任哲，四川大學，理學博士，暨南大學副研究員，碩士生導師。
廣東省生物物理學會理事，廣東省藥學會生物工程製藥專委會專家組副組長。
主要從事基因工程蛋白藥物，天然藥物抗病毒、抗腫瘤篩選，溶瘤病毒的構建以及基因敲除病毒減毒疫苗的研究，承擔國家級重大科研項目一項（十二五“863”項目），承擔省級科研項目六項（國家中醫藥管理局重點實驗室開放基金；廣東省醫學科研基金；廣東省教育部產學研引導項目；廣州市科技型中小企業技術創新基金項目；廣州市科技重點攻關項目、廣東省科技計畫項目）；作為核心成員參與國家級重大科研項目三項（國家自然科學基金和廣東聯合基金1項；國家自然科學基金2項）。獲得發明專利授權2項，發明專利公開8項；發表論文40餘篇，其中SCI論文13篇。
基本介紹
- 中文名：任哲
- 職業：教師
- 畢業院校：四川大學
- 學位/學歷：理學博士
- 專業方向：基因工程藥物/疫苗；抗病毒、抗腫瘤藥物研發
- 職務：暨南大學碩士生導師
人物經歷,學習經歷,工作經歷,研究方向,學術成果,主要論文,承擔課題,講授課程,
人物經歷
學習經歷
1990—1994 河南中醫學院 醫學學士
1997—2000 華南理工大學 工學碩士
2004—2007 四川大學 理學博士
工作經歷
1994—2008 鄭州大學第一附屬醫院
2008—2010 暨南大學 博士後
2010—至今 暨南大學
研究方向
基因工程藥物/疫苗；抗病毒、抗腫瘤藥物研發.
學術成果
主要論文
(1)Ren Z,Li S,Wang Q.L,Xiang Y.F,Cui Y.X,Wang Y.F,Qi R.B,Lu D.X,Zhang S.M, andZhang P.Z.Effect of siRNAs on HSV-1 plaque formation and relative expression levels of RR mRNA.Virologica sinica, 2011,26(1):40-46
(2)Ren Z, zhang C.H, Wang L.J, CuiY.X, Qi R.B,Yang C.R, Zhang Y.J,Wei X.Y, Lu D.X,Wang YF. In Vitro Anti-viral Activity of the Total Alkaloids from Tripterygium Hypoglaucum against Herpes Simplex Virus Type 1. Virologica Sinica, 2010,25(2)：107-114
(3)Ren Z, Zhang M.Y, Kitazato K, Kobayash N, Zhu Q.C, Zhang P.Z, Yang Z.R, Wang Y.F. Effect of siRNA on HSV-1 plaque formation and relative expression levels of UL39 mRNA[J]. Arch Virol, 2008,153(7): 1401-1406.
(4)LuoFan;LiuJunwei;WangYifei;XuMingfang;Ren Zhe*.PGG impairs herpes simplex virus type 1infection via blocking capsid assembly.Future Virol.2017, 13(7):
(5)LuoFan; Xu Mingfang;Wang Yifei,Ren Zhe*.Development of a Markerless Gene Deletion System for HSV-1. International Journal of Science and Research (IJSR), 2017, 6(6): 2414-2425
(6)Fang S.N;Wang Q.L;Wang L;LuoF;LiuJ.W;JinJ;JinL;RenZ*;WangY.F. HSV-UL18 DNA vaccine construction and immunodetection. J Med Oncl Ther. 2017,2(1):27-33
(7)Jin, Fujun; Zhao, Hongwei; Yuan, Xiao; Zou, Shiyu; Wang, Qiaoli; Ma, Chungwah;Ren, Zhe*; Wang, Yifei*. In vitro Protective Effect of Ganoderol A Isolated from Ganadermalucidum Against Ultraviolet A Radiation and its Anti-inflammatory Properties.TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH,2015,14(3):415-421
(8)Jin,Fujun;Li,Shen;Zheng, Kai;Zhuo,Cuiqin;Ma, Kaiqi;Chen, Maoyun;Wang,Qiaoli;Zhang,Peizhuo;Fan, Jianglin;Ren, Zhe*;Wang,Yifei*. Silencing Herpes Simplex Virus Type 1 Capsid Protein Encoding Genes by siRNA: A Promising Antiviral Therapeutic Approach. PLoS ONE；2014，9(5): e96623.
