基本介紹
- 中文名：魏華
- 民族：漢族
- 出生地：湖北武漢
- 出生日期：1982年2月
- 畢業院校：武漢大學
- 學位/學歷：理學博士
- 專業方向：高分子化學和生物醫用高分子材料
人物履歷,研究方向,科研項目,科研論文,
人物履歷
2000年9月至2004年6月畢業於武漢大學化學與分子科學學院化學基地班專業，獲理學學士學位，期間（2003年9月－2004年6月）赴中國科學院長春套用化學研究所高分子物理與化學國家重點實驗室交流，完成本科畢業設計（導師：姬相玲研究員）。
2004年9月至2009年6月在武漢大學化學與分子科學學院生物醫用高分子材料教育部重點實驗室高分子化學與物理專業獲理學博士學位（導師：卓仁禧院士和張先正教授）。
2010年2月至2011年8月在澳大利亞悉尼大學化學與生物分子工程系從事博士後研究（合作導師：Fariba Dehghani教授），同時與悉尼大學化學系聚合物與膠體重點實驗室（Key Centre for Polymer and Colloids，KCPC）主任Sebastien Perrier教授開展合作研究。
2011年9月至2014年8月在美國西雅圖華盛頓大學生物工程系任高級研究員（合作導師：Suzie H. Pun教授）。
2014年9月全職回國工作，加盟蘭州大學化學化工學院。
2017年1月擔任蘭州大學化學化工學院高分子科學與工程研究所所長、黨支部書記。
2019年11月南華大學全職教授。
研究方向
研究領域主要集中在高分子化學和生物醫用高分子材料，如利用可控聚合設計和製備智慧型藥物、基因載體材料，並通過體外細胞實驗和體內動物實驗評價其療效。
獲三星獎學金、寶鋼優秀學生特等獎學金、2010年湖北省優秀博士論文、2011年全國優秀博士論文提名獎、悉尼大學博士後獎學金等榮譽和獎勵。
科研項目
1. 第十一批中組部青年人才項目。
2. 國家自然科學基金面上項目“新型花形聚合物前藥載體的設計、合成及其腫瘤靶向性能研究”，項目號：51473072。
3. 國家自然科學基金青年基金項目“新型還原敏感性星形陽離子共聚物的設計、合成及其作為非病毒基因載體在體外和體內轉染效果的研究”，項目號21504035。
2. 國家自然科學基金面上項目“新型花形聚合物前藥載體的設計、合成及其腫瘤靶向性能研究”，項目號：51473072。
3. 國家自然科學基金青年基金項目“新型還原敏感性星形陽離子共聚物的設計、合成及其作為非病毒基因載體在體外和體內轉染效果的研究”，項目號21504035。
科研論文
1. Yunfei Wang, Zhizhen Wu, Zongwei Ma, Xiaoyan Tu, Sijie Zhao, Baoyan Wang, Liwei Ma, Hua Wei*. Promotion of micelle stability using cyclic hydrophilic moiety. Polymer Chemistry 2018. (IF: 5.375, Accepted on 04/16/2018)
2. Mingqi Wang, Yunfei Wang, Sijie Zhao, Xiaolong Zhang, Hua Wei*. Fabrication of reduction-responsive star-shaped amphiphilic block copolymers with click coupling-generated block junctions toward enhanced therapeutic efficacy. Macromolecular Chemistry and Physics 2018. (IF: 2.5, Accepted on 04/04/2018)
3. Xiaoyan Tu, Chao Meng, Xiaolong Zhang, Miaoge Jin, Xianshuo Zhang, Xuezhi Zhao, Yunfei Wang, Liwei Ma, Baoyan Wang, Minghu Liu, Hua Wei*. Fabrication of reduction-sensitive amphiphilic cyclic brush copolymer for controlled drug release. Macromolecular Bioscience 2018. (IF: 3.238, Accepted on 04/03/2018)
4. Huiru Yang, Xuezhi Zhao, Xiaolong Zhang, Liwei Ma, Baoyan Wang, Hua Wei*. Optimization of bioreducible micelles self-assembled from amphiphilic hyperbranched block copolymers for drug delivery. Journal of Polymer Science Part A: Polymer Chemistry 2018. (IF: 2.952, Accepted on 3/30/2018)
5. Xuezhi Zhao, Kaicheng Deng, Fangjun Liu, Xiaolong Zhang, Huiru Yang, Jinlei Peng, Liwei Ma, Baoyan Wang, Hua Wei*. Fabrication of conjugated amphiphilic triblock copolymer for drug delivery and fluorescence cell imaging. ACS Biomaterials Science and Engineering 2018, 4, 566-575. (IF: 3.234)
6. Xiaoyan Tu, Chao Meng, Yunfei Wang, Liwei Ma, Baoyan Wang, Jinlin He, Peihong Ni, Xiangling Ji, Mingzhu Liu, Hua Wei*. Fabrication of thermo-sensitive cyclic brush copolymer with enhanced therapeutic efficacy for anticancer drug delivery. Macromolecular Rapid Communications 2018, 1700744. (IF: 4.265, Selected as Back Cover)
7. Luping Zheng, Yunfei Wang, Xianshuo Zhang, Liwei Ma, Baoyan Wang, Xiangling Ji, Hua Wei*. Fabrication of hyperbranched block-statistical copolymer-based prodrug with dual sensitivities for controlled release. Bioconjugate Chemistry 2018, 29, 190-202. (IF: 4.818)
