黃艷新

黃艷新，男 ，畢業於吉林大學，東北師範大學生命科學學院教授、博士生導師。技術方向：①細胞生物信息學(免疫信息學)和系統生物學；②計算機輔助藥物分子設計。

基本介紹

• 中文名：黃艷新
• 民族：漢族
• 職業：東北師範大學教授
• 畢業院校：吉林大學

基本信息

1989年本科畢業於北京理工大學套用數學專業，計算機套用技術專業碩士、博士，細胞生物學專業博士後出站。目前主要從事生物信息學和系統生物學的理論和套用研究，主要研究內容包括抗腫瘤和抗糖尿病藥物分子計算機輔助篩選和實驗驗證，以及基於組學技術和計算系統生物學分析的藥物分子作用機制研究。承擔本科生《生物信息學》課程的教學工作。承擔完成國家、省部和市級科研項目十餘項。在國際、國內重要學術期刊發表論文40餘篇，獲省部級科技進步一等獎一項。

學習簡歷

1985.9-1989.7 北京理工大學套用數學系套用數學專業 本科生
1996.9-1999.3 長春理工大學計算機學院計算機套用專業 碩士研究生
2001.9-2004.12 吉林大學計算機科學與技術學院計算機套用技術專業 博士研究生

工作簡歷

1989.7-1996.8 長春第一汽車製造廠 助理工程師
1993.3-1994.5 日本共和電腦株式會社、日本富士通株式會社 工作、研修
1999.3-2009.4 吉林大學計算機科學與技術學院 講師、副教授
2006.12-2008.12 東北師範大學遺傳與細胞研究所 博士後
2009.4至今 東北師範大學生命科學學院 藥物基因和蛋白篩選國家工程實驗室 副教授、教授

研究方向

研究目標：抗腫瘤和抗糖尿病藥物分子篩選及其細胞作用機制研究。
招生意向：招收生物學、生物信息學、理論化學、藥物化學、數學和計算機科學等專業背景，以計算和生物學實驗相結合進行科學研究的碩士、博士研究生（最好能碩博連讀）。同時歡迎其它院校以上學科背景的保送研究生和調劑研究生。

科研項目

[1]藥物計算與實驗篩選產學研聯盟科技創新攻關平台. 長春市科技計畫項目（12ZX55）. 2013.12—2015.12. 項目負責人(在研).
[2]通過基因晶片數據分析與系統生物學建模方法識別誘導癌細胞凋亡藥物靶標. 省科技廳自然科學基金項目（20130101148JC）. 2013.1—2015.12. 項目負責人(在研).
[3]細胞凋亡信號轉導網路多尺度建模及其在新抗腫瘤藥物靶標識別方面的套用研究. 國家自然科學基金項目（61172183）. 2012.1-2015.12. 項目負責人(在研).
[4]基於藥效團和定量構效關係模型的計算機虛擬篩選平台. 吉林省中醫藥管理局資助項目(2011-zd16). 2011.12—2012.12. 項目負責人(結題).
[5]中藥有效成分和藥物分子作用靶標的計算機虛擬篩選. 吉林省中醫藥管理局資助項目(2010pt067). 2010.12—2011.12. 項目負責人(結題).
[6]細胞凋亡信號轉導網路的計算建模研究(20101503)，省科技廳自然科學基金項目，2010.1～2012.12, 項目負責人(結題).
[7]基於噬菌體展示庫的B細胞構象性表位預測算法及其套用研究(20080431048)，中國博士後科學基金項目，2006.12～2008.12, 項目負責人(結題).
[8]機器味覺識別研究，吉林大學青年教師科研基金，2002.12-2004.12, 項目負責人(結題).