(9)Jin,FuJun;Zhao,Hong-Wei;Yuan,Xiao;Wu,Zhi-Yun;Wang,Qiao-Li;Ma,Chung-Wah;Ren,Zhe*;Wang,Yi-Fei*.Protective Effects of Forsythiaside A, Forsythiaside B, and Phillyrin against UVA-Induced Cell Damage. Journal of Food and Nutrition Research；2014,2(9):587-593.
(10)Wu, Yanting; Jin, Fujun; Wang, Yiliang; Li, Feng; Wang, Lu; Wang, Qiaoli;Ren, Zhe; Wang, Yifei,In vitro and in vivo anti-inflammatory effects of theaflavin-3,3 '-digallate on lipopolysaccharide-induced inflammation, EUROPEAN JOURNAL OF PHARMACOLOGY, 2017,794:52-60
(11)Wu, Yanting; Jin, Fujun; Wang, Yiliang; Li, Feng;Ren, Zhe; Wang, Yifei,In vitro and in vivo inhibitory effects of 6-hydroxyrubiadin on lipopolysaccharide-induced inflammation, IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY,2017,39(3):107-116
(12)Zhuo, Cuiqin; Zheng, Danlin; He, Zhe; Jin, Ju;Ren, Zhe; Jin, Fujun; Wang, Yifei,HSV-1 enhances the energy metabolism of human umbilical cord mesenchymal stem cells to promote virus infection, FUTURE VIROLOGY,2017,12(7):349-360
(13)Wu, Chaoxi; Chen, Tian; Xin, Yanjiao; Zhang, Zhen;Ren, Zhe; Lei, Jing; Chu, Bin; Wang, Yifei; *Tang, Shunqing,Nanofibrous asymmetric membranes self-organized from chemically heterogeneous electrospun mats for skin tissue engineering, Biomedical Materials,2016,11(3):
(14)Zhang, Yi，Zhou, Shu-Yan，Yan, Hai-Zhao，Xu, Dan-Dan，Chen,(#)Hai-Xuan，Wang, Xiao-Yan，Wang, Xiao，Liu, Yu-Ting，Zhang, Li，Wang,Sheng，Zhou, Peng-Jun，Fu, Wu-Yu，Ruan, Bi-Bo，Ma, Dong-Lei，Wang, Ying，Liu,Qiu-Ying，Ren, Zhe，Liu, Zhong，Zhang, Rong，Wang, Yi-Fei，miR-203 inhibits proliferation and self-renewal of leukemia stem cells by targeting survivin and Bmi-1.，Scientific Reports，2016，6：19995-19995。
(15)Xu, Dan-dan; Zhou, Peng-jun; Wang, Ying; Zhang, Li; Fu, Wu-yu; Ruan, Bi-bo; Xu, Hai-peng; Hu, Chao-zhi; Tian, Lu; Qin, Jin-hong; Wang, Sheng; Wang, Xiao; Li, Yi-cheng; Liu, Qiu-ying;Zhe Ren;Rong Zhang;WangYi-fei.Reciprocal activation between STAT3 and miR-181b regulates the proliferation of esophageal cancer stem-like cells via the CYLD pathway, Molecular Cancer, 2016,15:
(16)Ma, Kaiqi; Jin, Fujun; Wang, Qiaoli;Ren, Zhe; Zheng, Kai; Wang, Yifei. siRNAs Targeting Viral Protein 5:The Major Capsid Protein of Herpes Simplex Virus-1 Affects its Propagation and Cytoskeleton. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH;2015,14(3):391-397
(17)Zheng, Kai; Xiang, Yangfei; Wang, Qiaoli; Jin, Fujun; Chen, Maoyun; Ma, Kaiqi;Ren, Zhe; Wang, Yifei. Calcium-signal facilitates herpes simplex virus type 1 nuclear transport through slingshot 1 and calpain-1 activation. VIRUS RESEARCH; 2014,188:32-37
(18)Xiang, Yangfei; Zheng, Kai; Zhong, Meigong; Chen, Jia; Wang, Xiao; Wang, Qiaoli; Wang, Shaoxiang;Ren, Zhe; Fan, Jianglin; Wang, Yifei. Ubiquitin-proteasome-dependent slingshot 1 downregulation in neuronal cells inactivates cofilin to facilitate HSV-1 replication. VIROLOGY; 2014,449:88-95
(19)Yangfei Xiang, Kai Zheng, Huaiqiang Ju, Shaoxiang Wang, Ying Pei, Weichao Ding, Zhenping Chen, Qiaoli Wang, Xianxiu Qiu, Meigong Zhong, Fanli Zeng,Zhe Ren, Chuiwen Qian, Ge Liu, Kaio Kitazato and Yifei Wang. Cofilin 1-Mediated Biphasic F-Actin Dynamics of Neuronal Cells Affect Herpes Simplex Virus 1 Infection and Replication. J. Virol. 2012, 86(16):8440-8451.
