《pallavicinins和pallambins的手性全合成研究》是賈彥興為項目負責人，北京大學為依託單位的面上項目。
基本介紹
- 中文名：pallavicinins和pallambins的手性全合成研究
- 項目類別：面上項目
- 項目負責人 ：賈彥興
- 依託單位 ：北京大學
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | Ergot alkaloids: synthetic approaches to lysergic acid and clavine alkaloids | 期刊論文 | Haichao Liu; Yanxing Jia(*) |
2 | Total Syntheses of Naucleamides A-C and E, Geissoschizine, Geissoschizol, (E)-Isositsirikine, and 16-epi-(E)-Isositsirikine | 期刊論文 | Li, Lei; Aibibula, Paruke; Jia, Qianlan; Jia, Yanxing(*) |
3 | A Simple and Efficient Synthesis of Secondary Alkylamines from Nitroalkanes | 期刊論文 | Zhi Huang; Jianbo Lv; Yanxing Jia(*) |
4 | A concise gram-scale synthesis of ht-13-A via a rhodium-catalyzed intramolecular C–H activation reaction | 期刊論文 | Pengyu Tao; Zhuang Chen; Yanxing Jia(*) |
5 | C–H bond activation in the total syntheses of natural products | 期刊論文 | Pengyu Tao; Yanxing Jia(*) |
6 | Eight-Step Total Synthesis of Phalarine by Bioinspired Oxidative Coupling of Indole and Phenol | 期刊論文 | Lei Li; Kuo Yuan; Qianlan Jia; Yanxing Jia(*) |
7 | Gram Scale Syntheses of (−)-Incarvillateine and Its Analogs. Discovery of Potent Analgesics for Neuropathic Pain | 期刊論文 | Bin Huang(#); Fengying Zhang(#); Gang Yu(#); Yan Song; Xintong Wang; Meiliang Wang; Zehui Gong; Ruibin Su; Yanxing Jia(*) |
8 | Enantioselective Total Syntheses of Pallambins A–D | 期刊論文 | Xiwu Zhang; Xinxian Cai; Bin Huang; Lei Guo; Zhongrun Gao; Yanxing Jia(*) |
9 | Asymmetric total synthesis of 3-epi-naucleamide A | 期刊論文 | Paruke Aibibula; Zhi Huang; Hongzheng Fu(*); Yanxing Jia(*) |
10 | Divergent Strategy in Natural Product Total Synthesis | 期刊論文 | Lei Li; Zhuang Chen; Xiwu Zhang; Yanxing Jia(*) |
11 | Protecting-Group-Free Enantioselective Synthesis of (-)-Pallavicinin and (+)-Neopallavicinin | 期刊論文 | Bin Huang; Lei Guo; Yanxing Jia(*) |
12 | ATen-Step Total Synthesis of Speradine C | 期刊論文 | Haichao Liu(#); Lijun Chen(#); Kuo Yuan; Yanxing Jia(*) |
13 | Synthetic approaches to natural products containing 2,3-dihydrobenzofuran skeleton | 期刊論文 | Zhuang Chen; Mallesham Pitchakuntla; Yanxing Jia(*) |
14 | 第四屆中國藥學會-以嶺生物醫藥創新獎 | 科研獎勵 | 賈彥興 |
15 | 3,4-橋環吲哚類生物鹼的合成進展 | 期刊論文 | 袁括; 賈彥興(*) |
16 | Type-II Pauson-Khand reaction of 1,8-enyne in the attempt of building 7/5 ring of (-)-caribenol A and DFT understanding | 期刊論文 | Yang Wang; Kang Liu; Zhi-Xiang Yu(*); Yanxing Jia(*) |
17 | Total Syntheses of Festuclavine, Pyroclavine, Costaclavine, epi-Costaclavine, Pibocin A, 9-Deacetoxyfumigaclavine C, Fumigaclavine G, and Dihydrosetoclavine | 期刊論文 | Liu, Haichao; Zhang, Xiwu; Shan, Dong; Pitchakuntla, Mallesham; Ma, Yongfan; Jia, Yanxing(*) |
18 | A palladium-catalyzed intramolecular carbonylative annulation reaction for the synthesis of 4,5-fused tricyclic 2-quinolones | 期刊論文 | Xiwu Zhang(#); Haichao Liu(#); Yanxing Jia(*) |
項目摘要
當前，追求天然產物的高效全合成是有機化學的前沿研究領域。無保護基全合成也是實現理想合成的重要策略之一。二萜類天然產物pallavicinins和pallambins是一種具有新穎梯形結構的多環多手性中心複雜化合物，目前僅有一例消旋全合成報導，且路線較為冗長，並涉及大量保護基的使用。有鑒於此，本項目擬以鈀催化的不對稱脫羧烯丙基化反應、選擇性氧化雙鍵、及串聯的選擇性加成/麥可加成等作為關鍵步驟，高效完成天然產物pallavicinins和pallambins的首次不對稱全合成，並力爭不使用任何保護基。本課題的開展對豐富無保護基法天然產物全合成具有重要的學術意義。