研究成果

2013年

[1]Wang HY, Huang YX*, Qi YF, Zhang Y, Bao YL, Sun LG, Zheng LH, Zhang YW, Ma ZQ*, Li YX*. Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis. Theor Biol Med Model. 2013; 10(1): 27.
[2]YF Qi, YX Huang*, HY Wang, Y Zhang, YL Bao, LG Sun, Y Wu, CL Yu, ZB Song, LH Zheng, Y Sun, GN Wang, YX Li*. Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling. BMC Bioinformatics. 2013, 14(1): 41.
[3]Wang YC, Zhang YW, Zheng LH, Bao YL, Wu Y*, Yu CL, Sun LG, Zhang Y, Huang YX, Sun Y, Li YX*. A new compound from liquid fermentation broth of Armillaria mellea and the determination of its absolute configuration. J Asian Nat Prod Res. 2013; 15(2): 203-8.
[4]PP Sun, HX Ju, ZB Liu, Q Ning, J Zhang, XW Zhao, YX Huang, ZQ Ma*, YX Li*. Bioinformatics Resources and Tools for Conformational B-Cell Epitope Prediction. Comput Math Method M. vol 2013, pp: 943636.
[5]Zhang Y, Bao YL*, Wu Y, Yu CL, Huang YX, Sun Y, Zheng LH, Li YX*. Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway. Mol Med Rep. 2013 Oct;8(4):967-72.
[6]YJ Meng, YW Zhang, HY Jiang*, YL Bao, Y Wu*, LG Sun, CL Yu, YX Huang, YX Li*. Chemical constituents from the roots of Zizyphus jujuba Mill. var. spinosa. BIOCHEM SYST ECOL. 2013 Oct, 50: 182–186.
[7]Niu TZ, Zhang YW, Bao YL, Wu Y, Yu CL, Sun LG, Yi JW, Huang YX, Li YX. A validated high-performance liquid chromatography method with diode array detection for simultaneous determination of nine flavonoids in Senecio cannabifolius Less. J Pharmceut Biomed Anal. 2013 Mar 25; 76: 44-8.
[8]YC Wang, YW Zhang, LH Zheng, YL Bao, Y Wu*, CL Yu, YX Huang, LG Sun, Y Zhang, XJ Jia, YX Li*. Four New Alkaloids from the Fermentation Broth of Armillaria mellea. Helvetica Chimica Acta. 2013 Feb, 96(2): 330.
[9]J Huang*, Ratmir Derda, YX Huang. Phage Display Informatics. Comput Math Method M. vol 2013, pp: 698395.

2012年

[1]C Fan, YX Huang*, YL Bao*, LG Sun, Y Wu, CL Yu, Y Zhang, ZB Song, LH Zheng, Y Sun, GN Wang, YX Li*. Virtual Screening of Specific Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors from the National Cancer Institute (NCI) Molecular Database. INT J MOL SCI. 2012, 13(12), 17185-17209.　
[2]YX Sun, YX Huang*, FL Li, HY Wang, C Fan, YL Bao, LG Sun, ZQ Ma, J Kong*, YX Li*. IVSPlat 1.0: an integrated virtual screening platform with a molecular graphical interface. CHEM CENT J. 2012, 6:2.
[3]WH Chen, WW Guo, YX Huang*, ZQ Ma*. PepMapper: A Collaborative Web Tool for Mapping Epitopes from Affinity-Selected Peptides. PLoS ONE 2012, 7(5): e37869.
[4]XW Zhao, JK Li, YX Huang*, ZQ Ma*, MH Yin*. Prediction of Bioluminescent Proteins Using Auto Covariance Transformation of Evolutional Profiles. INT J MOL SCI. 2012, 13(3), 3650-3660.
[5]Yang XG, Bao YL*, Huang YX, Sun LG, Zhang YW, Yu CL, Wu Y, Li YX*. 6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Eur J Pharmacol. 2012 Nov 15; 695(1-3):27-33.
[6]YY Li, YL Bao*, ZB Song, LG Sun, P Wu, Y Zhang, C Fan, YX Huang, Y Wu, CL Yu, Y Sun, LH Zheng, GN Wang, YX Li*. The Threonine Protease Activity of Testes-Specific Protease 50 (TSP50) Is Essential for Its Function in Cell Proliferation. PLoS ONE 2012, 7(5): e35030.
[7]ZL Cao, JZ Meng, XX Li, RP Wu, YX Huang, YX He*. The Epitope and Neutralization Mechanism of AVFluIgG01, a Broad-Reactive Human Monoclonal Antibody against H5N1 Influenza Virus. PLoS ONE 2012, 7(5): e38126.
[8]M Zheng, JN Wu, YX Huang, GX Liu, Y Zhou*, CG Zhou. Inferring Gene Regulatory Networks by Singular Value Decomposition and Gravitation Field Algorithm. PLoS ONE 2012, 7(12): e51141.
[9]M Zheng, YX Huang, W Shen, Y Zhong, JN Wu, GX Liu*, Y Zhou*. A novel scale-free network construction method and its application in gene expression profiles simulation. PROG BIOCHEM BIOPHYS. 2012, 39(6): 581-590.
[10]YW Zhang, H Lin, YL Bao, Y Wu, CL Yu, YX Huang, YX Li*. A new triterpenoid and other constituents from the stem bark of Juglans mandshurica. BIOCHEM SYST ECOL 2012, 44, 136-140.

