張照斌，男，博士，北京大學副教授。
基本介紹
- 中文名：張照斌
- 學位/學歷：博士
- 職業：教師
- 專業方向：環境毒理學/生態毒理學/環境與健康
- 任職院校：北京大學
個人經歷,主講課程,研究方向,學術成果,榮譽獎項,
個人經歷
2010.11-2011.8 在美國明尼蘇達大學做訪問學者
2009.8- 今 北京大學城市與環境學院副教授
2007.7-2009.7 北京大學城市與環境學院講師
2005.9-10月日本大阪大學作短期學習訪問
2005.7-2007.6 北京大學環境學院環境科學與工程專業博士後
主講課程
環境生物學（本）, 講課和實驗 , 北京大學 , 春季學期
環境毒理學（本）, 講課和實驗 , 北京大學 , 春季學期
環境污染與人體健康（本）, 講課 , 北京大學 , 秋季學期
環境生物化學與分子毒理學（研）, 講課 , 北京大學 , 春季學期
研究方向
研究方向包括環境健康、環境毒理、生態毒理，擅長分子機制、受體活性、高通量測序分析。
學術成果
2. 國家自然科學基金(20877003) 雌激素相關受體介導的環境內分泌干擾物質的信號通道研究 2009-2011.負責
3. 國家自然科學基金(20837003) 環境中PPCPs 的遷移轉化、生態健康風險及控制原理 2009-2012.專題負責
4. 國家自然科學基金委重點項目(40632009) 遼東灣中內分泌干擾物質的風險評價 2007-2009.參加
5. 國家科技部“973”計畫項目(2007CB407304) 京津渤區域複合污染過程、生態毒理效應及控制修復原理 2007-2011.參加
6.國家自然科學基金面上項目(21377007)，抗雌激素活性含芴化合物的魚類繁殖發育毒性及毒理機制研究，2014.1-2017.12.負責
7.國家自然科學基金委重點項目(41330637)：富營養化水體中新型內分泌干擾物質的污染特徵和複合生態毒理效應；執行時間：2014-2018。參加
8. 政府間國際科技創新合作重點專項（2016YFE0117800）；2016.12-2019.12.參加
9.國家重點研發計畫課題（2017YFF0211202）；化學品內分泌干擾活性高通量及高內涵快速篩查與確證技術研究，2017.07 -2020.12.負責
10.國家重點研發計畫課題（2017YFF0211202）；化學品內分泌干擾活性高通量及高內涵快速篩查與確證技術研究，2017.07 -2020.12.負責
論文：
Zhang, Zhaobin; Hu, Ying; Guo, Jilong; Yu, Tong; Sun, Libei; Xiao, Xuan; et al., Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice. Nature Communications. 8(14585):1-13; 2017.（highlighted，該文被Natureasia、Newscientist等國內外數百家媒體專題報導）
Libei Sun, Tong Yu, Jilong Guo,Zhaobin Zhang, Ying Hu, Xuan Xiao, Yingli Sun, Han Xiao, Junyu Li, Desheng Zhu, Linlin Sai & Jun Li; 2016. The estrogenicity of methylparaben and ethylparaben at doses close to the acceptable daily intake in immature Sprague-Dawley rats. Scientific Reports. 6(25173):1-9.
Yuyin Zhou, Mo Chen, Fanrong Zhao, Di Mu,Zhaobin Zhang, Jianying Hu, 2015. Ubiquitous Occurrence of Chlorinated Byproducts of Bisphenol A and Nonylphenol in Bleached Food Contacting Papers and Their Implications for Human Exposure. Environ. Sci. Technol., 49: 7218-7226.
Hong Zhang,Zhaobin Zhang, Tsuyoshi Nakanishi, Yi Wan, Youhei Hiromori, Hisamistu Nagase, Jianying Hu, 2015. Structure-Dependent Activity of Phthalate Esters and Phthalate Monoesters Binding to Human Constitutive Androstane Receptor. Chemical Research in Toxicology. 28(6): 1196-1204.
Fujun Ma,Zhaobin Zhang, Jialiong Jiang, and Jianying Hu. 2015. Chromium (VI) potentiates the DNA adducts (O-6-methylguanine) formation of N-nitrosodimethylamine in rat: Implication on carcinogenic risk. CHEMOSPHERE. 139: 256-259.
