, Yu P, Zhou AD, Zhang Y, Xie SJ, Liang ZR, Zhang CM, Zhou H, Qu LH. Wnt/β-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling.Oncotarget.2016 Jul 5;7(27):42513-4252

Zheng LL, Xu WL, Liu S, Sun WJ, Li JH, Wu J,Yang JH*,Qu LH*. tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers.Nucleic Acids Res.2016 Jul 8;44(W1):W185-93. (* Correspondence Author)

Wang ZL+, Li B,+Piccolo SR, Zhang XQ, Li JH, Zhou H,Yang JH*,Qu LH*. Integrative analysis reveals clinical phenotypes and oncogenic potentials of long non-coding RNAs across 15 cancer types.Oncotarget.2016 Jun 7;7(23):35044-55. (* Correspondence Author,+Co-first author)

Zheng LL, Li JH, Wu J, Sun WJ, Liu S, Wang ZL, Zhou H,Yang JH*,Qu LH*. deepBase v2.0: identification, expression, evolution and function of small RNAs, LncRNAs and circular RNAs from deep-sequencing data.Nucleic Acids Res.2016 Jan 4;44(D1):D196-202. (* Correspondence Author)ESI Highly Cited Paper

Sun WJ, Li JH, Liu S, Wu J, Zhou H, Qu LH*,Yang JH*.RMBase: a resource for decoding the landscape of RNA modifications from high-throughput sequencing data.Nucleic Acids Res.2016 Jan 4;44(D1):D259-65. (* Correspondence Author)ESI Highly Cited Paper

2015年

Liu S, Li JH, Wu J, Zhou KR, Zhou H,Yang JH*,Qu LH*. StarScan: a web server for scanning small RNA targets from degradome sequencing data.Nucleic Acids Res.2015 Jul 1;43(W1):W480-6. (* Correspondence Author)

Li JH, Liu S, Zheng LL, Wu J, Sun WJ, Wang ZL, Zhou H, Qu LH*,Yang JH*.Discovery of Protein-lncRNA Interactions by Integrating Large-Scale CLIP-Seq and RNA-Seq Datasets.Front Bioeng Biotechnol.2015 Jan 14;2:88. (* Correspondence Author,research paper invited by Carlo Maria Croce)

2014年

Zhang YJ,Yang JH, Shi QS, Zheng LL, Liu J, Zhou H, Zhang H, Qu LH. Rapid birth-and-death evolution of imprinted snoRNAs in the Prader-Willi syndrome locus: implications for neural development in Euarchontoglires.PLoS One.2014 Jun 19;9(6):e100329.

Gou LT+, Dai P+,Yang JH+,Xue Y, Hu YP, Zhou Y, Kang JY, Wang X, Li H, Hua MM, Zhao S, Hu SD, Wu LG, Shi HJ, Li Y, Fu XD, Qu LH, Wang ED, Liu MF. Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis.Cell Res.2014 Jun;24(6):680-700. (+Co-first author)CoverPaper,Research HighlightinCell Res.

Wen JZ, Liao JY, Zheng LL, Xu H,Yang JH, Guan DG, Zhang SM, Zhou H, Qu LH. A contig-based strategy for the genome-wide discovery of microRNAs without complete genome resources.PLoS One.2014 Feb 7;9(2):e88179.

Li JH, Liu S, Zhou H, Qu LH*,Yang JH*. starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data.Nucleic Acids Res.2014 Jan;42:D92-7. (* Correspondence Author)ESI Highly Cited Paper

Wen JZ, Liao JY, Zheng LL, Xu H,Yang JH, Guan DG, Zhang SM, Zhou H, Qu LH. A Contig-Based Strategy for the Genome-Wide Discovery of MicroRNAs without Complete Genome Resources.PLoS One.2014 Feb 7;9(2):e88179.

2013年

Yang JH, Li JH, Jiang S, Zhou H, Qu LH. ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data.Nucleic Acids Res.2013 Jan;41:D177-87.ESI Highly Cited Paper

Xiao ZD, Diao LT,Yang JH, Xu H, Huang MB, Deng YJ, Zhou H, Qu LH. Deciphering the transcriptional regulation of microRNA genes in humans with ACTLocater.Nucleic Acids Res.2013 Jan 7;41(1):e5.

Zheng LL, Wen YZ,Yang JH, Liao JY, Shao P, Xu H, Zhou H, Wen JZ, Lun ZR, Ayala FJ, Qu LH. Comparative transcriptome analysis of small noncoding RNAs in different stages of Trypanosoma brucei.RNA.2013 Jul;19(7):863-75.

Shao P, Liao JY, Guan DG,Yang JH, Zheng LL, Jing Q, Zhou H, Qu LH. Drastic expression change of transposon-derived piRNA-like RNAs and microRNAs in early stages of chicken embryos implies a role in gastrulation.RNA Biol.2012 Feb;9(2):212-

2011年

Yang JH, Li JH, Shao P, Zhou H, Chen YQ, Qu LH. starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data.Nucleic Acids Res.2011 Jan;39:D202-9.ESI Highly Cited Paper

2010年

Yang JH, Shao P, Zhou H, Chen YQ, Qu LH. deepBase: a database for deeply annotating and mining deep sequencing data.Nucleic Acids Res.2010 Jan;38:D123-30.

Zhang Y, Guan DG,Yang JH, Shao P, Zhou H, Qu LH. ncRNAimprint: a comprehensive database of mammalian imprinted noncoding RNAs.RNA.2010 Oct;16(10):1889-901.

2010以前

Zhang H+,Yang JH+, Zheng YS+, Zhang P, Chen X, Wu J, Xu L, Luo XQ, Ke ZY, Zhou H, Qu LH, Chen YQ. Genome-wide analysis of small RNA and novel MicroRNA discovery in human acute lymphoblastic leukemia based on extensive sequencing approach.PLoS One.2009 4(9):e6849. (+co-first author)

Shao P+,Yang JH+, Zhou H, Guan DG, Qu LH. Genome-wide analysis of chicken snoRNAs provides unique implications for the evolution of vertebrate snoRNAs.BMC Genomics.2009 Feb 22;10:86. (+co-first author)

Yang JH, Zhang XC, Huang ZP, Zhou H, Huang MB, Zhang S, Chen YQ, Qu LH. snoSeeker: an advanced computational package for screening of guide and orphan snoRNA genes in the human genome.Nucleic Acids Res.2006;34(18):5112-23.