黃國友，男，1984年生，工學博士，武漢大學土木建築工程學院副教授。
基本介紹
人物經歷,研究方向,主要成就,主要論文著作,專利,獲獎記錄,主要科研項目,社會任職,
人物經歷
學習經歷
2008.09-2013.03 西安交通大學航天航空學院，工學博士
2004.09-2008.07 西安交通大學理學院，理學學士
任職經歷
2020.04-今，武漢大學土木建築工程學院，副教授
2017.04-2020.03，西安交通大學生命科學與技術學院，副教授
2014.02-2015.02，美國聖路易斯華盛頓大學，醫學院及工程和套用科學學院，訪問學者
2013.04-2017.03，西安交通大學生命科學與技術學院，講師
研究方向
· 細胞微環境工程
· 生物力學/力學生物學
· 器官晶片
主要成就
主要論文著作
1. H. Liu, M. Wu, Y. Jia, L. Niu, G. Huang*, F. Xu*. The shape of fibroblasts regulates their responses to mechanical and biochemical cues in three dimensions. NPG Asia Materials, accepted
2. G. Jin, W. Li, F. Song, J. Zhao, M. Wang, Q. Liu, A. Li, G. Huang and F. Xu*. Fluorescent conjugated polymer nanovector for in vivo tracking and regulating the fate of stem cells for restoring infarcted myocardium. Acta Biomaterialia, accepted
3. L. Niu, Y. Jia, M. Wu, H. Liu, Y. Hong, Y. Hu, X. Zhang, D. Gao, F. Xu, G. Huang*. Matrix stiffness controls cardiac fibroblast differentiation through regulating YAP via AT1R. Journal of Cellular Physiology, 2020
4. B. Cheng, W. Wan, G. Huang, Y. Li, G.M. Genin, M.R.K. Mofrad, T.J. Lu, F. Xu, M. Lin*. Nanoscale integrin cluster dynamics controls cellular mechanosensing via FAKY397 phosphorylation. Science Advances, 6(10): eaax1909, 2020
5. M. Wang, B. Cheng, Y. Yang, H. Liu, G. Huang, L. Han, F. Li*, F. Xu*. Microchannel stiffness and confinement jointly induce the mesenchymal-amoeboid transition of cancer cell migration. Nano Letters, 19: 5949−5958, 2019
6. G. Zhao, X. Bao, G. Huang, F. Xu*, X. Zhang*. Differential effects of directional cyclic stretching on the functionalities of engineered cardiac tissues. ACS Applied Bio Materials, 2(8): 3508-3519, 2019
7. Y. Ji, Q. Yang, G. Huang, M. Shen, Z. Jian, M.J. Thoraval, Q. Lian, X. Zhang*, F. Xu*. Improved resolution and fidelity of droplet-based bioprinting by upward ejection. ACS Biomaterials Science & Engineering, 5(8): 4112-4121, 2019
8. G. Huang, F. Xu, G.M. Genin, T.J. Lu*. Mechanical microenvironments of living cells: a critical frontier in mechanobiology. Acta Mechanica Sinica, 35(2): 265-269, 2019
9. J. Tian, G. Huang, M. Lin, J. Qiu, B. Sha, T.J. Lu*, F. Xu*. A mechanoelectrical coupling model of neurons under stretching. Journal of the Mechanical Behavior of Biomedical Materials, 93: 213-221, 2019
10. H. Qing, G. Jin, G. Zhao, G. Huang, Y. Ma, X. Zhang, B. Sha, Z. Luo, T.J. Lu*, F. Xu*. Heterostructured silk-nanofiber-reduced graphene oxide composite scaffold for SH-SY5Y cell alignment and differentiation. ACS Applied Materials & Interfaces, 10(15), 39228–39237, 2018
11. G. Zhao, H. Qing, G. Huang, G.M. Genin, T.J. Lu, Z. Luo, F. Xu*, X. Zhang*. Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues. NPG Asia Materials, 10, 982-994, 2018
12. C. Ji, F. Song, G. Huang, S. Wang, H. Liu, S. Liu, L. Huang, S. Liu, J. Zhao, T.J. Lu*, F. Xu*. The protective effects of acupoint gel embedding on rats with myocardial ischemia-reperfusion injury. Life Sciences, 211: 51-62, 2018
13. Y. Ma, M. Lin, G. Huang, Y. Li, S. Wang, H. Yang, A. Li, T. J. Lu, F. Xu*. Three-dimensional spatiotemporal mechanical microenvironment: a hydrogel-based platform for guiding stem cell fate. Advanced Materials, 1705911, 2018
