主要研究領域包括3D智慧型數位化列印、計算機三維視覺、視覺形狀感知分析與處理、視頻圖像處理、計算機互動圖形學等。主持和參與國家自然科學基金（兩項，其中因取得突出研究進展獲首批國家青年科學基金-面上項目連續資助項目）、國家高技術研究計畫863項目（四項）、中國博士後科學基金（一等）、北京市自然科學基金、南京市科技領軍人才計畫等多項國家重大科研課題。在計算機視覺/計算機圖形學領域的IEEE Transactions on Visualization and Computer Graphics、IEEE Transactions on IP、IEEE Transactions on CSVT、IEEE Transactions on ITS、ICCV、CVPR等國際權威期刊/會議上發表學術論文30餘篇，相關技術申請國際/國家發明專利6項。著有《3D列印：三維智慧型數位化創造》（3D Printing: Three-Dimensional Creation via Intelligent Digitization）一書。研究成果套用到國產3D影視動漫製作當中，如國產三維動畫電影《麋鹿王》中的三維形狀漸變，該卡通片獲得第13 屆中國電影華表獎優秀卡通片獎、第二十七屆中國電影金雞獎最佳美術片提名獎。
* Huai-Yu Wu, Chunhong Pan, Qing Yang, Songde MA. "Consistent Correspondence between Arbitrary Manifold Surfaces". IEEE International Conference on Computer Vision (ICCV 2007), Rio de Janeiro, Brazil, October 14-20, 2007.
* Huai-Yu Wu, Hongbin Zha. "Robust Consistent Correspondence Between 3D Non-Rigid Shapes Based On 'Dual Shape-DNA'". IEEE International Conference on Computer Vision (ICCV 2011), Barcelona, Spain, 6-13 November, 2011.
* Huai-Yu Wu, Hongbin Zha, Tao Luo, Xu-Lei Wang, Songde MA. "Global and Local Isometry-Invariant Descriptor for 3D Shape Comparison and Partial Matching". IEEE Conference on Computer Vision and Pattern Recognitionn (CVPR 2010), pp.438-445, San Francisco, California, June 13-18, 2010.
* Huai-Yu Wu, Chunhong Pan, Hongbin Zha, Songde MA. "Model Transduction for Triangle Meshes". Journal of Computer Science and Technology (JCST), 25(3): 584-595, May 2010. SCI Indexed
* Huai-Yu Wu, Chunhong Pan, Kun Zeng, Qing Yang, Songde MA. "An Efficient Skeleton-Free Pose Retargetting Method for Triangular Meshes". Journal of Electronics ,Vol. no. 4, pp. 659-664, 2008. SCI Indexed
* Lingfeng Wang, Huai-Yu Wu, Chunhong Pan. " Manifold Regularized Local Sparse Representation for Face Recognition". IEEE Transactions on Circuits and Systems for Video Technology (TCSVT), 2014. SCI Indexed
* Lingfeng Wang, Huai-Yu Wu, Chunhong Pan. " Fast Image Upsampling via the Displacement Field". IEEE Transactions on Image Processing (TIP), 2014. SCI Indexed
* Lingfeng Wang, Hongping Yan, Huai-Yu Wu, Chunhong Pan. "Forward-Backward Mean-shift for Visual Tracking with Local Background Weighted Histogram". IEEE Transactions on Intelligent Transportation Systems (T-ITS), 2013, (accepted). SCI Indexed
* Huai-Yu Wu, Chunhong Pan, Jia Pan, Qing Yang, Songde MA. "A Sketch-based Interactive Framework for Real-time Mesh Segmentation". Computer Graphics International (CGI 2007), Petrópolis, RJ, Brazil, 2007.
* Jia Pan, Huai-Yu Wu, Chunhong Pan, Qing Yang. "A Novel Scheme for Efficient Cross-parameterization". Computer Graphics International (CGI 2007), Petrópolis, RJ, Brazil, 2007.
* LingFeng Wang, Huai-Yu Wu, Chunhong Pan. "Adaptive eLBP for Background Subtraction". The Asian Conference on Computer Vision (ACCV 2010), Queenstown, New Zealand, 2010.
