黃倩，女，1960年7月出生，中共黨員，醫學博士，研究員，腫瘤學博士生導師，上海交通大學附屬第一人民醫院中心實驗室主任，國家傑出青年科學基金獲得者、“百千萬人才工程”國家級人選。
基本介紹
- 中文名稱：黃倩
- 出生日期：1960年7月
- 職業：醫生
- 專業：醫學
- 學歷：醫學博士
黃倩，女，1960年7月出生，中共黨員，醫學博士，研究員，腫瘤學博士生導師，上海交通大學附屬第一人民醫院中心實驗室主任，國家傑出青年科學基金獲得者、“百千萬人才工程”國家級人選。
曾經在美國哈佛大學醫學院眼耳醫院、美國杜克大學醫學院、科羅拉多州立大學健康醫學中心等單位做博士後研究或合作研究，研究方向主要為眼部疾病及惡性腫瘤發病機理與基因治療。研究領域主要涉及惡性腫瘤發病機理、腫瘤新生血管形成和基因治療。對於抑癌基因Rb突變與視網膜母細胞瘤發生、發展關係的研究結果，獲得96年衛生部科技進步二等獎、97年國家科委科技進步三等獎。創建了以綠色螢光蛋白為標記的新型腫瘤皮窗模型，並利用該模型觀察到腫瘤早期新生血管形成過程。作為項目負責人承擔了國家自然科學基金委“傑出青年項目”、國家自然科學基金委“海外青年學者合作研究基金”、國家基礎研究重點發展規劃“973”項目、科技部“863”、上海市科委“優秀學科帶頭人”、“登山計畫”和上海市衛生局“百人計畫”、“醫學領軍人才”等多個項目。發表學術論文100多篇，其中SCI收錄30多篇。
曾獲得衛生部“科技進步二等獎”、國家“科技進步三等獎”。曾獲得1999年上海市衛生系統第七屆“銀蛇獎”一等獎，2000年“上海市十大傑出青年”，2000年上海市“巾幗建功立業標兵”、“三八紅旗手”，2001年全國“巾幗建功立業標兵”、“三八紅旗手”，2001年上海市科技精英等榮譽稱號。2004年度入選為國家人事部“新世紀百千萬人才工程”國家級培養對象。
學術論文 (#為通訊作者,*為共同第一作者)
1、Ye Feng,Wengjing Bao,Yanli Luo,Ling Tian,Xiafang Chen,Miaoying Yi,Hui Xiong,Qian Huang#. Phosphomimetic Mutants of Pigment Epithelium-Derived Factor with Enhanced Anti-Choroidal Melanoma Cell Activity In Vitro and In Vivo..IOVS,2012;10(53):6793-6802
2、Huang Q*, Li F, Liu XJ, Li WR, He ZM, Peng YL, Shen JP, Wolf F, Han GW, Wang XJ, Thorburn A, Bedford J, Li CY.. Caspase-mediated stimulation of tumor cell repopulation during Cancer Radiotherapy.Nature Medicine,2011;17:860-867
3、Liu XJ#, Qian QJ, Xu P, Wolf F, Zhang JF, Zhang DB, Li CY, Huang Q.. A Novel Conditionally Replicating ‘‘Armed’’ Adenovirus Selectively Targeting Gastrointestinal Tumors with Aberrant wnt Signaling.Human Gene Therapy,2011;71:4130-4137
4、Xinjian Liu#, Jinjun Li, Yuhua Tian, Ping Xu, Xiafang Chen, Kuangchen Xie, Zhengjun Qiu, Yufei Wang, Dabing Zhang, Frank Wolf, Chuanyuan Li, and Qian Huang.. Enhanced Pancreatic Cancer Gene Therapy by Combination of Adenoviral Vector Expressing c-erb-B2 (Her-2/neu)-Targeted Immunotoxin with a Replication-Competent Adenovirus or Etoposide. .Human Gene Therapy,2010;21:157-170
5、Xunda Ji #, Lin Cheng, Fang Wei, Huiming Li, Mengyun Wang, Yuhua Tian, Xunda Ji, Jufeng Zhang, Lin Cheng, Fang Wei, Huiming Li, Xinjian Liu, Xiafang Chen, Chuanyuan Li, Yufei Wang, Qian Huang.. Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model.Exp Eye Res.,2009;89:193-199
