黃贊(武漢大學生命科學學院教授)

教育經歷：
1990/09-1994/07，武漢大學學士
1994/09-1998/07，武漢大學碩士
2001/08-2006/05，Loyola University Chicago 博士
2006/01-2006/12，美國芝加哥大學腫瘤研究所博士後
2007/01-2010/02，美國西北大學醫學院博士後

工作經歷：
1998/08-2001/01 上海市兒童醫院研究助理
2001 Loyola University Chicago 研究助理
2010/03-至今：武漢大學生命科學學院教授、博士生導師

人才計畫：

教育部“新世紀優秀人才支持計畫”

湖北省楚天學者"楚天學子"

社會兼職：
美國血液學學會
亞太生物醫學免疫學學會常務理事
中國細胞生物學學會
中國生理學學會

主要研究領域及興趣：
實驗室致力於探索造血、血液腫瘤以及肝臟代謝疾病發生的分子基礎，主要研究內容有：
1）巨核細胞生成、骨髓增殖性腫瘤和急性髓系白血病發生機制：研究巨核細胞發育分化中的信號轉導、轉錄調控、表觀遺傳調控機制；探索骨髓增殖性腫瘤（原發性骨髓纖維化）發生的分子基礎和靶向干預；鑑定急性白血病細胞增殖、存活和惡變的關鍵因素和新生物學標誌物。
2）肝臟代謝病變發生機理：闡釋非酒精性肝臟脂肪變性、非酒精性脂肪肝炎、肝硬化到肝癌演化的分子機制；揭示肝臟缺血/再灌注損傷發生的決定性因素；特別關注天然免疫、泛素化/去泛素參與代謝調控從而影響此類疾病發生的分子機理。

教學課程：
1、生物化學（本科）
2、造血細胞發育與分化（研究生）
主持課題項目：
1.自然科學青年基金（2008-2010）
2.自然科學基金面上項目（2011-2013）
3.自然科學基金面上項目（2014-2017）
4.自然科學基金面上項目（2017-2020）
5.教育部博士點基金（2012-2014）
6.教育部“新世紀優秀人才支持計畫”（2013-2015）

