姜啟曉

姜啟曉，男，1983年11月生，山東青島人，博士，青島大學公共衛生學院副教授。

基本介紹

• 中文名：姜啟曉
• 學位/學歷：博士
• 職業：教師
• 專業方向：全氟化合物及其替代品的發育心血管毒性作用評價及作用機制研究
• 任職院校：青島大學

個人經歷

2007年本科畢業於青島大學醫學院，臨床醫學學士學位。2013年博士畢業於East Carolina University, Brody School of Medicine，獲Ph.D. in Pharmacology & Toxicology學位，現為青島大學公共衛生學院副教授。

主要從事毒理學的科研與教學工作，現為Society of Toxicology正式會員。

研究方向

1. 全氟化合物及其替代品的發育心血管毒性作用評價及作用機制研究

2. 大氣細顆粒污染物的發育毒性及心血管毒性作用評價及機制研究

學術成果

主持國家自然科學基金一項，參與一項。以通訊及第一作者共發表SCI論文15篇。

代表性科研成果

發表論文

1: Lv N, Zhao M, Han Y, Cui L, Zhong W, Wang C, Jiang Q*. The roles of bone morphogenetic protein 2 in perfluorooctanoic acid induced developmental cardiotoxicity and l-carnitine mediated protection. Toxicol Appl Pharmacol. 2018 Aug 1;352:68-76. doi: 10.1016/j.taap.2018.05.028. Epub 2018 May 23. PubMed PMID: 29800642.

2: Zhao M, Jiang Q*, Geng M, Zhu L, Xia Y, Khanal A, Wang C. The role of PPAR alpha in perfluorooctanoic acid induced developmental cardiotoxicity and l-carnitine mediated protection-Results of in ovo gene silencing. Environ Toxicol Pharmacol. 2017 Dec;56:136-144. doi: 10.1016/j.etap.2017.09.006. Epub 2017 Sep 14. PubMed PMID: 28934691.

3: Zhao M, Jiang Q*, Wang W, Geng M, Wang M, Han Y, Wang C. The Roles of Reactive Oxygen Species and Nitric Oxide in Perfluorooctanoic Acid-Induced Developmental Cardiotoxicity and l-Carnitine Mediated Protection. Int J Mol Sci. 2017 Jun 8;18(6). pii: E1229. doi: 10.3390/ijms18061229. PubMed PMID: 28594376; PubMd Central PMCID: PMC5486052.

4: Jiang Q*, Wang C, Xue C, Xue L, Wang M, Li C, Deng Z, Wang Q. Changes in the levels of l-carnitine, acetyl-l-carnitine and propionyl-l-carnitine are involved in perfluorooctanoic acid induced developmental cardiotoxicity in chicken embryo. Environ Toxicol Pharmacol. 2016 Dec;48:116-124. doi: 10.1016/j.etap.2016.10.017. Epub 2016 Oct 19. PubMed PMID: 27771504.

5: Jiang Q*, Ma W, Wu J, Wingard CJ, DeWitt JC. Perfluorooctanoic acid-induced toxicity in primary cultures of chicken embryo cardiomyocytes. Environ Toxicol. 2016 Nov;31(11):1580-1590. doi: 10.1002/tox.22162. Epub 2015 Jun 22. PubMed PMID: 26098785.

6: Jiang Q, Lust RM, DeWitt JC. Perfluorooctanoic acid induced-developmental cardiotoxicity: are peroxisome proliferator activated receptor α (PPARα) and bone morphorgenic protein 2 (BMP2) pathways involved? J Toxicol Environ Health A. 2013;76(11):635-50. doi: 10.1080/15287394.2013.789415. PubMed PMID: 23941634.

7: Jiang Q, Lust RM, Strynar MJ, Dagnino S, DeWitt JC. Perflurooctanoic acid induces developmental cardiotoxicity in chicken embryos and hatchlings. Toxicology. 2012 Mar 11;293(1-3):97-106. doi: 10.1016/j.tox.2012.01.005. Epub 2012 Jan 18. PubMed PMID: 22273728.

8: Jiang Q, Hao R, Wang W, Gao H, Wang C. SIRT1/Atg5/autophagy are involved in the antiatherosclerosis effects of ursolic acid. Mol Cell Biochem. 2016 Sep;420(1-2):171-84. doi: 10.1007/s11010-016-2787-x. Epub 2016 Aug 11. PubMed PMID: 27514536.

9: Jiang Q, Han Y, Gao H, Tian R, Li P, Wang C. Ursolic acid induced anti-proliferation effects in rat primary vascular smooth muscle cells is associated with inhibition of microRNA-21 and subsequent PTEN/PI3K. Eur J Pharmacol. 2016 Jun 15;781:69-75. doi: 10.1016/j.ejphar.2016.04.001. Epub 2016 Apr 13. PubMed PMID: 27085898.

10: Jiang Q, Wang D, Han Y, Han Z, Zhong W, Wang C. Modulation of oxidized-LDL receptor-1 (LOX1) contributes to the antiatherosclerosis effect of oleanolic acid. Int J Biochem Cell Biol. 2015 Dec;69:142-52. doi: 10.1016/j.biocel.2015.10.023. Epub 2015 Oct 25. PubMed PMID: 26510581.

11: Han Y, Zhao H, Jiang Q, Gao H, Wang C. Chemopreventive mechanism of polypeptides from Chlamy Farreri (PCF) against UVB-induced malignant transformation of HaCaT cells. Mutagenesis. 2015 Mar;30(2):287-96. doi: 10.1093/mutage/geu071. Epub 2014 Nov 12. PubMed PMID: 25392149.