(20)Xiaoyan Wang，Yafeng Wang，Zhe Ren，Chuiwen Qian，Yicheng Li，Qingduan Wang，Yan Zhang，Liyun Zheng，Jinhua Jiang，Chongren Yang，Dong Wang，Yingjun Zhang，Jianglin Fan，Yifei Wang. Protective Effects of 20(S)-Protopanaxtriol on Viral Myocarditis Infected by Coxsackievirus B3. Pathobiology. 2012,79:285–289
(21)Xiuping Lin , Xuefeng Zhou , Fazuo Wang , Kaisheng Liu , Bin Yang , Xianwen Yang ,Yan Peng , Juan Liu ,Zhe Renand Yonghong Liu. A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp. F00120 Isolated from a Deep Sea Sediment Sample Mar. Drugs 2012, 10, 106-115
(22)Xiang Y, Pei Y, Qu C, Lai Z,Ren Z, Yang K, Xiong S, Zhang Y, Yang C, Wang D, Liu Q, Kitazato K & Wang Y. In vitro Anti-Herpes Simplex Virus Activity of 1,2,4,6-Tetra-O-galloyl-beta-d-glucose from Phyllanthus emblica L. (Euphorbiaceae). Phytother Res, 2011，25（7）：975-982.
(23)Ju HQ, Xiang YF, Xin BJ, Pei Y, Lu JX, Wang QL, Xia M, Qian CW,Ren Z, Wang SY, Wang YF & Xing GW. Synthesis and in vitro anti-HSV-1 activity of a novel Hsp90 inhibitor BJ-B11. Bioorg Med Chem Lett , 2011，21：1675-1677.
(24)Pei Y,Xiang Y.F,Chen J.N,Lu C.H,Hao J,Du Q,Lai C.C,Qu C,Li S,Ju H.Q,Ren Z,Liu Q.Y,Xiong S,Qian C.W,Zeng F.L,Zhang P.Z,Yang C.R,Zhang Y.J,Xu J,Kitazato K,Wang Y.F. Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection.Antiviral Res.2011,89(1):98-108
承擔課題
1.廣東省科技計畫項目，2016A040402033 ，化妝品原料及成品的安全和功效性體外檢測評價技術服務平台的建設主持
2.國家十二五“863”重大課題，2012AA02A405-6，單純皰疹病毒基因敲除活疫苗研製主持
3.廣東省教育部產學研結合項目，2011B090400429，人幹細胞生長因子生產及其在醫學美容方向的套用研究主持
4.廣州市科技重大專項，2011Y1-00038-2，重組人幹細胞生長因子的中試研究主持
5. 國家自然科學基金面上項目，81573471，新型Hsp90抑制劑阻礙HSV-1組裝與釋放的分子機制研究參與
6. 國家自然科學基金面上項目，81274170，中藥余甘子活性成分PGG抗單純皰疹病毒I型的作用機制研究參與
7.國家自然科學基金廣東聯合基金，U0632010，南藥的抗病毒活性成分研究參與
講授課程
《基因工程》，《高級生物化學》，《細胞信號轉導理論與技術》
