基本介紹
- 中文名：張小寧
- 國籍：中國
- 出生日期：1971年10月
- 性別：男
科研領域,研究方向,承擔項目,發表論文,
科研領域
納米生物醫藥技術及其新藥成藥性。研究基於腫瘤微環境的、具有靶向給藥+聯合用藥+程式殺傷性能特徵的納米給藥系統，以期實現：①靶向遞送藥物至腫瘤組織部位—②進入腫瘤細胞微環境定量共同釋放藥物—③藥物協同作用並誘導細胞程式性凋亡。將該技術套用於難溶性藥物腫瘤靶向納米給藥系統，基因治療藥物納米給藥系統，抗腫瘤多藥耐藥納米給藥系統，並進行相關新藥的成藥性及生物學效應研究。
研究方向
1、難溶性藥物腫瘤靶向納米給藥系統：將被動靶向與主動靶向相結合：a）採用新型納米膠束載藥技術和新型藥用輔料，解決難溶性藥物給藥困難問題，並通過控制載藥納米粒尺寸大小，利用EPR被動靶向效應使載藥納米粒在腫瘤部位絮集； b）利用細胞表面腫瘤特異性受體，將其配體接枝修飾於載藥納米粒表面，增加藥物特異性主動靶向遞送轉運，以實現提高藥效和降低毒性作用目的。
2、小核酸藥物納米遞送系統：採用新型高分子材料載體和自組裝技術，設計構建小核酸藥物納米遞送系統，解決核酸藥物體內的高效靶向遞送、高效轉染與胞內功能表達等關鍵難題，促進小核酸等基因治療藥物技術的發展與套用。
3、抗腫瘤多藥耐藥靶向聯合用藥納米給藥系統：基於腫瘤靶向納米給藥技術，研究將具有抗腫瘤多藥耐藥和抗腫瘤作用的兩種不同藥理作用的藥物（化藥或核酸藥物）製成複方納米給藥系統製劑進行聯合用藥，靶向遞送複方藥物至腫瘤微環境，使其按確定比例在腫瘤細胞胞內微環境內同時釋放並發生藥理協同作用，實現顯著逆轉腫瘤多藥耐藥性，增加藥物敏感性和有效性。
承擔項目
發表論文
1. Keyang Huang, Huili Ma, Juan Liu, Shuaidong Huo, Anil Kumar, Tuo Wei, Xu Zhang, Shubin Jin, Yaling Gan, Paul C. Wang, Shengtai He*, Xiaoning Zhang*, and Xing-Jie Liang*. Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo. ACS NANO, 6(5), pp 4483-4493, 2012.
2. Mingshu Ma, Yanli Hao*, Nan Liu, Zhe Yin, Lan Wang, Xing-Jie Liang, Xiaoning Zhang*. A novel lipid-based nano-micelle of docetaxel: evaluated antitumor efficiency and biodistribution with optical imaging in vivo. In J Nanomedicine ,7, pp 3389-3398, 2012.
3. Zhe Yin, Nan Liu, Mingshu Ma, Lan Wang, Xing-Jie Liang, Yanli Hao*, Xiaoning Zhang*. A novel EGFR-targeted gene delivery system based on complexes self-assembled by EGF, DNA and activated PAMAM dendrimers, In J Nanomedicine 7, pp 4625-4635, 2012.
4. Nan Liu, Yanli Hao*, Zhe Yin, Mingshu Ma, Lan Wang, Xiaoning Zhang*. Self-Assembled Human Serum Albumin-Coated Complexes for Gene Delivery with Improved Transfection. Die Pharmazie, 67(2), pp 174-181, 2012/2.
5. Lan Wang, Yanli Hao*, Nan Liu, Zhe Yin, Mingshu Ma, Xiaoning Zhang*. Enhance the dissolution rate and oral bioavailability of pranlukast by preparing nanosuspensions with high-pressure homogenizing method. Drug Development and Industrial Pharmacy, 2012 (in press, doi:10.3109/03639045.2011.652636)
6. Xue Xue, Song You, Qiang Zhang, Yan Wu, Guo-zhang Zou, Paul C. Wang, Yu-liang Zhao, Yan Xu, Lee Jia, Xiaoning Zhang, Xing-Jie Liang*.Mitaplatin Increases Sensitivity of Tumor Cells to Cisplatin by Inducing Mitochondrial Dysfunction. Molecular Pharmaceutics, 2012, 9(3), 634−644
7. Xiaowei Ma, Yanyang Wu, Shubin Jin, Yuan Tian, Xiaoning Zhang, Yuliang Zhao, Li Yu, Xingjie Liang*. Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment. ACS NANO, 2011, 5(11):8629-8639
8. Feng-Yun J. Huang, Te-Wei Lee, Chih-Hao K. Kao, Chih-Hsien Chang, Xiaoning Zhang, Wan-Yu Lee, Wan-Jou Chen, Shu-Chi Wang, and Jem-Mau Lo. Imaging, Autoradiography, and Biodistribution of 188Re-Labeled PEGylated Nanoliposome in Orthotopic Glioma Bearing Rat Model.Cancer Biotherapy & Radiopharmaceuticals. 2011, 26(6): 717-725.
