杭海英 博士導師，研究員 中科院“百人計畫”獲得者男，1957年9月出生，現任中科院生物物理所研究員，曾任美國哥倫比亞大學放射腫瘤系助理教授。
基本介紹
- 中文名：杭海英
- 國籍：中國
- 職業：博士導師
- 畢業院校：四川大學
個人簡歷,論文論著,
個人簡歷
1982年四川大學生化專業本科畢業，1986年中科院動物所獲碩士學位，1994年美國科羅拉多州立大學放射衛生系獲博士學位。1994年－1997年在美國哥倫比亞大學放射研究中心做博士後研究。1997年－2004年 在美國哥倫比亞大學放射研究中心從事研究工作，擔任助理教授，主要研究DNA修復、細胞周期調控及與癌發生的關係。研究方向為分子腫瘤學。
論文論著
2015年
Chen C, Li N, Zhao Y*, Hang H*. Coupling Recombinase-mediated cassette exchange with somatic hypermutation for antibody affinity maturation in CHO cells
Li N, An L, Hang H*. Increased Sensitivity of DNA Damage Response-Deficient Cells to Stimulated Microgravity-Induced DNA Lesions
Zhang Z, Cai Z, Li K, Fang Y, An L, Hu Z*, Wang S*, Hang H*. The Effect of lonizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues
2014年
劉春春，趙雲，杭海英. 流式細胞術揭示出枯草芽孢桿菌多態異質性. 生物化學與生物物理進展
Yue H, Zhao Y, Hang H*. Improvement of engineered microbial production of alkanes through a dual-reporter screening system. 生物物理學報
2013年
Yang X, Sun S, Wang HF, Hang H*. Comparison of autotransporter and ice nucleation protein as carrier proteins for antibody display on the cell surface of Escherichia coli
Li T, Wang Z, Zhao Y, He W, An L, Liu S, Liu Y, Wang H, Hang H*. Checkpoint protein Rad9 plays an important role in nucleotide excision repair
2012年
Chen S , Qiu J, Chen C, Liu C, Liu Y, An L, Jia J, Tang J, Wu L, Hang H*. Affinity maturation of anti-TNF-α scFv with somatic hypermutation in non-B cells
Zhao Y, He W, Liu WF, Liu CC, Feng LK, Sun L, Yan YB, Hang HY*. Two distinct states of Escherichia coli cells that overexpress the recombinant heterogeneous β-galactosidase
2011年
Wang Y, An L, Jiang Y, Hang H*. Effects of Simulated Microgravity on Embryonic Stem Cells
Zhang C, Liu Y, Hu Z, An L, He Y, Hang H*. Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses
He W, Ma X, Yang X, Zhao Y, Qiu J, Hang H*. A role for the arginine methylation of Rad9 in checkpoint control and cellular sensitivity to DNA damage
2010年
An L, Wang Y, Liu Y, Yang X, Liu C, Hu Z, He W, Song W and Hang H*. Rad9 is required for B cell proliferation and immunoglobulin class switch recombination
Qiu J, Jung ST, Georgiou G, Hang HY*. Enrichment of Escherichia coli Spheroplasts Displaying scFv Antibodies specific for antigens expressed on the human cell surface
Cui P, Lin Q, Xin C, Han L, An L, Wang Y, Hu Z, Ding F, Zhang L, Hu S*, Hang H*, Yu J*. Hydroxyurea-induced Global Transcriptional Suppression in Mouse ES Cells
Han L, Hu Z, Liu Y, Wang X, Hopkins KM, Lieberman HB, Hang H*
2009年
Xu M, Bai L, Gong Y, Xie W, Hang H*, Jiang T. Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex
Cui Z, Chen X, Lu B, Park SK, Xu T, Xie Z, Xue P, Hou J, Hang H, Yates JR 3rd, Yang F. Preliminary quantitative profile of differential protein expression between rat L6 myoblasts and myotubes by stable isotope labeling with amino acids in cell culture
2008年
He W, Zhao Y, Zhang C, An L, Hu Z, Liu Y, Han L, Bi L, Xie Z, Xue P, Yang F, Hang H*. Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1
Zhang C, Zhang CX, He Y and Hang H*. Phosphorylation Sites on Tyr28 and the C-terminus of Rad9 are Required for Inhibition of Premature Chromosomal Condensation Across the Entire S Phase
Hu Z, Liu Y, Zhang C, Zhao Y, He W, Han L, Yang L, Hopkins KM, Yang X, Lieberman HB, Hang H*. Targeted deletion of Rad9 in mouse skin keratinocytes enhances genotoxin-induced tumor development
