黃盛豐

黃盛豐，男，廣東廣州人，博士，中山大學生命科學學院教授、博士生導師，有害生物控制與資源利用國家重點實驗室PI，2017年國家優秀青年基金獲得者，2018年入選教育部的國家重大人才工程青年項目。長期從事功能基因組學研究，以文昌魚、七鰓鰻和斑馬魚等水生動物為研究對象，開發算法工具與數學模型，分析動物基因組的序列多樣性及其演化模式，探索免疫系統的功能演化，發掘新穎免疫機制，並研究免疫與消化、生長和代謝之間的關係。承擔或參與國家自然科學基金項目3項、863課題1項、973課題2項、“藍色糧倉”計畫1項。發表SCI論文四十多篇。在Cell, Genome Research，Nature Communications，PNAS，Bioinformatics，Human Mutation，Free radical biology & medicine，Journal of Immunology和JBC等期刊上發表第一或通訊作者論文19篇。取得多項國內軟體著作權和發明專利，發布多個算法軟體和數學模型。相關成果曾獲得中國免疫學會青年學者獎、國家自然科學獎二等獎(第二完成人)、中國科協2016年度中國生命科學領域十大進展和中國藥學會科學技術一等獎(第二完成人)等。

基本介紹

• 中文名：黃盛豐
• 出生地：廣東廣州
• 學位/學歷：博士
• 專業方向：生物信息學，比較免疫學
• 任職院校：中山大學

研究方向

免疫學、生物信息學（生物統計、算法設計、基因組學）

因課題研究和實驗室發展需要，招收或招聘以下方向的研究生、博士後或者專職科研人員(長期有效)：

(1)生信、免疫基因組學和免疫遺傳學（免疫組/腸道微生物組/單細胞轉錄組/比較基因組學等），

(2)比較免疫學（黏膜免疫、水生動物免疫學等）。

講授課程

免疫學，生物科學綜合實驗

論文專著

• Jin Li, Yuhui Li, Zhaoyu Fan, Shenghui Chen, Xinyu Yan, Zirui Yue, Guangrui Huang, Shumin Liu, Hao Zhang, Meiling Dong, Anlong Xu# and Shengfeng Huang#. Two amphioxus ApeC-containing proteins bind to microbes and inhibit the TRAF6 Pathway. Frontiers in Immunology. 2021 Jul 30;12:715245.
• Yuhui Li, Jin Li, Xinyu Yan, Shenghui Chen, Chengyi Wu, Huiqing Huang, Yi Shi, Guangrui Huang, Meiling Dong, Anlong Xu# and Shengfeng Huang#. Broad distribution, high diversity and ancient origin of the ApeC-containing proteins. Molecular Phylogenetics and Evolution. 2021 Feb; 155:107009.
• Xinyu Yan, Shenghui Chen, Huiqing Huang, Ting Peng, Mengjiao Lan, Xia Yang, Meiling Dong, Shangwu Chen, Anlong Xu#, and Shengfeng Huang#. Functional variation of IL-1R associated kinases in the conserved MyD88-TRAF6 pathway during evolution. Journal of Immunology. 2020 Jan; 204(4):832-843.
• Xianan Fu, Ruihua Wang, Mingshi Li, Xinyu Yan, Huiqing Huang, Jin Li, Shenghui Chen, Zirui Yue, Shangwu Chen, Yingqiu Li, Meiling Dong, Anlong Xu#, Shengfeng Huang#. Chordate PIAS proteins act as conserved repressors of the TRAF6 self-polyubiquitination. Developmental & Comparative Immunology. 2020 Mar; 104:103554.
• Yi Shi, Zhaoyu Fan, Guang Li, Lei Zhang, Zirui Yue, Xinyu Yan, Anlong Xu# and Shengfeng Huang#. The family of amphioxus chitin synthases offers insight into the evolution of chitin formation in chordates. Molecular Phylogenetics and Evolution. 2020 Feb; 143: 106691.
• Muniba Faiza, Dongming Lan, Shengfeng Huang#, Yonghua Wang#. UPObase: An online database of unspecific peroxygenases. Database. 2019: baz122.
• Muniba Faiza, Shengfeng Huang#, Dongming Lan and Yonghua Wang#. New insights on unspecific peroxygenases: superfamily reclassification and evolution. BMC Evolutionary Biology. 2019 Mar 13; 19(1):76.
• 嚴信宇*, 黃盛豐*, 徐安龍, 人類抗體重排機制的起源, 科技導報, 2018;36(7):43-47.
• Ruihua Wang*,Shengfeng Huang*, Xianan Fu, Guangrui Huang, Xinyu Yan, Zirui Yue, Shangwu Chen, Yingqiu Li & Anlong Xu. The conserved ancient role of chordate PIAS as a multilevel repressor of the NF-κB pathway. Scientific Reports. Sci Rep. 2017 Dec 6;7(1):17063.
• Shengfeng Huang#,Mingjin Kang and Anlong Xu. HaploMerger2: rebuilding both haploid sub-assemblies from high-heterozygosity diploid genome assembly.Bioinformatics. 2017 Aug 15;33(16):2577-2579.
• Jose Ricardo Poole*,ShengFeng Huang*, Anlong Xu, Justine Bayet and Pontarotti Pierre. The RAG transposon is active through the deuterostome evolution and domesticated in jawed vertebrates.Immunogenetics. 2017 Jun;69(6):391-400.
• Xinyu Yan, Wenbin Meng, Fenfang Wu, Anlong Xu andShengfeng Huang#. The Nuclear DNA Content and Genetic Diversity of Lampetra morii.PLoS ONE. 2016 Jul 7;11(7):e0157494.
• Shengfeng Huang*, Xin Tao*, Shaochun Yuan*, Yuhang Zhang, Peiyi Li, Helen A. Beilinson, Ya Zhang, Wenjuan Yu, Pierre Pontarotti, Hector Escriva, Yann Le Petillon, Xiaolong Liu, Shangwu Chen, David G. Schatz, Anlong Xu. Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination.Cell. 2016 Jun 30;166(1):102-14.