9. Mi Wang, Yue Yuan, Yang Gao, Hongmei Ma, Hongtao Xu，Xiaoning Zhang, Weisan Pan*. Preparation and characterization of 5- fluorouracil pHsensitive niosome and its tumor targeted evaluation: in vitro and in vivo. Drug Development and Industrial Pharmacy, 38(9), pp 1134-1141, 2012.
10. Hongtao Xu, Ling He, Shu fangNie, Jin Guan, XiaoningZhang, Xing gangYang, Weisan Pan*. Optimized preparation of vinpocetine proliposomes by a novel method and in vivo evaluation of its pharmacokinetics in New Zealand rabbits. J. Controlled Release, 2009, Nov 16; 140(1):61-8.
11. Wei Wei, Sanjun Shi, Jie Liu, Xun Sun, Ke Ren, Dong Zhao, Xiaoning Zhang, Zhirong Zhang, Tao Gong. Lipid nanoparticles loaded with 10-hydroxycamptothecin-phospholipid complex developed for clinical application. J. Drug Targeting 2010,18(7):557-566.
12. Xiaoyu Chen, Xun Sun, Ke Ren, Xiaoning Zhang*, Zhirong Zhang, Tao Gong*. Enhanced aqueous solubility and bioavailability of capsaicin by the preparation of inclusion complex. Arzneimittel-Forschung (Drug Research)2010,60 (9): 571-574
13. Xuan Qin, Yang Yang, Tingting Fan, Tao Gong, Xiaoning Zhang, Yuan Huang*. Preparation, characterization and in vivo evaluation of bergenin phospholipids complex. ACTA Pharmacol. Sin. 2010, 31(1):127-136.
14. Chun-Yang Zhuang; Ning Li; Mi Wang; XiaoNing Zhang; Wei-San Pan; Jun-Jie Peng; Yu-Sheng Pan; Xin Tang. Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability. International Journal of Phamarceutics, 2010, 394(1-2):179-185.
15. Fang Fang, Changyang Gong, Zhiyong Qian, Xiaoning Zhang, Maling Gou, Chao you, Liangxue Zhou, Jiagang Liu, Yu Zhang, Gang Guo, Yingchun Gu, Feng Luo, Lijuan Chen, Xia Zhao, Yuquan Wei*. Honokiol Nanoparticles in Thermosensitive Hydrogel: Therapeutic Effects on Malignant Pleural Effusion. ACS-NANO 2009, 3 (12):4080-4088
16. Shaozhi Fu, Gang Guo, Changyang Gong, Shi Zeng, Hang Liang, Feng Luo, Xiaoning Zhang, Xia Zhao, Yuquan Wei, Zhiyong Qian*. Injectable Biodegradable Thermosensitive Hydrogel Composite for Orthopedic Tissue Engineering. 1. Preparation and Characterization of Nanohydroxyapatite/Poly(ethyleneglycol)-Poly(ε-caprolactone)-Poly(ethylene glycol) Hydrogel Nanocomposites. J. Phys. Chem. B. 2009, 113 (52):16518–16525
17.Huiming Lai, Feng Zhu, Wenmin Yuan, Na He, Zhirong Zhang, Xiaoning Zhang, Qin He. Development of multiple-unit colon-targeted drug delivery system by using alginate: in vitro and in vivo evaluation. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 37(11), pp 1347-1356, 2011/11.
18. Xuanmiao Zhang, Xun Sun, Jilong Li, Xiaoning Zhang, Tao Gong, Zhirong Zhang. Lipid nanoemulsions loaded with doxorubicin-oleic acid ionic complex: characterization, in vitro and in vivo studies. PHARMAZIE, 66(7), pp 496-505, 2011/7.
19. 孫敏敏,郝艷麗,邰文,劉楠,馬茗舒,殷哲,聶尚海,張小寧*. 白蛋白紫杉醇聚合物膠束抑瘤效果研究. 中國藥學雜誌, 2011, 46(3):55-59
20. 郝艷麗,王蘭,馬茗舒,劉楠,殷哲,張小寧*. 鴯鶓油納米乳劑對急性高脂血症小鼠血脂的影響.中國農業科技導報，2011,13(1):94-97
21. 王蘭,郝艷麗,劉楠,馬茗舒,張小寧. 星點設計-效應面法最佳化普倫斯特磷脂複合物的製備. 中國醫藥工業雜誌, 2011, 42(11):815-818
22. 邰文,孫敏敏,劉楠,黃志起,聶尚海,郝艷麗*,張小寧*. 套用動物活體生物發光技術觀察紫杉醇混合膠束的抑瘤效果. 藥學學報, 2010, .45(4): 530-534