8. Cai Zuo, Jinlei Peng, Yong Cong, Xianyin Dai, Xiaolong Zhang, Sijie Zhao, Xianshuo Zhang, Liwei Ma, Baoyan Wang, Hua Wei*. Fabrication of supramolecular star-shaped amphiphilic copolymers for ROS-triggered drug release. Journal of Colloid and Interface Science 2018, 514, 122-131. (IF: 4.233)
9. Xiaoyan Tu, Chao Meng, Zhe Liu, Lu Sun, Xianshuo Zhang, Ming kui Zhang, Mingrui Sun, Liwei Ma, Mingzhu Liu, Hua Wei*. Synthesis and phase transition of poly(N-isopropylacrylamide)-based thermo-sensitive cyclic brush polymer. Polymers 2017, 9, 301. (IF: 3.364)
10. Xufeng Zhou, Cong Chang, Yang Zhou, Lu Sun, Hua Xiang, Sijie Zhao, Liwei Ma, Guohua Zheng, Mingzhu Liu, Hua Wei*. A comparison study to investigate the effect of the drug-loading site on its delivey efficacy using double hydrophilic block copolymer-based prodrugs. Journal of Materials Chemistry B 2017, 5, 4443-4454. (IF: 4.543, Selected as Journal of Materials Chemistry B Emerging Investigators 2017 and Back Cover)
11. Lu Sun L, Yang Zhou, Xufeng Zhou, Qiang Fu, Sijie Zhao, Xiaoyan Tu, Xiaolong Zhang, Liwei Ma, Mingzhu Liu, Hua Wei*. Dual transitions of toothbrush-like double hydrophilic block copolymers. Polymer Chemistry 2017, 8, 500-504. (IF: 5.375)
12. Sijie Zhao, Huiru Yang, Cai Zuo, Lu Sun, Liwei Ma, Hua Wei*. pH-sensitive drug release of star-shaped micelles with OEG brush corona. RSC Advances 2016, 6, 111217-111225. (IF: 3.108)
13. Cai Zuo, Xianyin Dai, Sijie Zhao, Xiaoning Liu, Shenglong Ding, Liwei Ma, Mingzhu Liu, Hua Wei*. Fabrication of dual-redox responsive supramolecular copolymers using a reducible β-cyclodextran-ferrocene double-head unit. ACS Macro Letters 2016, 5, 873-878. (IF: 6.185)
14. Xiaoyan Tu, Minghu Liu, Hua Wei*. Recent progress on cyclic polymers: synthesis, bioproperties, and biomedical applications. Journal of Polymer Science Part A: Polymer Chemistry 2016, 54, 1447-1458. (IF: 2.952, Invited review)
15. Hua Wei*, Cuiyun Yu. Cyclodextrin-functionalized polymers as drug carriers for cancer therapy. Biomaterials Science 2015, 3, 1050-1060. (IF: 4.210, Invited review)
2. Mingqi Wang, Yunfei Wang, Sijie Zhao, Xiaolong Zhang, Hua Wei*. Fabrication of reduction-responsive star-shaped amphiphilic block copolymers with click coupling-generated block junctions toward enhanced therapeutic efficacy. Macromolecular Chemistry and Physics 2018. (IF: 2.5, Accepted on 04/04/2018)
3. Xiaoyan Tu, Chao Meng, Xiaolong Zhang, Miaoge Jin, Xianshuo Zhang, Xuezhi Zhao, Yunfei Wang, Liwei Ma, Baoyan Wang, Minghu Liu, Hua Wei*. Fabrication of reduction-sensitive amphiphilic cyclic brush copolymer for controlled drug release. Macromolecular Bioscience 2018. (IF: 3.238, Accepted on 04/03/2018)
4. Huiru Yang, Xuezhi Zhao, Xiaolong Zhang, Liwei Ma, Baoyan Wang, Hua Wei*. Optimization of bioreducible micelles self-assembled from amphiphilic hyperbranched block copolymers for drug delivery. Journal of Polymer Science Part A: Polymer Chemistry 2018. (IF: 2.952, Accepted on 3/30/2018)
