黨雲琨

黨雲琨，男，雲南大學生命科學中心研究員。

基本介紹

  • 中文名：黨雲琨
  • 國籍：中國
  • 畢業院校：加拿大University of British Columbia
  • 學位/學歷：博士
人物經歷,研究方向,主要論文,

人物經歷

1995.9-1999.6，中國農業大學理學學士學位
1999.9-2002.7，中國農業大學理學碩士學位
2003.9-2009.12，加拿大University of British Columbia博士學位
2010.4-2017.9，美國University of Texas Southwestern Medical Center，博士後、講師
2017.10-，雲南大學生命科學中心，研究員

研究方向

結合生物信息學和生化分子生物學，研究表觀遺傳和轉錄調控，專注於下列兩個方面問題：
1，DNA甲基化等表觀遺傳修飾的發生和調控機制，以及在發育和疾病中起著關鍵的作用。
2，密碼子偏好性對於基因在轉錄和翻譯層面的調控，為同義突變引起的疾病提供理論基礎。

主要論文

  1. Zhipeng Zhou#, Yunkun Dang#*, Mian Zhou, Haiyan Yuan, Yi Liu*, Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation. ELife (2018) 7:e33569
  2. Xiao Liu,Yunkun Dang, Toru Matsu-ura, Yubo He, Qun He, Christian I. Hong, Yi Liu, DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition. Molecular Cell (2017) 67:1-11
  3. Yunkun Dang#, Jiasen Cheng# , Xianyun Sun, Zhipeng Zhou, Yi Liu. Antisense transcription licenses nascent transcripts to be recognized by ERI-1 to mediate transcriptional gene silencing. Genes & Development, (2016) 30:2417-32.
  4. Zhipeng Zhou#, Yunkun Dang#, Mian Zhou, Lin Li, Chien-Hung Yu, Jingjing Fu, She Chen, and Yi Liu. Codon Usage is an Important Determinant of Gene Expression Levels Largely Through its Effects on Transcription. PNAS (2016) E6117-E6125.
  5. Chien-hung Yu#, Yunkun Dang#, Zhipeng Zhou#, Cheng Wu, Fangzhou Zhao, Matthew S. Sashs, Yi Liu. Codon Usage Influences the Local Rate of Translation Elongation to Regulate Co-translational Protein Folding. Molecular Cell (2015) 59:744-54（封面文章，Trend Biochem Sci (2015) 40:717-8專評）
  6. Yunkun Dang, Liande Li, Wei Guo, Zhihong Xue, Yi Liu. Convergent transcription induces dynamic DNA methylation at disiRNA loci. PLoS Genetics (2013) 9(9): e1003761
  7. Chang Ying Teng, Yunkun Dang, Jillian C. Danne, Ross F. Waller, Beverley R. Green. Genes of Dinoflagellates Are Transcribed by a Nuclear-Encoded Single-Subunit RNA Polymerase. PLoS One (2013) DOI: 10.1371/journal.pone.0065387
  8. Yunkun Dang, Qiuying Yang, Zhihong Xue, Yi Liu. RNA interference in fungi: pathways, functions, and applications. Eukaryotic Cell (2011) 10: 1148-1155
  9. Yunkun Dang, Beverley R. Green, Long transcripts from dinoflagellate chloroplast minicircles suggest "rolling circle" transcription. Journal of Biological Chemistry (2010) 285: 5196-5203.
    #共同第一作者；*通訊作者

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