尹淑濤

尹淑濤,中國農業大學食品科學與營養工程學院副教授,食品營養與安全系副系主任,中國國際工程諮詢公司專家庫成員。

基本介紹

人物經歷,研究方向,主講課程,學術成果,

人物經歷

教育背景
2011/10–2012/10,美國德州理工大學,藥理學,留學基金委聯合培養博士生
2009/09–2013/06,中國農業大學,營養與食品安全,博士生
2006/09–2009/06,中國農業大學,農產品加工與貯藏,碩士生
2002/09–2006/06,中國農業大學,食品科學與工程,本科生
工作經歷
2017/01-,中國農業大學,食品科學與營養工程學院,副教授
2013/06-2016/12,中國農業大學,食品科學與營養工程學院,講師

研究方向

1.食源性抗癌活性成分的篩選及作用評價
程式性細胞死亡(凋亡、自噬)的調控機制研究
2.食源性解毒代謝物質的篩選和作用機理研究
甘草香豆素、牛樟芝、薑黃素、維生素C,等
3.食源性真菌毒素的致毒機理研究
伏馬菌素、展青黴素,等
4.功能性食品的開發

主講課程

《天然產物化學》、《分子營養學研究進展》

學術成果

主要科研項目
1.國家自然科學基金青年項目,3'-去甲基化牛蒡子苷元誘導人肝癌細胞周期阻滯的作用和分子機制研究,2015/01-2017/12,主持
2.企業合作項目,香菇飲料產品開發,2017/04-2018/04,主持
3.北京人類營養與健康高精尖中心開放基金,甘草香豆素預防肝細胞脂凋亡的作用和機制研究,2016/01-2018/12,主持
4.教育部基本科研業務費,基於裸鼠腫瘤移植模型的牛蒡子苷元及其衍生物抗癌作用及機理研究,2014/10-2016/12,主持
5.國家自然科學基金面上項目,展青黴素抑制腎細胞自噬小體降解的分子機制和毒理學意義研究,2014/01-2017/12,參加
6.科技部科技支撐計畫專題,解毒代謝功能調節生物活性物質-多酚與萜類的研究與開發,2012/01-2015/12,1,參加
7.國家自然科學基金面上項目,31071533,五沒食子醯葡萄糖誘導腫瘤細胞類衰老現象及其分子機制研究,2011/01-2013/12,參加
8.國家自然科學基金面上項目,20876165,有機相辣根過氧化物酶電極電催化反應動力學的研究,2009/01-2012/12,參加
代表著作與論文
1.Yin, Shutao,Liu, Xiaoyi,Fan, Lihong,Hu, Hongbo. Mechanisms of
cell death induction by food-borne mycotoxins,Critical Reviews in Food Science and Nutrition,2017.01.26
2.Yin, Shutao,Guo, Xiao,Li, Jinghua,Fan, Linghong,Hu, Hongbo. Fumonisin B1 induces autophagic cell death via activation of ERN1-MAPK8/9/10pathway in monkey kidney MARC-145 cells,Archives of Toxicology,2016.4.01,90(4):985~996
3.Yin, Shutao,Dong, Yinhui,Li, Jinghua,Fan, Lihong,Wang, Lei,Lu,Junxuan,Vang, Ole,Hu, Hongbo. Methylseleninic acid potentiates multipletypes of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad,Apoptosis,2012.4.01,17(4):388~399
4.Yin, Shutao,Dong, Yinhui,Li, Jinhua,Lu,Junxuan,Hu, Hongbo. Penta-1,2,3,4,6-O-Galloyl-Beta-D-Glucose Induces Senescence-Like Terminal S-Phase Arrest in Human Hepatoma and Breast Cancer Cells,Molecular Carcinogenesis,2011.8.01,50(8):592~600
5.Yin, Shutao,Huo, Yazhen,Dong, Yinhui,Fan, Lihong,Yang, Hanchun,Wang, Leyuan,Ning, Yibao,Hu, Hongbo. Activation of c-Jun NH(2)-terminal kinase is required for porcine reproductive and respiratory syndrome virus-induced apoptosis but not for virus replication,Virus Research,2012.6.01,166(1-2):103~108
6.Chen, Ni,Yin, Shutao,Song, Xinhua,Fan, Lihong,Hu, Hongbo. Vitamin B-2 Sensitizes Cancer Cells to Vitamin-C-Induced Cell Death viaModulation of Akt and Bad Phosphorylation,Journal of Agricultural and FoodChemistry,2015.8.5,63(30):6739~6748
7.Zhang,Engxiang,Yin,Shutao,Song,Xinhua,Fan,Lihong,Ye,Min ,Hu,Hongbo,Glycycoumarin inhibits hepatocyte lipoapoptosis through activation
of autophagy and inhibition of ER stress/GSK-3-mediated mitochondrial pathway,
Scientific Report,2016.11.30
8.Huo,Yazhen,Win,Sanda,Than,Tin Aung,Yin,Shutao,Ye,Min,Hu,Hongbo,Kaplowitz,Neil,Antcin H Protects Against Acute Liver Injury ThroughDisruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria,Antioxidants& Redox Signaling,2017.02.10,26(5):207~220
9.Huo,Yazhen,Yin,Shutao,Yan,Mingzhu,Win,Sanda,Than,Tinaung,Aghajan,Mariam,Hu,Hongbo,Kaplowitz,Neil,Protective role of p53 inacetaminophen hepatotoxicity,Free Radical Biology and Medicine,2017.02.11
