周暉皓

周暉皓

周暉皓，博士，中山大學藥學院教授、博士生導師。中山大學“百人計畫二期”青年傑出人才項目，是廣東省“珠江人才計畫”引進創新創業團隊核心成員。主要運用結構生物學、生物化學方法，研究蛋白質翻譯等生命活動關鍵過程中的蛋白質的結構與功能，並針對這些蛋白質開展靶向藥物設計研究。已在包括Nature、Science在內的國際學術期刊發表了二十餘篇SCI研究論文。

基本介紹

  • 中文名：周暉皓
  • 畢業院校：中國科學技術大學
  • 學位/學歷：博士
  • 職業：教師
  • 職務：博士生導師
  • 主要成就：廣東省“珠江人才計畫”引進創新創業團隊核心成員
  • 職稱：教授
研究方向,人物經歷,教育經歷,工作經歷,教授課程,科研項目,學術成果,研究論文,專利申請,

研究方向

藥物靶標結構生物學
基於片段的藥物發現
藥物化學

人物經歷

教育經歷

2003.09 - 2009.06: 理學博士，中國科學技術大學生命科學學院，導師：牛立文教授、滕脈坤教授
2001.09 - 2003.06: 工學雙學士，中國科學技術大學計算機系
1999.09 - 2003.06: 理學學士，中國科學技術大學生命科學學院

工作經歷

2015.01 - 至今 中山大學藥學院教授
2009.09 - 2015.01 美國SCRIPPS研究所博士後，合作導師：Paul Schimmel教授、Xiang-Lei Yang教授

教授課程

主講和參與教學的課程包括：
本科生課程：《結構生物學與藥學研究》
《生物化學》
《生物化學與分子生物學實驗》
研究生課程：《結構生物學》。

科研項目

國家自然科學基金面上項目，81773636，課題負責人
廣東省自然科學基金自由申請項目，2017A030313123，課題負責人
廣東省引進創新創業團隊，2016ZT06Y337，團隊核心成員，子課題負責人
中山大學醫科重大項目培育項目，36000-31650008，課題負責人
中山大學“百人計畫二期”啟動項目，36000-18811200，課題負責人

