吳季輝

吳季輝

吳季輝，男，1982年畢業於中國科學技術大學生物系細胞生物學專業，1988在中國科學院生物物理所獲理學碩士學位。1995.1-1996.1，瑞士蘇黎世聯邦高工分子生物和生物物理研究所進修核磁實驗技術及蛋白質的結構修正方法。1982.10-1985.8，在中國科學院武漢病毒研究所工作，從事輪狀病毒的ds-RNA研究及植物病毒的保存等工作。1988.10－現在，在中國科學技術大學生命科學學院任教並從事核磁共振和結構生物學的研究工作。

基本介紹

  • 中文名：吳季輝
  • 國籍：中國
  • 民族：漢
  • 出生地：福建福州市
  • 出生日期：1956年11月
  • 職業：教授  博士生導師
  • 畢業院校：中國科學技術生物系細胞生物學
  • 主要成就：代表性研究論文
  • 代表作品：生物大分子多維核磁共振
人物簡介,研究領域,代表論著,

人物簡介

吳季輝，男，教授，博士生導師。
1982年畢業於中國科學技術大學生物系細胞生物學專業，1988在中國科學院生物物理所獲理學碩士學位。
1995.1-1996.1，瑞士蘇黎世聯邦高工分子生物和生物物理研究所進修核磁實驗技術及蛋白質的結構修正方法。
1982.10-1985.8，在中國科學院武漢病毒研究所工作，從事輪狀病毒的ds-RNA研究及植物病毒的保存等工作。
1988.10－現在，在中國科學技術大學生命科學學院任教並從事核磁共振和結構生物學的研究工作。

研究領域

蛋白質和核酸的核磁共振研究及生物核磁共振波譜學方法學研究，特別是蛋白質的結構測定及結構和功能關係，以及蛋白質-蛋白質，蛋白質-核酸，蛋白質-配基相互作用,結構基因組學研究中適於高通量結構測定以及代謝組學中的核磁共振方法學研究。

