常素華

常素華

中科院心理研究所，助理研究員

基本介紹

  • 中文名：常素華
  • 國籍：中國
  • 職業：助理研究員
  • 畢業院校：中國民航大學
個人信息,教育經歷,工作經歷,研究方向,科研經歷,發表文章,第一作者/通訊作者（含並列）文章,部分參與作者文章,

個人信息

常素華，助理研究員。

教育經歷

2009.9~今　 中科院心理研究所助理研究員，生物信息學，在職博士
2004.9~2007.7 中科院計算技術研究所/中科院北京基因組研究所，生物信息學，碩士
2000.9~2004.7 中國民航大學，信息與計算科學，本科

工作經歷

2010.3~今 中科院心理研究所，助理研究員
2014.5~2015.5 美國北卡羅來納大學教堂山分校（UNC-CH）訪問學者（院公派）
2008.6~2010.2 中科院心理研究所，研究實習員
2007.10~2008.1 德國呂貝克大學生物化學研究所訪問
2007.7~2008.5 中科院北京基因組研究所，研究實習員

研究方向

1．複雜疾病遺傳數據（GWAS）的關聯分析；
2．基於大規模遺傳學數據的通路及網路分析；
3．遺傳數據、表達數據及網路數據的整合分析。

科研經歷

ADHD相關表型的GWAS數據分析；
雙相情感障礙前額葉皮層基因表達數據的整合分析；
雙相情感障礙GWAS數據的基於通路分析；
精神分裂症GWAS數據的網路模組分析；
雙相情感障礙遺傳學資料庫BDgene及其與精神分裂症和重度抑鬱症的遺傳共享研究；
基於多數據集的注意缺陷多動障礙候選基因優先權排序算法及網路分析；
注意缺陷多動障礙遺傳學資料庫ADHDgene的構建；
重度抑鬱症多層次知識庫與分析平台MK4MDD 的構建；
基於通路分析的全基因組關聯數據分析平台i-GSEA4GWAS、ICSNPathway和iGSEA4GWAS v2的構建；
開發人類DNA甲基化與癌症資料庫MethyCancer；
禽流感病毒基因組序列的進化、變異分析，開發流感病毒資料庫IVDB。

發表文章

第一作者/通訊作者（含並列）文章

  1. Wang, J., Qu, S., Wang, W., Guo, L., Zhang, K., Chang, S.#, Wang, J.#, A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex. Journal of Psychiatric Research 82 (2016) 23-29.
  2. Chang, S.*, Wang, J., Zhang, K. & Wang, J.# Pathway-based analysis for genome-wide association study data of bipolar disorder provides new insights for genetic study. Protein Cell 6, 912-5 (2015).
  3. Chang, S.*, Fang, K., Zhang, K. & Wang, J.# Network-Based Analysis of Schizophrenia Genome-Wide Association Data to Detect the Joint Functional Association Signals. PLoS One 10, e0133404 (2015).
  4. Zhang, K.,Chang, S.*, Guo, L., Wang, J.# (2014) I-GSEA4GWAS v2: a web server for functional analysis of SNPs in trait-associated pathways identified from genome-wide association study.Protein & Cell. DOI 10.1007/s13238-014-0114-4
  5. Li, Z.,Chang, S.*, Zhang, L., Gao, L., Wang, J.# (2014). Molecular genetic studies of ADHD and its candidate genes: A review.Psychiatry Research. 219:10-24
  6. Chang, S.*, Gao, L., Li, Z., Zhang, W. N., Du, Y., & Wang, J.# (2013). BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder.Biol Psychiatry. doi: 10.1016/j.biopsych.2013.04.016
  7. Guo, L.Y., Zhang, W.N., Chang, S.*, Zhang, L.Y., Ott, J., & Wang, J.# (2012). MK4MDD: A Multi-Level Knowledge Base and Analysis Platform for Major Depressive Disorder. PLoS ONE
  8. Chang, S.*, Zhang, W.N., Gao, L., Wang, J.# 2012 Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources. Protein & Cell
  9. Zhang, L.Y., Chang, S.*, Li, Z., Zhang, K.L., Du, Y., Ott, J., and Wang, J.#, 2011 ADHDgene: a genetic database for attention deficit hyperactivity disorder. Nucleic Acids Res
  10. Zhu, X.X, Chang, S.*, Fang, K.C., Cui, S.J., Liu, J., …, Wang, J.# 2009. MyBASE: a database for genome polymorphism and gene function studies of Mycobacterium. BMC Microbiology.
  11. He, X.M., Chang, S.*, Zhang, J.J., Zhao, Q., Xiang, H.Z., …, and Wang, J.# 2008. MethyCancer: the database of human DNA methylation and cancer. Nucleic Acids
  12. Chang, S.*, Zhang, J. J., Liao, X. Y., Zhu, X. X., Wang, D. H., …, and Wang, J.#, 2007. Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research. Nucleic Acids Res

部分參與作者文章

  1. Zong L, Guan J, Ealy M, Zhang Q, Wang D, Wang H, …Chang S, …Wang J, …et al. (2015): Mutations in apoptosis-inducing factor cause X-linked recessive auditory neuropathy spectrum disorder.Journal of medical genetics
  2. Gao, L., Li, Z., Chang, S., & Wang, J. (2014). Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis.PLoS One, 9(3), e90407. doi: 10.1371/journal.pone.0090407
  3. Guo, L., Du, Y., Chang, S., Zhang, K., & Wang, J. (2014). rSNPBase: a database for curated regulatory SNPs.Nucleic Acids Res, 42 (D1): D1033-D1039. doi: 10.1093/nar/gkt1167
  4. Zhang, W. N., Chang, S. H., Guo, L. Y., Zhang, K. L., & Wang, J. (2013). The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies.J Affect Disord. doi: 10.1016/j.jad.2013.06.039
  5. Zhang, K.L, Chang, S.H., Cui, S.J., Guo, L.Y., Zhang, L.Y., and Wang, J., 2011 ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. Nucleic Acids Res
  6. Fang, K.C., Zhao, H.S., Sun, C.Y., Lam, C. M., Chang, S.H., …Vítor A.P. Martins dos Santos, Wang, J., 2011 Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction. BMC Systems Biology
  7. Zhang, J. J., Mamlouk, A.M., Martinetz, T., Chang, S.H., Wang, J., Hilgenfeld, R., 2011 PhyloMap: an algorithm for visualizing relationships of large sequence data sets and its application to the influenza A virus genome. BMC Bioinformatics
  8. Yan, H.Q., Chang, S.H., Tian, Z.X.,… Wang, J, Wang Y.P., 2011 Novel AroA from Pseudomonas putida Confers Tobacco Plant with High Tolerance to Glyphosate. PLoS ONE
  9. Zhang, L.Y, Chang, S.H., Wang, J., 2011 Synthetic biology: From the first synthetic cell to see its current situation and future development. Chinese Sci Bull
  10. Zhang, K.L, Cui, S.J., Chang, S.H., Zhang, L.Y., Wang, J. 2010. i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study. Nucleic Acids Res
  11. Zhang, Z., Sun, S., Zhu, X.P., Chang, S.H., Liu, X., Yu, C., Bu, D.B., and Chen, R.S. 2006, A novel scoring schema for peptide identification by searching protein sequence databases using tandem mass spectrometry data. BMC Bioinformatics

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