學術成果

研究論文

  1. Yingchen Ju, Zhihong Liu, Zizhen Zhang, Lijun Duan, Qi Liu, Qiong Gu, Cheng Zhang, Jun Xu*, Huihao Zhou*, Membrane binding of the insertion sequence of Proteus vulgaris L-amino acid deaminase stabilizes protein structure and increases catalytic activity, Sci Rep, 2017, 7, 13719.
  2. Xiaoling Xu, Huihao Zhou, Quansheng Zhou, Fei Hong, My-Nuong Vo, Wanqiang Niu, Zhiguo Wang, Xiaolin Xiong, Kanaha Nakamura, Keisuke Wakasugi, Paul Schimmel, Xiang-Lei Yang, An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function, RNA Biol, [Epub ahead of print]
  3. Jiewen Du, Xin Yan, Zhihong Liu, Lu Cui, Peng Ding, Xiaoqing Tan, Xiuming Li, Huihao Zhou, Qiong Gu, Jun Xu, cBinderDB: a covalent binding agent database, Bioinformatics, 2017, 33, 1258-1260.
  4. Yingchen Ju, Shuilong Tong, Yongxiang Gao, Wei Zhao, Qi Liu, Qiong Gu, Jun Xu, Liwen Niu*, Maikun Teng*, Huihao Zhou*, Crystal structure of a membrane-bound L-amino acid deaminase from Proteus vulgaris. J Struct Biol, 2016, 195, 306-315.
  5. Litao Sun, Ana Cristina Gomes, Weiwei He, Huihao Zhou, Xiaoyun Wang, David W. Pan, Paul Schimmel, Tao Pan, Xiang-Lei Yang, Evolutionary gain of alanine mischarging to non-cognate tRNAs with a G4:U69 base pair, J Am Chem Soc, 2016, 138, 12948-12955.
  6. Zhihong Liu, Peng Ding, Xin Yan, Minghao Zheng, Huihao Zhou, Yuehua Xu, Yunfei Du, Qiong Gu, Jun Xu, ASDB: a resource for probing protein functions with small molecules. Bioinformatics, 2016, 32, 1752-1754.
  7. Gongrui Guo, Yongxiang Gao, Zhongliang Zhu, Debiao Zhao, Zhihong Liu, Huihao Zhou*, Liwen Niu*, Maikun Teng*, Structural and biochemical insights into the DNA-binding mode of MjSpt4p:Spt5 complex at the exit tunnel of RNAPII, J Struct Biol, 2015, 192, 418-425.
  8. Weiwei He, Ge Bai, Huihao Zhou, Na Wei, Nicholas M. White, Janelle Lauer, Huaqing Liu, Yi Shi, Calin Dan Dumitru, Karen Lettieri, Veronica Shubayev, Albena Jordanova, Velina Guergueltcheva, Patrick R. Griffin, Robert W. Burgess, Samuel L. Pfaff, Xiang-Lei Yang, CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase, Nature, 2015, 526, 710-714.
  9. Long Li, Xiu Le, Ling Wang, Qiong Gu, Huihao Zhou, Jun Xu, Discovering new DNA gyrase inhibitors using machine learning approaches, RSC Adv, 2015, 5, 105600-105608.
  10. Jonathan D. Herman, Lauren R. Pepper, Joseph F. Cortese, Guillermina Estiu, Kevin Galinsky, Vanessa Zuzarte-Luis, Emily R. Derbyshire, Ulf Ribacke, Amanda K. Lukens, Sofia A. Santos, Vishal Patel, Clary B. Clish, William J. Sullivan Jr., Huihao Zhou, Selina E. Bopp, Paul Schimmel, Susan Lindquist, Jon Clardy, Maria M. Mota, Tracy L. Keller, Malcolm Whitman, Olaf Wiest, Dyann F. Wirth, Ralph Mazitschek1, The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med, 2015, 7, 288ra77.
  11. Qianzhi Ding, Chanjuan Li, Ling Wang, Yali Li, Huihao Zhou, Qiong Gua, Jun Xu, Identifying farnesoid X receptor agonists by naïve Bayesian and recursive partitioning approaches, MedChemComm, 2015, 6, 1393-1403.
  12. Ryuta Ishimura, Gabor Nagy, Ivan Dotu, Huihao Zhou, Xiang-Lei Yang, Paul Schimmel, Satoru Senju, Yasuharu Nishimura, Jeffrey H. Chuang, Susan L. Ackerman1, Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration. Science, 2014, 345, 455-459.
  13. Huihao Zhou, Litao Sun, Xiang-Lei Yang, Paul Schimmel, ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature, 2013, 494, 121-124.
  14. Huihao Zhou, Zhao Zha, Yang Liu, Hongtao Zhang, Juanjuan Zhu, Siyi Hu, Guodong Shen, Liansheng Cheng, Liwen Niu, Mark I. Greene, Maikun Teng, Jing Liu, Structural insight into the down-regulation of overexpressed p185(her2/neu) protein of transformed cells by the antibody chA21. J Biol Chem, 2011, 286, 31676-31683.
  15. Huihao Zhou, Qi Liu, Yongxiang Gao, Maikun Teng, Liwen Niu, Crystal structure of NusG N-terminal (NGN) domain from Methanocaldococcus jannaschii and its interaction with rpoE”. Proteins, 2009, 76, 784-793.
  16. Huihao Zhou, Qi Liu, Weili Yang, Yongxiang Gao, Maikun Teng, Liwen Niu, Monomeric tRNA (m(7)G46) methyltransferase from Escherichia coli presents a novel structure at the function-essential insertion. Proteins, 2009, 76, 512-515.
  17. Yang Liu, Huihao Zhou, Juanjuan Zhu, Yongxiang Gao, Liwen Niu, Jing Liu, Maikun Teng, Crystallization and preliminary crystallographic studies of the single-chain variable fragment of antibody chA21 in complex with an N-terminal fragment of ErbB2. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009, 65, 692-694.
  18. Shuilong Tong, Huihao Zhou, Yongxiang Gao, Zhiqiang Zhu, Xiao Zhang, Maikun Teng, Liwen Niu, Crystal structure of human osteoclast stimulating factor. Proteins, 2009, 75, 245-251.
  19. Yingji Cui, Heng Li, Xu Li, Yang Li, Huihao Zhou, Liwen Niua, Maikun Teng, Crystallization and preliminary crystallographic analysis of the second RRM of Pub1 from Saccharomyces cerevisiae. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009, 65, 108-110.
  20. Qi Liu, Yang Gao, Weili Yang, Huihao Zhou, Yongxiang Gao, Xiao Zhang, Maikun Teng, and Liwen Niu, Crystallization and preliminary crystallographic analysis of tRNA (m(7)G46) methyltransferase from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008, 64, 743-745.

專利申請

  1. Xiang-Lei Yang, Na Wei, Huihao Zhou, Paul Schimmel. Binding activity of aminoacyl-tRNA synthetase in Charcot-Marie-Tooth (CMT) neuropathy and CMT-related neurological disease. International Publication Number: WO2017066482, 2017-04-20.
  2. 劉兢，程聯勝，劉洋，周暉皓，滕脈坤，朱娟娟，魏海明，肖衛華，“一種抗原-抗體複合物晶體及其製備方法與抗原表位”，中國發明專利公開號：CN101418047,2011-04-20。

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