14. 徐峰, 張曉慧*, 鮑雪嬌, 趙國旭, 劉付生, 黃國友, 李昱輝和盧天健. 基於先進生物材料的心肌細胞力–電微環境體外構建. 力學進展, 48: 320-359, 2018
15. W. Zhang, G. Huang*, K. Ng, Y. Ji, B. Gao, Q. Huang, J. Zhou, T.J. Lu, F. Xu. Engineering ellipsoidal cap-like hydrogel particles as building blocks or sacrificial templates for three-dimensional cell culture. Biomaterials Science, 6(4): 885-892, 2018
16. 胡焱, 洪源, 師念園, 黃國友和趙昕*. 基於甲基丙烯酸酯明膠的神經幹細胞三維微環境的構建調控. 中國科技論文, 12(24): 2770-2776, 2017
17. G. Huang, F. Li, X. Zhao, Y. Ma, Y. Li, M. Lin, G. Jin, T.J. Lu, G.M. Genin and F. Xu*. Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment. Chemical Reviews, 117(20): 12764-12850, 2017
18. B. Cheng, M. Lin, G. Huang, Y.H. Li, B.H. Ji, G.M. Genin, V.S. Deshpande, T.J. Lu and F. Xu*. Energetics: An emerging frontier in cellular mechanosensing: Reply to comments on “Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses”. Physics of Life Reviews, 22-23: 130-135, 2017
19. B. Cheng, M. Lin, G. Huang, Y.H. Li, B.H. Ji, G.M. Genin, V.S. Deshpande, T.J. Lu and F. Xu*. Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses. Physics of Life Reviews, 22-23: 88-119, 2017
20. Y.L. Han, M.X. Li, Q.Z. Yang, G. Huang, H. Liu, Y.D. Qin, G.M. Genin, T.J. Lu* and F. Xu*. Collective wetting of a natural fibrous system and its application in pump-free droplet transfer. Advanced Functional Materials, 27(22): 1606607, 2017
21. G. Huang, M.X. Li, Q.Z. Yang, Y.H. Li, H. Liu, H. Yang and F. Xu*. Magnetically actuated droplet manipulation and its potential biomedical applications. ACS Applied Materials & Interfaces, 9(2): 1155-1166, 2017
22. B. Cheng, M. Lin, Y.H. Li, G. Huang, H. Yang, Guy M. Genin, Vikram S. Deshpande, T.J. Lu and F. Xu*. An integrated stochastic model of matrix-stiffness-dependent filopodial dynamics. Biophysical Journal, 111(9): 2051-2061, 2016
23. K.W. Yong, Y.H. Li, F.S. Liu, B. Gao, T.J. Lu, W.A.B. Wan Abas, W.K.Z. Wan Safwani, B. Pingguan-Murphy, Y. Ma, F. Xu and G. Huang*. Paracrine effects of adipose-derived stem cells on matrix stiffness-induced cardiac myofibroblast differentiation via angiotensin II type 1 receptor and Smad7. Scientific Reports, 6: 33067, 2016
24. G. Huang, L.M. Tian, K.-K. Liu, B. Hu, F. Xu, T.J. Lu, R.R. Naik and S. Singamaneni*. Elastoplastic deformation of silk micro- and nanostructures. ACS Biomaterials Science & Engineering, 2(6): 893-899, 2016
25. Y.H. Li, G. Huang, M. Li, L. Wang, E.L. Elson, T. J. Lu, G.M. Genin* and F. Xu*. An approach to quantifying 3D responses of cells to extreme strain. Scientific Reports, 6: 19550, 2016
26. Y.H. Li, G. Huang*, B. Gao, M.X. Li, G.M. Genin, T.J. Lu and F. Xu*. Magnetically-actuated cell-laden microscale hydrogels for probing strain-induced cell responses in three dimensions. NPG Asia Materials, 8: e238, 2016
27. H. Qi*, G. Huang, Y.L. Han, L. Wang*, S.Q. Wang, T.J. Lu and F. Xu. In vitro spatially organizing the differentiation in individual multicellular stem cell aggregates. Critical Reviews in Biotechnology, 36(1): 20-31, 2016
28. L. Wang, Y.H. Li, G. Huang, X. Zhang, B. Pingguan-Murphy, B. Gao, T.J. Lu and F. Xu*. Hydrogel-based methods for engineering cellular microenvironment with spatiotemporal gradients. Critical Reviews in Biotechnology, 36(3): 553-565, 2016
