曹巍(上海九院口腔頜面外科專家)

研究方向

口腔癌的臨床和基礎研究

口腔癌的分子分型研究

人物事跡

上海九院口腔頜面外科專家、副主任醫師曹巍主刀，在海南西部中心醫院麻醉科、口腔科、病理科等相關醫護人員的協助下，為患者實施全麻下全舌全口底頜頸聯合根治術+右下頜骨節段切+左股前外側皮瓣修復術+氣切術。代表著儋州市民如果存在口腔頜面頭頸部的腫瘤，足不出戶，即可在西部醫院享受到上海九院專家的診治。

“右下齦頰頜頸聯合根治術+胸大肌皮瓣修復術+氣管切開術”的手術複雜程度高，上海九院的曹巍副主任醫師參與了該手術，患者在博鰲超級醫院接受口腔癌根治術9天后順利出院。

獲獎榮譽

部分獲獎榮譽如下：

1、獲得2012年上海市研究生優秀成果（學位論文）（博士） EZH2和MAL基因與口腔鱗癌發生髮展的關係曹巍口腔醫學上海交通大學

2、獲得2013年度高等學校科學研究優秀成果獎（科學技術）科技進步獎二等獎一項

學術兼職

學術兼職如下：

上海口腔醫學會口腔頜面-頭頸腫瘤醫學專委會青年委員

中國臨床腫瘤學會頭頸腫瘤專業委員會委員

國際口腔頜面外科協會(ICOMS) Member

國際牙科研究協會(IADR) Member

全國衛生產業企業管理協會精準醫療分會理事

上海市級醫院肉瘤臨床診治中心分中心秘書

全國衛生產業企業管理協會精準醫療分會腫瘤診斷專委會副秘書長

中國臨床腫瘤學會(CSCO) 頭頸腫瘤專委會委員

美國癌症研究協會(AACR) Member

科研項目

以課題負責人承擔科研項目多項，其中國家自然基金青年項目一項，國家自然基金面上項目兩項，上海交通大學多學科交叉項目培育(醫工)面上一項，科技部國家重點研發計畫子課題一項。