6、Liu X#, Wu J, Zhang S, Li C, Huang Q.. Novel strategies to augment genetically delivered immunotoxin molecular therapy for cancer therapy .Cancer Gene Ther,2009;16:861-868
7、Xunda Ji #, Lin Cheng, Fang Wei, Huiming Li, Mengyun Wang, Yuhua Tian, Xiafang Chen, Yufei Wang, Frank Wolf, Chuanyuan Li, Qian Huang.. Non-invasive Visualization of Retinoblastoma Growth and Metastasis via Bioluminescence Imaging. .Invest Ophthalmol Vis Sci,2009;50:5544-5551
8、Jihong Wu#, Shenghai Zhang, Xiaobing Wu, Xiaoyan Dong, Ping Xu, Xinjian Liu, Chuanyuan Li, Qian HuangZhang, Lin Cheng, Fang Wei, Huiming Li, Xinjian Liu, Xiafang Chen, Chuanyuan Li, Yufei Wang, Qian Huang.. Enhanced transduction and improved photoreceptor survival of retinal degeneration by the combinatorial use of rAAV2 with a lower dose of adenovirus.Vision Research,2008;48:1648–1654
9、Shenghai Zhang#, Jihong Wu, Xiaobing Wu, Xiaoyan Dong, Xinjian Liu, Chuanyuan Li, Qian Huang. Distinctive gene transduction efficiencies of commonly used viral vectors in the retina..Curr Eye Res,2008;33:81-90
10、Jufeng Zhang#, Zhanli Wang, Fang Wei, Wei Qiu, Liangren Zhang, Qian Huang.. Computational modeling and functional analysis of Herpes simplex virus type-1 thymidine kinase and Escherichia coli cytosine deaminase fusion protein..Biochem Biophys Res Commun,2007;361:946-952
11、Hui Yu#, Jihong Wu, Huiming Li, Zhanli Wang, Xiafang Chen, Yuhua Tian, Miaoying Yi, Xunda Ji, Jialie Ma, Qian Huang.. nhibition of corneal neovascularization by recombinant adenovirus mediated sFlk-1 expression.Biochem Biophys Res Commun,2007;360:46-50
12、Qian Huang#, XiuWu Zhang, He Wang, Bin Yan, Mark W. Dewhirst, and ChuanYuan Li. A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells.Clinical Cancer Research,2004;10:1439-1445
13、Qian Huang#, JimK.H, Frank Lohr, Li Zhang, Rod Brun, Jeniffer Lanzen, John B. Little, Mark W. Dewhirst and Chuan-yuan Li. Heat-induced gene expression as a novel targeted cancer gene therapy strategy.Cancer Research,2000;60:3435-3439
14、Chuan-yuan Li, Siqing Shan,Qian Huang*, Rod Brun, Jeniffer Lanzen, Kang Hu, Pengnian Lin, and Mark W. Dewhirst. Initial stages of tumor cell-induced angiogenesis: Evaluation via skin window chambers in rodent models..Journal of the National Cancer Institute,2000;92:143-147.
