李偉(吉林農業大學中藥材學院)

李偉(吉林農業大學中藥材學院)

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吉林農業大學中藥材學院教授，男，1980年11月出生，遼寧北鎮市人，滿族，中共黨員，醫學博士，教授，博士生導師，澳大利亞昆士蘭大學訪問學者，現任中藥材學院院長助理，中藥學教研室主任。為吉林省第五批拔尖創新人才（三層次），吉林省首批高校科研春苗人才，學校首批青年拔尖創新人才。中華中醫藥學會中藥資源學分會委員，吉林省藥理學會理事，吉林省藥學會藥劑專業委員會和保健食品專業委員會委員，吉林省科技特派員，中國植物學會和藥理學會會員，主要從事藥用植物資源開發與利用研究工作。

基本介紹

  • 中文名：李偉
  • 國籍：中國
  • 民族：滿
  • 出生地：遼寧省北鎮市
  • 出生日期：1980年11月
  • 職業：教師
  • 畢業院校：吉林農業大學
  • 學位/學歷：博士/研究生
  • 專業方向：藥用植物資源學及藥理活性
  • 職務：院長助理
  • 學術代表作：《金銀花標準化加工與利用》、《中國藥用植物志》 
人物介紹,工作經歷,研究方向,代表性論文,主要著作,科研獲獎,

人物介紹

近年來，先後對人參、桔梗、五味子等多種長白山藥用植物進行化學成分及藥理活性研究，在《J Agr Food Chem》，《Food Chem Toxicol》和《Phytotherapy Res》等國內外期刊發表學術論文100餘篇，其中SCI收錄75篇；申請發明專利30項，授權11項。指導碩士研究生30名，承擔本科生和研究生《中藥鑑定學》和《中藥加工與炮製》等課程，吉林省優秀課《中藥鑑定學》帶頭人。先後主持國家自然科學基金、博士後面上基金和吉林省科技科技發展計畫等6項科研課題。獲得吉林省科技進步三等獎1項，吉林省自然科學學術成果一等獎1項，二等獎3項，長春市級科技進步一等獎和三等獎各1項。主/參編《金銀花標準化加工與利用》、《中國藥用植物志》等多部著作及教材

工作經歷

2000.9-2004.7 吉林農業大學中藥材學院，中藥學專業，獲得理學學士學位
2004.9-2007.7 吉林農業大學中藥材學院，中藥學專業，醫學碩士，主要從事植物化學成分分離與鑑定，導師，鄭毅男，教授
2009.7-2012.6 吉林大學白求恩醫學院，藥理學，醫學博士，主要從事內分泌藥理學，導師，陳立，教授
2012.8-現在 中國農業科學研特產研究所，博士後，主要從事人參次生代謝產物及生物活性，導師，王英平，研究員
2014.8-2015.8 澳大利亞The University of Queensland訪問學者，研究方向，天然產物分子內分泌，合作導師chenchen教授。
2007.9-現在 吉林農業大學中藥材學院，中藥學專業，講師，副教授，教授（破格）