5. Xuezhi Zhao, Kaicheng Deng, Fangjun Liu, Xiaolong Zhang, Huiru Yang, Jinlei Peng, Liwei Ma, Baoyan Wang, Hua Wei*. Fabrication of conjugated amphiphilic triblock copolymer for drug delivery and fluorescence cell imaging. ACS Biomaterials Science and Engineering 2018, 4, 566-575. (IF: 3.234)
6. Xiaoyan Tu, Chao Meng, Yunfei Wang, Liwei Ma, Baoyan Wang, Jinlin He, Peihong Ni, Xiangling Ji, Mingzhu Liu, Hua Wei*. Fabrication of thermo-sensitive cyclic brush copolymer with enhanced therapeutic efficacy for anticancer drug delivery. Macromolecular Rapid Communications 2018, 1700744. (IF: 4.265, Selected as Back Cover)
7. Luping Zheng, Yunfei Wang, Xianshuo Zhang, Liwei Ma, Baoyan Wang, Xiangling Ji, Hua Wei*. Fabrication of hyperbranched block-statistical copolymer-based prodrug with dual sensitivities for controlled release. Bioconjugate Chemistry 2018, 29, 190-202. (IF: 4.818)
8. Cai Zuo, Jinlei Peng, Yong Cong, Xianyin Dai, Xiaolong Zhang, Sijie Zhao, Xianshuo Zhang, Liwei Ma, Baoyan Wang, Hua Wei*. Fabrication of supramolecular star-shaped amphiphilic copolymers for ROS-triggered drug release. Journal of Colloid and Interface Science 2018, 514, 122-131. (IF: 4.233)
9. Xiaoyan Tu, Chao Meng, Zhe Liu, Lu Sun, Xianshuo Zhang, Ming kui Zhang, Mingrui Sun, Liwei Ma, Mingzhu Liu, Hua Wei*. Synthesis and phase transition of poly(N-isopropylacrylamide)-based thermo-sensitive cyclic brush polymer. Polymers 2017, 9, 301. (IF: 3.364)
10. Xufeng Zhou, Cong Chang, Yang Zhou, Lu Sun, Hua Xiang, Sijie Zhao, Liwei Ma, Guohua Zheng, Mingzhu Liu, Hua Wei*. A comparison study to investigate the effect of the drug-loading site on its delivey efficacy using double hydrophilic block copolymer-based prodrugs. Journal of Materials Chemistry B 2017, 5, 4443-4454. (IF: 4.543, Selected as Journal of Materials Chemistry B Emerging Investigators 2017 and Back Cover)
11. Lu Sun L, Yang Zhou, Xufeng Zhou, Qiang Fu, Sijie Zhao, Xiaoyan Tu, Xiaolong Zhang, Liwei Ma, Mingzhu Liu, Hua Wei*. Dual transitions of toothbrush-like double hydrophilic block copolymers. Polymer Chemistry 2017, 8, 500-504. (IF: 5.375)
12. Sijie Zhao, Huiru Yang, Cai Zuo, Lu Sun, Liwei Ma, Hua Wei*. pH-sensitive drug release of star-shaped micelles with OEG brush corona. RSC Advances 2016, 6, 111217-111225. (IF: 3.108)
13. Cai Zuo, Xianyin Dai, Sijie Zhao, Xiaoning Liu, Shenglong Ding, Liwei Ma, Mingzhu Liu, Hua Wei*. Fabrication of dual-redox responsive supramolecular copolymers using a reducible β-cyclodextran-ferrocene double-head unit. ACS Macro Letters 2016, 5, 873-878. (IF: 6.185)
14. Xiaoyan Tu, Minghu Liu, Hua Wei*. Recent progress on cyclic polymers: synthesis, bioproperties, and biomedical applications. Journal of Polymer Science Part A: Polymer Chemistry 2016, 54, 1447-1458. (IF: 2.952, Invited review)
15. Hua Wei*, Cuiyun Yu. Cyclodextrin-functionalized polymers as drug carriers for cancer therapy. Biomaterials Science 2015, 3, 1050-1060. (IF: 4.210, Invited review)