代表性論文：
1.Yang X, Lu B, Sun X, Han C, Fu C, Xu K, Wang M, Li D, Chen Z, Opal P, Wen Q, Crispino JD, Wang QF# &Huang Z#. ANP32A regulates histone H3 acetylation and promotes leukemogenesis.Leukemia. 2018;doi:10.1038/s41375-018-0010-7.
2. Ji YX*,Huang Z*, Yang X*, Wang X*, Zhao LP, Wang PX, Zhang XJ, Alves-Bezerra M, Cai L, Zhang P, Lu YX, Bai L, Gao MM, Zhao H, Tian S, Wang Y, Huang ZX, Zhu XY, Zhang Y, Gong J, She ZG, Li F, Cohen DE & Li H. The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Nat Med. 2018.
3. Yan FJ, Zhang XJ, Wang WX, Ji YX, Wang PX, Yang Y, Gong J, Shen LJ, Zhu XY,Huang Z# & Li H#. The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis.Hepatology. 2017;65(5):1492-1511.
4. Wang X, Mao W, Fang C, Tian S, Zhu X, Yang L,Huang Z# & Li H#. Dusp14 protects against hepatic ischaemia-reperfusion injury via Tak1 suppression.J Hepatol. 2017.
5. Lu B, Ren Y, Sun X, Han C, Wang H, Chen Y, Peng Q, Cheng Y, Cheng X, Zhu Q, Li W, Li HL, Du HN, Zhong B#,Huang Z#. Induction of INKIT by Viral Infection Negatively Regulates Antiviral Responses through Inhibiting Phosphorylation of p65 and IRF3.Cell Host Microbe. 2017;22(1):86-98 e84.
6. Yan FJ, Zhang XJ, Wang WX, Ji YX, Wang PX, Yang Y, Gong J, Shen LJ, Zhu XY,Huang Z#, Li H#. The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis.Hepatology. 2017;65(5):1492-1511.
7. Wang PX, Ji YX, Zhang XJ, Zhao LP, Yan ZZ, Zhang P, Shen LJ, Yang X, Fang J, Tian S, Zhu XY, Gong J, Zhang X, Wei QF, Wang Y, Li J, Wan L, Xie Q, She ZG, Wang Z,Huang Z, Li H. Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates.Nat Med. 2017;23(4):439-449.
8. Jin Q, Ren Y, Wang M, Suraneni PK, Li D, Crispino JD, Fan J#,Huang Z#. Novel function of FAXDC2 in megakaryopoiesis.Blood Cancer J. 2016;6(9):e478.
9. Lu B, Sun X, Chen Y, Jin Q, Liang Q, Liu S, Li Y, Zhou Y, Li W,Huang Z#. Novel function of PITH domain-containing 1 as an activator of internal ribosomal entry site to enhance RUNX1 expression and promote megakaryocyte differentiation.Cellular and Molecular Life Sciences: CMLS. 2015. 72(4): 821-832
10. Lin Y, Li D, Liang Q, Liu S, Zuo X, Li L, Sun X, Li W, Guo M,Huang Z#. miR-638 Regulates Differentiation and Proliferation in Leukemic Cells by Targeting Cyclin-dependent Kinase 2.J Biol Chem. 2015. 290(3): 1818-1828
11. Sun X, Lu B, Hu B, Xiao W, Li W,Huang Z#. Novel function of the chromosome 7 open reading frame 41 gene to promote leukemic megakaryocyte differentiation by modulating TPA-induced signaling.Blood Cancer J.2014. 4: e198
12. Liu L, Wen Q, Gong R, Gilles L, Stankiewicz MJ, Li W, Guo M, Li L, Sun X, Crispino JD,Huang Z#. PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN.Cell Death & Disease. 2014. 5: e988
13. Wang W, Cai J, Wu Y, Hu L, Chen Z, Hu J, Li W, Guo M,Huang Z#. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.Cellular and Molecular Life Sciences: CMLS.2013. 70(20): 3947-3958
14. Khan I*,Huang Z*, Wen Q, Stankiewicz MJ, Gilles L, Goldenson B, Schultz R, Diebold L, Gurbuxani S, Finke CM, Lasho TL, Koppikar P, Pardanani A, Stein B, Altman JK, Levine RL, Tefferi A, Crispino JD. AKT is a therapeutic target in myeloproliferative neoplasms.Leukemia.2013. 27(9): 1882-1890
15. Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V,Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Goldberg L, Birger Y, Izraeli S, Gamis AS, Smith FO, Woods WG, Taub J, Scherer CA, Bradner JE, Goh BC, Mercher T, Carpenter AE, Gould RJ, Clemons PA, Carr SA, Root DE, Schreiber SL, Stern AM, Crispino JD. Identification of Regulators of Polyploidization Presents Therapeutic Targets for Treatment of AMKL.Cell.2012. 150(3): 575-589
16. Wang W, Guo M, Hu L, Cai J, Zeng Y, Luo J, Shu Z, Li W#,Huang Z#. The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-kappaB signaling.J Biol Chem.2012. 287(51): 42856-42866
17.Huang Z, Dore LC, Li Z, Orkin SH, Feng G, Lin S, Crispino JD. GATA-2 reinforces megakaryocyte development in the absence of GATA-1.Mol Cell Biol. 2009;29(18):5168-5180.
18.Huang Z, Richmond TD, Muntean AG, Barber DL, Weiss MJ, Crispino JD. STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice.J Clin Invest. 2007;117(12):3890-3899.
專利：
John D. Crispino，Qiang Wen，Zan Huang，Andrew M. Robert J. Stern，Dimethyl fasudil for inducing polyploidization of megakaryocytes and for treating blood and bone marrow diseases and disorders，Issue Date: January 13, 2015, United States，8933071。

黃贊(武漢大學生命科學學院教授)

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