1、FHL1-RGS2-DDB1E3連線酶信號通路在口腔鱗癌發生、進展中作用機制研究

2、組蛋白甲基轉移酶EZH2介導的FHL1基因表觀遺傳學沉默在口腔鱗癌發生中作用和機制研究

3、lncRNA RC3H2-hsa-miR-101-3p軸調控口腔鱗癌進展關鍵驅動蛋白EZH2的機制研究

4、口腔癌防治靶點和分子標誌物的篩選和驗證

5、口腔鱗癌早期診斷相關長鏈非編碼RNA譜型的篩選和鑑定

學術論文

以第一作者或通訊作者發表SCI論文十餘篇，部分已發表英文論文如下：

作者	論文標題	期刊名	出版年	卷期頁碼
Ong HS, Gokavarapu S, Tian Z, Li J,Cao W（通訊作者）, Zhang CP	Does a mandibular access osteotomy improve survival in pT2 oral tongue cancers? Retrospective study at a single institution	Int J Oral Maxillofac Surg	2018	47(3):289-295
Shen Q, Chen Y, Gokavarapu S,Cao W（通訊作者）, Ji T	Primary intraosseous squamous cell carcinoma of the mandible: locoregional control and survival is significantly reduced if the tumour is more than 4cm in size	Br J Oral Maxillofac Surg	2018	56(1):48-53
Liu J, Xing Y, Xu L, Chen W,Cao W（通訊作者）, Zhang C	Decreased expression of pseudogene PTENP1 promotes malignant behaviours and is associated with the poor survival of patients with HNSCC	Sci Rep	2017	7:41179
Wang X,Cao W, Zhang J, Yan M, Xu Q, Wu X, Wan L, Zhang Z, Zhang C, Qin X, Xiao M, Ye D, Liu Y, Han Z, Wang S, Mao L, Wei W, Chen W	A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination	EMBO J	2017	36(9):1243-1260
Yang R, Liu Z, Peng C,Cao W（通訊作者）, Ji T	Maxillary ameloblastoma: Factors associated with risk of recurrence	Head Neck	2017	39(5):996-1000
Yang R, Liu Z, Gokavarapu S, Peng C, Ji T,Cao W（通訊作者）	Recurrence and cancerization of ameloblastoma: multivariate analysis of 87 recurrent craniofacial ameloblastoma to assess risk factors associated with early recurrence and secondary ameloblastic carcinoma	Chin J Cancer Res	2017	29(3):189-195
Cao W, Liu JN, Liu Z, Wang X, Han ZG, Ji T, Chen WT, Zou X	A three-lncRNA signature derived from the Atlas of ncRNA in cancer (TANRIC) database predicts the survival of patients with head and neck squamous cell carcinoma	Oral Oncol	2017	65:94-101
Lin C,Cao W（共同第一作者）, Ren Z, Tang Y, Zhang C, Yang R, Chen Y, Liu Z, Peng C, Wang L, Wang X, Ji T	GDNF secreted by nerves enhances PD-L1 expression via JAK2-STAT1 signaling activation in HNSCC	Oncoimmunology	2017	6(11):e1353860
Cao W, Liu Z, Gokavarapu S, Chen Y, Yang R, Ji T	Reformed smokers have survival benefits after head and neck cancer	Br J Oral Maxillofac Surg	2016	54(7):818-25
Cao W, Liu J, Xia R, Lin L, Wang X, Xiao M, Zhang C, Li J, Ji T, Chen W	X-linked FHL1 as a novel therapeutic target for head and neck squamous cell carcinoma	Oncotarget	2016	7(12):14537-50
Chen Y,Cao W（共同第一作者）, Gao X, Ong H, Ji T	Predicting postoperative complications of head and neck squamous cell carcinoma in elderly patients using random forest algorithm model	BMC Med Inform Decis Mak	2015	15:44
Liu J,Cao W（共同第一作者）, Chen W, Xu L, Zhang C	Decreased expression of Kallmann syndrome 1 sequence gene (KAL1) contributes to oral squamous cell carcinoma progression and significantly correlates with poorly differentiated grade	J Oral Pathol Med	2015	44(2):109-14
Gupta A,Cao W（共同第一作者）, Sadashivaiah K, Chen W, Schneider A, Chellaiah MA	Promising noninvasive cellular phenotype in prostate cancer cells knockdown of matrix metalloproteinase 9	ScientificWorldJournal	2013	2013:493689
Cui Z,Cao W（共同第一作者）, Li J, Song X, Mao L, Chen W	TRIM24 overexpression is common in locally advanced head and neck squamous cell carcinoma and correlates with aggressive malignant phenotypes	PLoS One	2013	8(5):e63887
Zhang S,Cao W（共同第一作者）, Wei K, Liu X, Xu Y, Yang C, Undt G, Haddad MS, Chen W	Expression of VEGF-receptors in TMJ synovium of rabbits with experimentally induced internal derangement	Br J Oral Maxillofac Surg	2013	51(1):69-73
Cao W, Feng Z, Cui Z, Zhang C, Sun Z, Mao L, Chen W	Up-regulation of enhancer of zeste homolog 2 is associated positively with cyclin D1 overexpression and poor clinical outcome in head and neck squamous cell carcinoma	Cancer	2012	118(11):2858-71
Cao W, Ribeiro Rde O, Liu D, Saintigny P, Xia R, Xue Y, Lin R, Mao L, Ren H	EZH2 promotes malignant behaviors via cell cycle dysregulation and its mRNA level associates with prognosis of patient with non-small cell lung cancer	PLoS One	2012	7(12):e52984
Cao W, Younis RH, Li J, Chen H, Xia R, Mao L, Chen W, Ren H	EZH2 promotes malignant phenotypes and is a predictor of oral cancer development in patients with oral leukoplakia	Cancer Prev Res (Phila)	2011	4(11):1816-24
Cao W, Zhang ZY, Xu Q, Sun Q, Yan M, Zhang J, Zhang P, Han ZG, Chen WT	Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma	Mol Cancer	2010	9:296