• Jie Li, Rui Li, Leiming You, Anlong Xu#, Yonggui Fu andShengfeng Huang#. Evaluation of two statistical methods provides insights into the complex patterns of alternative polyadenylation site switching.PLoS ONE. 2015 Apr 14; 10(4):e0124324.
• Shengfeng Huang, Zelin Chen, Xinyu Yan, Ting Yu, Guangrui Huang, Pierre Antoine Pontarotti, Qingyu Yan, Hongchen Zhao, Jie Li, Ping Yang, Ruihua Wang, Rui Li, Xin Tao, Ting Deng, Yiquan Wang, Guang Li, Qiujin Zhang, Sisi Zhou, Leiming You, Shaochun Yuan, Yonggui Fu, Fenfang Wu, Meiling Dong, Shangwu Chen, Anlong Xu. Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes.Nature communications. 2014 Dec 19; 5:5896.
• Guangrui Huang*,Shengfeng Huang*, Xinyu Yan, Ping Yang, Jun Lia, Weiya Xua, Lingling Zhang, Ruihua Wang, Yingcai Yu, Shaochun Yuan, Shangwu Chen, Guangbin Luo and Anlong Xu. Two apextrin-like proteins mediate extracellular and intracellular bacterial recognition in amphioxus.Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13469-74.
• Ping Yang*,Shengfeng Huang*, Xinyu Yan, Guangrui Huang, Xiangru Dong, Tingting Zheng, Dongjuan Yuan, Ruihuan Wang, Rui Li, Ying Tan and Anlong Xu. Origin of the phagocytic respiratory burst and its role in gut epithelial phagocytosis in a basal chordate.Free radical biology & medicine. 2014 May; 70C: 54-67.
• Shengfeng Huang#, Jie Li, Anlong Xu, Guangrui Huang, Leiming You. Small insertions are more deleterious than small deletions in human genomes.Human Mutation. 2013 Sep 18; 34(12): 1642-1649.
• Zelin Chen*,Shengfeng Huang*, Yuxin Li, Anlong Xu. AliquotG: an improved heuristic algorithm for genome aliquoting.PLoS ONE. 2013 May 14; 8(5): e64279.
• Shengfeng Huang*, Zelin Chen*, Guangrui Huang, Ting Yu, Jie Li, Yonggui Fu, Shaochun Yuan, Shangwu Chen, Anlong Xu. HaploMerger: Reconstructing allelic relationships for polymorphic diploid genome assemblies.Genome Research. 2012 May; 22(8): 1581-1588.
• Shengfeng Huang*, Ting Yu*, Zelin Chen, Shaochun Yuan, Shangwu Chen, Anlong Xu. More single-nucleotide mutations surround small insertions than small deletions in primates.Human Mutation. 2012 April 9; 33(7): 1099-1106.
• Huiqing Huang*,Shengfeng Huang*, Yanhong Yu, Shaochun Yuan, Rui Li, Xin Wang, Hongchen Zhao, Jun Li, Manyi Yang, Liqun Xu, Shangwu Chen, Anlong Xu. Functional characterization of a ficolin-mediated complement pathway in amphioxus.Journal of Biological Chemistry. 2011 Oct 21; 286(42):36739-48.
• Shengfeng Huang*, Xin Wang*, Qingyu Yan, Lei Guo, Shaochun Yuan, Meiling Dong, Shangwu Chen, Anlong Xu.The evolution and regulation of the mucosal immune complexity in the basal chordate amphioxus.Journal of Immunology. 2011 Feb 15;186(4):2042-55.
• Shengfeng Huang, Haozheng Tian, Zelin Chen, Ting Yu, Anlong Xu. The evolution of vertebrate tetraspanins: gene loss,retention, and massive positive selection after whole genome duplications.BMC Evolutionary Biology. 2010;10:306.
• Shaochun Yuan*,Shengfeng Huang*, Wei Zhang, Tao Wu, Meiling Dong, Yanhong Yu, Tong Liu, Kui Wu, Huiling Liu, Manyi Yang, Hongwei Zhang, Anlong Xu. An amphioxus TLR with dynamic embryonic expression pattern responses to pathogens and activates NF-kappaB pathway via MyD88.Molecular Immunology. 2009 Jul;46(11-12):2348-56.*co-first author
• Shengfeng Huang, Shaochun Yuan, Lei Guo, Yanhong Yu, Jun Li, Tao Wu, Tong Liu, Manyi Yang, Kui Wu, Huiling Liu, Jin Ge, Yingcai Yu, Huiqing Huang, Meiling dong, Cuiling Yu, Shangwu Chen, Anlong Xu. Genomic Analysis of the Immune Gene Repertoire of Amphioxus Reveals Extraordinary Innate Complexity and Diversity.Genome Research. 2008 Jul;18(7):1112-26.
• Shengfeng Huang, Shaochun Yuan, Meiling Dong, Jing Su, Cuiling Yu, Xiaojin Xie, Yang　Shen, xuesong Yu, Yanhong Yu, Shangwu Chen , Shicui Zhang, Pierre Pontarotti, Anlong Xu.　The phylogenetic analysis of tetraspanins projects the evolution of　cell-cell interactions from unicellular to multicellular organisms.Genomics. 2005 Dec; 86(6):674-684.