李占軍，吉林大學動物科學學院教授、博士生導師。
基本介紹
- 中文名：李占軍
- 國籍：中國
人物經歷,學術成果,榮譽獎勵,
人物經歷
2002—2006年，吉林大學動物科學學士。
2009—2011年，UW-Madison醫學院聯合培養博士。
2006—2012年，吉林大學動物學博士。
2012—2014年，吉林大學動物科學學院講師。
2014—2018年，吉林大學動物科學學院副教授。
現任吉林大學動物科學學院教授、博士生導師。
學術成果
研究領域
長期致力於疾病動物模型的構建及其在生物醫藥中的套用，利用CRISPR/Cas9 基因編輯技術，已成功構建20餘種疾病模型兔，10餘種疾病模型豬。
發表論文
以通訊作者或第一作者，在Nature Communication, Genome Biology, Hum Mol Genet、Cell Mol Life Sci、Disease Models & Mechanisms及Aging and Disease等領域內雜誌發表相關SCI論文30餘篇。
(1) Tingting Sui, Yuning Song, Zhiquan Liu, Mao Chen, Jichao Deng, Yuanyuan Xu, Liangxue Lai*, Zhanjun Li*, CRISPR-induced exon skipping is dependent on premature termination codon mutations, Genome Biology, GBIO-D-18-00763.
(2) Zhiquan Liu, Mao Chen, Dr. Siyu Chen, Jichao Deng , Yuning Song , Liangxue Lai*, Zhanjun Li*, Highly efficient RNA-guided base editing in rabbit, Nature Communications. 2018 Jul 13;9(1):2717.
(3) Zhiquan Liu, Mao Chen, Huanhuan Shan, Siyu Chen, Yuxin Xu, Yuning Song, Quanjun Zhang, Hongsheng Ouyang, Zhanjun Li*, Liangxue Lai*. Expanded targeting scope and enhanced base editing efficiency in rabbit using optimized xCas9(3.7). Cell Mol Life Sci. 2019 Apr 27.
(4) Tingjun Liu, Jun Wang, Xudong Xie, Ke Wang, Tingting Sui, Di Liu, Liangxue Lai, Hu Zhao, Zhanjun Li, and Jian Q Feng. 2DMP1 Ablation in the Rabbit Results in Mineralization Defects and Abnormalities in Haversian Canal/Osteon Microarchitecture. J Bone Miner Res. 2019 Mar 3.封面文章.
(5) Jichao Deng, Mao Chen, Zhiquan Liu, Yuning Song, Tingting Sui, Liangxue Lai, Zhanjun Li* The disrupted balance between hair follicles and sebaceous glands in Hoxc13-ablated rabbits. FASEB Journal. 2018 Aug 20:fj201800928RR.
(6) Tingting Sui, Li Xu, Yeh Siang Lau, Di Liu, Tingjun Liu, Yandi Gao, Liangxue Lai, Renzhi Han, Zhanjun Li*.Development of muscular dystrophy in a CRISPR-engineered mutant rabbit model with frame-disrupting ANO5 mutations. Cell Death Dis. 2018 May 22;9 (6):609.
(7) Tingting Su, Di Li, Tingjun Liu, Jichao Deng, Mao Chen, Yuanyuan Xu, Yuning Song, Hongsheng Ouyang, Liangxue La, Zhanjun L, LMNA-mutated Rabbits: A Model of Premature Aging Syndrome with Muscular Dystrophy and Dilated Cardiomyopathy, Aging Dis, 2018.2.16, 9(6).
(8) Tingting Sui, Lin Yuan, Huan Liu, Mao Chen, Jichao Deng, Yong Wang, Zhanjun Li, Liangxue Lai, CRISPR/Cas9-mediated mutation of PHEX in rabbit recapitulates human X-linked hypophosphatemia (XLH), Hum Mol Genet, 2016, 25(13): 2661-2671.
(9) Yuning Song, Lin Yuan, Yong Wang, Mao Chen, Jichao Deng, Qingyan Lv, Tingting Sui, Zhanjun Li, Liangxue Lai, Efficient dual sgRNA-directed large gene deletion in rabbit with CRISPR/Cas9 system, Cell Mol Life Sci, 2016, 73(15):2959-2968.
(10) Lin Yuan, Tingting Sui, Mao Chen, Jichao Deng, Yongye Huang, Jian Zeng, Qingyan Lv, Yuning Song, Li Zhanjun, Liangxue Lai, CRISPR/Cas9-mediated GJA8 knockout in rabbits recapitulates human congenital cataracts, Sci Rep, 2016, 6:22024.
(11) Tingting Sui, Yeh Siang Lau, Di Liu, Tingjun Liu, Li Xu, Yandi Gao, Liangxue Lai, Zhanjun Li*, Renzhi Han*, A novel rabbit model of Duchenne muscular dystrophy generated by CRISPR/Cas9. Dis Mod Mech, 2018 Jun 4;11(6).
(12) Mao Chen, Bin Yao, Qiang Bin, Jichao Deng, Yuning Song, Tingting Sui, Lina Zhou, Haobin Yao, Yuanyuan Xu, Daxin Pang, Hongsheng Ouyang, Zhanjun Li*, Liangxue Lai, Truncated C-terminus of fibrillin-1 induces Marfanoid-progeroid-lipodystrophy (MPL) syndrome in rabbit, Dis Mod Mech, 2018.03.07, 03(15).
(13) Qingyan Lv, Lin Yuan, Yuning Song, Tingting Sui, Zhanjun Li, Liangxue Lai, D-repeat in the XIST gene is required for X chromosome inactivation, RNA Biol, 2016, 13(2):172-176.
承擔項目
1．神經疾病大動物模型的建立及幹細胞治療評價，國家重點研發計畫，697萬元，2017.07-2021.12，課題負責人
2．豬孤雌胎兒發育阻滯的影響因素研究，國家自然基金，24萬元，2013.01-2015.12，項目負責人
3．廣譜抗病毒DRACO轉基因豬新品種培育，轉基因專項，54.6萬元，2014.01-2017.12，課題負責人
4．利用CRISPR/Cas9構建用於HIV-1研究的轉基因兔模型，博士後特別資助，2014.07-2015.07，15萬元，項目負責人
5．廣譜抗病毒轉基因豬的製備，博士後面上資助（一等），2013.09-2015.05，8萬元，項目負責人
榮譽獎勵
李占軍(3/10), 豬克隆與基因修飾技術創新及其在生物醫學模型中的套用, 吉林省科技廳, 自然科學, 省部一等獎, 2017.11.10 (賴良學，李小平，李占軍，歐陽紅生，鄧旭明，逄大欣，信吉閣，黃永業，周小青，黃嬌).