Guo Z, Chavez V, Singh P, Finger LD, Hang H, Hegde ML, Shen B. Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways
Wang S, Tang M, Pei B, Xiao X, Wang J, Hang H, Wu L. Cadmium-induced germline apoptosis in Caenorhabditis elegans: the roles of HUS1, p53, and MAPK signaling pathways
Pei B, Wang S, Guo X, Wang J, Yang G, Hang H, Wu L. Arsenite-induced germline apoptosis through a MAPK-dependent, p53-independent pathway in Caenorhabditis elegans
Yuan C, Jiao L, Yang L, Ying W, Hu Z, Liu J, Cui F, Li L, Qian L, Teng Y, Hang H, Qian X, Yang X. The up-regulation of 14-3-3 proteins in Smad4 deficient epidermis and hair follicles at catagen
2007年
Ning Tang, Gangjun Du, Nan Wang, Chunchun Liu, Haiying Hang*, Wei Liang*. Improving Penetration in Tumors with Nano-assemblies of Phospholipids and Doxorubicin
2006年
劉春春 杭海英*. 生物大分子相互作用檢測技術新進展———三色螢光級聯螢光共振能量轉移技術. 生物化學與生物物理進展
蘇華 杭海英*. 生理條件下的S期檢查點. 生物化學與生物物理進展
2004年
Hopkins KM, Auerbach W, Wang XY, Hande MP, Hang H, Wolgemuth DJ, Joyner AL, Lieberman HB. Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality
Hopkins KM, Wang X, Berlin A, Hang H, Thaker HM, Lieberman HB. Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue
Hang H* and Fox MH. Analysis of the mammalian cell cycle by flow cytometry. In Cell Cycl
2002年
Hang H*, Zhang Y, Dunbrack RL, Jr, Wang C, and Lieberman HB. Identification and Characterization of a Paralogue of Human Cell Cycle Checkpoint Gene HUS1
2000年
Komatsu K, Wharton W, Hang H, Wu C, Singh S, Lieberman HB, Pledger WJ, Wang HG. PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition
H. Hang, and H.B. Lieberman. Physical interactions among human checkpoint proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression
Komatsu K, Miyashita T, Hang H, Hopkins KM, Zheng W, Cuddeback S, Yamada M, Lieberman HB, Wang HG. Human homologue of S. pombe rad9 interacts with BCL-2/BCL-x L and promotes apoptosis
H. Hang, Rauth S.J., Hopkins K.M., Lieberman H.B. Mutant alleles of Schizosaccharomyces pombe rad9(+) alter hydroxyurea resistance, radioresistance and checkpoint control
1998年
H. Hang, S.J. Rauth, K.M. Hopkins, S.K. Davey. and H.B. Lieberman, Molecular cloning and tissue-specific expression of a murine orthologue of the Schizosaccharomyces pombe rad9 checkpoint control gene
1996年
H. Hang and M.H. Fox. Levels of 70-kDa heat shock protein through the cell cycle in several mammalian cell lines
H. Hang, DN. Hager, L. Goriparthi, KM. Hopkins, H. Shih and HB. Lieberman. Schizosaccharomyces pombe rad23 is allelic with swi10, a mating-type switching/ radioresistance gene that shares sequence homology with human and mouse ERCC1
1995年
H. Hang, L. He and M.H. Fox. Cell cycle variation of hsp70 levels in HeLa cells at 37o C and after a heat shock
H. Hang, L. He and M.H. Fox. Expression of hsp70 induced in CHO cells by 45.0o C hyperthermia is cell cycle associated and DNA synthesis dependent
1994年以前
H. Hang and M.H. Fox. Low pH suppresses synthesis of heat-shock proteins and thermotolerance, Radiation Research
E.D. Wieder, H. Hang and M.H. Fox. The measurement of intracellular pH using flow cytometry with carboxy-SNARF-1
H. Hang, B. Feng, Z. Zhang. Studies on relationship between Na,K-ATPase activity and sperm capacitation in Guinea pig, Science in China (series B)
