梁丹，發育生物學博士，教授，碩士生導師，博士生導師，國家衛生健康委配子及生殖道異常研究重點實驗室獨立PI。
基本介紹
- 中文名：梁丹
- 畢業院校：中國科學院上海生物化學與細胞生物所、安徽大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：發育生物學
- 職稱：教授
人物經歷,研究方向,主要成就,
人物經歷
2006.09-2010.07 安徽大學生命科學學院生物技術專業，學士
2010.09-2016.07 中國科學院上海生物化學與細胞生物所，博士
2017.02-2020.08 美國俄勒岡健康與科技大學胚胎幹細胞與基因治療中心，博士後
2020.09- 今 安徽醫科大學國家衛生健康委配子及生殖道異常研究重點實驗室，教授
研究方向
主要成就
1. Wu, Y*, Liang, D.*, Wang, Y., Bai, M., Tang, W., Bao, S., Yan, Z., Li, D., and Li, J. (2013). Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell Stem Cell 13, 659-662.（* 共同一作）(影響因子IF=25.3)
2. Guo, F. *, Li, X. *, Liang, D. *, Li, T. *, Zhu, P., Guo, H., Wu, X., Wen, L., Gu, T.P., Hu, B., et al. (2014). Active and passive demethylation of male and female pronuclear DNA in the Mammalian zygote. Cell stem cell 15, 447-458. （* 共同一作）(影響因子IF=25.3)
3. Bai, M.*, Liang, D.*, Wang, Y., Li, Q., Wu, Y., and Li, J. (2016). Spermatogenic Cell-Specific Gene Mutation in Mice via CRISPR-Cas9. J Genet Genomics 43, 289-296. （* 共同一作）(IF=4.1)
4. Liang, D., Wu, Y. and Li, J. (2015). Progress of CRISPR-Cas9 in stem cell research. Chinese Bulletin of Life Science 1, 27
5. Yang, H., Shi, L., Wang, B.A., Liang, D., Zhong, C., Liu, W., Nie, Y., Liu, J., Zhao, J., Gao, X., et al. (2012). Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. Cell 149, 605-617. (影響因子=32.4)
6. Yu, Y., Liang, D., Tian, Q., Chen, X., Jiang, B., Chou, B.K., Hu, P., Cheng, L., Gao, P., Li, J., et al. (2013). Stimulation of Somatic Cell Reprogramming by Eras-Akt-Foxo1 Signaling Axis. Stem Cells 32, 349-363. (影響因子=7.7)
7. Wu, Y., Zhou, H., Fan, X., Zhang, Y., Zhang, M., Wang, Y., Xie, Z., Bai, M., Yin, Q., Liang, D., et al. (2014). Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells. Cell Res 25, 67-69. (影響因子=12)
8. Zhu, W., Yao, X., Liang, Y., Liang, D., Song, L., Jing, N., Li, J., and Wang, G. (2015). Mediator Med23 deficiency enhances neural differentiation of murine embryonic stem cells through modulating BMP signaling. Development 142, 465-476. (影響因子=6.1)
9. Zuo, E., Cai, Y.J., Li, K., Wei, Y., Wang, B.A., Sun, Y., Liu, Z., Liu, J., Hu, X., Wei, W., Liang, D., et al. (2017). One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs. Cell Res 27, 933-945. (影響因子=14.7)
10. Ma, H., Marti-Gutierrez, N., Park, S.W., Wu, J., Hayama, T., Darby, H., Van Dyken, C., Li, Y., Koski, A., Liang, D., et al. (2018). Ma et al. reply. Nature 560, E10-E23. (影響因子=43.1)
11. Ma, H., Hayama, T., Van Dyken, C., Darby, H., Koski, A., Lee, Y., Gutierrez, N.M., Yamada, S., Li, Y., Andrews, M., Ahmed, R., Liang, D., et al. (2019). Deleterious mtDNA Mutations are Common in Mature Oocytes. Biol Reprod 102,607-619. (影響因子=3.0)
12. Ma, H., Van Dyken, C., Darby, H.,Mikhalchenko, A., Gutierrez, N.M., Koski, A., Liang, D., Li, Y., et al. (2020). Germline transmission of donor, maternal and paternal mtDNA in primates. Human Reproduction 00, 1-13. (影響因子=5.7)