15、Qian Huang*, Siqing Shan, Rod D. Braun, Jennifer Lanzen, Gopal Anyrhambatla, Garheng Kong, Michael Borelli, Peter Corry, Mark W. Dewhirst, and Chuan-yuan Li. . Noninvasive visualization of tumors in radent dorsal skin window chambers..Nature Biotechnology,1999;17:1033-1035
2、Huang Q*, Li F, Liu XJ, Li WR, He ZM, Peng YL, Shen JP, Wolf F, Han GW, Wang XJ, Thorburn A, Bedford J, Li CY.. Caspase-mediated stimulation of tumor cell repopulation during Cancer Radiotherapy.Nature Medicine,2011;17:860-867
3、Liu XJ#, Qian QJ, Xu P, Wolf F, Zhang JF, Zhang DB, Li CY, Huang Q.. A Novel Conditionally Replicating ‘‘Armed’’ Adenovirus Selectively Targeting Gastrointestinal Tumors with Aberrant wnt Signaling.Human Gene Therapy,2011;71:4130-4137
4、Xinjian Liu#, Jinjun Li, Yuhua Tian, Ping Xu, Xiafang Chen, Kuangchen Xie, Zhengjun Qiu, Yufei Wang, Dabing Zhang, Frank Wolf, Chuanyuan Li, and Qian Huang.. Enhanced Pancreatic Cancer Gene Therapy by Combination of Adenoviral Vector Expressing c-erb-B2 (Her-2/neu)-Targeted Immunotoxin with a Replication-Competent Adenovirus or Etoposide. .Human Gene Therapy,2010;21:157-170
5、Xunda Ji #, Lin Cheng, Fang Wei, Huiming Li, Mengyun Wang, Yuhua Tian, Xunda Ji, Jufeng Zhang, Lin Cheng, Fang Wei, Huiming Li, Xinjian Liu, Xiafang Chen, Chuanyuan Li, Yufei Wang, Qian Huang.. Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model.Exp Eye Res.,2009;89:193-199
6、Liu X#, Wu J, Zhang S, Li C, Huang Q.. Novel strategies to augment genetically delivered immunotoxin molecular therapy for cancer therapy .Cancer Gene Ther,2009;16:861-868
7、Xunda Ji #, Lin Cheng, Fang Wei, Huiming Li, Mengyun Wang, Yuhua Tian, Xiafang Chen, Yufei Wang, Frank Wolf, Chuanyuan Li, Qian Huang.. Non-invasive Visualization of Retinoblastoma Growth and Metastasis via Bioluminescence Imaging. .Invest Ophthalmol Vis Sci,2009;50:5544-5551
8、Jihong Wu#, Shenghai Zhang, Xiaobing Wu, Xiaoyan Dong, Ping Xu, Xinjian Liu, Chuanyuan Li, Qian HuangZhang, Lin Cheng, Fang Wei, Huiming Li, Xinjian Liu, Xiafang Chen, Chuanyuan Li, Yufei Wang, Qian Huang.. Enhanced transduction and improved photoreceptor survival of retinal degeneration by the combinatorial use of rAAV2 with a lower dose of adenovirus.Vision Research,2008;48:1648–1654
9、Shenghai Zhang#, Jihong Wu, Xiaobing Wu, Xiaoyan Dong, Xinjian Liu, Chuanyuan Li, Qian Huang. Distinctive gene transduction efficiencies of commonly used viral vectors in the retina..Curr Eye Res,2008;33:81-90
10、Jufeng Zhang#, Zhanli Wang, Fang Wei, Wei Qiu, Liangren Zhang, Qian Huang.. Computational modeling and functional analysis of Herpes simplex virus type-1 thymidine kinase and Escherichia coli cytosine deaminase fusion protein..Biochem Biophys Res Commun,2007;361:946-952
11、Hui Yu#, Jihong Wu, Huiming Li, Zhanli Wang, Xiafang Chen, Yuhua Tian, Miaoying Yi, Xunda Ji, Jialie Ma, Qian Huang.. nhibition of corneal neovascularization by recombinant adenovirus mediated sFlk-1 expression.Biochem Biophys Res Commun,2007;360:46-50
12、Qian Huang#, XiuWu Zhang, He Wang, Bin Yan, Mark W. Dewhirst, and ChuanYuan Li. A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells.Clinical Cancer Research,2004;10:1439-1445
13、Qian Huang#, JimK.H, Frank Lohr, Li Zhang, Rod Brun, Jeniffer Lanzen, John B. Little, Mark W. Dewhirst and Chuan-yuan Li. Heat-induced gene expression as a novel targeted cancer gene therapy strategy.Cancer Research,2000;60:3435-3439
14、Chuan-yuan Li, Siqing Shan,Qian Huang*, Rod Brun, Jeniffer Lanzen, Kang Hu, Pengnian Lin, and Mark W. Dewhirst. Initial stages of tumor cell-induced angiogenesis: Evaluation via skin window chambers in rodent models..Journal of the National Cancer Institute,2000;92:143-147.
15、Qian Huang*, Siqing Shan, Rod D. Braun, Jennifer Lanzen, Gopal Anyrhambatla, Garheng Kong, Michael Borelli, Peter Corry, Mark W. Dewhirst, and Chuan-yuan Li. . Noninvasive visualization of tumors in radent dorsal skin window chambers..Nature Biotechnology,1999;17:1033-1035