12: Han Y, Jiang Q, Gao H, Fan J, Wang Z, Zhong F, Zheng Y, Gong Z, Wang C. The anti-apoptotic effect of polypeptide from Chlamys farreri (PCF) in UVB-exposed HaCaT cells involves inhibition of iNOS and TGF-β1. Cell Biochem Biophys. 2015 Mar;71(2):1105-15. doi: 10.1007/s12013-014-0315-8. PubMed PMID: 25331675.

13: Gao H, Jiang Q, Han Y, Peng J, Wang C. shRNA-mediated EMMPRIN silencing inhibits human leukemic monocyte lymphoma U937 cell proliferation and increases chemosensitivity to adriamycin. Cell Biochem Biophys. 2015 Mar;71(2):827-35. doi: 10.1007/s12013-014-0270-4. PubMed PMID: 25260396.

14: Gao H, Jiang Q, Han Y, Peng J, Wang C. Hispidulin potentiates the antitumor effect of sunitinib against human renal cell carcinoma in laboratory models. Cell Biochem Biophys. 2015 Mar;71(2):757-64. doi: 10.1007/s12013-014-0260-6. PubMed PMID: 25260394.

15: Wang X, Jiang Q, Wang W, Su L, Han Y, Wang C. Molecular mechanism of polypeptides from Chlamys farreri (PCF)'s anti-apoptotic effect in UVA-exposed HaCaT cells involves HSF1/HSP70, JNK, XO, iNOS and NO/ROS. J Photochem Photobiol B. 2014 Jan 5;130:47-56. doi: 10.1016/j.jphotobiol.2013.11.005. Epub 2013 Nov 14. PubMed PMID: 24296267.

16: Liu S, Piao J, Liu Y, Tang J, Liu P, Yang D, Zhang L, Ge N, Jin Z, Jiang Q, Cui L. Radiosensitizing effects of different size bovine serum albumin-templated gold nanoparticles on H22 hepatoma-bearing mice. Nanomedicine (Lond). 2018 Jun;13(11):1371-1383. doi: 10.2217/nnm-2018-0059. Epub 2018 May 11. PubMed PMID: 29749804.

17: Han Y, Jiang Q, Wang Y, Li W, Geng M, Han Z, Chen X. The anti-prolifertive effects of oleanolic acid on A7r5 cells-Role of UCP2 and downstream FGF-2/p53/TSP-1. Cell Biol Int. 2017 Dec;41(12):1296-1306. doi: 10.1002/cbin.10838. Epub 2017 Aug 31. PubMed PMID: 28792088.

18: Zhang L, Zhang J, Jiang Q, Zhang L, Song W. Zinc binding groups for histone deacetylase inhibitors. J Enzyme Inhib Med Chem. 2018 Dec;33(1):714-721. doi: 10.1080/14756366.2017.1417274. Review. PubMed PMID: 29616828; PubMed Central PMCID: PMC6009916.

19: Kong D, Han Y, Wang C, Chen X, Jiang Q, Wang Q, Han Z. Cytoprotective Effects of Oleanolic Acid in Human Umbilical Vascular Endothelial Cells is Mediated Via UCP2/ROS/Cytochrome C/AIF Pathway. J Cardiovasc Pharmacol. 2016 Apr;67(4):344-50. doi: 10.1097/FJC.0000000000000360. PubMed PMID: 26771154.

20: Wang Z, Li P, Wang C, Jiang Q, Zhang L, Cao Y, Zhong W, Wang C. Protective effects of Arctium lappa L. root extracts (AREs) on high fat diet induced quail atherosclerosis. BMC Complement Altern Med. 2016 Jan 8;16:6. doi: 10.1186/s12906-016-0987-2. PubMed PMID: 26746431; PubMed Central PMCID: PMC4706685.

21: Zhang L, Han Y, Jiang Q, Wang C, Chen X, Li X, Xu F, Jiang Y, Wang Q, Xu W. Trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy. Med Res Rev. 2015 Jan;35(1):63-84. doi: 10.1002/med.21320. Epub 2014 Apr 29. Review. PubMed PMID: 24782318.

22: Xie J, Gao H, Peng J, Han Y, Chen X, Jiang Q, Wang C. Hispidulin prevents hypoxia-induced epithelial-mesenchymal transition in human colon carcinoma cells. Am J Cancer Res. 2015 Feb 15;5(3):1047-61. eCollection 2015. PubMed PMID: 26045985; PubMed Central PMCID: PMC4449434.

23: Gao H, Xie J, Peng J, Han Y, Jiang Q, Han M, Wang C. Hispidulin inhibits proliferation and enhances chemosensitivity of gallbladder cancer cells by targeting HIF-1α. Exp Cell Res. 2015 Mar 15;332(2):236-46. doi: 10.1016/j.yexcr.2014.11.021. Epub 2014 Dec 8. PubMed PMID: 25499970.

24: Zhang L, Chen Y, Jiang Q, Song W, Zhang L. Therapeutic potential of selective histone deacetylase 3 inhibition. Eur J Med Chem. 2019 Jan 15;162:534-542. doi: 10.1016/j.ejmech.2018.10.072. Epub 2018 Nov 17. Review. PubMed PMID: 30472601.

學術專著

Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances-Chapter 7，2015年由Springer旗下Humana出版社出版， ISBN：978-3-319-15517-3

主要科研項目

1. 國家自然科學基金面上項目，81872591，基於mtDNA甲基化的大氣顆粒物致心臟毒性機制及早期效應標誌物探索，2019/01-2023/12，57萬元，在研，參與

3. 國家自然科學基金青年項目，81502835 , 全氟辛酸（PFOA）誘導發育心臟毒性機制研究，2016/01-2018/12，18萬元，結題，主持

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