* LingFeng Wang, Huai-Yu Wu, Chunhong Pan. "Mean-shift Object Tracking with a Novel Back-Projection Calculation Method". The Asian Conference on Computer Vision (ACCV 2009), Xi’ an, China, 2009. (Oral: acceptance rate: 5.22%)
* Tao Luo, Huai-Yu Wu, Hongbin Zha. "Crease Detection on Noisy Meshes via Probabilistic Scale Selection". The Asian Conference on Computer Vision (ACCV 2009), Xi’ an, China, 2009. (Poster: acceptance rate: 25.22%)
* Huai-Yu Wu, LingFeng Wang, Tao Luo, Hongbin Zha. 3D Shape Consistent Correspondence by Using Laplace-Beltrami Spectral Embeddings. ACM SIGGRAPH VRCAI'2009 (The 8th ACM SIGGRAPH International Conference on Virtual-Reality Continuum and Its Applications in Industry), ACM Press, Yokohama, Japan, 14-15 Dec, 2009.
* Huai-Yu Wu, Tao Luo, LingFeng Wang, Xu-Lei Wang, Hongbin Zha. 3D Shape Retrieval by Using Manifold Harmonics Analysis with an Augmentedly Local Feature Representation. ACM SIGGRAPH VRCAI'2009 (The 8th ACM SIGGRAPH International Conference on Virtual-Reality Continuum and Its Applications in Industry), ACM Press, Yokohama, Japan, 14-15 Dec, 2009.
* Huai-Yu Wu, Chunhong Pan, Qing Yang, Jia Pan, Songde Ma. "Mean-value Laplacian Coordinates for Triangular Meshes". IEEE International Conference on Computer Graphics, Imaging and Visualization (CGIV 2006), Sydney, Australia, pp.
* Huai-Yu Wu, Qing Yang, Chunhong Pan. "An Efficient Skeleton-Free Mesh Deformation Method with Motion Capture Data". IEE International Conference on Visual Information Engineering (VIE 2006), Bangalore, India, pp.465–469, 2006.
* Kun Zeng, Liang Lin, Huai-Yu Wu, Chunhong Pan, Qing Yang. "Image Sketching Using Low-, Mid-level Vision Cues". Journal of Computational Information Systems, 2008.
* Lingfeng Wang, Huai-Yu Wu, Chunhong Pan. "Region-based Image Segmentation with Local Signed Difference Energy". Pattern Recognition Letters (PRL), 2013 (accepted). SCI Indexed
* Hong-Xia Wang, Chunhong Pan, Haifeng Gong, Huai-Yu Wu. "Facial Image Composition Based on Active Appearance Model". IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP 2008), 2008.
* Principal Investigator, National Natural Science Foundation of China (NSFC): "High-Quality 3D Dynamic Shape Capture Based on Random Regression Forests and Multi-Data Fusion",2013.01 - 2016.12 * Principal Investigator, National Natural Science Foundation of China (NSFC): "A Study of 3D Shape Match and Retrieval based on Manifold Harmonics Analysis", 2010.01 - 2012.12
* Principal Investigator, China Postdoctoral Science Foundation (The First Class): "Digital Geometry Processing for 3D Scanned Data based on the Laplace-Beltrami Eigenfunctions", 2008-2010
* Principal Investigator, Beijing Natural Science Foundation: "A Key Study on 3D Media Shape Retrieval", 2013.01 - 2015.06
* Main Investigator, National High Technology Program (China's 863 program): "Large-scale panoramic dynamic light field collecting and relighting system for complex and irregular multiple moving objects", 2009.1-2010.12 * Main Investigator, National High Technology Program (China's 863 program): "Individualized Transformation and Reuse Technology on Cartoon Material Library", 2005-2006
* Main Investigator, National High Technology Program (China's 863 program): "The Integrated Environment and Key Technology based on Virtual and Real Fusion Cooperation", 2009.1-2010.12
* Main Investigator, National High Technology Program (China's 863 program): "The research and applications of 3D Motion Capture System based on stereo vision methods", 2004.10-2005.10
