林正紅

林正紅，男，重慶大學生命科學學院博士生導師，百人計畫特聘教授。

基本介紹

• 中文名：林正紅
• 畢業院校：清華大學
• 學位/學歷：博士
• 專業方向：分子細胞生物學
• 職務：重慶大學生命科學學院博士生導師

人物經歷

教育背景

2003-2008：清華大學，生物科學與技術系， 博士

1998-2001：中國農業科學院研究生院，碩士

1994-1998：中國農業大學，動物科技學院，學士

科研經歷

2014.12-現在： 重慶大學生命科學學院‘百人計畫’學者、研究員、博士生導師

2012.07-2014.11：美國西北大學，Feinberg School of Medicine，研究助理教授

2009.12-2012.06：美國西北大學，Feinberg School of Medicine, 研究助理

2009.1-2009.11： 美國芝加哥大學，Ben May癌症生物學系，博士後

2008.09-2009.01：美國匹茲堡大學，醫學院，博士後

研究方向

分子細胞生物學。

我們主要利用生物化學，細胞生物學，分子生物學，遺傳與表觀遺傳學，生物信息學等多學科生物實驗手段，重點以去泛素化酶和去乙醯化酶為靶標，尋找其靶基因和調控因子，主攻癌症、兼顧其它如糖尿病、衰老性疾病、老年痴呆症等其它重大疾病的病理髮生機理及其關鍵基因的調控網路，為開發具有潛在治療價值的藥物提供新靶標。

學術成果

先後在Molecular Cell、Cell Reports、J Exp Med.、EMBO J. 、 Genes Dev. 、J Immunol.、 JBC等期刊上發表學術論文約20篇 。

1.Ling Dong; Le Yu; Chunrong Bai; Liu Liu; Hua Long; Lei Shi; Zhenghong Lin*. USP27-mediated Cyclin E Stabilization Drives Cell Cycle Progression and Hepatocellular Tumorigenesis. Oncogene, 2018 Mar, 10(1038) ; SCI 1區

2. Lei Shi*; Lihua Yu; Fagu iZou; Huimin Hu; Kun Liu; Zhenghong Lin*. Gene expression profiling and functional analysis reveals that p53 pathway-related gene expression is highly activated in cancer cells treated by cold atmosphe c plasma-activated medium. Peer J, 2017 Aug, 5: e3751;

3. Yuqiong Wang; Xiyu Zhang; Wei Tang; Zhenghong Lin; Limei Xu; Ruifen Dong; Yiluo Li; Jieyin Li; Zaixin Zhang; Xiangzhi Li; Ling Zhao; Jian-jun Wei; Changshun Shao; Beihua Kong; Zhaojian Liu. miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-κB in high-grade serous ovarian carcinoma. Cell Death Differ, 2017 Dec, 24(12): 2089~2100 ; SCI 1區

4. Yan Wu，Chunxiang Bian，Chunlin Zhen，Liu Liu，Zhenghong Lin，Muhammad Farrukh Nisar，Mei Wang，Joerg W.Bartsch，Enyi Huang，Ping Ji，Li Yang，Yanhong Yu，Junfeng Yang，Xuemei Jiang，Julia Li Zhong,*. Telomerase reverse transcriptase mediates EMT through NF-kappa B signaling in tongue squamous cell carcinoma. ONCOTARGET，2017.10.17，8（49）：85492~85503;

5. Xuebao Zhang，Juan Cai，Ze Zheng，Lisa Polin，Zhenghong Lin，Aditya Dandekar，Li Li，Fei Sun，Russell L Finley Jr，Deyu Fang，Zeng-Quan Yang，Kezhong Zhang*. A novel ER–microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progression. Cell Discovery，2015.9.8，1：15024

6. Sinyi Kong，Hongxin Dong，Jianxun Song，Muthusamy Thiruppathi，Bellur S.Prabhakar，Quan Qiu，Zhenghong Lin，Chini, Eduardo，Bin Zhang，Deyu Fang. Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKK alpha Phosphorylation. JOURNAL OF IMMUNOLOGY，2015.10.15，195（8）：3685~3693 ;

7. Lin Z*. SIRT7: from a Metabolic Regulator to a Disease Marker International Journal of Cancer Studies & Research (IJCR), 2015.2.23, 4(1): 63~66 ;