16. Wang CE, Wei H (共同第一作者), Tan N, Boydston AJ, Pun SH. Sunflower polymers for folate-mediated drug delivery. Biomacromolecules 2016, 17, 69-75. (IF: 5.246)
17. Wei H, Pun SH. Double-head agents: A powerful tool for synthesizing functional biomaterials. Material Matters 2015, 10, 11-14. (Invited review)
18. Wei H, Wang CE, Tan N, Boydston AJ, Pun SH. ATRP synthesis of sunflower polymers using cyclic multimacroinitiators. ACS Macro Letters 2015, 4, 938-941. (IF: 6.185)
19. Wei H, Zhuo RX, Zhang XZ. Design and development of polymeric micelles with cleavable links for intracellular drug delivery. Progress in Polymer Science 2013, 38, 503-535. (IF: 25.766)
20. Wei H, Chu DSH, Zhao J, Pahang JA, Pun SH. Synthesis and evaluation of cyclic cationic polymers for nucleic acid delivery. ACS Macro Letters 2013, 2, 1047-1050. (IF: 6.185)
21. Wei H, Volpatti LR, Sellers DL, Maris DO, Andrews IW, Hemphill AS, Chan LW, Chu DSH, Horner PJ, Pun SH. Dual-responsive, stabilized nanoparticles for efficient in vivo plasmid delivery. Angewandte Chemie International Edition 2013, 52, 5377-5381. (IF: 11.994, selected as Very Important Paper (VIP))
22. Wei H, Pahang JA, Pun SH. Optimization of brush-like cationic copolymers for non-viral gene delivery. Biomacromolecules 2013, 14, 275-284. (IF: 5.246)
23. Wei H, Schellinger JG, Chu DSH, Pun SH. Neuron-targeted copolymers with sheddable shielding blocks synthesized using a reducible, RAFT-ATRP double-head agent. Journal of the American Chemical Society 2012, 134, 16554-16557. (IF: 13.858)
17. Wei H, Pun SH. Double-head agents: A powerful tool for synthesizing functional biomaterials. Material Matters 2015, 10, 11-14. (Invited review)
18. Wei H, Wang CE, Tan N, Boydston AJ, Pun SH. ATRP synthesis of sunflower polymers using cyclic multimacroinitiators. ACS Macro Letters 2015, 4, 938-941. (IF: 6.185)
19. Wei H, Zhuo RX, Zhang XZ. Design and development of polymeric micelles with cleavable links for intracellular drug delivery. Progress in Polymer Science 2013, 38, 503-535. (IF: 25.766)
20. Wei H, Chu DSH, Zhao J, Pahang JA, Pun SH. Synthesis and evaluation of cyclic cationic polymers for nucleic acid delivery. ACS Macro Letters 2013, 2, 1047-1050. (IF: 6.185)
21. Wei H, Volpatti LR, Sellers DL, Maris DO, Andrews IW, Hemphill AS, Chan LW, Chu DSH, Horner PJ, Pun SH. Dual-responsive, stabilized nanoparticles for efficient in vivo plasmid delivery. Angewandte Chemie International Edition 2013, 52, 5377-5381. (IF: 11.994, selected as Very Important Paper (VIP))
22. Wei H, Pahang JA, Pun SH. Optimization of brush-like cationic copolymers for non-viral gene delivery. Biomacromolecules 2013, 14, 275-284. (IF: 5.246)
23. Wei H, Schellinger JG, Chu DSH, Pun SH. Neuron-targeted copolymers with sheddable shielding blocks synthesized using a reducible, RAFT-ATRP double-head agent. Journal of the American Chemical Society 2012, 134, 16554-16557. (IF: 13.858)
