吳旭東，博士，南京大學生命科學院副教授，承擔2項國家自然科學基金的資助（Nos. 81273569，Nos. 81001465），以及1項江蘇省自然科學基金的研究（BK2012726）。以第一作者或通訊作者在Gastroenterology, Hepatology, Biochem Pharmacol等高影響因子的雜誌發表多篇研究論文。
基本介紹
- 中文名：吳旭東
- 畢業院校：中國藥科大學
- 學位/學歷：博士
- 專業方向：分子藥理學
- 職稱：副教授
- 任職院校：南京大學
人物經歷,教育經歷,工作經歷,研究方向,科研成果,獲獎情況,
人物經歷
教育經歷
2006/12-2009/08美國維吉尼亞聯邦大學醫學院，免疫與微生物學，聯合培養博士
2003/09-2009/08中國藥科大學，分子藥理學，博士
1998/09-2003/06中國藥科大學，藥理學，本科
工作經歷
2011/12-至今，南京大學生命科學院，醫藥生物技術國家重點實驗室，副教授，碩導。
2009/08-2011/11，南京大學生命科學院，醫藥生物技術國家重點實驗室，講師。
研究方向
1、巨噬細胞炎症小體和極化機制。
2、內質網應激和線粒體途徑介導的細胞損傷。
科研成果
Xudong Wu, Travel Award, The American Society for Biochemistry and Molecular Biology, 2009, New Orleans, LA.
發表的相關論文：1.Lili Feng, Pingping Song, Hang Zhou, Ang Li, Yuxiang Ma, Xiong Zhang, Hailiang Liu; Ge Xu; Yang Zhou; Xuefeng Wu; Yan Shen; Yang Sun; Xudong Wu*; Qiang Xu*.Pentamethoxyflavanone regulates macrophage polarization and ameliorates sepsis in mice. Biochem Pharmacol.Available online 4 March 2014, doi:10.1016/j.bcp.2014.02.016
2.Hang Zhou, Xudong Wu*, Ang Li, Lili Feng, Zhe Gao, Xiong Zhang, YuxiangMa, Yang Sun, Yan Shen, Xuefeng Wu, Qiang Xu*Berberine ameliorates insulin resistance via preventing fatty acid-induced NLRP3 inflammasome activation and triggering autophagy of adipose tissue macrophages.Biochem Pharmacol.2014. (revised)
3.Xudong Wu, Lixin Sun, Weibin Zha, Elaine Studer, Li Chen, Phillip B. Hylemon,William M. Pandak Jr,Arun J. Sanyal, Luyong Zhang, Guangji Wang, Jie Chen, Jianying Wang, Huiping Zhou*. HIV protease inhibitors induce endoplasmic reticulum stress and disrupt barrier integrity in intestrinal epithelial cells.Gastroenterology 2010; 138 (1): 197-209.
4.Xudong Wu, Luyong Zhang, Emily Gurley, Elaine Studer, Jing Shang, Tao Wang, Cuifen Wang, Ming Yan, Zhenzhou Jiang, Phillip B. Hylemon, Arun J. Sanyal, William M. Pandak Jr, Huiping Zhou*. Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways.Hepatology 2008; 47(6):1905-1915.
5.Yun Wang, Luyong Zhang, Xudong Wu, Emily C. Gurley, Elaine Kennedy, Phillip B. Hylemon, William M. Pandak, Arun J. Sanyal, Huiping Zhou*. The role of CCAAT enhancer-binding protein homologous protein in human immunodeficiency virus protease-inhibitor–induced hepatic lipotoxicity in mice. Hepatology. 2013 Mar; 57(3):1005-16. doi: 10.1002/hep.26107.
6.HU Ling-Na, FANG Xian-Ying, LIU Hai-Liang, GAO Zhe, WU Xue-Feng, SUN Yang, WU Xu-Dong*, XU Qiang*. Protective effects of 18β-glycyrrhetinic acid on LPS-induced injury in intestinal epithelial cells. Chinese Journal of Natural Medicines. 2013, 11(1): 0024−0029.
7.YI Hong-Wei, MA Yu-Xiang, WANG Xiao-Ning, LU Jian, CAO Wei, WU Xu-Dong*. Ethanol promotes saturated fatty acid-induced hepatoxicity through ERstress response. Chinese Journal of Natural Medicines.2014. (accepted)
8.Lu Fan, Lingna Hu, Baofang Yang, Xianying Fang, Zhe Gao, Wanshuai Li, Yang Sun, Yan Shen, Xuefeng Wu, Yongqian Shu, Yanhong Gu, Xudong Wu*, Qiang Xu*. ErlotinibPromotes Endoplasmic Reticulum Stress-mediated Injury in Intestinal Epithelium. Toxicol Appl Pharmacol.2014. (accepted)
9.Li Chen, Sirikalaya Jarujaron, Xudong Wu, Lixin Sun, Weibin Zha, Guang Liang, Xuan Wang, Emily C. Gurley, Elaine J. Studer, Phillip B. Hylemon, William M. Pandak Jr., Luyong Zhang, Guangji Wang, Xiaokun Li, Paul Dent, Huiping Zhou*. HIV Protease Inhibitor Lopinavir-induced TNF-α and IL-6 Expression is Coupled to the Unfolded Protein Response and ERK Signaling Pathways in Macrophages. BiochemPharmacol 2009; 78(1): 70-77.
10.Xuefeng Wu, Jingjing Fan, Zijun Ouyang, Rui Ning, Wenjie Guo, Yan Shen, Xudong Wu, Yan Sun, Xu Q*.Tupistra chinensis extract attenuates murine fulminant hepatitis with multiple targets against activated T lymphocytes.J Pharm Pharmacol. 2014 Mar; 66(3):453-65. doi: 10.1111/jphp.12176.
獲獎情況
2010年獲得由南京市政府頒發的南京市第八屆自然科學優秀學術論文獎，題目為“Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways.”獲獎者為：吳旭東，張陸勇，尚靖，王濤，王翠芬，嚴明，江振洲。
美國ASBMB頒發的Travel Award(2009年，唯一獲獎人)