研究方向

1、藥用植物資源開發與利用

代表性論文

  1. Zhou Yan-dan, Hou Jin-gang, Liu Wei, Ren Shen, Wang Ying-ping, Zhang Rui, Chen Chen, Wang Zi*, Li Wei*. 20(R)-ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen-induced hepatotoxicity by suppressing PI3K/AKT pathway-mediated inflammation and apoptosis. International Immunopharmacology, 2018, 59, 21-30.
  2. Li Wei*, Chen Chen. Response to the Comments on Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice. J Agric Food Chem. 2018, 66(7):1734-1735.
  3. Hu Jun-Nan, Xu Xing-Yue,Li Wei*, Wang Yi-Ming, Liu Ying, Wang Zi, Wang Ying-Ping. Ginsenoside Rk1 ameliorates acetaminophen-induced hepatotoxicity in mice through inhibition of inflammation, oxidative stress, nitrative stress and apoptosis. J Ginseng Res, 2017.
  4. Hou Jin-gang, Xue Jian-jie, Zhao Xing-hua, Wang Zi, Li Wei*, Li Xin-dian, Zheng Yi-nan. Octyl ester of ginsenoside compound K as novel anti-hepatoma compound: synthesis and evaluation on murine H22 cells in vitroand in vivo, Chem Biol Drug Des, 2018.91(4):951-956
  5. Ma Zhi-na, Zhi Liu, Wang Zi, Ren Shen, Tang Shan, Wang Ying-ping, Xiao Sheng-yuan, Chen Chen, and Li Wei*. Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-κB signaling pathways,Food Chemical Toxicology, 2017.110, 62-73.
  6. Wang Zi, Hu Jun-nan, Yan Meng-han, Xing Jing-jing, Liu Wen-cong, Li Wei*. Caspase-mediated anti-apoptotic effect of Ginsenoside Rg5, a main rare ginsenoside, on Acetaminophen-induced Hepatotoxicity in Mice. J Agric Food Chem.2017,65(42):9226-9236.
  7. Ma Zhi-na, Li Yan-zi, Li Wei*, Yan Xiao-tong, Yang Ge, Zhang Jing, Zhao Li-chun, Yang Li-min. Nephroprotective effects of Saponins from leaves of Panax quinquefoliusagainst cisplatin-induced acute kidney injury. Int. J. Mol. Sci. 2017, 18(7), 1407.
  8. Qi Zhen-lan, Wang Zi,Li Wei*, Hou Jin-gang, Liu Ying, Li Xin-dian, Li Hui-ping, Wang Ying-Ping. Nephroprotective effects of Anthocyanins from the fruits of Panax ginseng(GFA) on cisplatin-induced acute kidney injury in mice. Phytotherapy Research. 2017,31: 1400-1409
  9. Xu Xing-yue, Hu Jun-nan, Liu Zhi, Zhang Rui, He Yu-fang, Hou Wei, Wang Zhi-qing, Yang Ge, Li Wei*. Saponins (ginsenosides) from the Leaves of Panax QuinquefoliusAmeliorated Acetaminophen-Induced Hepatotoxicity in Mice. J Agric Food Chem.2017, 65(18):3684-3692.
  10. Hu Jun-Nan, Liu Zhi, Wang Zi, Li Xin-Dian, Zhang Lian-Xue, Li Wei*, Wang Ying-Ping. Ameliorative Effects and Possible Molecular Mechanism of Action of Black Ginseng (Panax ginseng) on Acetaminophen-Mediated Liver Injury. Molecules, 2017, 22(4), 664.
  11. Liu Zhi, Wang Chong-Zhi, Zhu Xing-You, Wan Jin-Yi, Zhang Jing, Li Wei*, Ruan Chang-Chun (*), Yuan Chun-Su. Dynamic Changes in Neutral and Acidic Ginsenosides with Different Cultivation Ages and Harvest Seasons: Identification of Chemical Characteristics for Panax ginsengQuality Control,Molecules, 2017, 22(5), 734.
  12. Han Xin-yue, Hu Jun-nan, Wang Zi, Wei Sheng-nan, Zheng Si-wen, Wang Ying-ping, Li Wei *. 5-HMF Attenuates Liver Fibrosis in CCl4-Plus-Alcohol-Induced Mice by Suppression of Oxidative Stress. Journal of Nutritional Science and Vitaminology, 2017, 63(1):135-143.
  13. Li Wei, Qu Xin-Nan, Han Ye, Zheng Si-Wen, Wang Jia, and Wang Ying-Ping. Ameliorative Effect of 5-hydroxymethyl-2-furfural (5-HMF) on Acute Alcoholic Liver Oxidative Injury in Mice.Int. J. Mol. Sci. 2015, 16(2): 2446-2457.
  14. Li Wei, Yan Meng-Han, Liu Ying, Liu Zhi, Wang Zi, Chen Chen, Zhang Jing, Sun Yin-Shi. Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis. Nutrients, 2016, 8(9), 566.
  15. Li Wei, Tian Yu-Hong, Liu Ying, Wang Zi, Tang Shan, Zhang Jing, Wang Ying-Ping. Platycodin D exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis. The Journal of Toxicological Sciences, 2016, 41(3):417-428.
  16. Li Wei, Su Xiao-min, Han Ye, Xu Qi, Zhang Jing, Wang Zi, Wang Ying-ping. Maltol, a Maillard reaction product, exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis, RSC Adv., 2015, 5(123), 101850-101859.
  17. Li Wei, Xu Qi, He Yu-Fang, Liu Ying, Yang Shu-Bao, Wang Zi, Zhang Jing, Zhao Li-Chun. Anti-Tumor Effect of Steamed Codonopsis lanceolata in H22 Tumor-Bearing Mice and Its Possible Mechanism. Nutrients, 2015, 7(10):8294-8307.