Adam T. Zarth, Guang Cheng,Zhaobin Zhang, Mingyao Wang, Peter W. Villalta, Silvia Balbo, Stephen S. Hecht, 2014. Analysis of the benzene oxide-DNA adduct 7-phenylguanine by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry-parallel reaction monitoring: Application to DNA from exposed mice and humans. Chemico-Biological Interactions. 215: 40-45.
Zhaobin Zhang, Libei Sun, Ying Hu, Jian Jiao, Jianying Hu, 2013. Inverse antagonist activities of parabens on human oestrogen-related receptor γ(ERRγ): In vitro and in silico studies. Toxicology and Applied Pharmacology 270:16–22.
Ying Hu,Zhaobin Zhang, Libei Sun, Jian Jiao, Desheng Zhu, Jun Li, Mingwen Qi, 2013. The estrogenic effects of benzylparaben at low doses based on uterotrophic assay in SD rats. Food and Chemical Toxicology 53:69–74.
Zhang ZB, Jia CX, Hu Y, Sun LB, Jiao J, Li RB, Zhao L, Zhu DS, Li J, Tian YL, Bai HC, Hu JY, 2012. The estrogenic potential of salicylate esters and their possible risks in foods and cosmetics. Toxicology Letters. 209: 146-153.
Zhang ZB, Hu Y, Zhao L, Li J, Bai HC, Zhu DS, Hu JY, 2011. Estrogen agonist/antagonist properties of dibenzyl phthalate (DBzP) based on in vitro and in vivo assays. Toxicology Letters. 207: 7– 11.
Huang C,Zhang ZB, Wu SM, Zhao YB, Hu JY. 2010. In vitro and in vivo estrogenic effects of 17α-estadiol in medaka (Oryzias latipes). Chemosphere. 8(5): 608-612.
Hu JY,Zhang ZB, Wei QW, Zhen HJ, Zhao YB, Peng H, Wan Y, Giesy JP, Li LX, Zhang B. 2009. Malformations of the endangered Chinese sturgeon, Acipenser sinensis, and its causal agent. 6. Proceedings of the National Academy of Sciences of the United States of America, 106: 9339-9344.（highlighted，該文被Science網路新聞和路透社等上百家國際媒體專題報導）
Zhang ZB, Hu JY, 2008. Effects of p,p `-DDE exposure on gonadal development and gene expression in Japanese medaka (Oryzias latipes). Journal of Environmental Sciences-China, 20(3): 347-352.
Zhang ZB, Hu JY, Zhen HJ, Wu XQ, Huang C, 2008. Reproductive inhibition and transgenerational toxicity of triphenyltin on medaka (Oryzias latipes) at environmentally relevant levels. 9. Environmental Science & Technology, 42 (21), 8133-8139.（該文研究結果受到Science網路新聞報導引用）
Zhang ZB, Hu JY. 2007. Development and validation of endogenous reference genes for expression profiling of medaka（Oryzias latipes）exposed EDCs by quantitative real-time RT-PCR. Toxicological Sciences, 95: 356-368.
Zhang ZB, Hu JY, An W, Jin F, An LH, Tao S, Chen JS. 2005. Induction of vitellogenin mRNA in juvenile chinese sturgeon (Acipenser sinensis Gray) treated with 17beta-Estradiol and 4-Nonylphenol. Environmental Toxicology and Chemistry, 24 (8): 1944-1950.(該文曾被國際毒理化學學會(SETAC)網站以“全球內分泌干擾物質研究領域的2個發現”為題進行專門介紹).
An LH, Hu JY,Zhang ZB, Yang M. 2006. Quantitative PCR analysis of vitellogenin mRNA in so-iny mullet, Chelon haematocheilus, from Bo Sea, north of China. Analytical and Bioanalytical Chemistry, 1995-2001.
WanY, Hu JY, An W,Zhang ZB, An LH, Tatsuya Hattori, Mitsuaki Itoh, and Shigeki Masunaga. 2006. Congener-specific tissue distribution and hepatic sequestration of PCDD/Fs in wild herring gulls from Bohai Bay, North China: comparison to coplanar PCBs. Environmental Science & Technology, 40(5): 1462-1468.
Wan Y, Wei QW, Hu JY, Jin XH,Zhang ZB, Zhen H J, Liu J Y. 2007. Levels, tissue distribution, and age-related accumulation of synthetic musk fragrances in Chinese sturgeon (Acipenser sinensis): Comparison to organochlorines. Environmental Science & Technology, 41 (2): 424-430.
