李聯運

李聯運:女 ，武漢大學生命科學學院副教授、碩士生導師，學科專業：生物化學和分子生物學，研究方向：細胞信號轉導與蛋白質降解。

基本介紹

• 中文名：李聯運
• 畢業院校：四川大學
• 學位/學歷：博士
• 專業方向：生物化學和分子生物學
• 研究方向：表觀遺傳學與細胞信號轉導
• 職稱：副教授

人物簡介

教育經歷

2000-2005 北京大學生命科學學院博士

1994-1998 四川大學生物工程系本科

工作經歷

2009　武漢大學生命科學學院副教授

2005-2009 美國國立醫學院（National Institutes of Health）博士後

承擔課程

動物生物學實驗課（本科）

研究領域

表觀遺傳學與細胞信號傳導

代表論文

（1）Wang Xiang, JuLin-gao, Fan Jia-dong, Zhu Yuan, Liu Xiao-lan, Zhu Kun, Wu Min*, Li Lian-yun*.Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation.BiochimBiophysActa. 20141843:2592. (*Authors for correspondence)

（2）Shuaikun Su, Min Zhang, Lianyun Li, Min Wu. Polycomb group genes as the key regulators in gene silencing. Wuhan University Journal of Natural Sciences. 2014, 19:1.

（3）Quan-yi Zhao, Jia-dong Fan, Wei Hong, Lian-yun Li*, Min Wu*. Inhibition of cancer cell proliferation by 5-fluoro-2'-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway. Springerplus. 2012 1:65. (*Authors for correspondence)

（4）Xiang Wang, Kun Zhu, Shang-ze Li, Yi-fang Liao, Run-lei Du, Xiao-dong Zhang, Hong-bing Shu, An-Yuan Guo, Lian-yun Li*, Min Wu*. MLL1, a Histone H3K4 Methyltransferase, Regulates the Expression of TNF-α-mediated NF-κB Downstream Genes. J. Cell Sci. 2012 125:4058. (*Authors for correspondence)

（5）Nia Soetandyo, Qiu-yan Wang, Yi-hongYe*, and Lian-yun Li*. Role of intramembrane charged residues in the quality control of unassembled T-cell receptor -chains at the endoplasmic reticulum. J. Cell Sci. 2010 123:1031. (*Authors for correspondence)

（6）Lian-yun Li, Nia Soetandyo, Qiu-Yan Wang, Yi-Hong Ye. The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation. BiochimBiophysActa- Molecular Cell Research. 2009 1793:346.

（7）Wei Li, DaqiTu, Lian-yun Li, Thomas Wollert, Rodolfo Ghirlando, Axel T. Brunger, and Yihong Ye. Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2.ProcNatlAcadSci U S A. 2009 106:3722.

（8）Lian-yun Li, Dale Hailey, Nia Soetandyo, Wei Li, Jennifer Lippincott-Schwartz, Hong-bing Shu, Yi-hong Ye. Localization of A20 to a lysosome-associated compartment and its role in NF-kappaB signaling.BiochimBiophysActa- Molecular Cell Research. 2008 1783:1140.

（9）Qiu-yan Wang, Lian-yun Li, Yi-hongYe. Inhibition of p97-dependent protein degradation by Eeyarestatin I. J. Biol. Chem. 2008 283:7445.

（10）Qiu-yan Wang, Lian-yun Li, Yi-hongYe. Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3. J. Cell Biol. 2006 174:963.

（11）Lian-yun Li, Liang-hua Bin, Fu Li, Yi Liu, Dan-ying Chen, Zhong-he Zhai and Hong-bing Shu. TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways. J. Cell Sci. 2005 118:555.

（12）Liang-guo Xu, Yan-yi Wang, Ke-jun Han, Lian-yun Li, Zhong-he Zhai and Hong-bing Shu. VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling. Mol. Cell 2005 19:727.

（13）Yan-yi Wang*, Lian-yun Li*, Ke-jun Han, Zhong-he Zhai and Hong-bing Shu. A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Letters 2004 576:86. (*co-first authors)

（14）Liang-guo Xu, Lian-yun Li, Hong-bing Shu. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J. Biol. Chem. 2004 279:17278.

（15）Jun Huang, Lin Teng, Li-xia Li, Ting Liu, Lian-yun Li, Dan-ying Chen, Liang-guo Xu, Zhong-he Zhai and Hong-bing Shu. ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation. J. Biol. Chem. 2004 279:16847.

（16）Lian-yun Li*, Jiang-cheng Hu*, Liang-hua Bin, Li-xia Li, Ji-kun Zha, Liang-guo Xu, Zheng Zhang, Zhong-he Zhai and Hong-bing Shu. Recombinant soluble TRAIL induces apoptosis of cancer cells. Chinese Science Bulletin 2001 46:2073. (*co-first authors)

（17）Lian-yun Li and Hong-bing Shu. Molecular mechanisms of TRAIL-Induced apoptosis. Chinese Science Bulletin 2001 46:707.