10.Jin, Huan,Yin, Shutao,Song, Xinhua,Zhang, Enxiang,Fan, Lihong,Hu,Hongbo,p53 activation contributes to patulin-induced nephrotoxicity viamodulation of reactive oxygen species generation,Scientific Reports,2016.4.13
11.Guo,Xiao,Dong,Yinhui,Yin,Shutao,Zhao,Chong,Huo,Yazhen,Fan,Lihong,Hu,Hongbo,Patulin induces pro-survival functions via autophagyinhibition and p62 accumulation,Cell Death & Disease,2013.10.01
12.Dong, Yinhui,Yin, Shutao,Song, Xinhua,Huo, Yazhen,Fan, Lihong,Ye,Min,Hu, Hongbo. Involvement of ROS-p38-H2AX Axis in Novel CurcuminAnalogues-Induced Apoptosis in Breast Cancer Cells,Molecular Carcinogenesis,2016.4.01,55(4):323~334
13.Song, Xinhua,Yin, Shutao,Huo, Yazhen,Liang, Min,Fan, Lihong,Ye,Min ,Hu, Hongbo. Glycycoumarin ameliorates alcohol-induced hepatotoxicityvia activation of Nrf2 and autophagy,Free Radical Biology and Medicine,2015.89:135~146
14.Dong, Yinhui,Yin, Shutao,Jiang, Cheng,Luo, Xiaohe,Guo, Xiao,Zhao,Chong,Fan, Lihong,Meng, Yubing,Lu, Junxuan,Song, Xinhua,Zhang,Xudong,Chen, Ni,Hu, Hongbo,Involvement of autophagy induction inpenta-1,2,3,4,6-O-galloyl-beta-D-glucose-induced senescence-like growth arrestin human cancer cells,Autophagy,2014.2.1,10(2):296~310
15.Guo, Xiao,Yin, Shutao,Dong, Yinhui,Fan, Lihong,Ye, Min,Lu,Junxuan,Hu, Hongbo. Enhanced Apoptotic Effects by the Combination ofCurcumin and Methylseleninic Acid: Potential Role of Mcl-1 and FAK,MolecularCarcinogenesis,2013.11.01,52(11):879~889
16.Huo, Yazhen,Fan, Lihong,Yin, Shutao,Dong, Yinhui,Guo,Xiao,Yang, Hanchun,Hu, Hongbo. Involvement of unfolded protein response,p53 and Akt in modulation of porcine reproductive and respiratory syndromevirus-mediated JNK activation,Virology,2013.9.01,444(1-2):233~240
17.Tong, Jing,Yin, Shutao,Dong, Yinhui,Guo, Xiao,Fan, Lihong,Ye,Min,Hu, Hongbo. Pseudolaric Acid B Induces Caspase-Dependent Apoptosis andAutophagic Cell Death in Prostate Cancer Cells,Phytotherapy Research,2013.6.01,27(6):885~891
18.Zhao, Chong,Yin, Shutao,Dong, Yinhui,Guo, Xiao,Fan, Lihong,Ye,Min,Hu, Hongbo. Autophagy-dependent EIF2AK3 activation compromises ursolicacid-induced apoptosis through upregulation of MCL1 in MCF-7 human breastcancer cells Autophagy,2013.2.01,9(2):196~207
19.Zhang, Xudong,Song, Xinhua ,Yin, Shutao,Zhao, Chong,Fan,Lihong,Hu, Hongbo p21 induction plays a dual role in anti-cancer activityof ursolic acid,Experimental Biology and Medicine,2016.3.01,241(5):501~508
20.Li, Jinghua,Yin, Shutao,Dong, Yinhui,Fan, Lihong,Hu, Hongbo. p53 activation inhibits ochratoxin A-induced apoptosis in monkey and humankidney epithelial cells via suppression of JNK activation,Biochemical andBiophysical Research Communications,2011.7.29,411(2):458~463
21.Dong, Yinhui,Yin, Shutao,Li, Jinghua,Jiang, Cheng,Ye, Min,Hu,Hongbo,Bufadienolide compounds sensitize human breast cancer cells toTRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway,Apoptosis,2011.4.01,16(4):394~403
授權發明專利
扈洪波,宋鑫華,葉敏,尹淑濤,甘草香豆素作為PBK/TOPK蛋白抑制劑的新用途2015.06.17

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