2011年

[1]PP Sun, WH Chen, YX Huang*, HY Wang, ZQ Ma*, YH Lv*. Epitope prediction based on random peptide library screening: Benchmark datasets and prediction tools evaluation. Molecules 2011; 16(6): 4971-4993.
[2]WH Chen, PP Sun, Y Lu, WW Guo, YX Huang*, ZQ Ma*. MimoPro. a more efficient Web-based tool for epitope prediction using phage display libraries. BMC Bioinformatics 2011; 12: 199.
[3]ZB Song, YL Bao*, Y Zhang, XG Mi, P Wu, Y Wu, CL Yu, Y Sun, LH Zheng, YX Huang, B Liu, YX Li*. Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the NF-kappa beta (NF-κB) signaling pathway. Biochem J. 2011; 436(2): 457-467.
[4]Y Shi, YL Bao*, Y Wu*, CL Yu, YX Huang, Y Sun, LH Zheng, YX Li. Alantolactone Inhibits Cell Proliferation by Interrupting the Interaction between Cripto-1 and Activin Receptor Type II A in Activin Signaling Pathway. Journal of Biomolecular Screening. 2011; 16(5): 525-535.
[5]H Lin, YW Zhang, LH Zheng, XY Meng*, YL Bao, Y Wu, CL Yu, YX Huang, and YX Li*. Anthracene and Anthraquinone Derivatives from the Stem Bark of Juglans mandshurica Maxim. Helvetica Chimica Acta, 2011; 94(8): 1488-1495.

2010年

[1]Y Zhang, YL Bao*, MT Yang, Y Wu, CL Yu, YX Huang, Y Sun, LH Zheng, YX Li*. Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells. Int J Biochem Cell Biol, 2010, 42:1964–1972.
[2]M Wang, YL Bao*, Y Wu, CL Yu, XY Meng, YX Huang, Y Sun, LH Zheng, YX Li*. Basic FGF Downregulates TSP50 Expression via the ERK/Sp1 Pathway. Journal of Cellular Biochemistry. 2010, 111: 75-81.
[3]Y Zhang, L Zhou, YL Bao*, Y Wu, CL Yu, YX Huang, Y Sun, LH Zheng, YX Li*. Butyrate induces cell apoptosis through activation of JNKMAP kinase pathway in human colon cancer RKO cells. Chem. Biol. Interact. 2010, 185: 174-181.
[4]L Zhou, YL Bao*, Y Zhang, Y Wu, CL Yu, YX Huang, Y Sun, LH Zheng and YX Li*. Knockdown of TSP50 inhibits cell proliferation and induces apoptosis in P19 cells. IUBMB Life. 2010 Nov; 62(11): 825-832.

2009年

[1]ZB Song, YL Bao*, Y Wu, CL Yu, YX Huang, YX Li. Testes-Specific Protease 50 Promotes Tumorigenesis through Activation of NF-kB Signaling Pathway. 21st IUBMB & 12th FAOBMB International Congress of Biochemistry and Molecular Biology. 2009, 8: 59.

2008年

[1]YX Huang, YL Bao*, SY Guo, Y Wang, CG Zhou, YX Li*. Pep-3D-Search: a method for B-cell epitope prediction based on mimotope analysis. BMC Bioinformatics, 2008, 9:538.
[2]黃艷新, 鮑永利*, 李玉新*. 抗原表位預測的免疫信息學方法研究進展. 中國免疫學雜誌, 2008, Vol 24, No 9, pp 857-861.
[3]SX Zou, YX Huang, Y Wang, CG Zhou*. A Novel Method for Prediction of Protein Domain Using Distance-Based Maximal Entropy. Journal of Bionic Engineering 2008, Vol. 05, No. 03, pp 215-223.

2007年

[1]Y Wang, XY Feng, YX Huang, DB Pu, WG Zhou, YC Liang and CG Zhou*. a novel quantum swarm evolutionary algorithm and its applications. Neuro-computing, volume 70 (issues 4-6), January 2007, pp: 633-640.