An LH, Hu J Y, Zhu XY, Deng BS,Zhang ZB, Yang M, 2007. Crucian carp (Carassius carassius) VTG monoclonal antibody: Development and application. Ecotoxicology and Environmental Safety, 66 (2): 148-153.
An W, Hu JY, Wan Y, An LH,Zhang ZB. 2006. Deriving Site-Specific?2,2-Bis（chlorophenyl）-1,1- dichloroethylene quality criteria?of water and sediment for protection of common tern populations in Bohai Bay, North China. Environmental Science & Technology, 40 (8): 2511-2516.
賈成霞,張照斌,張清靖,劉盼,朱華,2012.虹鱒魚PPARα基因克隆、序列分析及其組織表達分布.中國水產科學.19(4): 707-714.
焦健,張照斌,胡建英,王金水. 2010. hVDR原核表達及其與重金屬鎘、鉛的結合活性.環境科學. 31(10):2469-2473.
侯彥峰,張照斌,胡建英. 2009.皮質醇影響青鱂鰓內鈉鉀ATP酶基因表達的研究.生態毒理學報. 4(2): 212-217.
張照斌,胡建英,賽思翔,趙硯彬,黃崇. 2008.青鱂魚ERRα的克隆、序列分析、組織表達及其對不同EDCs暴露的回響.環境科學, 29, 3153-3158. (EI收錄)
王琪,黃崇,張照斌,胡建英,張仁陟. 2008.實時定量RT-PCR方法檢測雌二醇誘導原代培養青鱂魚肝細胞的基因表達.環境科學學報, 12, 2568-2572.
施嘉琛,胡建英,常紅,萬禕,張照斌,相艷. 2008.北京溫榆河流域耐藥大腸桿菌的調查研究.中國環境科學, 28, 39-42. (EI收錄)
賽霖林,張照斌,胡建英,侯彥峰,賽道建. 2006.評價內分泌干擾物質壬基酚雌激素活性的方法-定量PCR監測卵黃蛋白原基因表達.環境科學, 27, 1825-1828. (EI收錄)
侯彥峰,張照斌,胡建英,范光麗. 2006.雌激素誘導下的卵黃蛋白原基因表達與雌雄同體.中國環境科學, 26, 599-602. (EI收錄)
張照斌,牛翠娟,朱華,胡紅霞. 2003.室內飼育西伯利亞鱘的血清性類固醇激素的周年變化.北京師範大學學報(自然科學版), 39, 519-524.
會議論文
Zhang ZB, Hu JY. 2004. Oral presentation: Quantification of juvenile chinese sturgeon VTG mRNA levels using real-time RT-PCR after in vivo treatment with E2 and 4-NP, International Symposium on Biotechnology for Environmental Pollution Control, Beijing, China.
Zhang ZB, Hu JY. 2004. Poster presentation: Induction of vitellogenin genes in Juvenile Chinese Sturgeon (Acipenser sinensis Gray) after in vivo Treatment with EDCs. China-Japan Joint Symposium on Environmental Chemistry, Beijing, China.
Zhang ZB, Hu JY, Hou YF, Sai LL. 2005. Platform oral presentation: Gene expression in gonad of medaka exposed to EDCs and new markers for assessing EDCs. SETAC North America 26th Annual Meeting. Baltimore, MD, USA.
Hu JY,Zhang ZB, Sai LL, Hou YF. 2005. Post presentation: Gene expression in medaka embryo and fry exposed to EDCs and new program for monitoring. SETAC North America 26th Annual Meeting. Baltimore, MD, USA.
Zhang ZB, Hu JY, Zhen HJ, 2008. Platform oral presentation: Inhibition of reproduction and malformation of offspring in medaka by triphenyltin exposure at environmentally relevant levels. 5th SETAC World Congress. Sydney, Australia.
授權發明專利
張照斌.雙酚芴及其衍生物在製備防治癌症藥物中的套用.授權日期：2014.02.19.專利號：201110093462.9.
張照斌、胡建英、安偉.魚類單卵或魚苗的RNA和DNA同步提取及魚卵和幼魚的性別鑑定方法.專利號：ZL 200510011322.7.
榮譽獎項
國家自然科學獎，2015.
唐立新獎教金教學名師獎，2017.
北京大學優秀班主任，2018 .
第三完成人獲國家自然科學二等獎，典型內分泌干擾物質的環境行為和生態毒理效應，獲獎時間：2015.12.16.