  18. Li Wei, Liu Ying, Wang Zi, Han Ye, Tian Yu-hong, Zhang Gui-shan, Sun Yin-shi, Wang Ying-ping. Platycodin D isolated from the aerial parts of Platycodon grandiflorum protects alcohol-induced liver injury in mice,Food & Function, 2015, 6(5): 1418-1427.
  19. Li Wei; Zhao Li-Chun, Sun Yin-Shi, Lei Feng-Jie, Wang Zi, Gui Xiong-Bin, Wang Hui. Optimization of Pressurized Liquid Extraction of Three Major Acetophenones from Cynanchum bungei using a Box-Behnken Design. Int. J. Mol. Sci. 2012, 13(11), 14533-14544.
  20. Li Wei, Zhang Ming, Gu Jian, Meng Zhao-jie, Wang Ying-ping, Chen Li, Zheng Yi-nan. Hypoglycemic effect of protopanaxadiol-type ginsenosides and compound K on Type 2 Diabetes mice induced by High-Fat Diet combining with Streptozotocin via suppression of hepatic gluconeogenesis. Fitoterapia. 2012, 83(1):192-198.
  21. Li Wei, Zhao Li-chun, Wang Zi, Zheng Yi-nan, Jian Liang, Wang Hui. Response Surface Methodology to Optimize Enzymatic Preparation of Deapio-platycodin D and Platycodin D from Radix Platycodi. Int. J. Mol. Sci. 2012, 13(4):4089-4100.
  22. Li Wei, Wang Zi, Wang Ying-ping, Jiang Chao, Liu Qun, Sun Yin-shi, Zheng Yi-nan.Pressurized liquid extraction combining LC-DAD-ESI/MS analysis as an alternative method to extract three major flavones in Citrus reticulata ‘Chachi’ (Guangchenpi), Food Chemistry. 2012, 130(4):1044-1049.
  23. Li Wei, Sun Yin-shi, Wang Zi, Zheng Yi-nan. Isolation and purification of saponins from Platycodon grandiflorum by semi-preparative high performance liquid chromatography and LC/ESI-MS. Journal of Liquid Chromatography & Related Technologies. 2012, 35(4):547-557.
  24. Li Wei, Zhang Ming, Wang Zi, Zheng Yi-nan, Wang Ying-ping, Zhang Jing. Simultaneous RP-HPLC Determination of Six Platycosides: Application to an Enzymatic Preparation Study. Chromatographia. 2011, 74(11-12):777-782.
  25. Li Wei, Zhang Ming, Zheng Yi-nan, Li Jing, Wang Ying-ping, Wang Yun-jing, Gu Jian, Jin Ying, Wang Hui, Chen Li. Snailase Preparation of Ginsenoside M1 from Protopanaxadiol-Type Ginsenoside and Their Protective Effects Against CCl4-Induced Chronic Hepatotoxicity in Mice. Molecules. 2011, 16(12):10093-10103.
  26. Li Wei, Wang Zi, Sun Yin-shi, Chen Li, Han Li-kun, Zheng Yi-nan. Application of response surface methodology to optimize ultrasonic-assisted extraction of four chromones in Radix Saposhnikoviae, Phytochemical Analysis, 2011, 22(4):313-321.
  27. Li Wei, Zhang Wei, Xiang Lan, Wang Zi, Zheng Yi-nan, Wang Ying-ping, Zhang Jing, Chen Li. Platycoside N: A New Oleanane-Type Triterpenoid Saponin from the Roots of Platycodon grandiflorum. Molecules. 2010, 15(12):8702-8708.
  28. Li Wei, Liu Zheng-bo, Wang Zi, Chen Li, Sun Yin-shi, Hou Jin-gang, Zheng Yi-nan. Application of accelerated solvent extraction to the investigation of saikosaponins from the roots of Bupleurum falcatum. J Sep Sci. 2010, 33(12):1870-1876.
  29. Li Wei,Wang Zi, Chen Li, Zhang Jing, Han Li-kun, Hou Jin-gang, Zheng Yi-nan.Pressurized liquid extraction followed by LC-ESI/MS for analysis of four chromones in Radix Saposhnikoviae. J.Sep. Sci. 2010, 33(17-18):2881-2887.
  30. Li Wei, Xiang Lan, Zhang Jing, Zheng Yi-nan, Han Li-kun, Saitoc Masato. A New triterpenoid saponin from the roots of Platycodon grandiflorum. Chin Chem Lett, 2007, 18(3):306-308.
  31. Li Wei, Shi lei-ling, Han li-qin, Zhang Jing. Development and validation of a RP-HPLC method for simultaneous determination of salicin and eight flavonoids in leaves of Salix matsudanaKoidz. Acta Chromatographica. 2013, 25(4):735-743.
  32. Han Ye, Xu Qi, Hu Jiang-ning, Han Xin-yue,Li Wei(*), Zhao Li-Chun. Maltol, a Food Flavoring Agent, Attenuates Acute Alcohol-induced Oxidative Damage in Mice. Nutrients, 2015, 7(1): 682-696.
  33. He YF, Nan ML, Sun JM, Meng ZJ, Li Wei (*), Zhang M. Design, Synthesis and Cytotoxicity of Cell Death Mechanism of Rotundic Acid Derivatives, Bioorganic & Medicinal Chemistry Letters, 2013, 23(9):2543–2547.
  34. Gu Jian, Li Wei (Co-first author), Xiao Dong, Compound K, a final intestinal metabolite of ginsenosides, enhances insulin secretion in MIN6 pancreatic β-cells by upregulation of GLUT2.Fitoterapia. 2013, 83(1):192-198.
  35. Guan Feng Ying, Gu Jian, Li Wei, Zhang Ming, Ji Yingshi, Li Jing, Chen Li, M. Hatch Grant. Compound K protects pancreatic islet cells against apoptosis through inhibition of the AMPK/JNK pathway in type 2 diabetic mice and in MIN6 β-cells. Life Sciences, 2014 27(1-2):42-49