代表論著

  1. Aiai Sun, Fudong Li, Zhonghua Liu, Yiyang Jiang, Jiahai Zhang, Jihui Wu, Yunyu Shi#.Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4.Protein Cell(2018) 9(8):738-742.[Full Text].
  2. Difei Xu, Rongsheng Ma, Jiahai Zhang, ... , Yunyu Shi, Jihui Wu, Qiang Wu, Zhiyong Zhang#, Ke Ruan#.Dynamic Nature of CTCF Tandem 11 Zinc Fingers in Multivalent Recognition of DNA As Revealed by NMR Spectroscopy.J. Phys. Chem Lett.(2018) 9(14):4020-4028.[Full Text].
  3. Xiaoling Bao, Heng Liu, Xing Liu, … , Jihui Wu#, Yunyu Shi#.Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.J. Mol. Cell Biol.(2018) 10(1):18-32.[Full Text].
  4. Xiaoling Bao, Heng Liu, Xing Liu,..., Xuebiao Yao#, Jihui Wu#, Yunyu Shi#Mitosis-specific acetylation tunes Ran effector binding for chromosome segregationJ. Mol. Cell Biol.(2017)[Full Text].
  5. Bin Wen, Weiwei Wang, Jiahai Zhang, Qingguo Gong, Yunyu Shi, Jihui Wu# and Zhiyong Zhang#.Structural and dynamic properties of the C-terminal region of the Escherichia coli RNA chaperone Hfq: integrative experimental and computational studies.Phys. Chem. Chem. Phys.(2017) 19:21152-21164.[Full Text].
  6. Yiyang Jiang, Fudong Li, Jihui Wu, Yunyu Shi, Qingguo Gong#Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCDPlos One(2017)[Full Text].
  7. Hongyu Bao, Na Wang, Chongyuan Wang,..., Jihui Wu#, Yunyu Shi#Structural basis for the specific recognition of 18S rRNA by APUM23Nucleic Acids Research(2017) 45(20):12005-12014[Full Text].
  8. Lingna Yang, Chongyuan Wang, Fudong Li,...,Jihui Wu, Yunyu Shi, Qingguo Gong#The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3–recognition element (MRE) motif with high affinity.J. Biol. Chem.(2017) 292:16221-16234[Full Text].
  9. Aiai Sun, Fudong Li, Zhonghua Liu, Yiyang Jiang, Jiahai Zhang, Jihui Wu#, Yunyu Shi#Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4Protein&Cell(2017).[Full Text].
  10. Ling Xu, Lijun Wang, Junhui Peng,...,Jihui Wu, Yajun Tang#, Yunyu Shi#Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions.Structure(2017) 25(12):1795-1808[Full Text].
  11. Pengzhi Wu, Xiaodan Liu, Lingna Yang, Yitong Sun, Qingguo Gong, Jihui Wu#, Yunyu Shi#The important conformational plasticity of DsrA sRNA for adapting multiple target regulation .Nucleic Acids Research(2017) 45(16):9625-9639[Full Text].
  12. Li Xu*, Aimin Cheng*, Min Huang,..., Jihui Wu, Catherine C. L., Ke Ruan#.Structural insight into the recognition of acetylated histone H3K56ac mediated by the bromodomain of CREB-binding protein.The FEBS journal(2017) 284(20):3422-3436.[Full Text].
  13. Jia Gao, E. Liang, Rongsheng Ma,..., Jihui Wu, Xuncheng Su, Wei He, Ke Ruan#Fluorine Pseudocontact Shifts Used for Characterizing the Protein–Ligand Interaction Mode in the Limit of NMR Intermediate ExchangeAngew. Chemie Int. Ed.(2017) 129(42):13162-13166[Full Text].
  14. J Liu, F Li, H Bao, Y Jiang, S Zhang, R Ma, J Gao, J Wu, K Ruan#.The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water‐mediated interaction network.The FEBS journal(2017) 284(7):1082-1095.[Full Text].
  15. J Liu, J Gao, F Li, R Ma, Q Wei, A Wang, J Wu, K Ruan#.NMR characterization of weak interactions between RhoGDI2 and fragment screening hits.BBA-General Subjects(2017) 1861(1):3061-3070.[Full Text].
  16. Qingtao Wei, Jiajing Chen, Juan Mi, Jiahai Zhang, Ke Ruan,* andJihui Wu*, NMR Backbone Assignment of Large Proteins by Using 13Ca-Only Triple-Resonance Experiments.Chem. Eur. J.(2016) 22, 9556-9564
  17. HongyuBao, FudongLi, ChongyuanWang, NaWang, YiyangJiang, YajunTang,JihuiWu*, and YunyuShi*，Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3.Journal of Biological Chemistry(2016) 291(32),16709-16719
  18. Zhonghua Liu, Fudong Li, Beibei Zhang, Sai Li,Jihui Wu# and Yunyu Shi#, Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex.Journal of Biological Chemistry(2015) 290:6630-6638
  19. Chongyuan Wang, Yuwei Zhu, Hongyu Bao, Yiyang Jiang, Chao Xu,Jihui Wu* and Yunyu Shi*, A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1.Nucleic Acids Research(2015) 44(2): 969-982
  20. Fudong Li, Debiao Zhao,Jihui Wu, Yunyu Shi. Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition.Cell Research(2014) 24:1490-1492
  21. ChongyuanWang, YuweiZhu, TamarB.Caceres, LeiLiu, JunhuiPeng, JunchenWang, JiajingChen, XuwenChen, Zhiyong Zhang, Xiaobing Zuo, Qingguo Gong, Maikun Teng, Joan M. Hevel,Jihui Wuand Yunyu Shi. Structural Determinants for the Strict Monomethylation Activity by Trypanosoma brucei Protein Arginine Methyltransferase 7.Structure(2014)22,756–768,May 6, 2014
  22. He Chao, Li Fudong, Zhang Jiahai,Wu Jihui, Shi Yunyu. Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 Recognition.J Biol Chem, 2013,288(7):4692-703
  23. Yu Qiu, Lei Liu, Chen Zhao, Chuanchun Han, Fudong Li, Jiahai Zhang, Yan Wang, Guohong Li, Yide Mei, Mian Wu,Jihui Wu, and Yunyu Shi. Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription.Genes & Development(2012)26:1376-1391
  24. Jie Wen, Pei Zhou,Jihui Wu. Efficient acquisition of high-resolution 4-D diagonal-suppressed methyl-methyl NOESY for large proteins.Journal of Magnetic Resonance(2012)218:128-132
  25. Yu QIU, Wen ZHANG, Chen ZHAO, Yan WANG, Weiwei WANG, Jiahai ZHANG, Zhiyong ZHANG, Guohong LI, Yunyu SHI, Xiaoming TU andJihui WU.Solution structure of the Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA.Biochem.J.(2012)442,527-538
  26. Jiangxin Liu, Jiahai Zhang, Yinshan Yang, Hongda Huang, Weiqun Shen, Qi Hu, Xingsheng Wang,Jihui Wu, and Yunyu Shi. Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor. Protein Science. (2008)
  27. Xiaogang Niu, Quan Chen, Jiahai Zhang, Weiqun Shen, Yunyu Shi, and Jihui Wu, Interesting Structural and Dynamical Behaviors Exhibited by the AF-6 PDZ Domain upon Bcr Peptide Binding. Biochemistry (2007)
  28. Dandan Wang, Jiahai Zhang, Xianju Jin, Jihui Wu, and Yunyu Shi, Investigation of the Structural Stability of hUBF HMG Box 5 by Native-State Hydrogen Exchange, Biochemistry (2007)
  29. Li, X., Zhang, J. H., Cao, Z. X.,Wu, J. H. and Shi, Y. Y., Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin, Protein Science (2006)
  30. Heyue Zhou, Yingqi Xu, Anding Huang, Jihui Wu, Yunyu Shi, Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from neurexin and Bcr,J Biol Chem. (2005) 280(14)
  31. Jihui Wu, Jing-song Fan, Steven M. Pascal, and Daiwen Yang, General Method for Suppression of Diagonal Peaks in Heteronuclear-Edited NOESY Spectroscopy, J. AM. CHEM. SOC. (2004)

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