2006年

[1]YX Huang, CG Zhou, Y Wang, YL Bao, Y Wu, YX Li*. A hybrid algorithm for solving generalized class cover problem. The 2nd International Conference on Natural Computation (ICNC), Xi’an China, Proceedings, Sep. 2006, Parts I, pp 610-619.
[2]SX Zou, YX Huang, Y Wang, CG Zhou*. Prediction of protein domains from sequence information using support vector machines. Third International Symposium on Neural Networks (ISNN 2006), Proceedings - Part III, 2006, pp 674-681.
[3]王岩, 路春一, 豐小月, 黃艷新, 鄒淑雪, 周春光*. 一種新的量子群進化算法研究. 小型微型計算機系統, 2006, Vol. 27, No. 8, pp 1478-1482.
[4]鄒淑雪, 王岩, 周春光*, 黃艷新. 一種基於支持向量機的模糊分類系統研究. 小型微型計算機系統, 2006, Vol. 27, No.4, pp 701-705.

2005年

[1]YX Huang, CG Zhou*. Recognizing Taste Signals Using A Clustering-based Fuzzy Neural Network. Chinese Journal of Electronics, Jan. 2005. Vol. 14, No.1, pp 21-25.
[2]YX Huang, Y Wang, WG Zhou, ZZ Yu, CG Zhou*. A Fuzzy Neural Network System Based on Generalized Class Cover and Particle Swarm Optimization. 2005 International Conference on Natural Computation (ICNC), Hefei, China, 2005: 119-128.
[3]Y Wang, XY Feng, YX Huang, WG Zhou, YC Liang and CG Zhou*. A Novel Quantum Swarm Evolutionary Algorithm for Solving 0-1 Knapsack Problem. Advances in Natural Computation, First International Conference (ICNC2005), Chang-Sha, China, Vol. 3611, 2005: 698-705.
[4]GX Liu, YX Zhu, WG Zhou, YX Huang, CG Zhou*, RX Wang. A Study on Protein Residue Contacts Prediction by Recurrent Neural Network. Journal of Bionics Engineering. Sep. 2005, Vol. 2, No. 3, pp 157-160.
[5]黃艷新, 周春光*, 鄒淑雪, 王岩. 一種求解類覆蓋問題的混合算法. 軟體學報, 2005, Vol. 16, No. 4, pp513-522.
[6]王岩, 周春光*, 黃艷新, 豐小月. 基於最小不確定性神經網路的茶味覺信號識別. 計算機研究與發展, 2005, Vol. 42, No. 1, pp 66-71.

2004年

[1]YX Huang, Y Wang, CG Zhou*, SX Zou, XW Yang and YC Liang. Reduction and Optimization For A Support-Vector-Machine-Based Fuzzy-Classification-System. Proceedings of the Third International Conference on Machine Learning and Cybernetics, Shang-Hai, China, 26-29 August, 2004, pp 3402-3407.
[2]YX Huang, CG Zhou*, SX Zou, Y Wang and YC Liang. A Rough-Set-Based Fuzzy-Neural-Network System For Taste Signal Identification. 2004 International Symposium on Neural Networks Proceedings (Part II), Da-Lian, China, 19-21, August, 2004, pp337-343.
[3]Y Wang, CG Zhou*, YX Huang, XY Feng. Training Minimal Uncertainty neural Networks by Bayesian Theorem and Particle Swarm Optimization. 11Th International Conference on Neural Information Processing, Nov. 2004, Calcutta, India, pp 579-584.
[4]Y Wang, CG Zhou*, YX Huang, YC Liang and XW Yang. A Boundary Method to Speed up Training Support Vector Machines. The International conference on Computational methods (ICCM2004), National University of Singapore, dec. 2004, Part II, pp 1209-1213.
[5]黃艷新, 周春光*, 鄒淑雪, 王岩. 一種基於類覆蓋和粒子群最佳化的模糊神經網路系統. 計算機研究與發展, 2004, Vol. 41, No.7, pp 1053-1061.
[6]黃艷新, 周春光*, 楊國慧, 鄒淑雪. 基於熵聚類模糊神經網路味覺信號識別的研究. 計算機研究與發展, 2004, Vol 41, No.3, pp414-419.

獲獎情況

(1)參加完成科研項目“智慧型計算建模及套用研究”，並作為主要完成人之一獲得吉林省科學技術進步一等獎（獲獎時間：2007年12月）。

(2)博士論文“計算機味覺信號識別的研究”被評為吉林大學2007年優秀博士學位論文二等獎（獲獎時間：2007年11月）。