29. Q.C. Zhang, X. Yang, P. Li, G. Huang, S. Feng, C. Shen, B. Han, X. Zhang, F. Jin, F. Xu* and T.J. Lu*. Bioinspired engineering of honeycomb structure – Using nature to inspire human innovation. Progress in Materials Science, 74: 332-400, 2015
30. K.W. Yong, Y.H. Li, G. Huang, T.J. Lu, W.K.Z. Wan Safwani, B. Pingguan-Murphy and F. Xu*. Mechano-regulation of cardiac myofibroblast differentiation: Implications for cardiac fibrosis and therapy. American Journal of Physiology-Heart and Circulatory Physiology, 309(4): H532-H542, 2015
31. D.T. Chong, X.S. Liu, H.J. Ma, G. Huang, Y.L. Han, X.Y. Cui, J.J. Yan and F. Xu*. Advances in fabricating double-emulsion and their biomedical applications. Microfluidics and Nanofluidics, 19(5): 1071-1090, 2015
32. Y.F. Ma, Y. Ji, G. Huang, K. Ling, X.H. Zhang* and F. Xu*. Bioprinting 3D cell-laden hydrogel microarray for screening human periodontal ligament stem cells response to extracellular matrix. Biofabrication, 7(4): 044105, 2015
33. K. Ling, G. Huang, J. Liu, X. Zhang, Y. Ma, T.J. Lu* and F. Xu*. Bioprinting-based high-throughput fabrication of three-dimensional MCF-7 human breast cancer cellular spheroids. Engineering, 1(2): 269-274, 2015
34. F.S. Liu, C.H. Li, S.B. Liu, G.M. Genin, G. Huang, T.J. Lu* and F. Xu*. Effect of viscoelasticity on skin pain sensation. Theoretical and Applied Mechanics Letters, 5(6): 222-226, 2015
35. L. Wang, M. Qiu, Q. Yang, Y. Li, G. Huang, M. Lin, T.J. Lu and F. Xu*. Fabrication of microscale hydrogels with tailored microstructures based on liquid bridge phenomenon. ACS Applied Materials & Interfaces, 7: 11134-11140, 2015
36. Z. Liu, Z. Wei, X.L. Zhu, G. Huang, F. Xu, J.H. Yang, Y. Osada, M. Zrínyi, J.H. Li* and Y.M. Chen*. Dextran-based hydrogel formed by thiol-Michael addition reaction for 3D cell encapsulation. Colloids and Surfaces B: Biointerfaces, 128: 140-148, 2015
37. S. Liu, P. Wang, G. Huang, L. Wang, J. Zhou, T.J. Lu, F. Xu and M. Lin*. Reaction-induced swelling of ionic gels. Soft Matter, 11(3): 449-455, 2015
38. 劉灝, 黃國友*, 李昱輝, 張曉慧, 盧天健和徐峰*. 基於水凝膠的“自下而上”組織工程技術研究進展. 中國科學-生命科學, 45(3): 256-270, 2015
39. Y.H. Li, G. Huang, X.H. Zhang, L. Wang, Y.N. Du, T.J. Lu and F. Xu*. Engineering cell alignment in vitro. Biotechnology Advances, 32: 347–365, 2014
40. H. Qi, G. Huang, Y.L. Han, Y.H. Li, X.H. Zhang, B. Pingguan-Murphy, T.J. Lu, F. Xu and L. Wang. Engineering artificial machines from designable DNA materials for biomedical applications. Tissue Engineering Part B: Reviews, 21(3): 288-297, 2014
41. L. Wang, G. Huang*, B.Y. Sha, S.Q. Wang, Y.L. Han, J.H. Wu, T.J. Lu and F. Xu*. Engineering three-dimensional cardiac microtissues for potential drug screening applications. Current Medicinal Chemistry, 21(22): 2497-2509, 2014
42. Y. Han, S. Wang, X.H. Zhang, Y.H. Li, G. Huang, H. Qi, B. Pingguan-Murphy, Y.H. Li, T.J. Lu* and F. Xu*. Engineering physical microenvironment for stem cell based regenerative medicine. Drug Discovery Today, 16: 763-773, 2014
43. Y.L. Han, W.Q. Wang, J. Hu, G. Huang, S.Q. Wang, W.G. Lee, T.J. Lu* and F. Xu*. Benchtop fabrication of three-dimensional reconfigurable microfluidic device from paper/polymer composite, Lab on a Chip, 3(24): 4745-4749, 2013