主要著作

  1. 主編，金銀花標準化生產及加工利用，化學工業出版社，2013年12月， 19萬字，ISBN：9787122192332。
  2. 副主編，林下參栽培技術，吉林科學技術出版社/吉林出版集團，2013年6月，ISBN 978-7-5384-6914-1
  3. 參編，中國藥用植物志，姜科等，2012年，北京大學出版社。

科研獲獎

[1]. 中藥有效成分快速提取，吉林省自然科學學術成果獎，一等獎，第一完成人，2012年。NO.20121025
[2]. 桔梗中皂苷類成分的分離、製備、測定及生物轉化，吉林省自然科學學術成果獎，二等獎，第一完成人。2013年，NO. 20132113
[3]. 救必應酸的製備及其衍生物的設計、合成及抗腫瘤活性的系列研究，吉林省自然科學學術成果獎，二等獎，第三完成人。2014年，NO. 20142127
[4]. 回響曲面法最佳化酶轉化製備白藜蘆醇的工藝最佳化，吉林省自然科學學術成果獎，三等獎，第三完成人，2014年，NO.20143121
[5]. 抗腫瘤人參皂苷M1衍生物的合成及結構最佳化, NO. 20120F-1-06-09，大連市科技進步一等獎，第9名，2012年。
[6]. 桔梗種質資源評價、品種選育及高效利用，長春市科技進步三等獎，第二名，2014年，NO.21014030402

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