8. Zhenghong Lin; Can Tan; Quan Qiu; Sinyi Kong; Heeyoung Yang; Fang Zhao; Zhaojian Liu; Jinping Li; Qingfei Kong; Beixue Gao; Terry Barrett; Guang-Yu Yang; Jianing Zhang; Deyu Fang*. Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1. Cell Discov, 2015 Apr, 1: 15028

9. Heeyoung Yang, Quan Qiu, Beixue Gao, Sinyi Kong, Zhenghong Lin and Deyu Fang. Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammation.J Exp Med. 2014 Nov 3 . (影響因子13.9)

10. Sinyi Kong, Muthusamy Thiruppathi, Quan Qiu, Zhenghong Lin, Hongxin Dong, Bellur S. Prabhakar, Eduardo Nunes Chini and Deyu Fang. DBC1 Is a Suppressor of B Cell Activation by Negatively Regulating Alternative NF-кB Transcriptional Activity. J Immunol.2014 Oct 31 . (影響因子5.5)

11. Zhenghong Lin* and Jinping Li. SIRT6 Links Immune Response and Metabolism to Cancer.Austin J Clin Pathol.2014;1(1) (*corresponding author)

12. Zhenghong Lin, Heeyoung Yang, Can Tan, Jinping Li, Zhaojian Liu, Qiu Quan, Sinyi Kong, Junsheng Ye, Beixue Gao and Deyu Fang. The Deubiquitinase USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation. Cell Reports.2013 Dec 11. (影響因子7.2)

13. Kyeorda L. Kemp, Zhenghong Lin, Fang Zhao, Beixue Gao, Jianxun Song, Kezhong Zhang and Deyu Fang. The serine-threonine kinase Inositol-requiring enzyme 1 α (IRE1α) promotes IL-4 production in T helper cells.J Biol Chem.2013 Nov 15;288(46):33272-82 . (影響因子4.7)

14. Quan Qiu, Ze Zheng, Lin Chang, Yuan-Si Zhao, Can Tan, Aditya Dandekar, Zheng Zhang, Zhenghong Lin, Ming Gui, Xiu Li, Tongshuai Zhang, Qingfei Kong, Hulun Li, Sha Chen, An Chen, Randal J Kaufman, Wei-Lei Yang, Hui-Kuan Lin, Donna Zhang, Harris Perlman, Edward Thorp, Kezhong Zhang, and Deyu Fang.Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. EMBO J. 2013 Aug 13. (影響因子10.8)

15. Po-Han Chen, Xiaoyan Chen, Zhenghong Lin, Deyu Fang, and Xiaolin He.The structural basis of R-spondin recognition by LGR5 and RNF43.Genes Dev.2013 Jun 11. (影響因子12.3)

16. Zhenghong Lin and Deyu Fang. The roles of SIRT1 in cancer.Genes Cancer.2013 Mar;4(3-4):97-104.

17. Zhenghong Lin*,Jinping Li, and Deyu Fang*. SIRT1 Involvement in Virus-mediated Diseases. JSM Microbiology1(2) : 1006 (2013) . (*corresponding author)

18. Zhenghong Lin, Heeyoung Yang, Qingfei Kong, Jinping Li, Sang-Myeong Lee, Beixue Gao, Hongxin Dong, Jianjun Wei, Jianxun Song, Donna D. Zhang, and Deyu Fang.USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppresscell apoptosis and is required for mouse embryonic development.Mol Cell. 2012 May 25;46(4):484-94. (影響因子14.2)

19. Xiaohua Yan#, Zhenghong Lin#, Feng Chen, Xingang Zhao, Hua Chen, Yuanheng Ning, and Ye-Guang Chen.Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol Chem. 2009 Oct 30;284(44):30097-104.( #Authors contributed equally to the work) . (影響因子5.5)

20. Zhenghong Lin, Chan Gao, Yuanheng Ning, Xi He, WeiWu, and Ye-Guang Chen. The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling. J Biol Chem.2008 Nov 28;283(48):33053-8 . (影響因子5.5)

21. YIN Chang-Cheng; WANG Shang-Zi; LIN Zheng-Hong; WANG Xiang-Bin; LIU Jing; HUANG Hua-Liang. An efficient approach to the synthesis of a high-quality random peptide repertoire. 生物化學與生物物理學報, 2003.10, 35(10): 921~924 ; SCI

獲獎情況

近年主持的科研項目：

國家自然科學基金面上項目， 中央高校前沿交叉項目等。