44. X. He, P.F. Wang, G. Huang, S.B. Liu, M.L. Xu, F. Xu, T.J. Lu, Development of a micro-indentation device for measuring the mechanical properties of soft materials. Theoretical & Applied Mechanics Letters, 3(5): 054004, 2013
45. Y.H. Li, G. Huang, X.H. Zhang, B.Q. Li, Y.M. Chen, T.L. Lu, T.J. Lu* and F. Xu*. Magnetic hydrogels and their potential biomedical applications, Advanced Functional Materials, 23(6): 660-672, 2013
46. G. Huang, S.H. Wang, X. He, X.H. Zhang, T.J. Lu* and F. Xu*. Helical spring template fabrication of cell-laden microfluidic hydrogels for tissue engineering. Biotechnology & Bioengineering, 110(3): 980-989, 2013
47. G. Huang, X.H. Zhang, Z.P. Xiao, Q.C. Zhang, J.X. Zhou, F. Xu* and T.J. Lu*. Cell-encapsulating microfluidic hydrogels with enhanced mechanical stability. Soft Matter, 8(41): 10687-10694, 2012
48. G. Huang, L. Wang, S.Q. Wang, Y.L. Han, J.H. Wu, Q.C. Zhang, F. Xu* and T.J. Lu*. Engineering three-dimensional cell mechanical microenvironment with hydrogels. Biofabrication, 4(4): 042001, 2012
49. Y. Fan, F. Xu*, G. Huang, T.J. Lu and W.L. Xing*. Single neuron capture and axonal development in three-dimensional microscale hydrogels. Lab on a Chip, 12(22): 4724-4731, 2012
50. G. Huang, L.H. Zhou, Q.C. Zhang, Y.M. Chen, W. Sun, F. Xu* and T.J. Lu*. Microfluidic hydrogels for tissue engineering. Biofabrication, 3(1): 012001, 2011
51. L.H. Zhou, G. Huang, S.Q. Wang, J.H. Wu, W.G. Lee, Y.M. Chen, F. Xu* and T.J. Lu*. Advances in cell-based biosensors using three-dimensional cell-encapsulating hydrogels, Biotechnology Journal, 6(12): 1466-1476, 2011
52. J.X. Zhou, G. Huang, M.E. Li and A.K. Soh*. Stress evolution in a phase-separating polymeric gel. Modelling and Simulation in Materials Science and Engineering, 18(2): 025002, 2010
53. 黃國友, 徐峰, 周麗宏, 周進雄, 陳詠梅和盧天健*. 載細胞水凝膠體系中微通道結構對營養物輸送能力的影響. 西安交通大學學報, 45(4): 115-120, 2010
54. 周麗宏, 陳自強, 黃國友, 翟曉, 陳詠梅, 徐峰和盧天健*. 細胞列印技術及套用. 中國生物工程雜誌, 30(12): 95-104, 2010
專利
1. 徐峰，黃國友，凌楷和盧天健, “一種基於水凝膠微孔板的細胞球原位製備方法”，中國發明專利，2017.06.06，專利號：ZL201510025985.8
2. 徐峰，何翔，王琳，王鵬飛，黃國友和盧天健，“多層PEG-DMA水凝膠的製備方法”，中國發明專利，2015.07.15，專利號：ZL201310722478.0
3. 黃國友，盧天健，徐峰和周麗宏，“一種力學增強型載細胞微通道水凝膠的製備方法”，中國發明專利，2013.10.16，專利號：ZL201110215024.5
4. 黃國友，盧天健，徐峰和周麗宏，“一種基於蔗糖纖維模板的載細胞微通道水凝膠的製備方法”，中國發明專利，2013.07.10，專利號：ZL201110213980.x
5. 徐峰，盧天健和黃國友，“一種基於活細胞的複雜三維微通道多孔支架的製備方法”，中國發明專利，2013.10.16，專利號：ZL201110259019.4
獲獎記錄
2019，陝西高等學校科學技術獎一等獎（排名第二）
2017，陝西省普通高校首批青年傑出人才
2016，陝西省普通高校青年托舉人才
2007，國家勵志獎學金，優秀學生，西安交通大學
主要科研項目
1. 血管緊張素II-1型受體在纖維化力學信號轉導中的作用機制，國家自然科學基金面上項目，2019/01-2022/12，主持
2. 三維基質硬化和軟化對心肌肌成纖維細胞表型轉化的作用及機制研究，國家自然科學基金青年科學基金，2017/01-2019/12，主持
3. 基質塑性影響成纖維細胞向化表型轉的作用研究，中國博士後科學基金特別資助，2019/06-2020/04，主持
4. 細胞纖維化表型記憶的力學生物學機制及干預作用，西安交通大學基本科研業務費青年人才培育項目，2018/01-2020/04，主持
5. 基質硬度調控下間充質幹細胞對心肌肌成纖維細胞表型轉化的作用，陝西省自然科學基礎研究計畫面上項目，2017/01-2018/12，主持
6. 基於磁力的高通量工程化心肌組織力學調控研究，西安交通大學基本科研業務費綜合交叉類面上項目，2014/01-2016/12，主持
社會任職
中國力學學會會員
中國生物醫學工程學會會員
中國生物材料學會會員
國際學術期刊評審專家：
Biomaterials
Biophysical Journal
Biofabrication
Acta Mechanica Sinica
Acta Biomaterialia
Journal of the Mechanical Behavior of Biomedical Materials
ACS Biomaterials Science & Engineering
Life Sciences
Biomedical Materials等
